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The map label for this gene is ftsI [H]

Identifier: 108760422

GI number: 108760422

Start: 6974382

End: 6976400

Strand: Reverse

Name: ftsI [H]

Synonym: MXAN_5610

Alternate gene names: 108760422

Gene position: 6976400-6974382 (Counterclockwise)

Preceding gene: 108758344

Following gene: 108761901

Centisome position: 76.33

GC content: 69.39

Gene sequence:

>2019_bases
GTGAGGGATTTCAAGGCGGCGCGGGCTCCCGAGCCCAACGCGAAGTGGCTGAAGCTGCGGGTACGGCTGCTGTTCGGGCT
GTTCCTGATGCTGCTCGGCGTCGCCTTTGGTCGTGCGGTGCAGCTCCAGGTCTTCGAGCAGGAGAAGCTGCGCGGCATGG
CGCAGGACCAGTACGTCCGGCACATCGAGATTCCGGCCCGCCGCGGCGACATCTTCGACCGGCGCGGCACGCCGCTGGCC
CAGAGCGTGGAGGTGGACTCCATCTGGGTGGACCCCTCCATGCTGCCCGACGTGAAGGCCGCGTCCCGGGCGCTGGCCAA
GGCGCTGAAGCTGGACCCGGACGAGCTGGGCGCGCGCCTGGCCCGGGCCAAGCGCTTCGCCTGGGTGAAACGCCAGGCCA
AGCCCGCCGAGGTCGCCGCGGTGAAGGCGCTGGCGCTGCCGGGCATGGGCTTCTCCAAGGAGCCCAAGCGATTCTACCCC
CAGCGAGAGCTGGGCGCCCACGTGGTGGGCACGGTGGGCATGGACGGCCGCGGCCTGGAGGGCCTGGAGTTGGCCTTCCA
GGACGAGCTGTCCGGGCAGAACTCCTCCACCTCCGGCTTCCGTGACGCCAAGGGCCGCAAGCTGCTGGTGCAGGGCGCGT
TGGATCCGCTCCAGCGCCAGGGCGCCGCCGTCACCCTCACGTTGGACCGCCACCTCCAGTACGTCGCGGAGAAGGCGCTC
AGCCGCGCGGTGGAGGACGCCAAGGCCGTGGCCGGCATGGCGGTGGTGTTGGATCCGCGCACGGGCGAGCTGCTCGCCGT
CGCCAACCACCCGCGCTTCAACCCCAATACGCCGGAGTCCAGCTCGCGCTCGGGCATGCGCAACCGCGCCGCCCTGGACA
CCTTCGAGCCGGGCTCCACGCTGAAGGCCTTCGTGGTGGCCGCGGCGATGGAAGAGAAGGCCATCACCGCCGACAGCCTC
TTCTTCTGTGAGAATGGCGCCTGGCGGGTGGGCCGCCATACCATCAACGACACCCATTCCTACGGCTGGCTCACCCCGCA
GGGCATCCTCCAGAAGTCCTCCAACATCTGTATGGCGAAGATTGCCCAGGCCATGGGACGGGAGAAGTTCGTGAAGGGCT
ACCAGTCCTTCGGCTTCGCCGAGCGCACCGGCCTGTCCCTGCCGGGAGAGGGGCGCGGCGTCCTGCCGTTCCCGAAGGCG
GAAGTCTCCCTGGCCACCCAGTCCTTCGGACAGGGGATGACGGCCACGGCGGTGCAGATTGCGGCCGCCTATGGTGCGCT
GGCCAACGATGGGGTGCTGATGCGGCCCTATCTGGTGTCGAAGGTGGTGGACCCGGACGGTGTCGTTCTGCTGGAAAACC
GTCCCACGGAGCTGCGCAGGGCGGTCTCCGCGAAGGTCGCCCGGCAGGTCGTGGGCATGCTCGAAAGCGTGGTGGTCAAG
GGAGGGACGGCCACCAAGGCCGCCATGGAGGACTACCGGGTGGCCGGAAAGACGGGCACCGCGCAGAAGGCAGACCCGGT
GGCGCGGGGGTATTCGGACAAGCGGATCGCCTCCTTTGTTGGGGTGGTACCGGCCGAGTCTCCGCGAGCAGTGATTCTTG
TCGTAGTGGACGAACCCAAGACGGACGTATACGGGGGGACCGTGGCTGCCCCTGCTTTCAAGGAGATTGCGACCGCCGCC
ATGGCTCACCTGGCCGTGCCCCCGTCCCGGACGGTGGCACCCGAGGTGGCCGTGGCCGCCGAGTCCCCTGCGCCTGCCGC
GGCGAAACCGGGGGCGAATGCCTCCGGTGCCGCCCGGACGGCACTGGCGGACGCGGTGACGGAGACCCCTGAACCCGGCA
CGGTGCGTGTGCCGGACCTTCAGGGAGAAGTAGGACGTGAGGCCGTGGTGAAGCTGCTCGCCGCGGCGCTGGAGCCACAG
GTATTGGGCAGTGGACGCGTGGTATCTCAAACCCCCGCCGCCGGTTCACTGGTGGAGAAGGGGGCCCGGGTGACGCTGGA
GCTCGCCGCGCGGCAATAA

Upstream 100 bases:

>100_bases
TGTCGGCGGAGAAGCCGGCGCGTGACAGCGGGGCGCGCGCGGAGGTCCCGGACGCCACGCAGCCCACCGTCCGCGTGGCG
GGCCGAGCCGGAGCCAGTCG

Downstream 100 bases:

>100_bases
GGCCGCGTCCGCTCCAGGCCCCGCTCTTGCAATGCGTGTGAAGGGGAAGAGATGAAGCTGACGGATGTCCTCGCAGGATG
TGGTGCCGAGCAGACCTCGG

Product: putative penicillin-binding protein

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MRDFKAARAPEPNAKWLKLRVRLLFGLFLMLLGVAFGRAVQLQVFEQEKLRGMAQDQYVRHIEIPARRGDIFDRRGTPLA
QSVEVDSIWVDPSMLPDVKAASRALAKALKLDPDELGARLARAKRFAWVKRQAKPAEVAAVKALALPGMGFSKEPKRFYP
QRELGAHVVGTVGMDGRGLEGLELAFQDELSGQNSSTSGFRDAKGRKLLVQGALDPLQRQGAAVTLTLDRHLQYVAEKAL
SRAVEDAKAVAGMAVVLDPRTGELLAVANHPRFNPNTPESSSRSGMRNRAALDTFEPGSTLKAFVVAAAMEEKAITADSL
FFCENGAWRVGRHTINDTHSYGWLTPQGILQKSSNICMAKIAQAMGREKFVKGYQSFGFAERTGLSLPGEGRGVLPFPKA
EVSLATQSFGQGMTATAVQIAAAYGALANDGVLMRPYLVSKVVDPDGVVLLENRPTELRRAVSAKVARQVVGMLESVVVK
GGTATKAAMEDYRVAGKTGTAQKADPVARGYSDKRIASFVGVVPAESPRAVILVVVDEPKTDVYGGTVAAPAFKEIATAA
MAHLAVPPSRTVAPEVAVAAESPAPAAAKPGANASGAARTALADAVTETPEPGTVRVPDLQGEVGREAVVKLLAAALEPQ
VLGSGRVVSQTPAAGSLVEKGARVTLELAARQ

Sequences:

>Translated_672_residues
MRDFKAARAPEPNAKWLKLRVRLLFGLFLMLLGVAFGRAVQLQVFEQEKLRGMAQDQYVRHIEIPARRGDIFDRRGTPLA
QSVEVDSIWVDPSMLPDVKAASRALAKALKLDPDELGARLARAKRFAWVKRQAKPAEVAAVKALALPGMGFSKEPKRFYP
QRELGAHVVGTVGMDGRGLEGLELAFQDELSGQNSSTSGFRDAKGRKLLVQGALDPLQRQGAAVTLTLDRHLQYVAEKAL
SRAVEDAKAVAGMAVVLDPRTGELLAVANHPRFNPNTPESSSRSGMRNRAALDTFEPGSTLKAFVVAAAMEEKAITADSL
FFCENGAWRVGRHTINDTHSYGWLTPQGILQKSSNICMAKIAQAMGREKFVKGYQSFGFAERTGLSLPGEGRGVLPFPKA
EVSLATQSFGQGMTATAVQIAAAYGALANDGVLMRPYLVSKVVDPDGVVLLENRPTELRRAVSAKVARQVVGMLESVVVK
GGTATKAAMEDYRVAGKTGTAQKADPVARGYSDKRIASFVGVVPAESPRAVILVVVDEPKTDVYGGTVAAPAFKEIATAA
MAHLAVPPSRTVAPEVAVAAESPAPAAAKPGANASGAARTALADAVTETPEPGTVRVPDLQGEVGREAVVKLLAAALEPQ
VLGSGRVVSQTPAAGSLVEKGARVTLELAARQ
>Mature_672_residues
MRDFKAARAPEPNAKWLKLRVRLLFGLFLMLLGVAFGRAVQLQVFEQEKLRGMAQDQYVRHIEIPARRGDIFDRRGTPLA
QSVEVDSIWVDPSMLPDVKAASRALAKALKLDPDELGARLARAKRFAWVKRQAKPAEVAAVKALALPGMGFSKEPKRFYP
QRELGAHVVGTVGMDGRGLEGLELAFQDELSGQNSSTSGFRDAKGRKLLVQGALDPLQRQGAAVTLTLDRHLQYVAEKAL
SRAVEDAKAVAGMAVVLDPRTGELLAVANHPRFNPNTPESSSRSGMRNRAALDTFEPGSTLKAFVVAAAMEEKAITADSL
FFCENGAWRVGRHTINDTHSYGWLTPQGILQKSSNICMAKIAQAMGREKFVKGYQSFGFAERTGLSLPGEGRGVLPFPKA
EVSLATQSFGQGMTATAVQIAAAYGALANDGVLMRPYLVSKVVDPDGVVLLENRPTELRRAVSAKVARQVVGMLESVVVK
GGTATKAAMEDYRVAGKTGTAQKADPVARGYSDKRIASFVGVVPAESPRAVILVVVDEPKTDVYGGTVAAPAFKEIATAA
MAHLAVPPSRTVAPEVAVAAESPAPAAAKPGANASGAARTALADAVTETPEPGTVRVPDLQGEVGREAVVKLLAAALEPQ
VLGSGRVVSQTPAAGSLVEKGARVTLELAARQ

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=568, Percent_Identity=36.6197183098592, Blast_Score=329, Evalue=4e-91,
Organism=Escherichia coli, GI1786854, Length=632, Percent_Identity=25.6329113924051, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 71325; Mature: 71325

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFKAARAPEPNAKWLKLRVRLLFGLFLMLLGVAFGRAVQLQVFEQEKLRGMAQDQYVR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHCCCHHHHHEE
HIEIPARRGDIFDRRGTPLAQSVEVDSIWVDPSMLPDVKAASRALAKALKLDPDELGARL
EEECCCCCCCCCCCCCCCCHHCEEECEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
ARAKRFAWVKRQAKPAEVAAVKALALPGMGFSKEPKRFYPQRELGAHVVGTVGMDGRGLE
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCC
GLELAFQDELSGQNSSTSGFRDAKGRKLLVQGALDPLQRQGAAVTLTLDRHLQYVAEKAL
CHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCEEEEEHHHHHHHHHHHHH
SRAVEDAKAVAGMAVVLDPRTGELLAVANHPRFNPNTPESSSRSGMRNRAALDTFEPGST
HHHHHHHHHHCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCH
LKAFVVAAAMEEKAITADSLFFCENGAWRVGRHTINDTHSYGWLTPQGILQKSSNICMAK
HHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHH
IAQAMGREKFVKGYQSFGFAERTGLSLPGEGRGVLPFPKAEVSLATQSFGQGMTATAVQI
HHHHHCHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
AAAYGALANDGVLMRPYLVSKVVDPDGVVLLENRPTELRRAVSAKVARQVVGMLESVVVK
HHHHHHHCCCCEEECHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GGTATKAAMEDYRVAGKTGTAQKADPVARGYSDKRIASFVGVVPAESPRAVILVVVDEPK
CCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCC
TDVYGGTVAAPAFKEIATAAMAHLAVPPSRTVAPEVAVAAESPAPAAAKPGANASGAART
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHH
ALADAVTETPEPGTVRVPDLQGEVGREAVVKLLAAALEPQVLGSGRVVSQTPAAGSLVEK
HHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHC
GARVTLELAARQ
CCEEEEEEECCC
>Mature Secondary Structure
MRDFKAARAPEPNAKWLKLRVRLLFGLFLMLLGVAFGRAVQLQVFEQEKLRGMAQDQYVR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHCCCHHHHHEE
HIEIPARRGDIFDRRGTPLAQSVEVDSIWVDPSMLPDVKAASRALAKALKLDPDELGARL
EEECCCCCCCCCCCCCCCCHHCEEECEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
ARAKRFAWVKRQAKPAEVAAVKALALPGMGFSKEPKRFYPQRELGAHVVGTVGMDGRGLE
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCC
GLELAFQDELSGQNSSTSGFRDAKGRKLLVQGALDPLQRQGAAVTLTLDRHLQYVAEKAL
CHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCEEEEEHHHHHHHHHHHHH
SRAVEDAKAVAGMAVVLDPRTGELLAVANHPRFNPNTPESSSRSGMRNRAALDTFEPGST
HHHHHHHHHHCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCH
LKAFVVAAAMEEKAITADSLFFCENGAWRVGRHTINDTHSYGWLTPQGILQKSSNICMAK
HHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCHHHHH
IAQAMGREKFVKGYQSFGFAERTGLSLPGEGRGVLPFPKAEVSLATQSFGQGMTATAVQI
HHHHHCHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
AAAYGALANDGVLMRPYLVSKVVDPDGVVLLENRPTELRRAVSAKVARQVVGMLESVVVK
HHHHHHHCCCCEEECHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHC
GGTATKAAMEDYRVAGKTGTAQKADPVARGYSDKRIASFVGVVPAESPRAVILVVVDEPK
CCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCC
TDVYGGTVAAPAFKEIATAAMAHLAVPPSRTVAPEVAVAAESPAPAAAKPGANASGAART
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHH
ALADAVTETPEPGTVRVPDLQGEVGREAVVKLLAAALEPQVLGSGRVVSQTPAAGSLVEK
HHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHC
GARVTLELAARQ
CCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]