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The map label for this gene is tenA [H]

Identifier: 108797337

GI number: 108797337

Start: 399087

End: 399776

Strand: Direct

Name: tenA [H]

Synonym: Mmcs_0357

Alternate gene names: 108797337

Gene position: 399087-399776 (Clockwise)

Preceding gene: 108797336

Following gene: 108797338

Centisome position: 6.99

GC content: 69.71

Gene sequence:

>690_bases
ATGGAGACGCCTGACGAATCGACGACGAACACCTGGTCGCAGCGGCTGTGGCACGAGACCGAGCCGATCTTCTCGGCGAT
CATGGCCCACCCGTTCATCTCCGGGCTCACCGACGGCACCCTGGACCCCGAGGTCTTCGCGCACTACGTCGCCCAGGACG
TCCACTACCTGCGCGACTACGCGCGGGCGCTCGCGGTGGTCGGCGCCAAGGCGCCGAGGCTGGCCGACACCGCGATGTTC
GCCCGCCACTCGGCCGAGATCGTCGAGGTGGAGCTGTCGCTGCACGAGACGCTGTTACCCGAGATCGGGCTGGACCCGGC
CGAGCTGGACCGCGTACCGGTGGCCCCCACCACCCGCGCCTACACCAGCTATCTGCTCGCGACGGTCTACGGCGGCAGCT
TCGCCGACGGCCTGGCGGCGATCCTGCCGTGCTACTGGATCTACGCGCGGGTGGGCGAGGAGTTGATCGGACGGGGATCG
CCCGACAGCCGCTACCAACGGTGGATCGACAGCTACGGGGGCGACGAGTTCGCCGCCACCGTCAAAGAGGTGCTCGAGCT
CACCGACCGCGTCGGCCCGACGCTGAAGCCGGCGGAGGAAGCGGCCGCCCGCGCCCACTACGTGACGACGGCACGGTATG
AGTGGATGTTCTTCGATGCGGCGCACCGCCGCGAGGCCTGGCCGGTCTGA

Upstream 100 bases:

>100_bases
ATCGGCGCCGCCGACCACGCCATGTACGCGGCCAAACGCGCCGGCGGCAACCAGTTCCGGCACGACGACCGGAGCGCCTG
CTGCTGATACGTTGGCCGCG

Downstream 100 bases:

>100_bases
CCATGGCGCCACACTCCTTCGACGCACCGGTCCGACGGTGGGAGGACATCCCGGGCTGGTTCGGCTGGCGGCAGGCACAG
GAGGAAGCCGTCGCCCACTT

Product: TenA family transcriptional regulator

Products: NA

Alternate protein names: Thiaminase II; Transcriptional activator tenA [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
METPDESTTNTWSQRLWHETEPIFSAIMAHPFISGLTDGTLDPEVFAHYVAQDVHYLRDYARALAVVGAKAPRLADTAMF
ARHSAEIVEVELSLHETLLPEIGLDPAELDRVPVAPTTRAYTSYLLATVYGGSFADGLAAILPCYWIYARVGEELIGRGS
PDSRYQRWIDSYGGDEFAATVKEVLELTDRVGPTLKPAEEAAARAHYVTTARYEWMFFDAAHRREAWPV

Sequences:

>Translated_229_residues
METPDESTTNTWSQRLWHETEPIFSAIMAHPFISGLTDGTLDPEVFAHYVAQDVHYLRDYARALAVVGAKAPRLADTAMF
ARHSAEIVEVELSLHETLLPEIGLDPAELDRVPVAPTTRAYTSYLLATVYGGSFADGLAAILPCYWIYARVGEELIGRGS
PDSRYQRWIDSYGGDEFAATVKEVLELTDRVGPTLKPAEEAAARAHYVTTARYEWMFFDAAHRREAWPV
>Mature_229_residues
METPDESTTNTWSQRLWHETEPIFSAIMAHPFISGLTDGTLDPEVFAHYVAQDVHYLRDYARALAVVGAKAPRLADTAMF
ARHSAEIVEVELSLHETLLPEIGLDPAELDRVPVAPTTRAYTSYLLATVYGGSFADGLAAILPCYWIYARVGEELIGRGS
PDSRYQRWIDSYGGDEFAATVKEVLELTDRVGPTLKPAEEAAARAHYVTTARYEWMFFDAAHRREAWPV

Specific function: Stimulates the production of several extracellular degradative enzymes at the transcriptional level, probably by interfering with degS and degU, which are required for this effect. Is not an essential protein, but affects the sporulation frequency [H]

COG id: COG0819

COG function: function code K; Putative transcription activator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiaminase-2 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6324517, Length=216, Percent_Identity=27.3148148148148, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325378, Length=213, Percent_Identity=28.169014084507, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324997, Length=214, Percent_Identity=26.6355140186916, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016084
- InterPro:   IPR004305 [H]

Pfam domain/function: PF03070 TENA_THI-4 [H]

EC number: =3.5.99.2 [H]

Molecular weight: Translated: 25593; Mature: 25593

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METPDESTTNTWSQRLWHETEPIFSAIMAHPFISGLTDGTLDPEVFAHYVAQDVHYLRDY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ARALAVVGAKAPRLADTAMFARHSAEIVEVELSLHETLLPEIGLDPAELDRVPVAPTTRA
HHHHHHHCCCCCHHHHHHHHHHHCCHHEEHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHH
YTSYLLATVYGGSFADGLAAILPCYWIYARVGEELIGRGSPDSRYQRWIDSYGGDEFAAT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHH
VKEVLELTDRVGPTLKPAEEAAARAHYVTTARYEWMFFDAAHRREAWPV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEECCHHCCCCCCC
>Mature Secondary Structure
METPDESTTNTWSQRLWHETEPIFSAIMAHPFISGLTDGTLDPEVFAHYVAQDVHYLRDY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
ARALAVVGAKAPRLADTAMFARHSAEIVEVELSLHETLLPEIGLDPAELDRVPVAPTTRA
HHHHHHHCCCCCHHHHHHHHHHHCCHHEEHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHH
YTSYLLATVYGGSFADGLAAILPCYWIYARVGEELIGRGSPDSRYQRWIDSYGGDEFAAT
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHH
VKEVLELTDRVGPTLKPAEEAAARAHYVTTARYEWMFFDAAHRREAWPV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEECCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1898926; 9384377 [H]