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The map label for this gene is hutH

Identifier: 108761888

GI number: 108761888

Start: 4042948

End: 4044474

Strand: Reverse

Name: hutH

Synonym: MXAN_3465

Alternate gene names: 108761888

Gene position: 4044474-4042948 (Counterclockwise)

Preceding gene: 108760913

Following gene: 108762890

Centisome position: 44.25

GC content: 69.94

Gene sequence:

>1527_bases
ATGTCGCGCCCCCGTATCCTCATCGACGGTGACACCCTGAAGCTCGAGGAAATCCTCCAGGTGGCTCGCAACGAGGCCAC
CGTGGAGCTGTCGCCCGACGCCGCCACCCGCGTGCGGGCCTCGCGCGCCCTGGTGGACCGCGTCGCCGCCGGAGACACGC
CCGCCTACGGCATCAACACCGGCTTTGGCACGTTGGCCGAGGTCCGCATCGACAAGAAGGACCTGCGCGACCTCCAGCGC
AACCTCATCCTCTCCCACGCGTGTGGCGTCGGCACGCCCCTCCCCCTTCCGGAAGCGCGGGCGCTCCTGCTGCTCCGCTG
CAACGTGCTCGCCAAGGGCTACTCCGGCATCCGCATGGAGACGCTGGCCCTGGCGCTGGACATGCTGAACCGGGACGTCG
TGCCCGTGGTCCCCGAGCGGGGCAGCGTGGGCGCCTCCGGGGATCTCGCCCCGCTGGCGCACCTGGCGCTCGTCTTCATC
GGCGAAGGTGAAGCCTTCTATCAGGGCCAGCGGATGCCCGCGAAGCAGGCGCTGGAGCGCGCCGGCCTGCAACCGGTGGT
GTTGGAGGCCAAGGAGGGCCTCGCCCTGGTGAACGGCACACAGGCCATGTGCGCGGTGGGCACCCTGCTCCAGCTTCGCG
CGGAGTCCCTGGCGGACATCGCCGACGTCGCGGGCGCCATGACGCTGGAGGGGCTGCTGGGAAGCCACAAGCCCTTCATT
CCTGAGATTCACGACGTCCGCGCGCACCCGGGCCAGAAGGACGTCGCGGCGCACCTGCGGCGCATCCTGGTGGACAGCGA
GCTGGTGGAGTCGCACGTCAACTGCAGCAAGGTGCAGGACCCCTACTCCCTGCGCTGCATGCCGCAGGTGCACGGCGCGG
CGCGCGAGGGCATCGCGTTCTCCCGGCGCATCCTGGAGGTGGAGGTCAACAGCGCGACGGACAACCCGCTCGTGTTCGCG
GACACGGAGCGCATCGTGTCGGGCGGCAACTTCCACGGCCAGCCCATCTCCCTGGCCATGGACGTGGTGGCGATGGCGCT
GACGCAACTGTCGTCCATCAGCGAGCGGCGCGTGGAGCAGCTCGTGAACCCGTCGCTGTCCAACCTGCCGGCGTTCCTGG
CGAAGAACTCCGGGTTGAACTCCGGCTTCATGATCGCGCAGGTGACCAGCGCCGCGCTGGTGGCCGAGTCCCGCGTGCTG
AGCCACCCCGCGTCCGTGGATTCGATTCCGTCATCCGCGGGCCGAGAGGACCACGTGTCCATGGGCATGACGGCGGCGCT
CAAGGGCCGTCAGGTCAGCGACTTCGCCCGTTCGTGCCTCGCGATTGAAATCCTGGTGGCGGCGCAGGCCCTGGACTTCC
GCCTGCCGCTGAAGCCCGGCAAGGGCGCCCTCGCGGCGTACGAGCTGGTGCGCTCGAAGGTCCCCCACATGGACAAGGAC
CGCGAGCTGCACCGGGACATCGAGGCGGTGAGCCAGCTCGTCGACTCTGGCGAGCTGCTCGCGGCGGTGCGCTCCGCCAC
GGCCTGA

Upstream 100 bases:

>100_bases
CTATACGAGCCCGGCCGGCGGGTGTAAAGCGCCCGCCAGCACCACCGCACCCGTTTACGTTAGGGTGCCCGCCCTTTCGT
CGCACCCATTGGAGTCCCGA

Downstream 100 bases:

>100_bases
CGCAGCACAAGCGACATCGACTTCTCCTACGATGACGAAGGGCCCGGAGCCGAGAGGTTACTCTTGGCACTCCGGGCCTT
TTTCATTTCATGCGCACGCT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSRPRILIDGDTLKLEEILQVARNEATVELSPDAATRVRASRALVDRVAAGDTPAYGINTGFGTLAEVRIDKKDLRDLQR
NLILSHACGVGTPLPLPEARALLLLRCNVLAKGYSGIRMETLALALDMLNRDVVPVVPERGSVGASGDLAPLAHLALVFI
GEGEAFYQGQRMPAKQALERAGLQPVVLEAKEGLALVNGTQAMCAVGTLLQLRAESLADIADVAGAMTLEGLLGSHKPFI
PEIHDVRAHPGQKDVAAHLRRILVDSELVESHVNCSKVQDPYSLRCMPQVHGAAREGIAFSRRILEVEVNSATDNPLVFA
DTERIVSGGNFHGQPISLAMDVVAMALTQLSSISERRVEQLVNPSLSNLPAFLAKNSGLNSGFMIAQVTSAALVAESRVL
SHPASVDSIPSSAGREDHVSMGMTAALKGRQVSDFARSCLAIEILVAAQALDFRLPLKPGKGALAAYELVRSKVPHMDKD
RELHRDIEAVSQLVDSGELLAAVRSATA

Sequences:

>Translated_508_residues
MSRPRILIDGDTLKLEEILQVARNEATVELSPDAATRVRASRALVDRVAAGDTPAYGINTGFGTLAEVRIDKKDLRDLQR
NLILSHACGVGTPLPLPEARALLLLRCNVLAKGYSGIRMETLALALDMLNRDVVPVVPERGSVGASGDLAPLAHLALVFI
GEGEAFYQGQRMPAKQALERAGLQPVVLEAKEGLALVNGTQAMCAVGTLLQLRAESLADIADVAGAMTLEGLLGSHKPFI
PEIHDVRAHPGQKDVAAHLRRILVDSELVESHVNCSKVQDPYSLRCMPQVHGAAREGIAFSRRILEVEVNSATDNPLVFA
DTERIVSGGNFHGQPISLAMDVVAMALTQLSSISERRVEQLVNPSLSNLPAFLAKNSGLNSGFMIAQVTSAALVAESRVL
SHPASVDSIPSSAGREDHVSMGMTAALKGRQVSDFARSCLAIEILVAAQALDFRLPLKPGKGALAAYELVRSKVPHMDKD
RELHRDIEAVSQLVDSGELLAAVRSATA
>Mature_507_residues
SRPRILIDGDTLKLEEILQVARNEATVELSPDAATRVRASRALVDRVAAGDTPAYGINTGFGTLAEVRIDKKDLRDLQRN
LILSHACGVGTPLPLPEARALLLLRCNVLAKGYSGIRMETLALALDMLNRDVVPVVPERGSVGASGDLAPLAHLALVFIG
EGEAFYQGQRMPAKQALERAGLQPVVLEAKEGLALVNGTQAMCAVGTLLQLRAESLADIADVAGAMTLEGLLGSHKPFIP
EIHDVRAHPGQKDVAAHLRRILVDSELVESHVNCSKVQDPYSLRCMPQVHGAAREGIAFSRRILEVEVNSATDNPLVFAD
TERIVSGGNFHGQPISLAMDVVAMALTQLSSISERRVEQLVNPSLSNLPAFLAKNSGLNSGFMIAQVTSAALVAESRVLS
HPASVDSIPSSAGREDHVSMGMTAALKGRQVSDFARSCLAIEILVAAQALDFRLPLKPGKGALAAYELVRSKVPHMDKDR
ELHRDIEAVSQLVDSGELLAAVRSATA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=494, Percent_Identity=49.1902834008097, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17567831, Length=503, Percent_Identity=45.3280318091451, Blast_Score=414, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_MYXXD (Q1D6R1)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631662.1
- ProteinModelPortal:   Q1D6R1
- SMR:   Q1D6R1
- STRING:   Q1D6R1
- GeneID:   4105633
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3465
- TIGR:   MXAN_3465
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   CKPDDTI
- ProtClustDB:   PRK09367
- BioCyc:   MXAN246197:MXAN_3465-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54181; Mature: 54050

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPRILIDGDTLKLEEILQVARNEATVELSPDAATRVRASRALVDRVAAGDTPAYGINT
CCCCCEEECCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
GFGTLAEVRIDKKDLRDLQRNLILSHACGVGTPLPLPEARALLLLRCNVLAKGYSGIRME
CCCCHHHEEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHH
TLALALDMLNRDVVPVVPERGSVGASGDLAPLAHLALVFIGEGEAFYQGQRMPAKQALER
HHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHEEECCCHHCCCCCCCHHHHHHH
AGLQPVVLEAKEGLALVNGTQAMCAVGTLLQLRAESLADIADVAGAMTLEGLLGSHKPFI
CCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PEIHDVRAHPGQKDVAAHLRRILVDSELVESHVNCSKVQDPYSLRCMPQVHGAAREGIAF
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECHHHHHHHHHCHHH
SRRILEVEVNSATDNPLVFADTERIVSGGNFHGQPISLAMDVVAMALTQLSSISERRVEQ
HEEEEEEEECCCCCCCEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LVNPSLSNLPAFLAKNSGLNSGFMIAQVTSAALVAESRVLSHPASVDSIPSSAGREDHVS
HHCCCHHHCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
MGMTAALKGRQVSDFARSCLAIEILVAAQALDFRLPLKPGKGALAAYELVRSKVPHMDKD
HCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHCCCCCCH
RELHRDIEAVSQLVDSGELLAAVRSATA
HHHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SRPRILIDGDTLKLEEILQVARNEATVELSPDAATRVRASRALVDRVAAGDTPAYGINT
CCCCEEECCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
GFGTLAEVRIDKKDLRDLQRNLILSHACGVGTPLPLPEARALLLLRCNVLAKGYSGIRME
CCCCHHHEEECHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHH
TLALALDMLNRDVVPVVPERGSVGASGDLAPLAHLALVFIGEGEAFYQGQRMPAKQALER
HHHHHHHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHEEECCCHHCCCCCCCHHHHHHH
AGLQPVVLEAKEGLALVNGTQAMCAVGTLLQLRAESLADIADVAGAMTLEGLLGSHKPFI
CCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PEIHDVRAHPGQKDVAAHLRRILVDSELVESHVNCSKVQDPYSLRCMPQVHGAAREGIAF
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECHHHHHHHHHCHHH
SRRILEVEVNSATDNPLVFADTERIVSGGNFHGQPISLAMDVVAMALTQLSSISERRVEQ
HEEEEEEEECCCCCCCEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LVNPSLSNLPAFLAKNSGLNSGFMIAQVTSAALVAESRVLSHPASVDSIPSSAGREDHVS
HHCCCHHHCHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
MGMTAALKGRQVSDFARSCLAIEILVAAQALDFRLPLKPGKGALAAYELVRSKVPHMDKD
HCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHCCCCCCH
RELHRDIEAVSQLVDSGELLAAVRSATA
HHHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA