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The map label for this gene is eccCb1 [H]

Identifier: 108797048

GI number: 108797048

Start: 79714

End: 81516

Strand: Direct

Name: eccCb1 [H]

Synonym: Mmcs_0067

Alternate gene names: 108797048

Gene position: 79714-81516 (Clockwise)

Preceding gene: 108797047

Following gene: 108797049

Centisome position: 1.4

GC content: 68.44

Gene sequence:

>1803_bases
ATGACGGCGTCGAGGCAGGCCGCCGAACAGAAGGTCCTTCGCGAGGTCGTCCTCGATCAGCTCACGACGGGCGAGATCCG
CGCCTACCGGATGTGGCTGCCGCCCCTGACCGATCCCACGCCGGTCGACGAACTCGTCGAGCGCGACCATCAGCGCCGGC
CGCTGCGGTTCGGGTTGGGCATTATGGACGAACCCCGCAGGCACCGCCAGGACATCTGGGGTGTCGACGTGTCCGCCGCG
GGCGGCAACATCGCGATCGGCGGGGCACCGCAGACCGGTAAGTCGACGTTCCTGCAGACGTTGATCCTGTCGGCGGCGGC
CACCCACTCCCCGCGCGACGTGCAGTTCTACTGCGTCGACCTCGGCGGCGGCGGTCTGATGTACCTCGAGGATCTGCCGC
ACGTCGGCGGCGTCGCCACCCGTGCCGAACCGGACCGTGTCAACCGCGTGGTCGCCGAGGTGAAAGCCGTTCAGCGGCAA
CGAGAGCGGACCTTCAAGGAGTTGCGGGTCGGGTCGATCGCGGGCTACCGGCAGATGCGGGAGGATCCGAACAACCCGGC
CGCCGCCGATCCGTTCGGCGACGTGTTCCTGGTGATCGACGGGTGGCCGGCGTTCGTCGCGGAGTTCCCCGACCTCGAAC
CGGTCGTCCAGGACCTGGCCGGTCAGGGCCTCGCGTTCGGGGTGCACGTGATCATCTCGACGCCGCGCTGGACCGAGTTG
AAGTCACGCGTCCGCGACTACCTCGGCACCAAGATCGAGTTCCGGCTCGGCGATGTGAACGAGACGCAGATCGACCGCAT
CACCCGCGAGATCCCGGCGAACCGGCCGGGCCGGGCGATCTCGATGGAGAAGCACCATCTGATGATGGGCGTGCCACGCC
TCGACGGGCAGCACAGCGCGGGCAACCTCGTCCCGGCGATCACGTCGGCCGTCGCCCAGATCGCCGCCCGGCACACGGTT
CGGGCGCCGCAGGTGCGGGTGCTGCCGGAACGGGTCCATCTCGACGAACTCGACCCCAACCCGCCGGGACCCGACGCCGA
CTACCGCACGCGGTGGCGCATTCCGCTGGGTGTGCGGGAATCCGATCTCAGCGTCGCCTACAACGAGATGCAGATGACGC
CGCATCTGTTGATCTTCGGTGCGCCCAAGTCCGGCAAAACGACGATCGCCCACGCGGTGGCGCAGGCGATCTGCCGCCGC
AACAGTCCCCAGCAAGTGCGGTTCATGCTGGCCGACTATCGGTCGGCGTTGCTGGACGCGGTGCCCCAGAGCCACCTTCT
CGACGCAGGTGCGGTCAACCGCAATCACGCATCGCTCGAGGCGGCAATCAAGGCGTTGGCGACCAACCTGCAGAAGCGAC
TGCCGCCGCCGGACCTCACCACGGCCCAGTTGCGGTCGCGGTCGTGGTGGAGCGGACCCGACGTGGTGCTGCTGGTCGAC
GACTGGCACATGATCGTCGCGGCGTCCGGCATGGTGCCGCCGATGGCACCGCTGGCCCCACTGCTTCCCGCGGCCGCCGA
CATCGGCCTGCACATCATCGTGACCTGCCAGATGAGCCAGGCGCATCGGGCCACCATGGACAAGTTCGTGGGGGCGGCGT
ACGGCGCCGGGACCCCGACGCTGTTCCTGTCCGGGGAGAAGACGGAGTTCCCCTCGAGCGAGATCAAACTGCGGAAACGG
CCGCCTGGCCAGGCGCTTCTGGTGTCGCCGGACGGTAAGGAGGTGGTCCAGGCCGCCTACGTTGACCCCCCGGCCGATCC
ACTGGAAGAAGAAGTGTTAGCACCACCCCCACAGGGCGGTTAG

