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The map label for this gene is murE [H]

Identifier: 108761901

GI number: 108761901

Start: 6972807

End: 6974330

Strand: Reverse

Name: murE [H]

Synonym: MXAN_5609

Alternate gene names: 108761901

Gene position: 6974330-6972807 (Counterclockwise)

Preceding gene: 108760422

Following gene: 108762254

Centisome position: 76.31

GC content: 68.7

Gene sequence:

>1524_bases
ATGAAGCTGACGGATGTCCTCGCAGGATGTGGTGCCGAGCAGACCTCGGGCGGCCGTTCCGCGGTTGACGTCACCGGTGT
GACGCAGGACTCGCGGCGCGTGAAGCCGGGAGACCTGTTCGTCGCCATTCCTGGCACGAAGGAGGATGGGGCCCAGTTCA
TCGGTGAGGCCGTGTCCCGTGGCGCCGTGGCGGTGGTGTCGGAGAAGCCGGTGCCGTCCTCTCAGGTGCCCTTCTTCAAG
GTGAGCAGCGCTCGAAAGGCGCTGGCGCTCATCGCGGCCAACTTCTACGGCCGCCCGGCGGACCAGCTGACGTTGCTGGG
CATCACCGGTACGAACGGGAAGACGACCACCAGCTACCTGCTGGAGGCCATGAGCACCGCAGCGTACGCGTCCACCGGCG
TCATCGGGACGCTGGGCTACAAGTTCGCTGGCCGCACGGTGGAGTGCGCCAACACCACGCCGGATCCGCTGGAGCTGCAC
CGCATCCTCCGGGAGATGGTGGAGGCGGGCGTGGAGACGGTCATCATGGAGGTGTCCAGCCATGCGCTCGCGCAGGAGCG
CGTGCACGGGTTGACCTTCAAGGCCGCGGGCTTCTCCAACCTGAGCCGCGACCACCTCGACTACCACAAGGACATGGAGG
ACTACTTCCAGTCCAAGCGGAAGCTCTTCGCGGAGAACCTGTCCGCCACGGGCGTGGCGGTGGTGAACGGCGACGACACC
TACGCCAGCCGCATCTACAACGAGCAGCGCGGCCAGAAGCGCATGGCGTGGAAGTTCAGCCGTCAGGGCTCCGGGGAGAT
TTCCGCGGCCGACGTGAGCTTCTCGCTCCAGGGCATCAAGGGCGTGCTGAAGACGCCCGCCGGCGACATCCCGCTCAAGA
GCAAGCTCCTGGGGCCCCACAACCTGGAGAACATCCTCCTGGCGGTGGGCATTGGCCTGGGCGCGGGCTTCGCGCGGCGC
GACGTGCAGGAAGGCATCGAGCGGATGATGCCGGTGGCCGGCCGCATGGAGCGCGTGGAGAACTACGGTCCGTCTGGCGC
CCCCGCGGTGCTGGTGGACTACGCGCACACGGATGACGCGCTCAAGCGCTCCATCGAGGCGGCGCGCTCGCTGGCCAAGG
GCCGCGTCATCGCGGTGTTCGGCTGCGGCGGGGACCGCGACAAGGGCAAGCGTCCGCTGATGGGCGCGGTGGCGGGTGAG
GGCGCCGACCTGGCCGTCGTCACCAGCGACAACCCCCGCACCGAGGACCCGGAGGAGATCATCTCGCAGGTGACCGCGGG
CATCGAGAAGAGCGGCCTGCGCCGCATCTCCGCCGGCAAGGCGAAGAGCGGTGAGAAGGGCTACCTGGTCGACGCGGACC
GCCGCGCGGCCATCGAGCAGGCCATCAGCCTGGCGTCCGCGGACGACGTCGTCCTCATCGCGGGCAAGGGCCACGAGACG
TACCAGCAGGTCGGCGAGGAGAAGCTCGTGTTCGACGACCGGCAGGTGGCCGCGAAGGCGCTGGCCAACCGCATCGCTGG
CTGA

