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The map label for this gene is yhdH [C]

Identifier: 108797073

GI number: 108797073

Start: 107049

End: 108014

Strand: Direct

Name: yhdH [C]

Synonym: Mmcs_0092

Alternate gene names: 108797073

Gene position: 107049-108014 (Clockwise)

Preceding gene: 108797072

Following gene: 108797074

Centisome position: 1.88

GC content: 71.22

Gene sequence:

>966_bases
GTGAAAGCGCTTCTCGCGCAGGAACTCTCGGGGCCATCCGGTCTGGTCTACACCGATGTCGATGATCCCGCCTCCGACGG
GGCGGTGATCATCGACGTCGGTGCGGCCGGCGTCTGCTTCCCCGACCTCCTGCTGTTGCGCGGTGAGTACCAGCTCAAGC
TGGAGCCGCCGTTCATCCCCGGTATGGAGGTGGCCGGTACGGTCCGGTCGGCGCCCGACTCGTCCGGATTCATGCCCGGG
CAACGGGTTTCGGCGTTCACGTTGATGGGCGGTTTCGCCGAGCGGGTCGCGGCGTTGCCCGACAGTGTGATCCCGACGCC
CGACGGGGTCGACGACGCCTCGGCGGCGGCGCTGCTGGGCAACTACTACACGATGCAGTTCGCCCTGGCCCGCCGCGGCG
GGCTGACGCCGGGGGAGACCGTGCTGGTGCTCGGTTCGGCCGGCGGCGTGGGCACCGCGGCCATCCAGCTCGCGAAGGCG
CAGGGCGCCACCGTGATCGCGATGGTTCACCGTTCCGGCGCCGAGGAGTTCATCCGCGGTCTGGGCGCCGACGTGGTGCT
GCCGCTGACCGACGGGTGGCGACAAGCCGTCCTCGACGCCACCGACGGGCGCGGCGTCGACATCGTGGTCGACCCGATCG
GCGGTCCCGCCTTCGACGACGCGGTGCGGGTGCTGGCTCCGGAGGGGCGGCTGCTGGTGATCGGATTCGCCGCGGGCGGC
GGCATACCCACCGTGAAGGTGAACCGGTTGCTGCTGCGCAACGTGAGCGTCGTCGGGGTCGGCTGGGGCGAATTCGTCAG
GCGCAACCCGAGTGCGCAGGCTGCCGTCGGCGCCGAATTGGCGGCCCTGGTCGAGGCGGGTCTGCGTCCGCCCCCGCCCG
TGTGCTATCCGCTCGCCGAGGGTCCGGCGGCGTTGCAGGCGCTGGCCGACGGGGAGATCAAGGGCAAGTTGGTCCTGCAA
CCGTGA

Upstream 100 bases:

>100_bases
CCTTCACCAAGGTGCCCACCCTCGACGACGTCGCGTCCCGGTGGGGTGAGATCACCGATCTGTCCGCAGCGCAGCAGGCC
AGCTTCAAGCTCGGCTGACT

Downstream 100 bases:

>100_bases
CGAGCGTCAGCGTGTTGGCGTTCGACGTCTTCGGGACCGTCGTGGACTGGCGGTCCAGTGTCATCGCCCAACTCGAGGAG
TTCGGGCGTGCGCACGGGGT

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MKALLAQELSGPSGLVYTDVDDPASDGAVIIDVGAAGVCFPDLLLLRGEYQLKLEPPFIPGMEVAGTVRSAPDSSGFMPG
QRVSAFTLMGGFAERVAALPDSVIPTPDGVDDASAAALLGNYYTMQFALARRGGLTPGETVLVLGSAGGVGTAAIQLAKA
QGATVIAMVHRSGAEEFIRGLGADVVLPLTDGWRQAVLDATDGRGVDIVVDPIGGPAFDDAVRVLAPEGRLLVIGFAAGG
GIPTVKVNRLLLRNVSVVGVGWGEFVRRNPSAQAAVGAELAALVEAGLRPPPPVCYPLAEGPAALQALADGEIKGKLVLQ
P

Sequences:

>Translated_321_residues
MKALLAQELSGPSGLVYTDVDDPASDGAVIIDVGAAGVCFPDLLLLRGEYQLKLEPPFIPGMEVAGTVRSAPDSSGFMPG
QRVSAFTLMGGFAERVAALPDSVIPTPDGVDDASAAALLGNYYTMQFALARRGGLTPGETVLVLGSAGGVGTAAIQLAKA
QGATVIAMVHRSGAEEFIRGLGADVVLPLTDGWRQAVLDATDGRGVDIVVDPIGGPAFDDAVRVLAPEGRLLVIGFAAGG
GIPTVKVNRLLLRNVSVVGVGWGEFVRRNPSAQAAVGAELAALVEAGLRPPPPVCYPLAEGPAALQALADGEIKGKLVLQ
P
>Mature_321_residues
MKALLAQELSGPSGLVYTDVDDPASDGAVIIDVGAAGVCFPDLLLLRGEYQLKLEPPFIPGMEVAGTVRSAPDSSGFMPG
QRVSAFTLMGGFAERVAALPDSVIPTPDGVDDASAAALLGNYYTMQFALARRGGLTPGETVLVLGSAGGVGTAAIQLAKA
QGATVIAMVHRSGAEEFIRGLGADVVLPLTDGWRQAVLDATDGRGVDIVVDPIGGPAFDDAVRVLAPEGRLLVIGFAAGG
GIPTVKVNRLLLRNVSVVGVGWGEFVRRNPSAQAAVGAELAALVEAGLRPPPPVCYPLAEGPAALQALADGEIKGKLVLQ
P

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=328, Percent_Identity=28.3536585365854, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13236495, Length=328, Percent_Identity=28.3536585365854, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI41872631, Length=315, Percent_Identity=30.7936507936508, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI28557745, Length=310, Percent_Identity=30.9677419354839, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI18379349, Length=307, Percent_Identity=29.9674267100977, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI194239676, Length=327, Percent_Identity=28.4403669724771, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI22538446, Length=256, Percent_Identity=29.6875, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI22538444, Length=256, Percent_Identity=29.6875, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI24308257, Length=316, Percent_Identity=27.5316455696203, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789651, Length=331, Percent_Identity=26.8882175226586, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=327, Percent_Identity=26.605504587156, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=350, Percent_Identity=25.4285714285714, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=330, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=351, Percent_Identity=25.0712250712251, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=352, Percent_Identity=24.4318181818182, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24581345, Length=248, Percent_Identity=27.4193548387097, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920632, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330659, Length=252, Percent_Identity=27.3809523809524, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 32690; Mature: 32690

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALLAQELSGPSGLVYTDVDDPASDGAVIIDVGAAGVCFPDLLLLRGEYQLKLEPPFIP
CCCHHHHHCCCCCCEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCC
GMEVAGTVRSAPDSSGFMPGQRVSAFTLMGGFAERVAALPDSVIPTPDGVDDASAAALLG
CCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHC
NYYTMQFALARRGGLTPGETVLVLGSAGGVGTAAIQLAKAQGATVIAMVHRSGAEEFIRG
CHHEEEEEEHHCCCCCCCCEEEEEECCCCCCHHHEEEECCCCCEEEEEEECCCHHHHHHH
LGADVVLPLTDGWRQAVLDATDGRGVDIVVDPIGGPAFDDAVRVLAPEGRLLVIGFAAGG
CCCCEEEECCCCHHHHHEECCCCCCEEEEEECCCCCCHHHHHEEECCCCCEEEEEEECCC
GIPTVKVNRLLLRNVSVVGVGWGEFVRRNPSAQAAVGAELAALVEAGLRPPPPVCYPLAE
CCCEEEEHHEECCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCC
GPAALQALADGEIKGKLVLQP
CHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKALLAQELSGPSGLVYTDVDDPASDGAVIIDVGAAGVCFPDLLLLRGEYQLKLEPPFIP
CCCHHHHHCCCCCCEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEECCCCCC
GMEVAGTVRSAPDSSGFMPGQRVSAFTLMGGFAERVAALPDSVIPTPDGVDDASAAALLG
CCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHC
NYYTMQFALARRGGLTPGETVLVLGSAGGVGTAAIQLAKAQGATVIAMVHRSGAEEFIRG
CHHEEEEEEHHCCCCCCCCEEEEEECCCCCCHHHEEEECCCCCEEEEEEECCCHHHHHHH
LGADVVLPLTDGWRQAVLDATDGRGVDIVVDPIGGPAFDDAVRVLAPEGRLLVIGFAAGG
CCCCEEEECCCCHHHHHEECCCCCCEEEEEECCCCCCHHHHHEEECCCCCEEEEEEECCC
GIPTVKVNRLLLRNVSVVGVGWGEFVRRNPSAQAAVGAELAALVEAGLRPPPPVCYPLAE
CCCEEEEHHEECCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCC
GPAALQALADGEIKGKLVLQP
CHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA