BacMap

Definition	Mycobacterium sp. MCS chromosome, complete genome.
Accession	NC_008146
Length	5,705,448

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The map label for this gene is ephD [H]

Identifier: 108797284

GI number: 108797284

Start: 341567

End: 342427

Strand: Reverse

Name: ephD [H]

Synonym: Mmcs_0304

Alternate gene names: 108797284

Gene position: 342427-341567 (Counterclockwise)

Preceding gene: 108797285

Following gene: 108797283

Centisome position: 6.0

GC content: 70.27

Gene sequence:

>861_bases
GTGAACGCCGGGCAGACCTTCGGCGGCGGTGTCGCGGTCATCACGGGGGCGGGCGCCGGCATCGGCGCCGGGCTGGCGCG
CCACGCCGCCCGCCTGGGCATGACGGTGGTGCTCGCCGACGTCGACGGCGACGCGATCGCCGCGCTGCGCGACGAACTGT
CGGACCAGGGCGCCACCGCTTTCGACATGGTCTGCGACGTCAGGGATTTCGCGGCCGTCGAGGAGCTGGCGCAACGCACC
TACCGCGACATCGGCCCGGTGCGCCTGCTCGTCAACAACGCCGGCGTCGAACAGTTCGGCTACCTGTGGGACACCCCGGT
CGAGAACTGGCAGCGTGTCGTCGACATCAACGTCAGCGGCGTCTTCCACGGTGTCCGGGCATTCCTGCCGATGATGATCG
AGGCGCGCACCCCGGCGTGGGTGTGGAATCTCAGCTCGATCGGCGGCGTCGCCGTCGTCCCCCTGCAGGCGCCCTACATC
ATGAGCAAACACGCCGTGCTCGCCCTGACGGAGTGCCTGGCGCTCGAAGTCCAACTGGCCGAACACGACCACATCCACGT
GCAGGCGGTGCTGCCCGGCGCGGTCACGTCCAACATCTTCGAGTCGGCGGGCGGCGTCACGGACGGGGACGTCGGCGCGG
CAGAGTCCCAGCGGCTGGCGATGCTCGACATCAAGGCGGCCGCGATGGACCCCCTGGCCGCGGCAGAGGTGGTGTTCGAC
CAGGCCGCCGACGGCCGGTTCTACCTGCTCACGCAGCCCGAGTACGTCGGCAACGCGATGGCCGAACGCGCCGATGTGCT
GACCACGCAGCGGGCACCGCTGCTGCGCACCAAACCGCGTTTCGACCCCGCACAGCACTGA

Upstream 100 bases:

>100_bases
GGGCTGGAGTTCACCGAGATGGAGGTCATCCTCGACACCACCAATTCGGTTCTGCTGTCCGAGTATTCAGCCGACCCCGC
CGCCGCGGGCGCCTGAGGTC

Downstream 100 bases:

>100_bases
GAGGACTTCGGGTGCGCATCACCGACAGGGTGTTCGTCGTGACCGGTGCCGGTAACGGTATGGGCCGGCAGGTGACGCTC
GACCTCCTGCGCCGGGGTGC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MNAGQTFGGGVAVITGAGAGIGAGLARHAARLGMTVVLADVDGDAIAALRDELSDQGATAFDMVCDVRDFAAVEELAQRT
YRDIGPVRLLVNNAGVEQFGYLWDTPVENWQRVVDINVSGVFHGVRAFLPMMIEARTPAWVWNLSSIGGVAVVPLQAPYI
MSKHAVLALTECLALEVQLAEHDHIHVQAVLPGAVTSNIFESAGGVTDGDVGAAESQRLAMLDIKAAAMDPLAAAEVVFD
QAADGRFYLLTQPEYVGNAMAERADVLTTQRAPLLRTKPRFDPAQH

Sequences:

