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The map label for this gene is tpa [H]

Identifier: 108797327

GI number: 108797327

Start: 383933

End: 385312

Strand: Reverse

Name: tpa [H]

Synonym: Mmcs_0347

Alternate gene names: 108797327

Gene position: 385312-383933 (Counterclockwise)

Preceding gene: 108797328

Following gene: 108797326

Centisome position: 6.75

GC content: 70.22

Gene sequence:

>1380_bases
ATGACGCTCACCAACGAGACCACCCTGCCCAACGGCCTGTCGGTCGACGACGCCCGCGCCGAGGCCGCCCGCGCCTACGA
ACTCGACCGCAAGCACGTCTTCCACTCCTGGTCGGCGCAGGCCGAGATCTCGCCCATGGTGATCACCGCCGCGCAGGGCA
GCTACATCTGGGACGGTGAGGGTCGGCGCCTGCTGGACTTCTCCTGCCAGCTGGTCAACACCAACATCGGCCACCAGCAC
CCGAAGGTCGTCGCCGCCATCCAGGCGCAGGCCGCCAAGCTGTGCACGGTCGCCCCGCAGCACGCCAACGACGCCCGCTC
CGAGGCCGCCCGGCTGATCGCCGAGCGCACCCCCGGCGAGCTGAACCGGATCTTCTTCACCAACGGCGGCGCCGACGCCG
TCGAGCATGCGGTGCGGATGGCGCGGCTGCACACCGGCAAGTACAAGGTGCTCAGCCGTTACCGCTCGTATCACGGCGGC
ACCGAGACGGCGATCAACCTGACCGGTGACCCGCGCCGGTGGCCCAACGACCACGGCAACGCCGGCGTCGTGCACTTCTT
CGGCCCGTTCCTGTACCGCTCGCAGTTCCACGCCACCACCGAGGCCGAGGAGTCGGCCCGCGCGCTGGCCCACCTCGAGG
ACATCGTCCGACTCGAGGGTCCGTCGACGATCGCCGCGATCGTGCTGGAGTCCATCCCCGGCACCGCGGGCATCATGGTC
CCCCCGCCCGGTTACCTGGCCGGTGTCCGCGACATCTGCGACCGCTACGGCATCGTGATGATCGCCGACGAGGTGATGGC
CGGCTTCGGGCGCAGCGGTAAGTGGTTCTCCATCGACCACTTCGACGTCACCCCCGACCTGCTGACCTTCGCCAAGGGCG
TCAACTCCGGTTACGTGCCGCTCGGTGGCGTCGCGATCGGCCCGGCCATCGCCGAGACCTTCGCCCATCGCCCCTACCCG
GGCGGGCTGACCTACTCCGGGCATCCGCTCGCGACGGCGGCGGCCGTGGCCACCATCAACGCGATGGAGGAGGAGGACAT
CGTCGGCAACGCCGCCCGCATCGGCGCCGAGGTGCTCGGACCCGGTCTGGCCGAACTCGCGGCCCGCCACCCGAGCGTCG
GCGAGGTCCGCGGCACCGGCGTGTTCTGGGCGATCGAACTGGTCGCCAATCCGCAGACCCGCGAACCGCTGGCCCCGTAC
GGCGCGAGCAGCGCAGCGATGAACGCCGTGGTCGCCGCGTGTAAGGCGAACGGCCTGCTGCCGTTCGCGAACTTCAACCG
GATCCACGCCGTACCGCCGTGCACGGTCACCGCCGACGAAGTCCGCGAAGGTCTCGCGATCCTCGACCAGGCACTCGACG
TCGCCGACTCGCACCTGTAA

Upstream 100 bases:

>100_bases
CGCAGAACAACTAATTTTCGCGCCGAGAGTACGGTTGTTGCACGCATCGCCCGAGTAGCGGCGTCAACAACCGTACTTTC
GGCGCAGGAGGAGAATTCCC

Downstream 100 bases:

>100_bases
CCGTCGCTGACACCCCCTCGCCGGAAGACGCCGGCGCCTCGGCATCCGTAGGGTTGGTGGCCAGGGTTGGTGGGCCGGTG
GTCGGCACGTGCGCAACGAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTLTNETTLPNGLSVDDARAEAARAYELDRKHVFHSWSAQAEISPMVITAAQGSYIWDGEGRRLLDFSCQLVNTNIGHQH
PKVVAAIQAQAAKLCTVAPQHANDARSEAARLIAERTPGELNRIFFTNGGADAVEHAVRMARLHTGKYKVLSRYRSYHGG
TETAINLTGDPRRWPNDHGNAGVVHFFGPFLYRSQFHATTEAEESARALAHLEDIVRLEGPSTIAAIVLESIPGTAGIMV
PPPGYLAGVRDICDRYGIVMIADEVMAGFGRSGKWFSIDHFDVTPDLLTFAKGVNSGYVPLGGVAIGPAIAETFAHRPYP
GGLTYSGHPLATAAAVATINAMEEEDIVGNAARIGAEVLGPGLAELAARHPSVGEVRGTGVFWAIELVANPQTREPLAPY
GASSAAMNAVVAACKANGLLPFANFNRIHAVPPCTVTADEVREGLAILDQALDVADSHL

Sequences:

>Translated_459_residues
MTLTNETTLPNGLSVDDARAEAARAYELDRKHVFHSWSAQAEISPMVITAAQGSYIWDGEGRRLLDFSCQLVNTNIGHQH
PKVVAAIQAQAAKLCTVAPQHANDARSEAARLIAERTPGELNRIFFTNGGADAVEHAVRMARLHTGKYKVLSRYRSYHGG
TETAINLTGDPRRWPNDHGNAGVVHFFGPFLYRSQFHATTEAEESARALAHLEDIVRLEGPSTIAAIVLESIPGTAGIMV
PPPGYLAGVRDICDRYGIVMIADEVMAGFGRSGKWFSIDHFDVTPDLLTFAKGVNSGYVPLGGVAIGPAIAETFAHRPYP
GGLTYSGHPLATAAAVATINAMEEEDIVGNAARIGAEVLGPGLAELAARHPSVGEVRGTGVFWAIELVANPQTREPLAPY
GASSAAMNAVVAACKANGLLPFANFNRIHAVPPCTVTADEVREGLAILDQALDVADSHL
>Mature_458_residues
TLTNETTLPNGLSVDDARAEAARAYELDRKHVFHSWSAQAEISPMVITAAQGSYIWDGEGRRLLDFSCQLVNTNIGHQHP
KVVAAIQAQAAKLCTVAPQHANDARSEAARLIAERTPGELNRIFFTNGGADAVEHAVRMARLHTGKYKVLSRYRSYHGGT
ETAINLTGDPRRWPNDHGNAGVVHFFGPFLYRSQFHATTEAEESARALAHLEDIVRLEGPSTIAAIVLESIPGTAGIMVP
PPGYLAGVRDICDRYGIVMIADEVMAGFGRSGKWFSIDHFDVTPDLLTFAKGVNSGYVPLGGVAIGPAIAETFAHRPYPG
GLTYSGHPLATAAAVATINAMEEEDIVGNAARIGAEVLGPGLAELAARHPSVGEVRGTGVFWAIELVANPQTREPLAPYG
ASSAAMNAVVAACKANGLLPFANFNRIHAVPPCTVTADEVREGLAILDQALDVADSHL

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=29.0865384615385, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI24119277, Length=421, Percent_Identity=30.4038004750594, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI37574042, Length=439, Percent_Identity=30.0683371298405, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI13994255, Length=452, Percent_Identity=28.3185840707965, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI226442705, Length=439, Percent_Identity=29.6127562642369, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI226442709, Length=391, Percent_Identity=30.690537084399, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI284507298, Length=334, Percent_Identity=29.0419161676647, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI188536080, Length=384, Percent_Identity=24.7395833333333, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI38679950, Length=384, Percent_Identity=24.7395833333333, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI38679946, Length=384, Percent_Identity=24.7395833333333, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=33.8028169014084, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI145693181, Length=392, Percent_Identity=32.1428571428571, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=33.4134615384615, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1789759, Length=364, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=27.6960784313726, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786991, Length=341, Percent_Identity=26.3929618768328, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786349, Length=299, Percent_Identity=28.4280936454849, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=434, Percent_Identity=29.7235023041475, Blast_Score=175, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI25144271, Length=438, Percent_Identity=27.3972602739726, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=28.8329519450801, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI25144274, Length=430, Percent_Identity=25.3488372093023, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=378, Percent_Identity=23.5449735449735, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=454, Percent_Identity=27.7533039647577, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324432, Length=424, Percent_Identity=23.5849056603774, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324386, Length=381, Percent_Identity=22.5721784776903, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI161085790, Length=432, Percent_Identity=32.4074074074074, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28574759, Length=433, Percent_Identity=32.3325635103926, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI21357415, Length=420, Percent_Identity=27.8571428571429, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21356575, Length=376, Percent_Identity=30.8510638297872, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281366494, Length=389, Percent_Identity=21.8508997429306, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24667139, Length=389, Percent_Identity=21.8508997429306, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24667143, Length=389, Percent_Identity=21.8508997429306, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 48874; Mature: 48742

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTNETTLPNGLSVDDARAEAARAYELDRKHVFHSWSAQAEISPMVITAAQGSYIWDGE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCC
GRRLLDFSCQLVNTNIGHQHPKVVAAIQAQAAKLCTVAPQHANDARSEAARLIAERTPGE
CCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
LNRIFFTNGGADAVEHAVRMARLHTGKYKVLSRYRSYHGGTETAINLTGDPRRWPNDHGN
CCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
AGVVHFFGPFLYRSQFHATTEAEESARALAHLEDIVRLEGPSTIAAIVLESIPGTAGIMV
CCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEE
PPPGYLAGVRDICDRYGIVMIADEVMAGFGRSGKWFSIDHFDVTPDLLTFAKGVNSGYVP
CCCHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCE
LGGVAIGPAIAETFAHRPYPGGLTYSGHPLATAAAVATINAMEEEDIVGNAARIGAEVLG
ECCEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
PGLAELAARHPSVGEVRGTGVFWAIELVANPQTREPLAPYGASSAAMNAVVAACKANGLL
CCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
PFANFNRIHAVPPCTVTADEVREGLAILDQALDVADSHL
CCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLTNETTLPNGLSVDDARAEAARAYELDRKHVFHSWSAQAEISPMVITAAQGSYIWDGE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCC
GRRLLDFSCQLVNTNIGHQHPKVVAAIQAQAAKLCTVAPQHANDARSEAARLIAERTPGE
CCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
LNRIFFTNGGADAVEHAVRMARLHTGKYKVLSRYRSYHGGTETAINLTGDPRRWPNDHGN
CCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCC
AGVVHFFGPFLYRSQFHATTEAEESARALAHLEDIVRLEGPSTIAAIVLESIPGTAGIMV
CCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEE
PPPGYLAGVRDICDRYGIVMIADEVMAGFGRSGKWFSIDHFDVTPDLLTFAKGVNSGYVP
CCCHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCE
LGGVAIGPAIAETFAHRPYPGGLTYSGHPLATAAAVATINAMEEEDIVGNAARIGAEVLG
ECCEEHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
PGLAELAARHPSVGEVRGTGVFWAIELVANPQTREPLAPYGASSAAMNAVVAACKANGLL
CCHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
PFANFNRIHAVPPCTVTADEVREGLAILDQALDVADSHL
CCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]