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The map label for this gene is yeaP [H]

Identifier: 108797336

GI number: 108797336

Start: 397961

End: 399073

Strand: Direct

Name: yeaP [H]

Synonym: Mmcs_0356

Alternate gene names: 108797336

Gene position: 397961-399073 (Clockwise)

Preceding gene: 108797334

Following gene: 108797337

Centisome position: 6.98

GC content: 69.99

Gene sequence:

>1113_bases
GTGCCAGTGGGTGAAGGGGGGTCGCTGGTGCACTGGTTTCGTCGGTGGTGGCGGCAGCCCGACCACTTCGACTGGATCAC
CGGGTATCTGGCTGCGCGCGGCATGCTCGGGGTGGCGCGCTGGAATCTGGCGTCCAGCACCGTGGCGTTGGCGCTCGTCC
CGGCGGTCCTCGCGATGAGTTCCCGGGGGCCGGATGCCGGGCCGGACCAGGTGCTGAGCCGGATCGCGGTGCTCGGTGGG
TTGTGCGCCGCGACGCTGTGGGTGGTGCGCTGGCCCACCCGCGCGCAGTCCGTCGCCTACATCCTGGCGGCCAACCTGTT
CATCACGCTGGCGTGCTACGTGCAGGACGACCCGATGGTCGGGTTGATGGGCTGTACGGTCTTCGCCACCACCGGCGGCT
ACATCGCGCTGTTCCACACGCCCGGATACATGCTGTACAACTTCGGGGTCGCGCTGTATGTCGGTGTGCTGCAGACGGTT
CGGCTCGCGGTCGAGACCTCTGACCCCGCGTTGGCCGTCGGCCTGCTGCTGCTGGTCCTGGTGCTCAACGTCGCGGTGCC
GTTCGCCGTGCAGGCCATCGTGCATGCGCTGGGGGTGGATCTGCTGCGGGCCGCCCGCGACCCGCTCACAGGCCTGCTCA
ACCGTCGGGCGGTGTACCAGCAGATCGAGCAGCTCCTCAGCTCCCATCGCGACCGGCACGTCCATCTCGCGGTGGCGGTG
GTCGACCTCGACGACTTCAAACAGCTCAACGACAGTCACGGACACGCGATCGGTGACGAGGCGCTCGTCGCCGTCGCCCA
GGCGCTGCGCGCCGGGGCGGGTGAGGGGGCGGTGGTGGGCCGGCTCGGAGGTGAGGAGTTCGTGCTCGCCGAACTGCTCG
AGGCCGGCCAGATCGACCACTGGGCGCAGCGCATGTGCACCGCGGTGGACGTGGTCCCGTTCCCCGTCACCGCCAGCGTC
GGTGTCGCGGCGGTATGCCTGCCCCTGCCCGCCGACGACGATGCACAGACCGTGATCCACATGCTCATCGGCGCCGCCGA
CCACGCCATGTACGCGGCCAAACGCGCCGGCGGCAACCAGTTCCGGCACGACGACCGGAGCGCCTGCTGCTGA

Upstream 100 bases:

>100_bases
TGGGGTCCACCCCGGTGCGTTACCCGCAGCGGTGCCCCGTCAACCCCGCGCTGCGTTAGGCTGCGGCGGGCACTGCCGGT
GGGTTCCAGCGAACTCGTGG

Downstream 100 bases:

>100_bases
TACGTTGGCCGCGATGGAGACGCCTGACGAATCGACGACGAACACCTGGTCGCAGCGGCTGTGGCACGAGACCGAGCCGA
TCTTCTCGGCGATCATGGCC

Product: diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MPVGEGGSLVHWFRRWWRQPDHFDWITGYLAARGMLGVARWNLASSTVALALVPAVLAMSSRGPDAGPDQVLSRIAVLGG
LCAATLWVVRWPTRAQSVAYILAANLFITLACYVQDDPMVGLMGCTVFATTGGYIALFHTPGYMLYNFGVALYVGVLQTV
RLAVETSDPALAVGLLLLVLVLNVAVPFAVQAIVHALGVDLLRAARDPLTGLLNRRAVYQQIEQLLSSHRDRHVHLAVAV
VDLDDFKQLNDSHGHAIGDEALVAVAQALRAGAGEGAVVGRLGGEEFVLAELLEAGQIDHWAQRMCTAVDVVPFPVTASV
GVAAVCLPLPADDDAQTVIHMLIGAADHAMYAAKRAGGNQFRHDDRSACC

Sequences:

>Translated_370_residues
MPVGEGGSLVHWFRRWWRQPDHFDWITGYLAARGMLGVARWNLASSTVALALVPAVLAMSSRGPDAGPDQVLSRIAVLGG
LCAATLWVVRWPTRAQSVAYILAANLFITLACYVQDDPMVGLMGCTVFATTGGYIALFHTPGYMLYNFGVALYVGVLQTV
RLAVETSDPALAVGLLLLVLVLNVAVPFAVQAIVHALGVDLLRAARDPLTGLLNRRAVYQQIEQLLSSHRDRHVHLAVAV
VDLDDFKQLNDSHGHAIGDEALVAVAQALRAGAGEGAVVGRLGGEEFVLAELLEAGQIDHWAQRMCTAVDVVPFPVTASV
GVAAVCLPLPADDDAQTVIHMLIGAADHAMYAAKRAGGNQFRHDDRSACC
>Mature_369_residues
PVGEGGSLVHWFRRWWRQPDHFDWITGYLAARGMLGVARWNLASSTVALALVPAVLAMSSRGPDAGPDQVLSRIAVLGGL
CAATLWVVRWPTRAQSVAYILAANLFITLACYVQDDPMVGLMGCTVFATTGGYIALFHTPGYMLYNFGVALYVGVLQTVR
LAVETSDPALAVGLLLLVLVLNVAVPFAVQAIVHALGVDLLRAARDPLTGLLNRRAVYQQIEQLLSSHRDRHVHLAVAVV
DLDDFKQLNDSHGHAIGDEALVAVAQALRAGAGEGAVVGRLGGEEFVLAELLEAGQIDHWAQRMCTAVDVVPFPVTASVG
VAAVCLPLPADDDAQTVIHMLIGAADHAMYAAKRAGGNQFRHDDRSACC

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=157, Percent_Identity=36.3057324840764, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787802, Length=337, Percent_Identity=25.8160237388724, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788085, Length=186, Percent_Identity=29.5698924731183, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081881, Length=166, Percent_Identity=36.144578313253, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693134, Length=210, Percent_Identity=28.0952380952381, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788956, Length=176, Percent_Identity=34.0909090909091, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786584, Length=164, Percent_Identity=31.0975609756098, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787541, Length=166, Percent_Identity=34.3373493975904, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787262, Length=189, Percent_Identity=30.6878306878307, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787816, Length=169, Percent_Identity=30.1775147928994, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788381, Length=164, Percent_Identity=33.5365853658537, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082007, Length=170, Percent_Identity=30, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 39496; Mature: 39365

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVGEGGSLVHWFRRWWRQPDHFDWITGYLAARGMLGVARWNLASSTVALALVPAVLAMS
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHHH
SRGPDAGPDQVLSRIAVLGGLCAATLWVVRWPTRAQSVAYILAANLFITLACYVQDDPMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCE
GLMGCTVFATTGGYIALFHTPGYMLYNFGVALYVGVLQTVRLAVETSDPALAVGLLLLVL
EHHHHEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VLNVAVPFAVQAIVHALGVDLLRAARDPLTGLLNRRAVYQQIEQLLSSHRDRHVHLAVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VDLDDFKQLNDSHGHAIGDEALVAVAQALRAGAGEGAVVGRLGGEEFVLAELLEAGQIDH
EEHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCHH
WAQRMCTAVDVVPFPVTASVGVAAVCLPLPADDDAQTVIHMLIGAADHAMYAAKRAGGNQ
HHHHHHHHHHCCCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
FRHDDRSACC
CCCCCCCCCC
>Mature Secondary Structure 
PVGEGGSLVHWFRRWWRQPDHFDWITGYLAARGMLGVARWNLASSTVALALVPAVLAMS
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHHH
SRGPDAGPDQVLSRIAVLGGLCAATLWVVRWPTRAQSVAYILAANLFITLACYVQDDPMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCE
GLMGCTVFATTGGYIALFHTPGYMLYNFGVALYVGVLQTVRLAVETSDPALAVGLLLLVL
EHHHHEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VLNVAVPFAVQAIVHALGVDLLRAARDPLTGLLNRRAVYQQIEQLLSSHRDRHVHLAVAV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
VDLDDFKQLNDSHGHAIGDEALVAVAQALRAGAGEGAVVGRLGGEEFVLAELLEAGQIDH
EEHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCHH
WAQRMCTAVDVVPFPVTASVGVAAVCLPLPADDDAQTVIHMLIGAADHAMYAAKRAGGNQ
HHHHHHHHHHCCCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
FRHDDRSACC
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]