>Translated_286_residues
MNAGQTFGGGVAVITGAGAGIGAGLARHAARLGMTVVLADVDGDAIAALRDELSDQGATAFDMVCDVRDFAAVEELAQRT
YRDIGPVRLLVNNAGVEQFGYLWDTPVENWQRVVDINVSGVFHGVRAFLPMMIEARTPAWVWNLSSIGGVAVVPLQAPYI
MSKHAVLALTECLALEVQLAEHDHIHVQAVLPGAVTSNIFESAGGVTDGDVGAAESQRLAMLDIKAAAMDPLAAAEVVFD
QAADGRFYLLTQPEYVGNAMAERADVLTTQRAPLLRTKPRFDPAQH
>Mature_286_residues
MNAGQTFGGGVAVITGAGAGIGAGLARHAARLGMTVVLADVDGDAIAALRDELSDQGATAFDMVCDVRDFAAVEELAQRT
YRDIGPVRLLVNNAGVEQFGYLWDTPVENWQRVVDINVSGVFHGVRAFLPMMIEARTPAWVWNLSSIGGVAVVPLQAPYI
MSKHAVLALTECLALEVQLAEHDHIHVQAVLPGAVTSNIFESAGGVTDGDVGAAESQRLAMLDIKAAAMDPLAAAEVVFD
QAADGRFYLLTQPEYVGNAMAERADVLTTQRAPLLRTKPRFDPAQH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=195, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI40807363, Length=202, Percent_Identity=30.6930693069307, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI7706318, Length=268, Percent_Identity=26.865671641791, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI25282469, Length=224, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310128830, Length=203, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI310115468, Length=203, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI44680136, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI44680133, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI17738292, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI31542939, Length=199, Percent_Identity=30.6532663316583, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI210032110, Length=193, Percent_Identity=26.9430051813472, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI32483357, Length=189, Percent_Identity=32.2751322751323, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI33667109, Length=192, Percent_Identity=32.8125, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=189, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI142976729, Length=198, Percent_Identity=26.2626262626263, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI19923817, Length=203, Percent_Identity=27.0935960591133, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4503817, Length=175, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI157739938, Length=192, Percent_Identity=30.2083333333333, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=29.5081967213115, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI87082100, Length=246, Percent_Identity=34.9593495934959, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787335, Length=194, Percent_Identity=28.3505154639175, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=193, Percent_Identity=29.0155440414508, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787905, Length=124, Percent_Identity=36.2903225806452, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788459, Length=206, Percent_Identity=28.1553398058252, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789208, Length=196, Percent_Identity=27.0408163265306, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787820, Length=141, Percent_Identity=31.2056737588652, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=28.643216080402, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=29.7435897435897, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25147288, Length=198, Percent_Identity=32.8282828282828, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=205, Percent_Identity=32.6829268292683, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=198, Percent_Identity=30.8080808080808, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193203117, Length=193, Percent_Identity=26.9430051813472, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=26.9430051813472, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=192, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=174, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=267, Percent_Identity=25.0936329588015, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71997402, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=206, Percent_Identity=29.126213592233, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281364892, Length=172, Percent_Identity=35.4651162790698, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24649181, Length=201, Percent_Identity=29.8507462686567, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=201, Percent_Identity=29.8507462686567, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357041, Length=200, Percent_Identity=28.5, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640492, Length=196, Percent_Identity=29.5918367346939, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24644339, Length=200, Percent_Identity=29.5, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI23397609, Length=194, Percent_Identity=32.9896907216495, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI116007236, Length=197, Percent_Identity=31.4720812182741, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI116007238, Length=197, Percent_Identity=31.4720812182741, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641232, Length=197, Percent_Identity=32.994923857868, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24584748, Length=205, Percent_Identity=32.1951219512195, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076933, Length=205, Percent_Identity=32.1951219512195, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510726, Length=203, Percent_Identity=31.0344827586207, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648944, Length=196, Percent_Identity=27.5510204081633, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639444, Length=191, Percent_Identity=30.3664921465969, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581726, Length=198, Percent_Identity=26.7676767676768, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358495, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281364494, Length=205, Percent_Identity=30.7317073170732, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007234, Length=204, Percent_Identity=29.9019607843137, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355319, Length=192, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584752, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24648693, Length=199, Percent_Identity=31.1557788944724, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21355889, Length=199, Percent_Identity=31.1557788944724, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 30359; Mature: 30359

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGQTFGGGVAVITGAGAGIGAGLARHAARLGMTVVLADVDGDAIAALRDELSDQGATA
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCHH
FDMVCDVRDFAAVEELAQRTYRDIGPVRLLVNNAGVEQFGYLWDTPVENWQRVVDINVSG
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCHHCCEEEEEEEHHH
VFHGVRAFLPMMIEARTPAWVWNLSSIGGVAVVPLQAPYIMSKHAVLALTECLALEVQLA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCHHHHCHHHHHHHHHHHEEEEEC
EHDHIHVQAVLPGAVTSNIFESAGGVTDGDVGAAESQRLAMLDIKAAAMDPLAAAEVVFD
CCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHHH
QAADGRFYLLTQPEYVGNAMAERADVLTTQRAPLLRTKPRFDPAQH
CCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNAGQTFGGGVAVITGAGAGIGAGLARHAARLGMTVVLADVDGDAIAALRDELSDQGATA
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCHH
FDMVCDVRDFAAVEELAQRTYRDIGPVRLLVNNAGVEQFGYLWDTPVENWQRVVDINVSG
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCHHCCEEEEEEEHHH
VFHGVRAFLPMMIEARTPAWVWNLSSIGGVAVVPLQAPYIMSKHAVLALTECLALEVQLA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCHHHHCHHHHHHHHHHHEEEEEC
EHDHIHVQAVLPGAVTSNIFESAGGVTDGDVGAAESQRLAMLDIKAAAMDPLAAAEVVFD
CCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHCCCHHHHHHHHH
QAADGRFYLLTQPEYVGNAMAERADVLTTQRAPLLRTKPRFDPAQH
CCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]