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The map label for this gene is hdl IVa [H]

Identifier: 108797074

GI number: 108797074

Start: 108026

End: 108637

Strand: Direct

Name: hdl IVa [H]

Synonym: Mmcs_0093

Alternate gene names: 108797074

Gene position: 108026-108637 (Clockwise)

Preceding gene: 108797073

Following gene: 108797075

Centisome position: 1.89

GC content: 69.93

Gene sequence:

>612_bases
GTGTTGGCGTTCGACGTCTTCGGGACCGTCGTGGACTGGCGGTCCAGTGTCATCGCCCAACTCGAGGAGTTCGGGCGTGC
GCACGGGGTGGACGCCGACTGGGCGGCGTTCGCCGACGCCTGGCGGGCCGGCTATGTGCCGTCGATGGACCGGGTGCGCC
GCGGTGAGCTGCCGTGGACCCGACTCGACGACCTGCACCGGATGACGCTCGTCGATCTGCTTGCCGCCGAGCACATCTCG
GTCGGGGACGAGGCCGTCGACGAGCTCACCCGGGCCTGGCACCGGCTGGACCCGTGGCCCGACAGCGTCGCGGGACTGAC
GCGGCTCAAACGCCGCTACGTCATCACCCCGCTGTCCAACGGCAACGTGTCACTGCTGACGAACATGGCCAAGCGGGCCG
GGCTGCCATGGGACTGTGTCCTGTCGGCCGAGCTGTTCCGGCACTACAAACCCGACCCCGAGGCCTATCTCGGCTGCGCC
GACCTGCTCGACGTCACCCCCGATGAGCTGATGCTCGTCGCCGCGCACCGATCCGATCTGCGCGCCGCACGCGAGGCGGG
TCTGCGCACCGCATACGTGTCCCGGCCACTGGAATACGGCCCCGGACGGTAG

Upstream 100 bases:

>100_bases
CCGTGTGCTATCCGCTCGCCGAGGGTCCGGCGGCGTTGCAGGCGCTGGCCGACGGGGAGATCAAGGGCAAGTTGGTCCTG
CAACCGTGACGAGCGTCAGC

Downstream 100 bases:

>100_bases
GTCCGAATGCCGGCCGAGGGCGAATTCGACGTGCTGGCAAGCGATTTTCTCGATCTGGCGGACCAGCTCGGGGCATGACC
GGGCAGCGTACCGTGGGGGA

Product: haloacid dehalogenase, type II

Products: NA

Alternate protein names: 2-haloalkanoic acid dehalogenase IVA; Halocarboxylic acid halidohydrolase IVA; L-2-haloacid dehalogenase IVA [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLAFDVFGTVVDWRSSVIAQLEEFGRAHGVDADWAAFADAWRAGYVPSMDRVRRGELPWTRLDDLHRMTLVDLLAAEHIS
VGDEAVDELTRAWHRLDPWPDSVAGLTRLKRRYVITPLSNGNVSLLTNMAKRAGLPWDCVLSAELFRHYKPDPEAYLGCA
DLLDVTPDELMLVAAHRSDLRAAREAGLRTAYVSRPLEYGPGR

Sequences:

>Translated_203_residues
MLAFDVFGTVVDWRSSVIAQLEEFGRAHGVDADWAAFADAWRAGYVPSMDRVRRGELPWTRLDDLHRMTLVDLLAAEHIS
VGDEAVDELTRAWHRLDPWPDSVAGLTRLKRRYVITPLSNGNVSLLTNMAKRAGLPWDCVLSAELFRHYKPDPEAYLGCA
DLLDVTPDELMLVAAHRSDLRAAREAGLRTAYVSRPLEYGPGR
>Mature_203_residues
MLAFDVFGTVVDWRSSVIAQLEEFGRAHGVDADWAAFADAWRAGYVPSMDRVRRGELPWTRLDDLHRMTLVDLLAAEHIS
VGDEAVDELTRAWHRLDPWPDSVAGLTRLKRRYVITPLSNGNVSLLTNMAKRAGLPWDCVLSAELFRHYKPDPEAYLGCA
DLLDVTPDELMLVAAHRSDLRAAREAGLRTAYVSRPLEYGPGR

Specific function: Catalyzes the hydrolytic dehalogenation of small (S)-2- haloalkanoic acids to yield the corresponding (R)-2- hydroxyalkanoic acids. Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-3 [H]

COG id: COG1011

COG function: function code R; Predicted hydrolase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. S-2- haloalkanoic acid dehalogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006388
- InterPro:   IPR006402
- InterPro:   IPR006328
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.8.1.2 [H]

Molecular weight: Translated: 22798; Mature: 22798

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAFDVFGTVVDWRSSVIAQLEEFGRAHGVDADWAAFADAWRAGYVPSMDRVRRGELPWT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCHH
RLDDLHRMTLVDLLAAEHISVGDEAVDELTRAWHRLDPWPDSVAGLTRLKRRYVITPLSN
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCC
GNVSLLTNMAKRAGLPWDCVLSAELFRHYKPDPEAYLGCADLLDVTPDELMLVAAHRSDL
CCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHEEEHHHHHHH
RAAREAGLRTAYVSRPLEYGPGR
HHHHHHCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLAFDVFGTVVDWRSSVIAQLEEFGRAHGVDADWAAFADAWRAGYVPSMDRVRRGELPWT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCHH
RLDDLHRMTLVDLLAAEHISVGDEAVDELTRAWHRLDPWPDSVAGLTRLKRRYVITPLSN
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCC
GNVSLLTNMAKRAGLPWDCVLSAELFRHYKPDPEAYLGCADLLDVTPDELMLVAAHRSDL
CCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHEEEHHHHHHH
RAAREAGLRTAYVSRPLEYGPGR
HHHHHHCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1376111 [H]