Upstream 100 bases:

>100_bases
TCCAGGAGGACGGTGAGGTCAAACCCCGCCAGTCCACCCGCAACCGGGTGCGGATCCACAAGTTCACCGCGACCCCGATC
TTCGATACGGCGGTGACGTC

Downstream 100 bases:

>100_bases
TATCTAACGAGAGCTTCACAGCAACGTTGGTGGTAATCCGCCAGCAAATAAGTCGGGGGATGAGTCCGGAGACGACGGGG
TAGGTATGCCCGAGTCGTTC

Product: cell divisionFtsK/SpoIIIE

Products: NA

Alternate protein names: ESX conserved component Cb1; Type VII secretion system protein EccCb1; T7SS protein EccCb1 [H]

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MTASRQAAEQKVLREVVLDQLTTGEIRAYRMWLPPLTDPTPVDELVERDHQRRPLRFGLGIMDEPRRHRQDIWGVDVSAA
GGNIAIGGAPQTGKSTFLQTLILSAAATHSPRDVQFYCVDLGGGGLMYLEDLPHVGGVATRAEPDRVNRVVAEVKAVQRQ
RERTFKELRVGSIAGYRQMREDPNNPAAADPFGDVFLVIDGWPAFVAEFPDLEPVVQDLAGQGLAFGVHVIISTPRWTEL
KSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAISMEKHHLMMGVPRLDGQHSAGNLVPAITSAVAQIAARHTV
RAPQVRVLPERVHLDELDPNPPGPDADYRTRWRIPLGVRESDLSVAYNEMQMTPHLLIFGAPKSGKTTIAHAVAQAICRR
NSPQQVRFMLADYRSALLDAVPQSHLLDAGAVNRNHASLEAAIKALATNLQKRLPPPDLTTAQLRSRSWWSGPDVVLLVD
DWHMIVAASGMVPPMAPLAPLLPAAADIGLHIIVTCQMSQAHRATMDKFVGAAYGAGTPTLFLSGEKTEFPSSEIKLRKR
PPGQALLVSPDGKEVVQAAYVDPPADPLEEEVLAPPPQGG

Sequences:

>Translated_600_residues
MTASRQAAEQKVLREVVLDQLTTGEIRAYRMWLPPLTDPTPVDELVERDHQRRPLRFGLGIMDEPRRHRQDIWGVDVSAA
GGNIAIGGAPQTGKSTFLQTLILSAAATHSPRDVQFYCVDLGGGGLMYLEDLPHVGGVATRAEPDRVNRVVAEVKAVQRQ
RERTFKELRVGSIAGYRQMREDPNNPAAADPFGDVFLVIDGWPAFVAEFPDLEPVVQDLAGQGLAFGVHVIISTPRWTEL
KSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAISMEKHHLMMGVPRLDGQHSAGNLVPAITSAVAQIAARHTV
RAPQVRVLPERVHLDELDPNPPGPDADYRTRWRIPLGVRESDLSVAYNEMQMTPHLLIFGAPKSGKTTIAHAVAQAICRR
NSPQQVRFMLADYRSALLDAVPQSHLLDAGAVNRNHASLEAAIKALATNLQKRLPPPDLTTAQLRSRSWWSGPDVVLLVD
DWHMIVAASGMVPPMAPLAPLLPAAADIGLHIIVTCQMSQAHRATMDKFVGAAYGAGTPTLFLSGEKTEFPSSEIKLRKR
PPGQALLVSPDGKEVVQAAYVDPPADPLEEEVLAPPPQGG
>Mature_599_residues
TASRQAAEQKVLREVVLDQLTTGEIRAYRMWLPPLTDPTPVDELVERDHQRRPLRFGLGIMDEPRRHRQDIWGVDVSAAG
GNIAIGGAPQTGKSTFLQTLILSAAATHSPRDVQFYCVDLGGGGLMYLEDLPHVGGVATRAEPDRVNRVVAEVKAVQRQR
ERTFKELRVGSIAGYRQMREDPNNPAAADPFGDVFLVIDGWPAFVAEFPDLEPVVQDLAGQGLAFGVHVIISTPRWTELK
SRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAISMEKHHLMMGVPRLDGQHSAGNLVPAITSAVAQIAARHTVR
APQVRVLPERVHLDELDPNPPGPDADYRTRWRIPLGVRESDLSVAYNEMQMTPHLLIFGAPKSGKTTIAHAVAQAICRRN
SPQQVRFMLADYRSALLDAVPQSHLLDAGAVNRNHASLEAAIKALATNLQKRLPPPDLTTAQLRSRSWWSGPDVVLLVDD
WHMIVAASGMVPPMAPLAPLLPAAADIGLHIIVTCQMSQAHRATMDKFVGAAYGAGTPTLFLSGEKTEFPSSEIKLRKRP
PGQALLVSPDGKEVVQAAYVDPPADPLEEEVLAPPPQGG

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). May link the cytosolic components of the system with the membrane components. Responsible for multiple suppressive effects on macrophages and req

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 FtsK domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR002543 [H]

Pfam domain/function: PF01580 FtsK_SpoIIIE [H]

EC number: NA

Molecular weight: Translated: 65635; Mature: 65504

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASRQAAEQKVLREVVLDQLTTGEIRAYRMWLPPLTDPTPVDELVERDHQRRPLRFGLG
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHCCCC
IMDEPRRHRQDIWGVDVSAAGGNIAIGGAPQTGKSTFLQTLILSAAATHSPRDVQFYCVD
CCCCCHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
LGGGGLMYLEDLPHVGGVATRAEPDRVNRVVAEVKAVQRQRERTFKELRVGSIAGYRQMR
ECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDPNNPAAADPFGDVFLVIDGWPAFVAEFPDLEPVVQDLAGQGLAFGVHVIISTPRWTEL
CCCCCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEECCCHHHH
KSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAISMEKHHLMMGVPRLDGQHSA
HHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCCCC
GNLVPAITSAVAQIAARHTVRAPQVRVLPERVHLDELDPNPPGPDADYRTRWRIPLGVRE
CCHHHHHHHHHHHHHHHHCCCCCCEEECHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCC
SDLSVAYNEMQMTPHLLIFGAPKSGKTTIAHAVAQAICRRNSPQQVRFMLADYRSALLDA
CCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VPQSHLLDAGAVNRNHASLEAAIKALATNLQKRLPPPDLTTAQLRSRSWWSGPDVVLLVD
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEC
DWHMIVAASGMVPPMAPLAPLLPAAADIGLHIIVTCQMSQAHRATMDKFVGAAYGAGTPT
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCE
LFLSGEKTEFPSSEIKLRKRPPGQALLVSPDGKEVVQAAYVDPPADPLEEEVLAPPPQGG
EEECCCCCCCCCHHCEEECCCCCCEEEECCCCHHHHHHHCCCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
TASRQAAEQKVLREVVLDQLTTGEIRAYRMWLPPLTDPTPVDELVERDHQRRPLRFGLG
CCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHCCCC
IMDEPRRHRQDIWGVDVSAAGGNIAIGGAPQTGKSTFLQTLILSAAATHSPRDVQFYCVD
CCCCCHHHHHHHCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
LGGGGLMYLEDLPHVGGVATRAEPDRVNRVVAEVKAVQRQRERTFKELRVGSIAGYRQMR
ECCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDPNNPAAADPFGDVFLVIDGWPAFVAEFPDLEPVVQDLAGQGLAFGVHVIISTPRWTEL
CCCCCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHCCCCEEEEEEEEEECCCHHHH
KSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAISMEKHHLMMGVPRLDGQHSA
HHHHHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCCCC
GNLVPAITSAVAQIAARHTVRAPQVRVLPERVHLDELDPNPPGPDADYRTRWRIPLGVRE
CCHHHHHHHHHHHHHHHHCCCCCCEEECHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCC
SDLSVAYNEMQMTPHLLIFGAPKSGKTTIAHAVAQAICRRNSPQQVRFMLADYRSALLDA
CCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VPQSHLLDAGAVNRNHASLEAAIKALATNLQKRLPPPDLTTAQLRSRSWWSGPDVVLLVD
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEC
DWHMIVAASGMVPPMAPLAPLLPAAADIGLHIIVTCQMSQAHRATMDKFVGAAYGAGTPT
CCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCE
LFLSGEKTEFPSSEIKLRKRPPGQALLVSPDGKEVVQAAYVDPPADPLEEEVLAPPPQGG
EEECCCCCCCCCHHCEEECCCCCCEEEECCCCHHHHHHHCCCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]