The gene/protein map for NC_008146 is currently unavailable.
Definition Mycobacterium sp. MCS chromosome, complete genome.
Accession NC_008146
Length 5,705,448

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The map label for this gene is limC [H]

Identifier: 108797315

GI number: 108797315

Start: 372346

End: 373176

Strand: Reverse

Name: limC [H]

Synonym: Mmcs_0335

Alternate gene names: 108797315

Gene position: 373176-372346 (Counterclockwise)

Preceding gene: 108797317

Following gene: 108797314

Centisome position: 6.54

GC content: 65.22

Gene sequence:

>831_bases
ATGGGTTCCCTGGACGGAAAAGTCGCGTTCATCACCGGTGCCGCCCGAGGGCAGGGCCGCAGCCATGCGGTACGCCTGGC
GGCCGACGGCGCCGACATCATCGGCGTCGACATCTGCGCCGACATCGAGTCGAACGGGTATCCGATGGCCACCCGCGACG
AGCTCGACGAGACTGTCGCGCTGGTGGAGGCCCAGGGTGGAAAAATGCTGGGATCTGTCGCCGACGTTCGCGACTTCCAC
GCGCTCAGAACGGCGTTGGACGCCGGCGTCGAACACTTCGGCCGCCTCGACATCGTCTGCGCCAACGCCGGTATCGCGAC
GATGGCCTTCCGCGAACTGACGATCGAGGAAGACCTCGAGATGTGGAACGACGTCGTCGACGTCAACCTGGTGGGTTCCT
TCCACACCGCGAAGGCCGCCATCCCCCATCTGATCGCCGGTCAACGCGGCGGGTCCATCGTGTTCACCAGTTCGACCGCG
GGCCTGCGCGGTTTCGGCGGACTGCAGGGCGGCGGCCTGGGCTATGCGGCCTCCAAACACGGAATCGTCGGGCTGATGCG
AACCCTGGCCAATGCGCTTGCACCGCACAGTATCCGGGTCAACACCGTCCATCCGACCGCGGTCAACACGATGATGGCGG
TGAATCCCGCGATGACCGCGTTCCTCGAGAACTATCCCGACGGCGGTCCGCATCTGCAGAATCCGATGCCGGTGCAACTG
CTCGAGCCGGAGGAGATCAGCAGCGCGATCGCCTATCTCGTCTCCGACGAGGCCAAACACGTCACCGGGGTCACCTTCCC
TGTCGACGCCGGCTTCTGCAACAAGCTGTGA

Upstream 100 bases:

>100_bases
CCGGTTCACCCATCCTCACCCCCTTGCCGACAGCCGAGTAACTAGGTTACCGTCTGCTCACAGTAACGCGGTTACTCACT
GTGTCGACGAAGCGAGGATC

Downstream 100 bases:

>100_bases
ACGAGCGCAACGGACGGGTCGCCGGTAAGCGGGTCGTCGTCACCGGGGCCGCACGAGGGATGGGGCGCAGCCACGCCGTC
CGGTTGGCCGAAGAGGGCGC

Product: short chain dehydrogenase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: (4R,6S)-carveol dehydrogenase; CDH; Carveol dehydrogenase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MGSLDGKVAFITGAARGQGRSHAVRLAADGADIIGVDICADIESNGYPMATRDELDETVALVEAQGGKMLGSVADVRDFH
ALRTALDAGVEHFGRLDIVCANAGIATMAFRELTIEEDLEMWNDVVDVNLVGSFHTAKAAIPHLIAGQRGGSIVFTSSTA
GLRGFGGLQGGGLGYAASKHGIVGLMRTLANALAPHSIRVNTVHPTAVNTMMAVNPAMTAFLENYPDGGPHLQNPMPVQL
LEPEEISSAIAYLVSDEAKHVTGVTFPVDAGFCNKL

Sequences:

>Translated_276_residues
MGSLDGKVAFITGAARGQGRSHAVRLAADGADIIGVDICADIESNGYPMATRDELDETVALVEAQGGKMLGSVADVRDFH
ALRTALDAGVEHFGRLDIVCANAGIATMAFRELTIEEDLEMWNDVVDVNLVGSFHTAKAAIPHLIAGQRGGSIVFTSSTA
GLRGFGGLQGGGLGYAASKHGIVGLMRTLANALAPHSIRVNTVHPTAVNTMMAVNPAMTAFLENYPDGGPHLQNPMPVQL
LEPEEISSAIAYLVSDEAKHVTGVTFPVDAGFCNKL
>Mature_275_residues
GSLDGKVAFITGAARGQGRSHAVRLAADGADIIGVDICADIESNGYPMATRDELDETVALVEAQGGKMLGSVADVRDFHA
LRTALDAGVEHFGRLDIVCANAGIATMAFRELTIEEDLEMWNDVVDVNLVGSFHTAKAAIPHLIAGQRGGSIVFTSSTAG
LRGFGGLQGGGLGYAASKHGIVGLMRTLANALAPHSIRVNTVHPTAVNTMMAVNPAMTAFLENYPDGGPHLQNPMPVQLL
EPEEISSAIAYLVSDEAKHVTGVTFPVDAGFCNKL