Upstream 100 bases:

>100_bases
GGTGGAGAAGGGGGCCCGGGTGACGCTGGAGCTCGCCGCGCGGCAATAAGGCCGCGTCCGCTCCAGGCCCCGCTCTTGCA
ATGCGTGTGAAGGGGAAGAG

Downstream 100 bases:

>100_bases
GCCCGAGCCTCCCAAGCCCCGTCGACCCGCCCGCCCATCTCTCACACCATGGCAGCTTCCTTCAGCGACGAAGAGGTGGT
GCAGGCGACCGGGGCGACCC

Product: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase

Products: NA

Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MKLTDVLAGCGAEQTSGGRSAVDVTGVTQDSRRVKPGDLFVAIPGTKEDGAQFIGEAVSRGAVAVVSEKPVPSSQVPFFK
VSSARKALALIAANFYGRPADQLTLLGITGTNGKTTTSYLLEAMSTAAYASTGVIGTLGYKFAGRTVECANTTPDPLELH
RILREMVEAGVETVIMEVSSHALAQERVHGLTFKAAGFSNLSRDHLDYHKDMEDYFQSKRKLFAENLSATGVAVVNGDDT
YASRIYNEQRGQKRMAWKFSRQGSGEISAADVSFSLQGIKGVLKTPAGDIPLKSKLLGPHNLENILLAVGIGLGAGFARR
DVQEGIERMMPVAGRMERVENYGPSGAPAVLVDYAHTDDALKRSIEAARSLAKGRVIAVFGCGGDRDKGKRPLMGAVAGE
GADLAVVTSDNPRTEDPEEIISQVTAGIEKSGLRRISAGKAKSGEKGYLVDADRRAAIEQAISLASADDVVLIAGKGHET
YQQVGEEKLVFDDRQVAAKALANRIAG

Sequences:

>Translated_507_residues
MKLTDVLAGCGAEQTSGGRSAVDVTGVTQDSRRVKPGDLFVAIPGTKEDGAQFIGEAVSRGAVAVVSEKPVPSSQVPFFK
VSSARKALALIAANFYGRPADQLTLLGITGTNGKTTTSYLLEAMSTAAYASTGVIGTLGYKFAGRTVECANTTPDPLELH
RILREMVEAGVETVIMEVSSHALAQERVHGLTFKAAGFSNLSRDHLDYHKDMEDYFQSKRKLFAENLSATGVAVVNGDDT
YASRIYNEQRGQKRMAWKFSRQGSGEISAADVSFSLQGIKGVLKTPAGDIPLKSKLLGPHNLENILLAVGIGLGAGFARR
DVQEGIERMMPVAGRMERVENYGPSGAPAVLVDYAHTDDALKRSIEAARSLAKGRVIAVFGCGGDRDKGKRPLMGAVAGE
GADLAVVTSDNPRTEDPEEIISQVTAGIEKSGLRRISAGKAKSGEKGYLVDADRRAAIEQAISLASADDVVLIAGKGHET
YQQVGEEKLVFDDRQVAAKALANRIAG
>Mature_507_residues
MKLTDVLAGCGAEQTSGGRSAVDVTGVTQDSRRVKPGDLFVAIPGTKEDGAQFIGEAVSRGAVAVVSEKPVPSSQVPFFK
VSSARKALALIAANFYGRPADQLTLLGITGTNGKTTTSYLLEAMSTAAYASTGVIGTLGYKFAGRTVECANTTPDPLELH
RILREMVEAGVETVIMEVSSHALAQERVHGLTFKAAGFSNLSRDHLDYHKDMEDYFQSKRKLFAENLSATGVAVVNGDDT
YASRIYNEQRGQKRMAWKFSRQGSGEISAADVSFSLQGIKGVLKTPAGDIPLKSKLLGPHNLENILLAVGIGLGAGFARR
DVQEGIERMMPVAGRMERVENYGPSGAPAVLVDYAHTDDALKRSIEAARSLAKGRVIAVFGCGGDRDKGKRPLMGAVAGE
GADLAVVTSDNPRTEDPEEIISQVTAGIEKSGLRRISAGKAKSGEKGYLVDADRRAAIEQAISLASADDVVLIAGKGHET
YQQVGEEKLVFDDRQVAAKALANRIAG

Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]

COG id: COG0769

COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family. MurE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786273, Length=486, Percent_Identity=39.7119341563786, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1786274, Length=340, Percent_Identity=24.4117647058824, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR005761 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.13 [H]

Molecular weight: Translated: 53712; Mature: 53712

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTDVLAGCGAEQTSGGRSAVDVTGVTQDSRRVKPGDLFVAIPGTKEDGAQFIGEAVSR
CCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCC
GAVAVVSEKPVPSSQVPFFKVSSARKALALIAANFYGRPADQLTLLGITGTNGKTTTSYL
CEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHH
LEAMSTAAYASTGVIGTLGYKFAGRTVECANTTPDPLELHRILREMVEAGVETVIMEVSS
HHHHHHHHHHHCCCEECCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HALAQERVHGLTFKAAGFSNLSRDHLDYHKDMEDYFQSKRKLFAENLSATGVAVVNGDDT
HHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
YASRIYNEQRGQKRMAWKFSRQGSGEISAADVSFSLQGIKGVLKTPAGDIPLKSKLLGPH
HHHHHHHHHCCCHHHHEEECCCCCCCEEEEEEEEEHHHHHHHHCCCCCCCCCHHHCCCCC
NLENILLAVGIGLGAGFARRDVQEGIERMMPVAGRMERVENYGPSGAPAVLVDYAHTDDA
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCHHH
LKRSIEAARSLAKGRVIAVFGCGGDRDKGKRPLMGAVAGEGADLAVVTSDNPRTEDPEEI
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEHCCCCCCCEEEEECCCCCCCCHHHH
ISQVTAGIEKSGLRRISAGKAKSGEKGYLVDADRRAAIEQAISLASADDVVLIAGKGHET
HHHHHHCHHHHCCHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCCHH
YQQVGEEKLVFDDRQVAAKALANRIAG
HHHCCCCCEEECHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLTDVLAGCGAEQTSGGRSAVDVTGVTQDSRRVKPGDLFVAIPGTKEDGAQFIGEAVSR
CCHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCC
GAVAVVSEKPVPSSQVPFFKVSSARKALALIAANFYGRPADQLTLLGITGTNGKTTTSYL
CEEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHH
LEAMSTAAYASTGVIGTLGYKFAGRTVECANTTPDPLELHRILREMVEAGVETVIMEVSS
HHHHHHHHHHHCCCEECCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HALAQERVHGLTFKAAGFSNLSRDHLDYHKDMEDYFQSKRKLFAENLSATGVAVVNGDDT
HHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
YASRIYNEQRGQKRMAWKFSRQGSGEISAADVSFSLQGIKGVLKTPAGDIPLKSKLLGPH
HHHHHHHHHCCCHHHHEEECCCCCCCEEEEEEEEEHHHHHHHHCCCCCCCCCHHHCCCCC
NLENILLAVGIGLGAGFARRDVQEGIERMMPVAGRMERVENYGPSGAPAVLVDYAHTDDA
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCHHH
LKRSIEAARSLAKGRVIAVFGCGGDRDKGKRPLMGAVAGEGADLAVVTSDNPRTEDPEEI
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEHCCCCCCCEEEEECCCCCCCCHHHH
ISQVTAGIEKSGLRRISAGKAKSGEKGYLVDADRRAAIEQAISLASADDVVLIAGKGHET
HHHHHHCHHHHCCHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCCHH
YQQVGEEKLVFDDRQVAAKALANRIAG
HHHCCCCCEEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA