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The map label for this gene is fabG [C]

Identifier: 108797072

GI number: 108797072

Start: 106183

End: 107046

Strand: Direct

Name: fabG [C]

Synonym: Mmcs_0091

Alternate gene names: 108797072

Gene position: 106183-107046 (Clockwise)

Preceding gene: 108797071

Following gene: 108797073

Centisome position: 1.86

GC content: 66.9

Gene sequence:

>864_bases
ATGCCAGGAGTGCAGGATCGCGTCATCGTCGTCACCGGAGCCGGCGGAGGGCTGGGCCGTGAGTACGCGCTGACGCTGGC
CCGCGAGGGCGCCGCGGTCGTCGTCAACGACCTCGGCGGTGCGCGCGACGGCACCGGCGCCGGATCGGCGATGGCCGATC
AGGTGGTCGACGAGATCAAGGCCGCGGGTGGCCGGGCCGCGGCCAACTACGACTCCGTCGCCGAACCCGAGGGCGCCGAG
AACATCATCAAGACCGCGATCGACGAGTTCGGCAAGGTCGACGGTGTGGTGAGCAACGCGGGCATCCTGCGCGACGGCAC
GTTCCACAAGATGACGTTCGAGAACTGGGACGCGGTGCTCAAGGTGCACCTGTACGGCGGGTACAACGTGATCCGTGCGG
CGTGGCCGCACTTCCGTGAGCAGAGCTTCGGCCGCGTCGTCGTCGCCACCTCGACCAGCGGGCTGTTCGGCAACTTCGGC
CAGGCCAACTACGGCGCAGCGAAACTCGGCCTCGTCGGCCTGATCAACACGCTCGCCCAGGAAGGCGCGAAGTACAACAT
CAAGACCAACGCCGTCGCACCGATCGCCGCGACCCGGATGACGCAGGACATCCTGCCGCCGGAGGTCTTCGAGAAGCTCA
CGCCGGAGTACGTCGCGCCGGTCGTCGCGCACCTGATGACCGAGGAACTGACCGACACCGACTCGATCTTCATCGTCGGC
GGCGGCAAAATACAGCGGGCAGCGCTCTTTCAGAACGAAGGTACTACCTTCACCAAGGTGCCCACCCTCGACGACGTCGC
GTCCCGGTGGGGTGAGATCACCGATCTGTCCGCAGCGCAGCAGGCCAGCTTCAAGCTCGGCTGA

Upstream 100 bases:

>100_bases
GGAAACTCGCCCGTCGCCTCTTTTAGCGATTTCGGCGTGCCTGGTCGCGCTGAGCGCGACCGAGCACGCCGAAATCACAA
CTGAACCCGAAAGGAACCCC

Downstream 100 bases:

>100_bases
CTGTGAAAGCGCTTCTCGCGCAGGAACTCTCGGGGCCATCCGGTCTGGTCTACACCGATGTCGATGATCCCGCCTCCGAC
GGGGCGGTGATCATCGACGT

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MPGVQDRVIVVTGAGGGLGREYALTLAREGAAVVVNDLGGARDGTGAGSAMADQVVDEIKAAGGRAAANYDSVAEPEGAE
NIIKTAIDEFGKVDGVVSNAGILRDGTFHKMTFENWDAVLKVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSGLFGNFG
QANYGAAKLGLVGLINTLAQEGAKYNIKTNAVAPIAATRMTQDILPPEVFEKLTPEYVAPVVAHLMTEELTDTDSIFIVG
GGKIQRAALFQNEGTTFTKVPTLDDVASRWGEITDLSAAQQASFKLG

Sequences:

>Translated_287_residues
MPGVQDRVIVVTGAGGGLGREYALTLAREGAAVVVNDLGGARDGTGAGSAMADQVVDEIKAAGGRAAANYDSVAEPEGAE
NIIKTAIDEFGKVDGVVSNAGILRDGTFHKMTFENWDAVLKVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSGLFGNFG
QANYGAAKLGLVGLINTLAQEGAKYNIKTNAVAPIAATRMTQDILPPEVFEKLTPEYVAPVVAHLMTEELTDTDSIFIVG
GGKIQRAALFQNEGTTFTKVPTLDDVASRWGEITDLSAAQQASFKLG
>Mature_286_residues
PGVQDRVIVVTGAGGGLGREYALTLAREGAAVVVNDLGGARDGTGAGSAMADQVVDEIKAAGGRAAANYDSVAEPEGAEN
IIKTAIDEFGKVDGVVSNAGILRDGTFHKMTFENWDAVLKVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSGLFGNFGQ
ANYGAAKLGLVGLINTLAQEGAKYNIKTNAVAPIAATRMTQDILPPEVFEKLTPEYVAPVVAHLMTEELTDTDSIFIVGG
GKIQRAALFQNEGTTFTKVPTLDDVASRWGEITDLSAAQQASFKLG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=278, Percent_Identity=49.6402877697842, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=34.6613545816733, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI40254992, Length=211, Percent_Identity=34.5971563981043, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=28.6274509803922, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4503817, Length=199, Percent_Identity=27.6381909547739, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI25282469, Length=265, Percent_Identity=27.1698113207547, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI40807363, Length=240, Percent_Identity=27.5, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=29.4736842105263, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI5031737, Length=190, Percent_Identity=29.4736842105263, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=35.2631578947368, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082100, Length=186, Percent_Identity=31.1827956989247, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789208, Length=207, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787526, Length=234, Percent_Identity=28.2051282051282, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787905, Length=208, Percent_Identity=27.4038461538462, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790717, Length=203, Percent_Identity=26.6009852216749, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789057, Length=215, Percent_Identity=30.6976744186047, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=193, Percent_Identity=30.0518134715026, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082160, Length=236, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=186, Percent_Identity=27.4193548387097, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=274, Percent_Identity=49.6350364963504, Blast_Score=287, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI25147288, Length=215, Percent_Identity=34.4186046511628, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=217, Percent_Identity=30.8755760368664, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=239, Percent_Identity=28.4518828451883, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=199, Percent_Identity=29.1457286432161, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=179, Percent_Identity=29.0502793296089, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=198, Percent_Identity=29.2929292929293, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=194, Percent_Identity=26.2886597938144, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=234, Percent_Identity=29.0598290598291, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=234, Percent_Identity=29.0598290598291, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=231, Percent_Identity=26.4069264069264, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=28.4210526315789, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=202, Percent_Identity=26.7326732673267, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=281, Percent_Identity=53.3807829181495, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI18859837, Length=281, Percent_Identity=47.6868327402135, Blast_Score=254, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=29.7619047619048, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=27.1794871794872, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=29.8429319371728, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=196, Percent_Identity=28.0612244897959, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=27.6264591439689, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356301, Length=195, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737361, Length=204, Percent_Identity=27.9411764705882, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24644339, Length=189, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30162; Mature: 30031

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGVQDRVIVVTGAGGGLGREYALTLAREGAAVVVNDLGGARDGTGAGSAMADQVVDEIK
CCCCCCCEEEEECCCCCCCHHHEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AAGGRAAANYDSVAEPEGAENIIKTAIDEFGKVDGVVSNAGILRDGTFHKMTFENWDAVL
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCEEECCCEEEEECCCCCEEE
KVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSGLFGNFGQANYGAAKLGLVGLINTLAQ
EEEEECCCHHHHHHCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EGAKYNIKTNAVAPIAATRMTQDILPPEVFEKLTPEYVAPVVAHLMTEELTDTDSIFIVG
CCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEE
GGKIQRAALFQNEGTTFTKVPTLDDVASRWGEITDLSAAQQASFKLG
CCCEEEEEEECCCCCEEEECCCHHHHHHHCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
PGVQDRVIVVTGAGGGLGREYALTLAREGAAVVVNDLGGARDGTGAGSAMADQVVDEIK
CCCCCCEEEEECCCCCCCHHHEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AAGGRAAANYDSVAEPEGAENIIKTAIDEFGKVDGVVSNAGILRDGTFHKMTFENWDAVL
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCCCEEECCCEEEEECCCCCEEE
KVHLYGGYNVIRAAWPHFREQSFGRVVVATSTSGLFGNFGQANYGAAKLGLVGLINTLAQ
EEEEECCCHHHHHHCCHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EGAKYNIKTNAVAPIAATRMTQDILPPEVFEKLTPEYVAPVVAHLMTEELTDTDSIFIVG
CCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEE
GGKIQRAALFQNEGTTFTKVPTLDDVASRWGEITDLSAAQQASFKLG
CCCEEEEEEECCCCCEEEECCCHHHHHHHCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]