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The map label for this gene is fabG [H]

Identifier: 108797479

GI number: 108797479

Start: 555553

End: 556239

Strand: Reverse

Name: fabG [H]

Synonym: Mmcs_0499

Alternate gene names: 108797479

Gene position: 556239-555553 (Counterclockwise)

Preceding gene: 108797481

Following gene: 108797467

Centisome position: 9.75

GC content: 65.79

Gene sequence:

>687_bases
ATGAACACCGAAAACGTCGTAGCCCTGGTGAGCGGGGCCAATCGCGGACTGTGTCGGCACTTCGCCGAACAACTCATCGC
CCGGGGCGCCAAGGTCTACGCGGGCGCCCGTAAACCCGAGACCGTCGACCTGCCCGGCGCGATACCGGTGCAACTCGACA
TCACAGATCCCGAATCCATCAGGCGCGCTGCGGAGTTCGCGGCCGATGTCAACGTCGTCATCAACAACGCCGGCGTCTCG
ACGCAATCCACTCTGCTCGACGGATCACTCGACGACATCCGGCTGGAGATGGAGACGCACTACTTCGGCACGCTGCAGGT
GCTCCGGGCGTTCGCCCCGATCATCGAACGTAACGGCGGAGGGGCCGTCCTCAACGTGCTGTCGGTGTTGTCGTGGTTCC
ATCCGCCGACCAGCGGTGCCTACTCGGCCGCGAAGGCCGCGGCCTGGGCGCTGACCGACGCGGTGCGAACAGAGTTGGCG
CCAAAGGGAATTCACGTCGCCGCACTGCACGTCGGCTACATGGACACCGATATGGTCAGCTACATCCCCGCCGACCAGAA
GTCCGACCCGGGTGCCATAGCGGAACTCGCGCTCGACGGCCTGTTCGCCGGTGAGAACGAGATCCTCGGCGACGCGTTGA
CCCGCGACGTGAAGGCGGCGCTGTCGGGGGCGCCACGTCAGCGGTAG

Upstream 100 bases:

>100_bases
AGTGGTGATGTCATCGATGCTCCTCGCCTGTGATGGTGCCACGGGGAATGTCGTCAGCGCGATCGGCGTTCCCCCGGAAG
TCCGAACTGGAGGAGGCGCC

Downstream 100 bases:

>100_bases
CAGTATGAGTCCGACGAAGCGTCGCCACCCTGCAGCCGGATCTGATGCACCCGCAGGCCGCGGAATTCCTCGCCGTGCGG
GAAGAAGCTCTCGTCGATAC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MNTENVVALVSGANRGLCRHFAEQLIARGAKVYAGARKPETVDLPGAIPVQLDITDPESIRRAAEFAADVNVVINNAGVS
TQSTLLDGSLDDIRLEMETHYFGTLQVLRAFAPIIERNGGGAVLNVLSVLSWFHPPTSGAYSAAKAAAWALTDAVRTELA
PKGIHVAALHVGYMDTDMVSYIPADQKSDPGAIAELALDGLFAGENEILGDALTRDVKAALSGAPRQR

Sequences:

>Translated_228_residues
MNTENVVALVSGANRGLCRHFAEQLIARGAKVYAGARKPETVDLPGAIPVQLDITDPESIRRAAEFAADVNVVINNAGVS
TQSTLLDGSLDDIRLEMETHYFGTLQVLRAFAPIIERNGGGAVLNVLSVLSWFHPPTSGAYSAAKAAAWALTDAVRTELA
PKGIHVAALHVGYMDTDMVSYIPADQKSDPGAIAELALDGLFAGENEILGDALTRDVKAALSGAPRQR
>Mature_228_residues
MNTENVVALVSGANRGLCRHFAEQLIARGAKVYAGARKPETVDLPGAIPVQLDITDPESIRRAAEFAADVNVVINNAGVS
TQSTLLDGSLDDIRLEMETHYFGTLQVLRAFAPIIERNGGGAVLNVLSVLSWFHPPTSGAYSAAKAAAWALTDAVRTELA
PKGIHVAALHVGYMDTDMVSYIPADQKSDPGAIAELALDGLFAGENEILGDALTRDVKAALSGAPRQR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=202, Percent_Identity=28.7128712871287, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706318, Length=195, Percent_Identity=29.2307692307692, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI223718074, Length=195, Percent_Identity=27.6923076923077, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI119392083, Length=205, Percent_Identity=27.8048780487805, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI7705925, Length=176, Percent_Identity=30.6818181818182, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=202, Percent_Identity=31.6831683168317, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786701, Length=190, Percent_Identity=30.5263157894737, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI87082100, Length=196, Percent_Identity=30.1020408163265, Blast_Score=67, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17570069, Length=189, Percent_Identity=30.1587301587302, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=189, Percent_Identity=29.6296296296296, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358495, Length=247, Percent_Identity=27.5303643724696, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24643142, Length=190, Percent_Identity=29.4736842105263, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116007236, Length=218, Percent_Identity=29.3577981651376, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639444, Length=197, Percent_Identity=27.9187817258883, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 24088; Mature: 24088

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTENVVALVSGANRGLCRHFAEQLIARGAKVYAGARKPETVDLPGAIPVQLDITDPESI
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCEEEEECCCHHHH
RRAAEFAADVNVVINNAGVSTQSTLLDGSLDDIRLEMETHYFGTLQVLRAFAPIIERNGG
HHHHHHHCCEEEEEECCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCC
GAVLNVLSVLSWFHPPTSGAYSAAKAAAWALTDAVRTELAPKGIHVAALHVGYMDTDMVS
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHH
YIPADQKSDPGAIAELALDGLFAGENEILGDALTRDVKAALSGAPRQR
HCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNTENVVALVSGANRGLCRHFAEQLIARGAKVYAGARKPETVDLPGAIPVQLDITDPESI
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCEECCCCCCEEEEECCCHHHH
RRAAEFAADVNVVINNAGVSTQSTLLDGSLDDIRLEMETHYFGTLQVLRAFAPIIERNGG
HHHHHHHCCEEEEEECCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCC
GAVLNVLSVLSWFHPPTSGAYSAAKAAAWALTDAVRTELAPKGIHVAALHVGYMDTDMVS
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHH
YIPADQKSDPGAIAELALDGLFAGENEILGDALTRDVKAALSGAPRQR
HCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1556094; 8905232; 9278503; 1314802 [H]