Specific function: Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=284, Percent_Identity=30.9859154929577, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI15277342, Length=280, Percent_Identity=31.0714285714286, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI32483357, Length=274, Percent_Identity=27.3722627737226, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI31542939, Length=260, Percent_Identity=30.3846153846154, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI40254992, Length=268, Percent_Identity=31.3432835820896, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4758504, Length=268, Percent_Identity=30.9701492537313, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI126723750, Length=277, Percent_Identity=26.7148014440433, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI5031737, Length=276, Percent_Identity=27.536231884058, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI7705925, Length=271, Percent_Identity=29.1512915129151, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI224922801, Length=189, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI33667109, Length=209, Percent_Identity=29.1866028708134, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI126723191, Length=201, Percent_Identity=29.3532338308458, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI19923817, Length=279, Percent_Identity=25.089605734767, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI83715985, Length=207, Percent_Identity=32.8502415458937, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI40254986, Length=143, Percent_Identity=32.1678321678322, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=203, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789208, Length=278, Percent_Identity=31.6546762589928, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787335, Length=270, Percent_Identity=32.5925925925926, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082100, Length=273, Percent_Identity=32.2344322344322, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI2367175, Length=263, Percent_Identity=31.1787072243346, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082160, Length=271, Percent_Identity=26.1992619926199, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789378, Length=263, Percent_Identity=28.1368821292776, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788459, Length=268, Percent_Identity=27.6119402985075, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=274, Percent_Identity=29.1970802919708, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787526, Length=280, Percent_Identity=25.7142857142857, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786812, Length=271, Percent_Identity=26.9372693726937, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367365, Length=281, Percent_Identity=28.1138790035587, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787905, Length=274, Percent_Identity=26.6423357664234, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788891, Length=281, Percent_Identity=29.8932384341637, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=277, Percent_Identity=31.0469314079422, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560676, Length=269, Percent_Identity=27.8810408921933, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=279, Percent_Identity=26.5232974910394, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=273, Percent_Identity=27.8388278388278, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=272, Percent_Identity=31.6176470588235, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=220, Percent_Identity=29.5454545454545, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=283, Percent_Identity=28.6219081272085, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=273, Percent_Identity=27.1062271062271, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=278, Percent_Identity=29.4964028776978, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=277, Percent_Identity=25.9927797833935, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=211, Percent_Identity=27.4881516587678, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=280, Percent_Identity=28.2142857142857, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=287, Percent_Identity=25.4355400696864, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=232, Percent_Identity=31.4655172413793, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=279, Percent_Identity=29.3906810035842, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=282, Percent_Identity=26.5957446808511, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=212, Percent_Identity=29.7169811320755, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=215, Percent_Identity=29.7674418604651, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=209, Percent_Identity=30.1435406698565, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17558628, Length=210, Percent_Identity=30.4761904761905, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=283, Percent_Identity=26.1484098939929, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=275, Percent_Identity=25.0909090909091, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=280, Percent_Identity=27.5, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=286, Percent_Identity=25.5244755244755, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=27.7372262773723, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=278, Percent_Identity=29.4964028776978, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324126, Length=275, Percent_Identity=30.9090909090909, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355319, Length=277, Percent_Identity=30.6859205776173, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24644339, Length=268, Percent_Identity=31.3432835820896, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357041, Length=283, Percent_Identity=31.095406360424, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI23397609, Length=276, Percent_Identity=32.2463768115942, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI18859837, Length=272, Percent_Identity=30.8823529411765, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571526, Length=275, Percent_Identity=30.9090909090909, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24643142, Length=276, Percent_Identity=30.7971014492754, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=31.8897637795276, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357673, Length=268, Percent_Identity=27.2388059701493, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=278, Percent_Identity=29.136690647482, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644337, Length=179, Percent_Identity=32.4022346368715, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640492, Length=220, Percent_Identity=26.3636363636364, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581726, Length=230, Percent_Identity=29.1304347826087, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 28819; Mature: 28688

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MGSLDGKVAFITGAARGQGRSHAVRLAADGADIIGVDICADIESNGYPMATRDELDETVA
CCCCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHEE
LVEAQGGKMLGSVADVRDFHALRTALDAGVEHFGRLDIVCANAGIATMAFRELTIEEDLE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHH
MWNDVVDVNLVGSFHTAKAAIPHLIAGQRGGSIVFTSSTAGLRGFGGLQGGGLGYAASKH
HHHHEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GIVGLMRTLANALAPHSIRVNTVHPTAVNTMMAVNPAMTAFLENYPDGGPHLQNPMPVQL
HHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEE
LEPEEISSAIAYLVSDEAKHVTGVTFPVDAGFCNKL
ECHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
GSLDGKVAFITGAARGQGRSHAVRLAADGADIIGVDICADIESNGYPMATRDELDETVA
CCCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHEE
LVEAQGGKMLGSVADVRDFHALRTALDAGVEHFGRLDIVCANAGIATMAFRELTIEEDLE
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHH
MWNDVVDVNLVGSFHTAKAAIPHLIAGQRGGSIVFTSSTAGLRGFGGLQGGGLGYAASKH
HHHHEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCC
GIVGLMRTLANALAPHSIRVNTVHPTAVNTMMAVNPAMTAFLENYPDGGPHLQNPMPVQL
HHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEE
LEPEEISSAIAYLVSDEAKHVTGVTFPVDAGFCNKL
ECHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10473585 [H]