Click here to switch to the map view.

The map label for this gene is frdB [H]

Identifier: 108797232

GI number: 108797232

Start: 292201

End: 292953

Strand: Reverse

Name: frdB [H]

Synonym: Mmcs_0252

Alternate gene names: 108797232

Gene position: 292953-292201 (Counterclockwise)

Preceding gene: 108797233

Following gene: 108797231

Centisome position: 5.13

GC content: 64.81

Gene sequence:

>753_bases
ATGAGCTACCAGGCGAAGATGCGGGTGTGGCGCGGCGACGACGAGGGCGGCGCACTGCAGGACTACACCGTCGAGGTCAA
CGAGGGTGAGGTCGTCCTCGACATCATCCACCGCCTGCAGCAGACGCAGACCGGTGACCTCGCGGTGCGCTGGAACTGCA
AGGCCGGGAAGTGCGGATCGTGTTCGGCGGAGATCAACGGCCGGCCGCGTCTTCTGTGTATGACCCGGATGTCGACGTTC
GGCGAGAGCGAGACGGTCACGGTGACGCCGCTGCGGGCGTTCCCCGTGATCCGCGACCTCGTCACCGACGTGTCGTTCAA
CTACGAGAAGGCCCGCGAGATCCCGTCGTTCACCCCGCCCAAGGATCTGCAACCCGGTGAGTACCGGATGGCGCAGGAGG
ACGTGAACCGCTCGCAGGAGTTCCGCAAGTGCATCGAGTGCTTCCTGTGCCAGAACACCTGCCACGTGGTGCGCGACCAC
GAGGAGAACAAGAAGGAGTTCGCCGGGCCCCGCTACCTGATGCGGATGGCCGAACTGGACATGCATCCGCTCGACGTGCA
CGCCCGTCGCGCCGAGGACTCCCAGGAGGTGCACGGCCTCGGCTACTGCAACATCACCAAGTGCTGCACCGAGGTCTGCC
CCGAACACATCAAGATCACCGACAACGCGCTGATCCCGATGAAGGAGCGCGTTGCCGACCGCAAGTACGACCCGGTCGTC
TGGCTGGGCAACAAGCTGTTCAGGCGGAAGTGA

Upstream 100 bases:

>100_bases
TGCCGATGCGCGACGACCTGCTCGAGCTGCTGGACATCGAAGAACTCCAGAAGTACTACACCGACGAGGAACTCGCCAAC
CACCCGGCAAGGAGGGGCTC

Downstream 100 bases:

>100_bases
TCCACGTCACGCTCGGGTAGCCTCGGTACCAAGCAGCCAATCAACGACGAAAGGCAGCCTGATGACCCTCAGTCACACGC
ACAGCCTCAACGACATCCGA

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSYQAKMRVWRGDDEGGALQDYTVEVNEGEVVLDIIHRLQQTQTGDLAVRWNCKAGKCGSCSAEINGRPRLLCMTRMSTF
GESETVTVTPLRAFPVIRDLVTDVSFNYEKAREIPSFTPPKDLQPGEYRMAQEDVNRSQEFRKCIECFLCQNTCHVVRDH
EENKKEFAGPRYLMRMAELDMHPLDVHARRAEDSQEVHGLGYCNITKCCTEVCPEHIKITDNALIPMKERVADRKYDPVV
WLGNKLFRRK

Sequences:

>Translated_250_residues
MSYQAKMRVWRGDDEGGALQDYTVEVNEGEVVLDIIHRLQQTQTGDLAVRWNCKAGKCGSCSAEINGRPRLLCMTRMSTF
GESETVTVTPLRAFPVIRDLVTDVSFNYEKAREIPSFTPPKDLQPGEYRMAQEDVNRSQEFRKCIECFLCQNTCHVVRDH
EENKKEFAGPRYLMRMAELDMHPLDVHARRAEDSQEVHGLGYCNITKCCTEVCPEHIKITDNALIPMKERVADRKYDPVV
WLGNKLFRRK
>Mature_249_residues
SYQAKMRVWRGDDEGGALQDYTVEVNEGEVVLDIIHRLQQTQTGDLAVRWNCKAGKCGSCSAEINGRPRLLCMTRMSTFG
ESETVTVTPLRAFPVIRDLVTDVSFNYEKAREIPSFTPPKDLQPGEYRMAQEDVNRSQEFRKCIECFLCQNTCHVVRDHE
ENKKEFAGPRYLMRMAELDMHPLDVHARRAEDSQEVHGLGYCNITKCCTEVCPEHIKITDNALIPMKERVADRKYDPVVW
LGNKLFRRK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=239, Percent_Identity=28.4518828451883, Blast_Score=81, Evalue=7e-16,
Organism=Escherichia coli, GI1790596, Length=206, Percent_Identity=26.6990291262136, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786943, Length=217, Percent_Identity=27.1889400921659, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533915, Length=204, Percent_Identity=25.9803921568627, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322987, Length=221, Percent_Identity=27.6018099547511, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=28.0172413793103, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17137106, Length=218, Percent_Identity=27.9816513761468, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28806; Mature: 28675

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS01090 TATD_2 ; PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQAKMRVWRGDDEGGALQDYTVEVNEGEVVLDIIHRLQQTQTGDLAVRWNCKAGKCGS
CCCCCCEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
CSAEINGRPRLLCMTRMSTFGESETVTVTPLRAFPVIRDLVTDVSFNYEKAREIPSFTPP
CCCCCCCCCEEEEEEEHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
KDLQPGEYRMAQEDVNRSQEFRKCIECFLCQNTCHVVRDHEENKKEFAGPRYLMRMAELD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHCCHHHHHHHHHCC
MHPLDVHARRAEDSQEVHGLGYCNITKCCTEVCPEHIKITDNALIPMKERVADRKYDPVV
CCCCCHHHHCCCCCHHHCCCCCCCHHHHHHHHCHHHEEECCCCCCCHHHHHHCCCCCCEE
WLGNKLFRRK
EECCHHHCCC
>Mature Secondary Structure 
SYQAKMRVWRGDDEGGALQDYTVEVNEGEVVLDIIHRLQQTQTGDLAVRWNCKAGKCGS
CCCCCEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
CSAEINGRPRLLCMTRMSTFGESETVTVTPLRAFPVIRDLVTDVSFNYEKAREIPSFTPP
CCCCCCCCCEEEEEEEHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
KDLQPGEYRMAQEDVNRSQEFRKCIECFLCQNTCHVVRDHEENKKEFAGPRYLMRMAELD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHCCHHHHHHHHHCC
MHPLDVHARRAEDSQEVHGLGYCNITKCCTEVCPEHIKITDNALIPMKERVADRKYDPVV
CCCCCHHHHCCCCCHHHCCCCCCCHHHHHHHHCHHHEEECCCCCCCHHHHHHCCCCCCEE
WLGNKLFRRK
EECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]