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The map label for this gene is mdmC [H]

Identifier: 108797124

GI number: 108797124

Start: 160747

End: 161412

Strand: Direct

Name: mdmC [H]

Synonym: Mmcs_0144

Alternate gene names: 108797124

Gene position: 160747-161412 (Clockwise)

Preceding gene: 108797123

Following gene: 108797125

Centisome position: 2.82

GC content: 70.27

Gene sequence:

>666_bases
GTGCGCGTGAGCGAGCCGAATCCGCAGGCGGTCGACCAGCTTTTCGACCGGTTGCTGCACACCGAGGACGATGCGTTGAT
CGCGGCCAGGGAGTCCGCGGCGGCGGCCGGGATGCCGCAGATCGAGGTGTCCGCGCAGCACGGCAGGCTGCTGTTGCTGC
TGGCGAGCGTCACCCACGCGCGCCGGGTGCTGGAGATCGGCACCCTCGCCGGGTACAGCACGATCAACCTGGCCCGCGGT
GTCGGGCCCGACGGGCGCGTCGTCACCCTCGAATTCGACCCCCGCCACGCCGAGGTGGCCCGCACGAACCTGGCCCGCGC
CGGCGTCGCGGACCAGGTGGAGGTGCTGGTCGGCGCGGCGCTCGACACCCTGCCGACGCTGCAGCACGGCGCACCGTTCG
ACCTGGTGTTCATCGACGCCGACAAGGAGAACAACGTCGCCTACGTCGAATGGGCGATCAAACTCGGCAGGCCGGGCACG
GTGATCGTCGTGGACAACGTCACCCGCATGGGCCGGATCTACGACCCGGCGCCCGACGACCTCCAGGCCCAGGCCGTGCG
CGAGATGCTCGAGATGATGGGTTCGCATCCGAGGCTGAGCACCGCGGCGATCCAGACGGTCGGGGCCAAGAACTGGGACG
GATTCGCGGTCGCGGTCGTGACGTGA

Upstream 100 bases:

>100_bases
GGTCGCCGAGGCCGTGATGGGTCCGGAGGTCGCCCACGTGCTGCGGGTGGTCTACGCCAAGGAGGGGGTCCGGATGGGTG
GCGGTAGCAAGGGTTAACGT

Downstream 100 bases:

>100_bases
CGGCGAATCTGGGTATCACAGGCGGCATGGGGATCTGCTACCGAAACGGCATGCTGACCGTCGACCGGGTGGTCAACGCC
TCTCCGGCGGAGGTGTGGTC

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MRVSEPNPQAVDQLFDRLLHTEDDALIAARESAAAAGMPQIEVSAQHGRLLLLLASVTHARRVLEIGTLAGYSTINLARG
VGPDGRVVTLEFDPRHAEVARTNLARAGVADQVEVLVGAALDTLPTLQHGAPFDLVFIDADKENNVAYVEWAIKLGRPGT
VIVVDNVTRMGRIYDPAPDDLQAQAVREMLEMMGSHPRLSTAAIQTVGAKNWDGFAVAVVT

Sequences:

>Translated_221_residues
MRVSEPNPQAVDQLFDRLLHTEDDALIAARESAAAAGMPQIEVSAQHGRLLLLLASVTHARRVLEIGTLAGYSTINLARG
VGPDGRVVTLEFDPRHAEVARTNLARAGVADQVEVLVGAALDTLPTLQHGAPFDLVFIDADKENNVAYVEWAIKLGRPGT
VIVVDNVTRMGRIYDPAPDDLQAQAVREMLEMMGSHPRLSTAAIQTVGAKNWDGFAVAVVT
>Mature_221_residues
MRVSEPNPQAVDQLFDRLLHTEDDALIAARESAAAAGMPQIEVSAQHGRLLLLLASVTHARRVLEIGTLAGYSTINLARG
VGPDGRVVTLEFDPRHAEVARTNLARAGVADQVEVLVGAALDTLPTLQHGAPFDLVFIDADKENNVAYVEWAIKLGRPGT
VIVVDNVTRMGRIYDPAPDDLQAQAVREMLEMMGSHPRLSTAAIQTVGAKNWDGFAVAVVT

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=152, Percent_Identity=34.8684210526316, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI6466450, Length=124, Percent_Identity=34.6774193548387, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI205830453, Length=124, Percent_Identity=34.6774193548387, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI205830451, Length=124, Percent_Identity=34.6774193548387, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4502969, Length=124, Percent_Identity=34.6774193548387, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI72001127, Length=131, Percent_Identity=37.4045801526718, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565612, Length=155, Percent_Identity=34.1935483870968, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23731; Mature: 23731

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSEPNPQAVDQLFDRLLHTEDDALIAARESAAAAGMPQIEVSAQHGRLLLLLASVTHA
CCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHCCCCEEEEECCCCEEEEEEHHHHHH
RRVLEIGTLAGYSTINLARGVGPDGRVVTLEFDPRHAEVARTNLARAGVADQVEVLVGAA
HHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHH
LDTLPTLQHGAPFDLVFIDADKENNVAYVEWAIKLGRPGTVIVVDNVTRMGRIYDPAPDD
HHHHCCCCCCCCEEEEEEECCCCCCEEEEEEEEEECCCCEEEEECCCHHCCEECCCCCCC
LQAQAVREMLEMMGSHPRLSTAAIQTVGAKNWDGFAVAVVT
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEEC
>Mature Secondary Structure
MRVSEPNPQAVDQLFDRLLHTEDDALIAARESAAAAGMPQIEVSAQHGRLLLLLASVTHA
CCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHCCCCEEEEECCCCEEEEEEHHHHHH
RRVLEIGTLAGYSTINLARGVGPDGRVVTLEFDPRHAEVARTNLARAGVADQVEVLVGAA
HHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHH
LDTLPTLQHGAPFDLVFIDADKENNVAYVEWAIKLGRPGTVIVVDNVTRMGRIYDPAPDD
HHHHCCCCCCCCEEEEEEECCCCCCEEEEEEEEEECCCCEEEEECCCHHCCEECCCCCCC
LQAQAVREMLEMMGSHPRLSTAAIQTVGAKNWDGFAVAVVT
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]