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The map label for this gene is eccCa1 [H]

Identifier: 108797047

GI number: 108797047

Start: 77480

End: 79717

Strand: Direct

Name: eccCa1 [H]

Synonym: Mmcs_0066

Alternate gene names: 108797047

Gene position: 77480-79717 (Clockwise)

Preceding gene: 108797046

Following gene: 108797048

Centisome position: 1.36

GC content: 67.52

Gene sequence:

>2238_bases
ATGACCACGAAGAAGTTCACCCCGATCATCAAACGGGGTCCTCGGCTGACCCCAGGCGAGATCACCGTCACCCCACCCGA
TGATCTGGGCGTGGAGATCCCGCCGTCGGGTATTCAGCGTGCGCTGCCGTGGGTGATGGGCGGCTGCATGCTCGGGATGA
TCTCGATCATGATCTTCACCGGCGTCCGGCAGCTCTCGCCCTACATGCTGATGATGCCGCTGATGATGGTGATGGCCACG
GTCGGCTTCATGGCCGGCGGCGGGTCGGGCGCCAAGCGGGTGCCCGAGATCAACGCCGACCGCAAGGAATACCTGCGGTA
CCTGTCGGGTCTGCGCACTCGCGTCACGTCGTCGGCCGCCGCGCAGGTGACGTTCTTCAACTACCACGCACCGCATCCCG
AGGATCTGCTGTCGATCATCGGCACGAACCGCCAGTGGTCGCGTCAGGCCAACAGCGAGTTCTTCGCCGCGACGCGGATC
GGTCTGGGTTCCGAACCGGCGGTGGACCGGCTGCTCAAACCCTCCATCGGAGACGTCAACGGGCTCGCCGGTCCGCAGGC
CGCCCCGCAACCGCACCTCGAACCGGTCAGCCACATGTGGGTGACCAAGTTCCTGCGCACCCACGGCCTCATCCATGACT
GTCCGAAACTGCTTCAGCTGCGGTCGTTTCCGACCATCGCGATCGGCGGTGACCCCGACGGCTCCGCCGCCCTGCTGGCG
GCGATGATCTGCCACCTCGCGGTCTTCCATCCACCGGATCTGCTCCAGCTGCGGGTGCTCACCGACAACCCGGAGGACCC
GAACTGGAGCTGGCTCAAATGGCTTCCGCACGTTCAGCACCAGAGCGACGTCGACGCCGCCGGACCCACCCGCATGGTGT
TCACCCGGCCGGACGGGTTGAGCGATCTCACCGCGCGCGGACCGCACACCGCCGATTCGGCGCCCAGCGGCCCGTACGTC
GTCGTGGTCGACCTCACCGGTGGCCGCGCCGGATTCCCGGCCGACGGCCGCGCCGGGGTCACGGTGCTCACGCTCGGCAA
CCACAACGGCTCGGCCTACCGGATCCGGGTCGCGGCCGACGGCACCGCCGACGACCGGATGCCGAACTCGTCCTTCCGGC
TGGTCACCAACAGCAGCGACCGGCTCACCCCCGGCCAGGCCGGCCGCATCGCCCGCAAGCTCGCGGGCTGGTCCATCACC
GGCGCGATCATCGACAAGAACGTGCGGGTGCAGAAGAAGGTCGCCACCGAGTGGCACCAGCTCGTCGGCGCCCAGACCGT
GGAAGAGGTGACCCCGGCGCGCTGGCGGATGTTCGCCGACACCGACCGCGACCGGCTGAAGATCCCGTTCGGGCACGAGC
TGCGGACCGGCGACATCATGTATCTCGACATCAAGGAGGGCGCGGAGTTCGGCGCGGGCCCGCACGGGATGCTGATCGGC
ACCACCGGTTCGGGTAAGTCGGAATTCCTTCGGACGCTGATCCTCTCGCTCGCGGCGACCCACCATCCCGATCAGGTGAA
CCTGCTGCTGACCGACTTCAAGGGCGGGTCGACCTTCCTCGGCATGGAGAAACTGCCGCACACCGCGGCGGTGGTGACCA
ACATGGAAGAGGAAGCCGAACTCGTCAGCCGCATGGGTGAGGTGCTCACCGGCGAACTGGACCGGCGGCAGTCGATCCTG
CGGCAGGCCGGTATGCAGGTCGGGGCCGCGGGCGCGCTGTCCGGTGTGGCGGAGTACGAGAAGCACCGCGAACGCGGCGC
CGACCTGCCGCCGCTGCCGACACTGTTCGTCGTCGTCGACGAATTCGCCGAACTGCTGCAGAACCACCCGGACTTCATCG
CGCTGTTCGACCGCATCTGCCGGGTGGGCCGCTCACTGCGGGTGCATCTGCTGCTGGCCACCCAGTCGCTGAACACCGGC
GGGGTGCGCATCGACAAGCTCGAGCCGAACCTCACGTATCGAATCGCGTTGCGCACCACCAGCTCCGCGGAGTCCAAGGC
GGTGATCGGGACGCCGGAGGCGCAGTACATCACCAACAAGGAGAGCGGTGTCGGCTTCCTGCGCGTCGGCATGGAGGACC
CGGTGAAGTTCCAGAGCGTCTACACCGGCAACCCCTACGTCCCGGCGACGACGGTCCAGGAGGACGGTGAGGTCAAACCC
CGCCAGTCCACCCGCAACCGGGTGCGGATCCACAAGTTCACCGCGACCCCGATCTTCGATACGGCGGTGACGTCATGA

Upstream 100 bases:

>100_bases
CACGACACCCTGCCCGCGAACCCCAACCCGCGCAAGGTCGGCGAGGACGGTCCGGTGGCGGGCGCCCGACCGGGAGGCAG
CCGATGACTGGAGTCGCTCG

Downstream 100 bases:

>100_bases
CGGCGTCGAGGCAGGCCGCCGAACAGAAGGTCCTTCGCGAGGTCGTCCTCGATCAGCTCACGACGGGCGAGATCCGCGCC
TACCGGATGTGGCTGCCGCC

Product: cell divisionFtsK/SpoIIIE

Products: NA

Alternate protein names: ESX conserved component Ca1; Type VII secretion system protein eccCa1; T7SS protein eccCa1 [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MTTKKFTPIIKRGPRLTPGEITVTPPDDLGVEIPPSGIQRALPWVMGGCMLGMISIMIFTGVRQLSPYMLMMPLMMVMAT
VGFMAGGGSGAKRVPEINADRKEYLRYLSGLRTRVTSSAAAQVTFFNYHAPHPEDLLSIIGTNRQWSRQANSEFFAATRI
GLGSEPAVDRLLKPSIGDVNGLAGPQAAPQPHLEPVSHMWVTKFLRTHGLIHDCPKLLQLRSFPTIAIGGDPDGSAALLA
AMICHLAVFHPPDLLQLRVLTDNPEDPNWSWLKWLPHVQHQSDVDAAGPTRMVFTRPDGLSDLTARGPHTADSAPSGPYV
VVVDLTGGRAGFPADGRAGVTVLTLGNHNGSAYRIRVAADGTADDRMPNSSFRLVTNSSDRLTPGQAGRIARKLAGWSIT
GAIIDKNVRVQKKVATEWHQLVGAQTVEEVTPARWRMFADTDRDRLKIPFGHELRTGDIMYLDIKEGAEFGAGPHGMLIG
TTGSGKSEFLRTLILSLAATHHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMEEEAELVSRMGEVLTGELDRRQSIL
RQAGMQVGAAGALSGVAEYEKHRERGADLPPLPTLFVVVDEFAELLQNHPDFIALFDRICRVGRSLRVHLLLATQSLNTG
GVRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFQSVYTGNPYVPATTVQEDGEVKP
RQSTRNRVRIHKFTATPIFDTAVTS

