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The map label for this gene is ephD [H]

Identifier: 108797283

GI number: 108797283

Start: 340767

End: 341555

Strand: Reverse

Name: ephD [H]

Synonym: Mmcs_0303

Alternate gene names: 108797283

Gene position: 341555-340767 (Counterclockwise)

Preceding gene: 108797284

Following gene: 108797282

Centisome position: 5.99

GC content: 68.19

Gene sequence:

>789_bases
GTGCGCATCACCGACAGGGTGTTCGTCGTGACCGGTGCCGGTAACGGTATGGGCCGGCAGGTGACGCTCGACCTCCTGCG
CCGGGGTGCGCTGGTCGCGGCGGCCGACGTCGACGAAGTGGGACTGACCGGCACGGCACGGCTCGCGATGGCCGGGACCC
GGCTGTCCACCCACGTTCTCGACGTCACGGACAGGGACGCGGTCGCCGCCATGCCGGGCCGGGTGGTCGACGTCCACGGC
CGGGTCGACGGGCTGGTCAACATCGCCGGCGTCATCCACCGGTTCGCGCCGTTCATCGACCTGCCCCCGGAGACGGCCGA
TCGCATCATGGCCGTCAACTTCACCGGCACGGTCGACATGTGCCGCGCGTTCCTGCCCGTCCTCCTGGCCCGCCCGGAGG
CGAACCTGACGAACATGTCGAGCCTGTCGGCGTTGCTGCCCTTCGCCAGCCAGACGCTGTACAGCGCCAGCAAGGGCGCG
GTCAAACAGTTCAGCGAAGGCCTCTACGCCGAGCTGTGCGATACGAATGTCCATGTGGTGACGGTCTTTCCGGGCAACGT
CGCCACGGAGCTGACCAGTAACTCGGGTGTCGAGATGCTCGACGCCGGCGGTAAGAAGGTCCGGTCCACCACGCCGGAGG
CGGCGGGCCGCAAGATCGTCGACGGCATCGCCGAGGACCGTTTCCGGGTACTCATCGGTGCCGACGCACACAGCCTCGAC
GTGCTGGCGCGGGTGTCGGCGAAACGCACCACCAGGTTGGTCGCCAAACAGATCAAGTCGGTGCTGTGA

Upstream 100 bases:

>100_bases
ACGCGATGGCCGAACGCGCCGATGTGCTGACCACGCAGCGGGCACCGCTGCTGCGCACCAAACCGCGTTTCGACCCCGCA
CAGCACTGAGAGGACTTCGG

Downstream 100 bases:

>100_bases
ACTACGGTGCCATGAACTTCGGTGCCATGAACTACGACGTCATCGTCGTCGGATTCGGCGCAGCCGGTGCGGCAGCCGCG
ATCGAGGCCGCCGACCGTGG

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MRITDRVFVVTGAGNGMGRQVTLDLLRRGALVAAADVDEVGLTGTARLAMAGTRLSTHVLDVTDRDAVAAMPGRVVDVHG
RVDGLVNIAGVIHRFAPFIDLPPETADRIMAVNFTGTVDMCRAFLPVLLARPEANLTNMSSLSALLPFASQTLYSASKGA
VKQFSEGLYAELCDTNVHVVTVFPGNVATELTSNSGVEMLDAGGKKVRSTTPEAAGRKIVDGIAEDRFRVLIGADAHSLD
VLARVSAKRTTRLVAKQIKSVL

Sequences:

>Translated_262_residues
MRITDRVFVVTGAGNGMGRQVTLDLLRRGALVAAADVDEVGLTGTARLAMAGTRLSTHVLDVTDRDAVAAMPGRVVDVHG
RVDGLVNIAGVIHRFAPFIDLPPETADRIMAVNFTGTVDMCRAFLPVLLARPEANLTNMSSLSALLPFASQTLYSASKGA
VKQFSEGLYAELCDTNVHVVTVFPGNVATELTSNSGVEMLDAGGKKVRSTTPEAAGRKIVDGIAEDRFRVLIGADAHSLD
VLARVSAKRTTRLVAKQIKSVL
>Mature_262_residues
MRITDRVFVVTGAGNGMGRQVTLDLLRRGALVAAADVDEVGLTGTARLAMAGTRLSTHVLDVTDRDAVAAMPGRVVDVHG
RVDGLVNIAGVIHRFAPFIDLPPETADRIMAVNFTGTVDMCRAFLPVLLARPEANLTNMSSLSALLPFASQTLYSASKGA
VKQFSEGLYAELCDTNVHVVTVFPGNVATELTSNSGVEMLDAGGKKVRSTTPEAAGRKIVDGIAEDRFRVLIGADAHSLD
VLARVSAKRTTRLVAKQIKSVL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI310128830, Length=264, Percent_Identity=26.8939393939394, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI310115468, Length=264, Percent_Identity=26.8939393939394, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI20149619, Length=198, Percent_Identity=28.2828282828283, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI40807363, Length=261, Percent_Identity=24.5210727969349, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4503817, Length=246, Percent_Identity=26.4227642276423, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI66933014, Length=189, Percent_Identity=30.6878306878307, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7706318, Length=203, Percent_Identity=27.5862068965517, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542939, Length=197, Percent_Identity=30.9644670050761, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI22507405, Length=230, Percent_Identity=28.695652173913, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI142976729, Length=260, Percent_Identity=23.4615384615385, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI210032110, Length=234, Percent_Identity=23.9316239316239, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI150247226, Length=225, Percent_Identity=31.1111111111111, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40548397, Length=191, Percent_Identity=31.9371727748691, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI214010158, Length=191, Percent_Identity=31.9371727748691, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI214010156, Length=191, Percent_Identity=31.9371727748691, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI22758144, Length=191, Percent_Identity=31.9371727748691, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI87082100, Length=194, Percent_Identity=28.3505154639175, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790717, Length=186, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787820, Length=205, Percent_Identity=29.2682926829268, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=26.4248704663212, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=215, Percent_Identity=31.6279069767442, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=216, Percent_Identity=28.7037037037037, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=189, Percent_Identity=31.2169312169312, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=235, Percent_Identity=24.6808510638298, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=191, Percent_Identity=29.3193717277487, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=155, Percent_Identity=29.6774193548387, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=226, Percent_Identity=24.3362831858407, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=190, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6322227, Length=196, Percent_Identity=26.530612244898, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323882, Length=197, Percent_Identity=23.8578680203046, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=218, Percent_Identity=32.1100917431193, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355631, Length=227, Percent_Identity=29.0748898678414, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=27.2277227722772, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357041, Length=197, Percent_Identity=28.4263959390863, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640492, Length=197, Percent_Identity=25.8883248730964, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281364892, Length=236, Percent_Identity=25.8474576271186, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28571526, Length=196, Percent_Identity=30.1020408163265, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24649181, Length=206, Percent_Identity=30.0970873786408, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161076933, Length=198, Percent_Identity=29.2929292929293, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584748, Length=198, Percent_Identity=29.2929292929293, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356301, Length=258, Percent_Identity=24.8062015503876, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27737; Mature: 27737

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITDRVFVVTGAGNGMGRQVTLDLLRRGALVAAADVDEVGLTGTARLAMAGTRLSTHVL
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCHHHEEECCCCEEEEE
DVTDRDAVAAMPGRVVDVHGRVDGLVNIAGVIHRFAPFIDLPPETADRIMAVNFTGTVDM
ECCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHH
CRAFLPVLLARPEANLTNMSSLSALLPFASQTLYSASKGAVKQFSEGLYAELCDTNVHVV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHCCCCEEEE
TVFPGNVATELTSNSGVEMLDAGGKKVRSTTPEAAGRKIVDGIAEDRFRVLIGADAHSLD
EEECCCEEEEECCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
VLARVSAKRTTRLVAKQIKSVL
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRITDRVFVVTGAGNGMGRQVTLDLLRRGALVAAADVDEVGLTGTARLAMAGTRLSTHVL
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCHHHEEECCCCEEEEE
DVTDRDAVAAMPGRVVDVHGRVDGLVNIAGVIHRFAPFIDLPPETADRIMAVNFTGTVDM
ECCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHH
CRAFLPVLLARPEANLTNMSSLSALLPFASQTLYSASKGAVKQFSEGLYAELCDTNVHVV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHCCCCEEEE
TVFPGNVATELTSNSGVEMLDAGGKKVRSTTPEAAGRKIVDGIAEDRFRVLIGADAHSLD
EEECCCEEEEECCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
VLARVSAKRTTRLVAKQIKSVL
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]