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The map label for this gene is groEL

Identifier: 108762020

GI number: 108762020

Start: 6125850

End: 6127499

Strand: Direct

Name: groEL

Synonym: MXAN_4895

Alternate gene names: 108762020

Gene position: 6125850-6127499 (Clockwise)

Preceding gene: 108759998

Following gene: 108759226

Centisome position: 67.02

GC content: 67.03

Gene sequence:

>1650_bases
ATGGCGAAGGACATTCTTTTCGACGTGCGCGCGCGTGAGGCCATCCTCCGCGGCGTCAACATCCTGGCCGACGCGGTCAA
GGTCACCCTGGGCCCCAAGGGCCGCAACGTCGTCATCGAGAAGAGCTTCGGCTCCCCGACCATCACCAAGGACGGTGTGA
CGGTCGCCAAGGAGATCGAGCTCGAGAACAAGTTCGAGAACATGGGCGCGCAGATGGTCAAGGAGGTTGCCTCCAAGACG
TCTGACGTCGCCGGTGACGGCACCACCACGGCCACCGTGCTGGCGCAGGCCATCTTCCGCGAGGGCGCGAAGCTGGTCGC
CGCGGGCCACAACCCGATGGACATCAAGCGCGGCATCGACAAGGCCGTGGGCGCCATCGTCGCCGAGCTGAAGAAGCTGG
CCAAGCCGACCAAGGACAAGAAGGAGATTGCCCAGGTCGGTACCATCTCCGCCAACGGTGACGAGACCATCGGCACCATC
ATCGCGGACGCGATGGAGAAGGTGGGCAAGGAAGGCGTCATCACCGTCGAAGAGGCCAAGGGCCTGGAGACGACGCTGGA
CGTGGTCGAAGGCATGCAGTTCGACCGCGGCTACCTGTCCCCGTACTTCGTGACGGACCCGGAGCGCATGGAGGCGGCGC
TCAACGACGCGCTCATCCTCATCAACGAGAAGAAGATCTCCTCGATGAAGGACCTCCTGCCCATCCTGGAGCAGGTTGCC
CGCGCCGGTAAGCCCCTGCTCATCATCGCCGAGGACATCGAGGGCGAGGCCCTGGCCACCCTGGTGGTCAACAAGATCCG
CGGCGTGCTGAACGTGTGCGCGGTGAAGGCGCCGGGCTTCGGTGACCGCCGCAAGGCCATGCTCGAGGACATCGCCACCC
TGACGGGCGGCCGGATGATCGCCGAGGACCTGGGCATCAAGCTGGACACCATCACCCTCCAGGACCTGGGCCGCGCGAAG
CGCATCACGGTGGACAAGGACAACACCACCATCGTCGACGGTGCCGGTGGCCAGCAGGAGATCGAAGCGCGCGTGAAGCA
GATCCGCGCCCAGATCGAGGAGACCTCCAGCGACTACGACCGCGAGAAGCTCCAGGAGCGCCTGGCGAAGCTCGTGGGCG
GCGTGGCCGTCATCAACGTCGGCGCGGCCACCGAGACGGAGATGAAGGAGAAGAAGGCCCGCGTCGAGGACGCGCTCAAC
GCGACCCGCGCGGCCGTCGAAGAGGGCGTCGTCCCTGGCGGCGGCGTGGCCTACATCCGCTGCCTCAAGGCGCTGGACGG
CCTGCAGCTGTCCGGCGGTGAGAAGTTCGGCGTGGACATCATCCGCCGCGCCGTCGAGGAGCCCCTCCGCCAGATCGTCG
GCAACGGCGGCCTGGAGGGCAGCGTGGTGGTGAACAAGGTCAAGGAGTCCTCCGGTCCGTTCGGCTTCAACGCCGCCACG
GGCACCTACGAGGACCTGCTGGCCGCCGGCGTCATCGACCCGGCCAAGGTCAGCCGCACCGCGCTGCAGAACGCGGCGTC
CGTGTCCTCGCTGATGCTCACCACCGAGGCCATGGTGGCGGAGCGTCCGAAGGAGGAGAAGGACCTCCCCGCCGGCGGTG
GCATGGGCGGGATGGGTGGCATGGGCGGTATGGGCGGTATGGGCATGTAG

Upstream 100 bases:

>100_bases
TCGACGGCGAGGAGCACCTCATCCTCCGTGAAGAGGATGTGCTCGGCGTGATCGAGAAGTAATCCGGCTTCCCCCACTCT
TCCTTCAAGGAACCATCCAA

Downstream 100 bases:

>100_bases
TCCGCCCCTCACCCCGGCATCCGTCCGGGGTGACGTCCTGAACGCGGCCTCCGGCCCCTCATGGGGACCCGGGGGCCGTC
GTCTTTGTGGGCTGGGTGGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MAKDILFDVRAREAILRGVNILADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIELENKFENMGAQMVKEVASKT
SDVAGDGTTTATVLAQAIFREGAKLVAAGHNPMDIKRGIDKAVGAIVAELKKLAKPTKDKKEIAQVGTISANGDETIGTI
IADAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYLSPYFVTDPERMEAALNDALILINEKKISSMKDLLPILEQVA
RAGKPLLIIAEDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKAMLEDIATLTGGRMIAEDLGIKLDTITLQDLGRAK
RITVDKDNTTIVDGAGGQQEIEARVKQIRAQIEETSSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALN
ATRAAVEEGVVPGGGVAYIRCLKALDGLQLSGGEKFGVDIIRRAVEEPLRQIVGNGGLEGSVVVNKVKESSGPFGFNAAT
GTYEDLLAAGVIDPAKVSRTALQNAASVSSLMLTTEAMVAERPKEEKDLPAGGGMGGMGGMGGMGGMGM

Sequences:

>Translated_549_residues
MAKDILFDVRAREAILRGVNILADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIELENKFENMGAQMVKEVASKT
SDVAGDGTTTATVLAQAIFREGAKLVAAGHNPMDIKRGIDKAVGAIVAELKKLAKPTKDKKEIAQVGTISANGDETIGTI
IADAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYLSPYFVTDPERMEAALNDALILINEKKISSMKDLLPILEQVA
RAGKPLLIIAEDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKAMLEDIATLTGGRMIAEDLGIKLDTITLQDLGRAK
RITVDKDNTTIVDGAGGQQEIEARVKQIRAQIEETSSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALN
ATRAAVEEGVVPGGGVAYIRCLKALDGLQLSGGEKFGVDIIRRAVEEPLRQIVGNGGLEGSVVVNKVKESSGPFGFNAAT
GTYEDLLAAGVIDPAKVSRTALQNAASVSSLMLTTEAMVAERPKEEKDLPAGGGMGGMGGMGGMGGMGM
>Mature_548_residues
AKDILFDVRAREAILRGVNILADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIELENKFENMGAQMVKEVASKTS
DVAGDGTTTATVLAQAIFREGAKLVAAGHNPMDIKRGIDKAVGAIVAELKKLAKPTKDKKEIAQVGTISANGDETIGTII
ADAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYLSPYFVTDPERMEAALNDALILINEKKISSMKDLLPILEQVAR
AGKPLLIIAEDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKAMLEDIATLTGGRMIAEDLGIKLDTITLQDLGRAKR
ITVDKDNTTIVDGAGGQQEIEARVKQIRAQIEETSSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALNA
TRAAVEEGVVPGGGVAYIRCLKALDGLQLSGGEKFGVDIIRRAVEEPLRQIVGNGGLEGSVVVNKVKESSGPFGFNAATG
TYEDLLAAGVIDPAKVSRTALQNAASVSSLMLTTEAMVAERPKEEKDLPAGGGMGGMGGMGGMGGMGM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=51.8867924528302, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=51.8867924528302, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI5453607, Length=546, Percent_Identity=22.3443223443223, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI38455427, Length=155, Percent_Identity=30.9677419354839, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=67.680608365019, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.7958412098299, Blast_Score=537, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=50, Blast_Score=205, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.4351145038168, Blast_Score=545, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322350, Length=563, Percent_Identity=21.6696269982238, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322524, Length=124, Percent_Identity=29.0322580645161, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=51.8939393939394, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=51.8939393939394, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.2846299810247, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.2846299810247, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.2846299810247, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=43.7386569872958, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=36.5348399246704, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=36.5348399246704, Blast_Score=337, Evalue=1e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_MYXXD (Q1D2S1)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633052.1
- ProteinModelPortal:   Q1D2S1
- SMR:   Q1D2S1
- STRING:   Q1D2S1
- GeneID:   4105766
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4895
- TIGR:   MXAN_4895
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- PhylomeDB:   Q1D2S1
- ProtClustDB:   PRK00013
- BioCyc:   MXAN246197:MXAN_4895-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57895; Mature: 57763

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDILFDVRAREAILRGVNILADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHH
LENKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQAIFREGAKLVAAGHNPMDIKRGID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
KAVGAIVAELKKLAKPTKDKKEIAQVGTISANGDETIGTIIADAMEKVGKEGVITVEEAK
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCC
GLETTLDVVEGMQFDRGYLSPYFVTDPERMEAALNDALILINEKKISSMKDLLPILEQVA
CHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHH
RAGKPLLIIAEDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKAMLEDIATLTGGRMI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
AEDLGIKLDTITLQDLGRAKRITVDKDNTTIVDGAGGQQEIEARVKQIRAQIEETSSDYD
HHHHCCEEEEEEHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC
REKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALNATRAAVEEGVVPGGGVAYIR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
CLKALDGLQLSGGEKFGVDIIRRAVEEPLRQIVGNGGLEGSVVVNKVKESSGPFGFNAAT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC
GTYEDLLAAGVIDPAKVSRTALQNAASVSSLMLTTEAMVAERPKEEKDLPAGGGMGGMGG
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MGGMGGMGM
CCCCCCCCC
>Mature Secondary Structure 
AKDILFDVRAREAILRGVNILADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIE
CCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCHHHHHHH
LENKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQAIFREGAKLVAAGHNPMDIKRGID
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
KAVGAIVAELKKLAKPTKDKKEIAQVGTISANGDETIGTIIADAMEKVGKEGVITVEEAK
HHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCC
GLETTLDVVEGMQFDRGYLSPYFVTDPERMEAALNDALILINEKKISSMKDLLPILEQVA
CHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHH
RAGKPLLIIAEDIEGEALATLVVNKIRGVLNVCAVKAPGFGDRRKAMLEDIATLTGGRMI
HCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHH
AEDLGIKLDTITLQDLGRAKRITVDKDNTTIVDGAGGQQEIEARVKQIRAQIEETSSDYD
HHHHCCEEEEEEHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCC
REKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALNATRAAVEEGVVPGGGVAYIR
HHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
CLKALDGLQLSGGEKFGVDIIRRAVEEPLRQIVGNGGLEGSVVVNKVKESSGPFGFNAAT
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCC
GTYEDLLAAGVIDPAKVSRTALQNAASVSSLMLTTEAMVAERPKEEKDLPAGGGMGGMGG
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MGGMGGMGM
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA