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The map label for this gene is menA [H]

Identifier: 108760974

GI number: 108760974

Start: 4111072

End: 4111995

Strand: Direct

Name: menA [H]

Synonym: MXAN_3530

Alternate gene names: 108760974

Gene position: 4111072-4111995 (Clockwise)

Preceding gene: 108760127

Following gene: 108761657

Centisome position: 44.98

GC content: 69.37

Gene sequence:

>924_bases
GTGAGCACGTCGGTTCCGGCGCCGGGCCCGCTGTCGGTGAAGCCCCGTCCCGGGGTGAAGCACTGGGTGATGGCGGCGCG
CCCCAAGACGCTGACGGCGGCGCTGGTGCCGGTGTTGGTGGGCACGGGGCTCGCGTTCGGCTCGGGCGTGGGGCGCCTGC
TGCCCGCGTTGGCAGCGCTGCTGGGCGCGGTGCTCATCCAGATTGGCACCAACTTCATCAACGACTACTACGACTTCAAG
AAGGGCGCCGACACGCACGAACGGCTGGGCCCTCAGCGCGTGACGCAGAGTGGCCTCATCGCGCCGGGCACTGTGCTGGC
GGGCGCGGGCGTGTGCTTTGCGCTGGCCACGGCCGTGGGCATGTACCTGGTGGCGGTGGGCGGCTGGCCCATCATCGCCA
TCGGCCTGACGTCGCTGCTGTGCGGCTACGCATACACGGGCGGCCCCTTTCCCCTGGGCTACAATGGCCTGGGAGACGTG
TTCGTCTTCATCTTTTTCGGCTTGGTGGCGGTGACGGGGACCTACTACGTGCAGGCGGGGACGGTGGACCCCGCGGCGTG
GTGGGCGGCGGTTCCCGTGGGCGCCAGCGGCACCATGCTCATCGTCGTCAACAACCTGCGCGACGTGACGACGGACGTGA
AGGCTGGCAAGCGCACCCTGGCGGTCCGCTTCGGCACGGGCGTGGGGAAGGCGGAGTACCTCCTCCTCCTGGTGCTGTCG
TACGCCACGCCCTTCGCGATGTACGCGCTGAAGCTGGCCAGCCCCTGGGTGTTCCTGTCCCTGCTGAGCCTGCCCCTGGC
GGTTCCCCCGTTGCGGCAGGTGTTGAAGCAGGAGGGGGCCGCGCTGAATCCGGCGCTGGGGTCCACGGCCAGACTCCAGC
TCGTGTTTGGAGTGCTGTTCGCGTTGGGCCTCTACCTGCGATGA

Upstream 100 bases:

>100_bases
AAGCCTACGTCCGTGAAGTCCTCGGGTTCCTCCAGACTCCCTGGTACGAGGCCCCGCAGTTCGACAGCCCCATGCCCGTG
CGCGAGGGAAGGGTGGCGTC

Downstream 100 bases:

>100_bases
TGTGAGGCCATGCGGATTGCCCAGGTTTCGCTCATTCCCCTCCGGTTGGAGCTGCGCCAGCCCCTGAAGACGTCACAAGG
GGGGCACGCGGTGCGAGAAG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSTSVPAPGPLSVKPRPGVKHWVMAARPKTLTAALVPVLVGTGLAFGSGVGRLLPALAALLGAVLIQIGTNFINDYYDFK
KGADTHERLGPQRVTQSGLIAPGTVLAGAGVCFALATAVGMYLVAVGGWPIIAIGLTSLLCGYAYTGGPFPLGYNGLGDV
FVFIFFGLVAVTGTYYVQAGTVDPAAWWAAVPVGASGTMLIVVNNLRDVTTDVKAGKRTLAVRFGTGVGKAEYLLLLVLS
YATPFAMYALKLASPWVFLSLLSLPLAVPPLRQVLKQEGAALNPALGSTARLQLVFGVLFALGLYLR

Sequences:

>Translated_307_residues
MSTSVPAPGPLSVKPRPGVKHWVMAARPKTLTAALVPVLVGTGLAFGSGVGRLLPALAALLGAVLIQIGTNFINDYYDFK
KGADTHERLGPQRVTQSGLIAPGTVLAGAGVCFALATAVGMYLVAVGGWPIIAIGLTSLLCGYAYTGGPFPLGYNGLGDV
FVFIFFGLVAVTGTYYVQAGTVDPAAWWAAVPVGASGTMLIVVNNLRDVTTDVKAGKRTLAVRFGTGVGKAEYLLLLVLS
YATPFAMYALKLASPWVFLSLLSLPLAVPPLRQVLKQEGAALNPALGSTARLQLVFGVLFALGLYLR
>Mature_306_residues
STSVPAPGPLSVKPRPGVKHWVMAARPKTLTAALVPVLVGTGLAFGSGVGRLLPALAALLGAVLIQIGTNFINDYYDFKK
GADTHERLGPQRVTQSGLIAPGTVLAGAGVCFALATAVGMYLVAVGGWPIIAIGLTSLLCGYAYTGGPFPLGYNGLGDVF
VFIFFGLVAVTGTYYVQAGTVDPAAWWAAVPVGASGTMLIVVNNLRDVTTDVKAGKRTLAVRFGTGVGKAEYLLLLVLSY
ATPFAMYALKLASPWVFLSLLSLPLAVPPLRQVLKQEGAALNPALGSTARLQLVFGVLFALGLYLR

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=298, Percent_Identity=32.2147651006711, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1790365, Length=295, Percent_Identity=36.9491525423729, Blast_Score=159, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17737429, Length=293, Percent_Identity=30.3754266211604, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31904; Mature: 31773

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSVPAPGPLSVKPRPGVKHWVMAARPKTLTAALVPVLVGTGLAFGSGVGRLLPALAAL
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHH
LGAVLIQIGTNFINDYYDFKKGADTHERLGPQRVTQSGLIAPGTVLAGAGVCFALATAVG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MYLVAVGGWPIIAIGLTSLLCGYAYTGGPFPLGYNGLGDVFVFIFFGLVAVTGTYYVQAG
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEC
TVDPAAWWAAVPVGASGTMLIVVNNLRDVTTDVKAGKRTLAVRFGTGVGKAEYLLLLVLS
CCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHH
YATPFAMYALKLASPWVFLSLLSLPLAVPPLRQVLKQEGAALNPALGSTARLQLVFGVLF
HHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ALGLYLR
HHHHHCC
>Mature Secondary Structure 
STSVPAPGPLSVKPRPGVKHWVMAARPKTLTAALVPVLVGTGLAFGSGVGRLLPALAAL
CCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHH
LGAVLIQIGTNFINDYYDFKKGADTHERLGPQRVTQSGLIAPGTVLAGAGVCFALATAVG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MYLVAVGGWPIIAIGLTSLLCGYAYTGGPFPLGYNGLGDVFVFIFFGLVAVTGTYYVQAG
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEC
TVDPAAWWAAVPVGASGTMLIVVNNLRDVTTDVKAGKRTLAVRFGTGVGKAEYLLLLVLS
CCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHH
YATPFAMYALKLASPWVFLSLLSLPLAVPPLRQVLKQEGAALNPALGSTARLQLVFGVLF
HHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ALGLYLR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]