Sequences:

>Translated_745_residues
MTTKKFTPIIKRGPRLTPGEITVTPPDDLGVEIPPSGIQRALPWVMGGCMLGMISIMIFTGVRQLSPYMLMMPLMMVMAT
VGFMAGGGSGAKRVPEINADRKEYLRYLSGLRTRVTSSAAAQVTFFNYHAPHPEDLLSIIGTNRQWSRQANSEFFAATRI
GLGSEPAVDRLLKPSIGDVNGLAGPQAAPQPHLEPVSHMWVTKFLRTHGLIHDCPKLLQLRSFPTIAIGGDPDGSAALLA
AMICHLAVFHPPDLLQLRVLTDNPEDPNWSWLKWLPHVQHQSDVDAAGPTRMVFTRPDGLSDLTARGPHTADSAPSGPYV
VVVDLTGGRAGFPADGRAGVTVLTLGNHNGSAYRIRVAADGTADDRMPNSSFRLVTNSSDRLTPGQAGRIARKLAGWSIT
GAIIDKNVRVQKKVATEWHQLVGAQTVEEVTPARWRMFADTDRDRLKIPFGHELRTGDIMYLDIKEGAEFGAGPHGMLIG
TTGSGKSEFLRTLILSLAATHHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMEEEAELVSRMGEVLTGELDRRQSIL
RQAGMQVGAAGALSGVAEYEKHRERGADLPPLPTLFVVVDEFAELLQNHPDFIALFDRICRVGRSLRVHLLLATQSLNTG
GVRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFQSVYTGNPYVPATTVQEDGEVKP
RQSTRNRVRIHKFTATPIFDTAVTS
>Mature_744_residues
TTKKFTPIIKRGPRLTPGEITVTPPDDLGVEIPPSGIQRALPWVMGGCMLGMISIMIFTGVRQLSPYMLMMPLMMVMATV
GFMAGGGSGAKRVPEINADRKEYLRYLSGLRTRVTSSAAAQVTFFNYHAPHPEDLLSIIGTNRQWSRQANSEFFAATRIG
LGSEPAVDRLLKPSIGDVNGLAGPQAAPQPHLEPVSHMWVTKFLRTHGLIHDCPKLLQLRSFPTIAIGGDPDGSAALLAA
MICHLAVFHPPDLLQLRVLTDNPEDPNWSWLKWLPHVQHQSDVDAAGPTRMVFTRPDGLSDLTARGPHTADSAPSGPYVV
VVDLTGGRAGFPADGRAGVTVLTLGNHNGSAYRIRVAADGTADDRMPNSSFRLVTNSSDRLTPGQAGRIARKLAGWSITG
AIIDKNVRVQKKVATEWHQLVGAQTVEEVTPARWRMFADTDRDRLKIPFGHELRTGDIMYLDIKEGAEFGAGPHGMLIGT
TGSGKSEFLRTLILSLAATHHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMEEEAELVSRMGEVLTGELDRRQSILR
QAGMQVGAAGALSGVAEYEKHRERGADLPPLPTLFVVVDEFAELLQNHPDFIALFDRICRVGRSLRVHLLLATQSLNTGG
VRIDKLEPNLTYRIALRTTSSAESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFQSVYTGNPYVPATTVQEDGEVKPR
QSTRNRVRIHKFTATPIFDTAVTS

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as esxA (ESAT-6) and esxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis [H]

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FtsK domain [H]

Homologues:

Organism=Escherichia coli, GI1787117, Length=219, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002543 [H]

Pfam domain/function: PF01580 FtsK_SpoIIIE [H]

EC number: NA

Molecular weight: Translated: 81113; Mature: 80982

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKKFTPIIKRGPRLTPGEITVTPPDDLGVEIPPSGIQRALPWVMGGCMLGMISIMIFT
CCCCCCCHHHHCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVRQLSPYMLMMPLMMVMATVGFMAGGGSGAKRVPEINADRKEYLRYLSGLRTRVTSSAA
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
AQVTFFNYHAPHPEDLLSIIGTNRQWSRQANSEFFAATRIGLGSEPAVDRLLKPSIGDVN
EEEEEEECCCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCC
GLAGPQAAPQPHLEPVSHMWVTKFLRTHGLIHDCPKLLQLRSFPTIAIGGDPDGSAALLA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
AMICHLAVFHPPDLLQLRVLTDNPEDPNWSWLKWLPHVQHQSDVDAAGPTRMVFTRPDGL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEECCCCC
SDLTARGPHTADSAPSGPYVVVVDLTGGRAGFPADGRAGVTVLTLGNHNGSAYRIRVAAD
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEC
GTADDRMPNSSFRLVTNSSDRLTPGQAGRIARKLAGWSITGAIIDKNVRVQKKVATEWHQ
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
LVGAQTVEEVTPARWRMFADTDRDRLKIPFGHELRTGDIMYLDIKEGAEFGAGPHGMLIG
HHHHHHHHHCCCHHEEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEE
TTGSGKSEFLRTLILSLAATHHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMEEEAE
ECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECHHHCCCHHHHHHCCHHHHH
LVSRMGEVLTGELDRRQSILRQAGMQVGAAGALSGVAEYEKHRERGADLPPLPTLFVVVD
HHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EFAELLQNHPDFIALFDRICRVGRSLRVHLLLATQSLNTGGVRIDKLEPNLTYRIALRTT
HHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCEEEEEEEEEC
SSAESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFQSVYTGNPYVPATTVQEDGEVKP
CCCCCCEEEECCCCCEEECCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
RQSTRNRVRIHKFTATPIFDTAVTS
CHHCCCCEEEEEEECCCCCHHHCCC
>Mature Secondary Structure 
TTKKFTPIIKRGPRLTPGEITVTPPDDLGVEIPPSGIQRALPWVMGGCMLGMISIMIFT
CCCCCCHHHHCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVRQLSPYMLMMPLMMVMATVGFMAGGGSGAKRVPEINADRKEYLRYLSGLRTRVTSSAA
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCE
AQVTFFNYHAPHPEDLLSIIGTNRQWSRQANSEFFAATRIGLGSEPAVDRLLKPSIGDVN
EEEEEEECCCCCHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCC
GLAGPQAAPQPHLEPVSHMWVTKFLRTHGLIHDCPKLLQLRSFPTIAIGGDPDGSAALLA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHH
AMICHLAVFHPPDLLQLRVLTDNPEDPNWSWLKWLPHVQHQSDVDAAGPTRMVFTRPDGL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEECCCCC
SDLTARGPHTADSAPSGPYVVVVDLTGGRAGFPADGRAGVTVLTLGNHNGSAYRIRVAAD
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEC
GTADDRMPNSSFRLVTNSSDRLTPGQAGRIARKLAGWSITGAIIDKNVRVQKKVATEWHQ
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
LVGAQTVEEVTPARWRMFADTDRDRLKIPFGHELRTGDIMYLDIKEGAEFGAGPHGMLIG
HHHHHHHHHCCCHHEEEEECCCCCEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEE
TTGSGKSEFLRTLILSLAATHHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMEEEAE
ECCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECHHHCCCHHHHHHCCHHHHH
LVSRMGEVLTGELDRRQSILRQAGMQVGAAGALSGVAEYEKHRERGADLPPLPTLFVVVD
HHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EFAELLQNHPDFIALFDRICRVGRSLRVHLLLATQSLNTGGVRIDKLEPNLTYRIALRTT
HHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCEEEEEEEEEC
SSAESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFQSVYTGNPYVPATTVQEDGEVKP
CCCCCCEEEECCCCCEEECCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
RQSTRNRVRIHKFTATPIFDTAVTS
CHHCCCCEEEEEEECCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]