Click here to switch to the map view.

The map label for this gene is irlS [H]

Identifier: 108761146

GI number: 108761146

Start: 4018389

End: 4019747

Strand: Direct

Name: irlS [H]

Synonym: MXAN_3451

Alternate gene names: 108761146

Gene position: 4018389-4019747 (Clockwise)

Preceding gene: 108758444

Following gene: 108762926

Centisome position: 43.97

GC content: 73.14

Gene sequence:

>1359_bases
GTGAGGTTGGTCCGGCGGATGTGGCTGTGGGGCGCGGTGGTGCCCGTGGTGGCGGTGGTCGCCGCGCTGGGCGTGGCTGT
CCAGGTGTTCCGCGTGGTGCTCGAACGGACGTTGGACGAAGCCTTGCTGTCGCAAGCCGCCGCGGAGAGCGTGAGCCTCT
TCGACGCGCCGGATGGGCGCCCGCATCTGCACGTGGAGCCCTCCCCGTTGGCGGGAGAGGTGCGCGCCTTCGTCCCCGCG
ACGCGGCTCTATGGCCCGGATGGGACGCTGCTCTCCGTCTTCCCGCCCGAGTCACCCACCGTCTACGAACGGGTGCTACC
CGAGGACGGGCCCACGTCGCGGCTGGAGACGCAGCGTCTGGGCTCGGGCCTGCGGCTTCGCGTGCTGACGGTGCAGGTGC
GCTCGCCGAAGGGCGTGCCCCATGTCCTGCAGTTGGTGGCGTCCCTGGGGACGGTGGACCAGGCGGTGGGCACCTTCACC
TCCGTCGCCACCGTGCTGGCGTTGCTCCTGGGCGGGGTGCTGATTGGCATCCAGGGCTGGCAGGCGAGGGGGCTCGCGCG
ACGGCTTCATGGCATCGCGGACCAGGTGGCTCGCTCGCGCGACGGAGGCATGGTGGCCCCGGTGCCCGTGGATGAGCCCC
GGGACGAAATCATGGAGGTGCGCCTGGCGCTGACCGAGGCCGCGGTGCGCGTGCGCGCCGCGCGTGAAGCGCAAGAACGC
CTCATCGCGCGCGCCGCGCACGAGCTGCGCACGCCGCTGGCCCTCATGCGCACCGGCTTGGACCTGGCGCTGCGGCGCGA
GCGTGGCGCGGAGGAGTTGCGCACCGTGCTGGAGGAGAACCGGCGCGAGGTAGACCGGTTGGCCAGCGTCGCCGGTGCGC
TGCTGGAGCTGTCGGCGGCGGGCGGCGCCCTCGATTTTCAGCAGGGGGATTTGCGCGGGCTGCTCGACGAAGCCGCCGCG
GGGGCCTGGGCGGAGGCGGACCGTCGCGGTGTGTCGCTGCGCGTGGTAGGCCCCGACGAGGCCGACTGCCGGATGGATGC
GATGGCGGTTCGTCGAGCGGTGGACAACCTGCTGGCCAACGCCCTCCGCTACGCGCCTCGTGGGTCCGAGGTGCGGCTGG
AGCTGGCGCACCGGGACGCGCATTGGGAAGTCGCTGTCCAGGACGAGGGGCGCGGCATCCCGGAGACGCACCGTGAGGAC
GTCTTCACGCCTTTCCACCGCCTGGAGCGGGACGCGGGGGGCGTGGGGTTGGGACTCAGTCTCGTGCGCGAGGTGGCGCG
GGGCCATGGTGGCGACGCGCGCGTGGTGGAAAGCCCGGGCCCGGGCGCGCGGGTGCTGCTGACGCTGCCTGGCCGGTGA

Upstream 100 bases:

>100_bases
TGGGCTACGTGCGCACGAAGCTGACCGAGGTGGGCGCGGAAGGGGTGACCATCCAGGCGGTGCGTGGCGTGGGCTTCCGG
TTGGTGATTGAGGGCGCTCG

Downstream 100 bases:

>100_bases
GCCCGGGAGCGTTCGTCGAGCCCGGGGGCAGTGGCCCGTGTTCGCGCGTGTCTCCCACATCTGCCTCCGGTACAACGCCG
CCGGAATTCATCCCTTCCGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MRLVRRMWLWGAVVPVVAVVAALGVAVQVFRVVLERTLDEALLSQAAAESVSLFDAPDGRPHLHVEPSPLAGEVRAFVPA
TRLYGPDGTLLSVFPPESPTVYERVLPEDGPTSRLETQRLGSGLRLRVLTVQVRSPKGVPHVLQLVASLGTVDQAVGTFT
SVATVLALLLGGVLIGIQGWQARGLARRLHGIADQVARSRDGGMVAPVPVDEPRDEIMEVRLALTEAAVRVRAAREAQER
LIARAAHELRTPLALMRTGLDLALRRERGAEELRTVLEENRREVDRLASVAGALLELSAAGGALDFQQGDLRGLLDEAAA
GAWAEADRRGVSLRVVGPDEADCRMDAMAVRRAVDNLLANALRYAPRGSEVRLELAHRDAHWEVAVQDEGRGIPETHRED
VFTPFHRLERDAGGVGLGLSLVREVARGHGGDARVVESPGPGARVLLTLPGR

Sequences:

>Translated_452_residues
MRLVRRMWLWGAVVPVVAVVAALGVAVQVFRVVLERTLDEALLSQAAAESVSLFDAPDGRPHLHVEPSPLAGEVRAFVPA
TRLYGPDGTLLSVFPPESPTVYERVLPEDGPTSRLETQRLGSGLRLRVLTVQVRSPKGVPHVLQLVASLGTVDQAVGTFT
SVATVLALLLGGVLIGIQGWQARGLARRLHGIADQVARSRDGGMVAPVPVDEPRDEIMEVRLALTEAAVRVRAAREAQER
LIARAAHELRTPLALMRTGLDLALRRERGAEELRTVLEENRREVDRLASVAGALLELSAAGGALDFQQGDLRGLLDEAAA
GAWAEADRRGVSLRVVGPDEADCRMDAMAVRRAVDNLLANALRYAPRGSEVRLELAHRDAHWEVAVQDEGRGIPETHRED
VFTPFHRLERDAGGVGLGLSLVREVARGHGGDARVVESPGPGARVLLTLPGR
>Mature_452_residues
MRLVRRMWLWGAVVPVVAVVAALGVAVQVFRVVLERTLDEALLSQAAAESVSLFDAPDGRPHLHVEPSPLAGEVRAFVPA
TRLYGPDGTLLSVFPPESPTVYERVLPEDGPTSRLETQRLGSGLRLRVLTVQVRSPKGVPHVLQLVASLGTVDQAVGTFT
SVATVLALLLGGVLIGIQGWQARGLARRLHGIADQVARSRDGGMVAPVPVDEPRDEIMEVRLALTEAAVRVRAAREAQER
LIARAAHELRTPLALMRTGLDLALRRERGAEELRTVLEENRREVDRLASVAGALLELSAAGGALDFQQGDLRGLLDEAAA
GAWAEADRRGVSLRVVGPDEADCRMDAMAVRRAVDNLLANALRYAPRGSEVRLELAHRDAHWEVAVQDEGRGIPETHRED
VFTPFHRLERDAGGVGLGLSLVREVARGHGGDARVVESPGPGARVLLTLPGR

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates irlR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=319, Percent_Identity=28.2131661442006, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=29.0441176470588, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790551, Length=243, Percent_Identity=30.8641975308642, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787894, Length=243, Percent_Identity=30.8641975308642, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=27.8301886792453, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=25.8181818181818, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=23.828125, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=24.8091603053435, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081816, Length=249, Percent_Identity=27.710843373494, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=27.3858921161826, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=282, Percent_Identity=27.6595744680851, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=27.6422764227642, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082128, Length=221, Percent_Identity=26.2443438914027, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=24.7826086956522, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48700; Mature: 48700

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVRRMWLWGAVVPVVAVVAALGVAVQVFRVVLERTLDEALLSQAAAESVSLFDAPDGR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCC
PHLHVEPSPLAGEVRAFVPATRLYGPDGTLLSVFPPESPTVYERVLPEDGPTSRLETQRL
CEEEECCCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHC
GSGLRLRVLTVQVRSPKGVPHVLQLVASLGTVDQAVGTFTSVATVLALLLGGVLIGIQGW
CCCCEEEEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHEECCCH
QARGLARRLHGIADQVARSRDGGMVAPVPVDEPRDEIMEVRLALTEAAVRVRAAREAQER
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIARAAHELRTPLALMRTGLDLALRRERGAEELRTVLEENRREVDRLASVAGALLELSAA
HHHHHHHHHHCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGALDFQQGDLRGLLDEAAAGAWAEADRRGVSLRVVGPDEADCRMDAMAVRRAVDNLLAN
CCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
ALRYAPRGSEVRLELAHRDAHWEVAVQDEGRGIPETHREDVFTPFHRLERDAGGVGLGLS
HHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
LVREVARGHGGDARVVESPGPGARVLLTLPGR
HHHHHHHCCCCCCEEEECCCCCCEEEEECCCC
>Mature Secondary Structure
MRLVRRMWLWGAVVPVVAVVAALGVAVQVFRVVLERTLDEALLSQAAAESVSLFDAPDGR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCC
PHLHVEPSPLAGEVRAFVPATRLYGPDGTLLSVFPPESPTVYERVLPEDGPTSRLETQRL
CEEEECCCCCCCHHHHHHHHHHEECCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHC
GSGLRLRVLTVQVRSPKGVPHVLQLVASLGTVDQAVGTFTSVATVLALLLGGVLIGIQGW
CCCCEEEEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHEECCCH
QARGLARRLHGIADQVARSRDGGMVAPVPVDEPRDEIMEVRLALTEAAVRVRAAREAQER
HHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIARAAHELRTPLALMRTGLDLALRRERGAEELRTVLEENRREVDRLASVAGALLELSAA
HHHHHHHHHHCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGALDFQQGDLRGLLDEAAAGAWAEADRRGVSLRVVGPDEADCRMDAMAVRRAVDNLLAN
CCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
ALRYAPRGSEVRLELAHRDAHWEVAVQDEGRGIPETHREDVFTPFHRLERDAGGVGLGLS
HHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
LVREVARGHGGDARVVESPGPGARVLLTLPGR
HHHHHHHCCCCCCEEEECCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]