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The map label for this gene is czcD [H]

Identifier: 108797486

GI number: 108797486

Start: 561580

End: 562476

Strand: Reverse

Name: czcD [H]

Synonym: Mmcs_0506

Alternate gene names: 108797486

Gene position: 562476-561580 (Counterclockwise)

Preceding gene: 108797487

Following gene: 108797484

Centisome position: 9.86

GC content: 70.23

Gene sequence:

>897_bases
ATGGGCGCCGGTCACGATCATCAGCACGGGACCGACACCCGTGTCAGCAGGATGCTCATCGCCGCCGCCGTCCTCACCGC
GTTCTTCGTCCTCGAACTGGTCACCGCGCTGTGGATCGACTCGATCGCCCTGCTCGCGGACGCCGGGCACATGCTCACCG
ACCTCGTCGCGATGTTCATGGGGCTGACCGCCGTCCTGCTCGCCCGGCGCGGCAGCGCCTCGCCCGCCCGCACCTACGGC
TGGCACCGGGCCGAGGTGTTCACCGCGGTCGCCAACGCCGTCCTGCTGCTCGCGATGGCGGTGTTCATCCTCTACGAGGC
GGTTGAACGACTCGGCGACGCGCCGGACGTTCCGGGTGTGCCGATGATCGTGGTCGCACTGGCCGGGCTGGCCGCCAACG
CCGTGGTCGTCCTGCTGCTGCGGTCGCACTCCAAGGAGAGCCTCGCGGTCAAGGGCGCCTACATGGAGGTCGTCGCCGAT
ACGGTCGGCAGCATCGGGGTGCTCATCGCGGGCATCGTGACGGTGACGACAAGCTGGCCGTACGCCGACGTCGTGGTGGC
GGTGTTCGTCGCGCTGTGGGTGCTGCCGAGGGCGATCTCGCTGGCCCGGGCGGCCCTGCGGATCCTCTCGGAATCCTCGC
CGGCCCACATCGACGTCGACGAGCTCAAGACGGCGCTGTGCGCGGTCGAGGGCGTGACCGAGGTGCACGATCTGCACGTG
TGGACGCTGGTCCCGGGCAAGGACGTCGTGACCGCGCATCTGACGTCGGCCCGCGATTCGGCCCGCGTGCTCGACGACGC
CCGCGCGGTGCTGGCCGCCCGCGGGCTGGACCATGCGACGGTGCAGGTCGAGCCGCCCGGTGAAACCGACTGCAACTGCG
AGAGCAACGACTGGTAG

Upstream 100 bases:

>100_bases
CGATCGGCGGTCAGCTGACCCGCTTCTGGTCTGCCTGGCTGTAGTGCGCGGGCGGCGGGGCCTCTTGCGATATATGCGAC
TTCACGCATAGATTGCTGGC

Downstream 100 bases:

>100_bases
CGGCGCTCCCCCGACCGCGACGGCCTCAGCTGAGCCCGAACTCCGCCCGCGCCGAGGGATCGCAGTCGTCGAGCAGGTCG
AGGCAGCGCTGGTACTCGTC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MGAGHDHQHGTDTRVSRMLIAAAVLTAFFVLELVTALWIDSIALLADAGHMLTDLVAMFMGLTAVLLARRGSASPARTYG
WHRAEVFTAVANAVLLLAMAVFILYEAVERLGDAPDVPGVPMIVVALAGLAANAVVVLLLRSHSKESLAVKGAYMEVVAD
TVGSIGVLIAGIVTVTTSWPYADVVVAVFVALWVLPRAISLARAALRILSESSPAHIDVDELKTALCAVEGVTEVHDLHV
WTLVPGKDVVTAHLTSARDSARVLDDARAVLAARGLDHATVQVEPPGETDCNCESNDW

Sequences:

>Translated_298_residues
MGAGHDHQHGTDTRVSRMLIAAAVLTAFFVLELVTALWIDSIALLADAGHMLTDLVAMFMGLTAVLLARRGSASPARTYG
WHRAEVFTAVANAVLLLAMAVFILYEAVERLGDAPDVPGVPMIVVALAGLAANAVVVLLLRSHSKESLAVKGAYMEVVAD
TVGSIGVLIAGIVTVTTSWPYADVVVAVFVALWVLPRAISLARAALRILSESSPAHIDVDELKTALCAVEGVTEVHDLHV
WTLVPGKDVVTAHLTSARDSARVLDDARAVLAARGLDHATVQVEPPGETDCNCESNDW
>Mature_297_residues
GAGHDHQHGTDTRVSRMLIAAAVLTAFFVLELVTALWIDSIALLADAGHMLTDLVAMFMGLTAVLLARRGSASPARTYGW
HRAEVFTAVANAVLLLAMAVFILYEAVERLGDAPDVPGVPMIVVALAGLAANAVVVLLLRSHSKESLAVKGAYMEVVADT
VGSIGVLIAGIVTVTTSWPYADVVVAVFVALWVLPRAISLARAALRILSESSPAHIDVDELKTALCAVEGVTEVHDLHVW
TLVPGKDVVTAHLTSARDSARVLDDARAVLAARGLDHATVQVEPPGETDCNCESNDW

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=319, Percent_Identity=30.0940438871473, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=27.3615635179153, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI289803013, Length=291, Percent_Identity=28.5223367697594, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289803009, Length=291, Percent_Identity=28.5223367697594, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289803007, Length=291, Percent_Identity=28.5223367697594, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI289803003, Length=291, Percent_Identity=28.5223367697594, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI64762489, Length=291, Percent_Identity=28.5223367697594, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI20070323, Length=322, Percent_Identity=25.4658385093168, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=30.2013422818792, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI52351208, Length=133, Percent_Identity=39.0977443609023, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI14210520, Length=228, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI52352803, Length=130, Percent_Identity=39.2307692307692, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI222080086, Length=129, Percent_Identity=30.2325581395349, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI40255009, Length=129, Percent_Identity=30.2325581395349, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=36.1111111111111, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17555794, Length=314, Percent_Identity=31.5286624203822, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17555796, Length=311, Percent_Identity=31.5112540192926, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193210990, Length=316, Percent_Identity=28.1645569620253, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32564488, Length=304, Percent_Identity=25.3289473684211, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323899, Length=140, Percent_Identity=35, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=123, Percent_Identity=40.650406504065, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=166, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583858, Length=338, Percent_Identity=28.1065088757396, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656728, Length=337, Percent_Identity=27.299703264095, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656724, Length=337, Percent_Identity=27.299703264095, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656720, Length=337, Percent_Identity=27.299703264095, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656715, Length=337, Percent_Identity=27.299703264095, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357035, Length=337, Percent_Identity=27.299703264095, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585900, Length=152, Percent_Identity=30.2631578947368, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585898, Length=152, Percent_Identity=30.2631578947368, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585896, Length=152, Percent_Identity=30.2631578947368, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921672, Length=152, Percent_Identity=30.2631578947368, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24645863, Length=109, Percent_Identity=35.7798165137615, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=27.4647887323944, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=27.4647887323944, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 31462; Mature: 31331

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAGHDHQHGTDTRVSRMLIAAAVLTAFFVLELVTALWIDSIALLADAGHMLTDLVAMFM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
GLTAVLLARRGSASPARTYGWHRAEVFTAVANAVLLLAMAVFILYEAVERLGDAPDVPGV
HHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
PMIVVALAGLAANAVVVLLLRSHSKESLAVKGAYMEVVADTVGSIGVLIAGIVTVTTSWP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YADVVVAVFVALWVLPRAISLARAALRILSESSPAHIDVDELKTALCAVEGVTEVHDLHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHEEE
WTLVPGKDVVTAHLTSARDSARVLDDARAVLAARGLDHATVQVEPPGETDCNCESNDW
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
GAGHDHQHGTDTRVSRMLIAAAVLTAFFVLELVTALWIDSIALLADAGHMLTDLVAMFM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
GLTAVLLARRGSASPARTYGWHRAEVFTAVANAVLLLAMAVFILYEAVERLGDAPDVPGV
HHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
PMIVVALAGLAANAVVVLLLRSHSKESLAVKGAYMEVVADTVGSIGVLIAGIVTVTTSWP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
YADVVVAVFVALWVLPRAISLARAALRILSESSPAHIDVDELKTALCAVEGVTEVHDLHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHEEE
WTLVPGKDVVTAHLTSARDSARVLDDARAVLAARGLDHATVQVEPPGETDCNCESNDW
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA