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The map label for this gene is thiD [H]

Identifier: 108797544

GI number: 108797544

Start: 624291

End: 625139

Strand: Reverse

Name: thiD [H]

Synonym: Mmcs_0564

Alternate gene names: 108797544

Gene position: 625139-624291 (Counterclockwise)

Preceding gene: 108797547

Following gene: 108797543

Centisome position: 10.96

GC content: 70.55

Gene sequence:

>849_bases
ATGACCGATACGCGATACCTGCCACTCGCCCCACCCGGCCAGACCCCGGCGCGGGTGATGACCATCGCGGGCACCGACTC
CGGCGGTGGCGCGGGGATCCAGGCCGACTCCCGCACCTTCGCCATGCTCGGCGTCCACGGCTGTGTCGCGGTGGTCGCCG
TCACCGTACAGAACTCCGTGGGCGTCAAGGGTTTCCACGAGATCCCCATCGACGTCATCACCGGGCAGATCGAGGCGGTG
GTCTCCGACATCGGCATCCAGGCGGCCAAGACCGGGATGCTGGCCTCTTCGGAGATCATCACCGCCGTCGCCGAGACGTG
GCGTCGCCTGCGGCCCGCACCGCTGGTCGTCGACCCGGTGTGCGCCTCCATGCACGGCGATCCGCTGCTGCATCCGTCGG
CGCTCGACGCACTGCGCTCCGAACTGTTCCCCCTCGCCACCCTGGTCACCCCCAACCTCGACGAGGTGCGGCTGATCACC
GGGATCGACGTCACCGACGCCGCCTCCCAGCGCGACGCGGCGCGGGCGCTGCATGCGCTCGGCCCACAGTGGGCACTGGT
CAAAGGCGGCCACCTGCGCTCGTCGGCGTACAGCCCCGATCTGCTGTTCGACGGCTCCGAGTTCCACGAGTTCGGCGCCG
ACCGCATCGACACCGGCCACGACCACGGCGCGGGCGACACCCTGGCGGCCGCCACGGCCTCCGCACTCGCGCACGGCTAC
TCCGTCCCCGACGCGGTCGCGTTCGCCAAACAGTGGGTGACCGAATGTCTGCGCGCCGCATACCCGTTGGGCCACGGCCA
CGGTCCGGTCTCCGCGCTGTTCAGGCTGAGCGCCGATGAACCTCGATGA

Upstream 100 bases:

>100_bases
CCACCGACCACGCGGGAGCGCGCACCAGCGCGCTGAGAGGACGACTGGGGTCGTCGACCGTACGAACCTGACCGGGTAAT
GCCGGCGTAGGGAGTTTTCG

Downstream 100 bases:

>100_bases
CATCGCCGGCGTCGCCCACGAACCGGCGGGCACACCGCGCGGGGTGGTGCTGCTGACCCACGGCGCCGGGGGTAACCGGG
ACGCGCCGCTGCTGGTCAGG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MTDTRYLPLAPPGQTPARVMTIAGTDSGGGAGIQADSRTFAMLGVHGCVAVVAVTVQNSVGVKGFHEIPIDVITGQIEAV
VSDIGIQAAKTGMLASSEIITAVAETWRRLRPAPLVVDPVCASMHGDPLLHPSALDALRSELFPLATLVTPNLDEVRLIT
GIDVTDAASQRDAARALHALGPQWALVKGGHLRSSAYSPDLLFDGSEFHEFGADRIDTGHDHGAGDTLAAATASALAHGY
SVPDAVAFAKQWVTECLRAAYPLGHGHGPVSALFRLSADEPR

Sequences:

>Translated_282_residues
MTDTRYLPLAPPGQTPARVMTIAGTDSGGGAGIQADSRTFAMLGVHGCVAVVAVTVQNSVGVKGFHEIPIDVITGQIEAV
VSDIGIQAAKTGMLASSEIITAVAETWRRLRPAPLVVDPVCASMHGDPLLHPSALDALRSELFPLATLVTPNLDEVRLIT
GIDVTDAASQRDAARALHALGPQWALVKGGHLRSSAYSPDLLFDGSEFHEFGADRIDTGHDHGAGDTLAAATASALAHGY
SVPDAVAFAKQWVTECLRAAYPLGHGHGPVSALFRLSADEPR
>Mature_281_residues
TDTRYLPLAPPGQTPARVMTIAGTDSGGGAGIQADSRTFAMLGVHGCVAVVAVTVQNSVGVKGFHEIPIDVITGQIEAVV
SDIGIQAAKTGMLASSEIITAVAETWRRLRPAPLVVDPVCASMHGDPLLHPSALDALRSELFPLATLVTPNLDEVRLITG
IDVTDAASQRDAARALHALGPQWALVKGGHLRSSAYSPDLLFDGSEFHEFGADRIDTGHDHGAGDTLAAATASALAHGYS
VPDAVAFAKQWVTECLRAAYPLGHGHGPVSALFRLSADEPR

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=42.578125, Blast_Score=179, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6325378, Length=264, Percent_Identity=32.9545454545455, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324517, Length=303, Percent_Identity=32.3432343234323, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324997, Length=299, Percent_Identity=31.438127090301, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29388; Mature: 29256

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTRYLPLAPPGQTPARVMTIAGTDSGGGAGIQADSRTFAMLGVHGCVAVVAVTVQNSV
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCC
GVKGFHEIPIDVITGQIEAVVSDIGIQAAKTGMLASSEIITAVAETWRRLRPAPLVVDPV
CCCCHHHCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECHH
CASMHGDPLLHPSALDALRSELFPLATLVTPNLDEVRLITGIDVTDAASQRDAARALHAL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
GPQWALVKGGHLRSSAYSPDLLFDGSEFHEFGADRIDTGHDHGAGDTLAAATASALAHGY
CCCEEEEECCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
SVPDAVAFAKQWVTECLRAAYPLGHGHGPVSALFRLSADEPR
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDTRYLPLAPPGQTPARVMTIAGTDSGGGAGIQADSRTFAMLGVHGCVAVVAVTVQNSV
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCC
GVKGFHEIPIDVITGQIEAVVSDIGIQAAKTGMLASSEIITAVAETWRRLRPAPLVVDPV
CCCCHHHCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECHH
CASMHGDPLLHPSALDALRSELFPLATLVTPNLDEVRLITGIDVTDAASQRDAARALHAL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHC
GPQWALVKGGHLRSSAYSPDLLFDGSEFHEFGADRIDTGHDHGAGDTLAAATASALAHGY
CCCEEEEECCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
SVPDAVAFAKQWVTECLRAAYPLGHGHGPVSALFRLSADEPR
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]