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The map label for this gene is ggt [H]

Identifier: 108759847

GI number: 108759847

Start: 1623695

End: 1625503

Strand: Reverse

Name: ggt [H]

Synonym: MXAN_1383

Alternate gene names: 108759847

Gene position: 1625503-1623695 (Counterclockwise)

Preceding gene: 108758995

Following gene: 108761090

Centisome position: 17.78

GC content: 71.42

Gene sequence:

>1809_bases
ATGGACTGTTCAGACAGCGCGAGGAGGGCTGAACCCGTGAAGGACACGAGCTTCCGCGGTGCGGTGCTGAAGCGAGGGCT
GCTGGCCGCGGTGATGATGGTGGCGTGTGTGGCGCAGGCGGCGCGGCCCTACCGGGGCGGCGCGGTGGCCACGGCCTACC
CGCAGGCGAGCGCGGCGGCGTTGGAGATGCTGGAGAAGGGCGGCAACGCCACGGACGCGGCGGTGGCGGCGGCCTTCGTG
GCGGCGGTGGTGGGTCCCTACCACTCCGGCGTTGGCGGCGGCGGCTTCGCATTGGTGCACGACGCCAAGAGCGGCGACAC
GAAGGTGCTGGATTTCCGCGAGGTGGCCCCCAAGGCGGCCACGCGCGACATGTACGTGAAGGACGGCAAGGTGGTGCCGG
GCCTGTCCACGGACGGCGCGCTGAGCGTGGCGGTGCCGGGCGCCGTCGCGGGCTACCTGGAGCTGCTCAAGGCGCACGGA
AAGTTGAAGCCGGCGGTGGTGCTGGCGCCGGCCATCGCGGCGGCACGCAAGGGCATGTGGGTGACGCCGCGCTACCGCAC
CATGGCGGAGGGCCGGCTGGCCTGTCTGAGCCGGGACGCGGAGGCCTCACGCGTGTTCCTGGTGAAGAATGCCCAGGGCC
AGTGGGAACCCCCGCCCGTGGGGCACGTCATCCGCCAGCCCGACCTGGCGCGTACGCTGTCCTCCATCGCGAAGGGGGGC
GCCAAGGCCTTCTATGCGGGGCCGGTGGCGAAGGCCATCGCCACGTCGGTCCAGGCTGGCGGCGGCATCCTCACCCAGGA
GGACCTCGCGGCCTACAAGACGCGGAGCGCCACGCCCCTGGAGGGCACGTACCGCGGCCACCGCATCCTCACCATGCCGC
CGCCGAGCGCGGGGGGCGTGGCCGTCATCCAGGTGCTGACCGCGATGGAGCAACTGCGCCCCCAGGGCGTGACGTTCCGC
GACGCGGAGGCGCTGCACCTCTACGCGGAAGCCGTGCGGCGGGCCTACGTGGACCGCGCGAAGTACCTGGGGGACCCGGC
CTTCGTGGACGTGCCCCTGGCGCGGCTGGTGTCACCCGGCCACGTCGCGGACCTGGCGGGCTCCATCGACCCGAAGAAGG
CCACGCCCAGCGCGTCGCTGCTGGCGCCGAAGGAAGGCGTGCGGGGCTCCACGCTGACGGACGAGCCCACCACCCTGACG
CCCGAGCCGGAGAAGAAGAACACCACGCACATCTCCGTCATCGACAAGGACGGCAACGCGGTGGCGATGACGACCACGGT
GAACTACGGCTTCGGCTCGTGCGTGGTGGCCAAGGGCACCGGCGTGCTGCTCAACGATGAGATGGATGACTTCGCCGCGC
AGCCGGGCGTGCCCAACGCGTACGGCCTGGTGACGGGCGAGCCCAACGCCATCGCACCGGGCAAGGTTCCGCTGTCCTCC
ATGGCCCCCACGCTGGTGTTCTCCAAGGAAGACCCCCGGCGCGTCATGCTCGCGGTGGGCAGCCCTGGCGGCTCCACCAT
CCCCACCACCGTCATCCAGGTCATCAGCAACGTGGTGGACCACGGCATGGACGTGGCGCGAGCGGTGAATGAAGGCCGCG
TGCATCACCAGTACCTGCCCGACGAGCTGTGGGTGGACAAGTGGGGCCTGGAGCCGGCGACGCTGTCCGTGCTGGAGGCC
AAGGGCCACAAGGTGCGCCGCGTGGAGCAGTGGGGCGACGCGGAGGCCGTCTACAGCGACCCGAAGACGGGGCTGCGCTT
CTCCGCGAGTGACCCGCGCAACGAGGGCGCCGCCCTGGGACAGGATTGA

Upstream 100 bases:

>100_bases
TACCGGGACACATGTAGTCCGTCTGGTCCCCTGGCGTCGCCGGACTGGAGGGTAGGCTTTTGTCGCCCGGGTAACACATC
ACCCAGGACGAAAGCCAGCG

Downstream 100 bases:

>100_bases
GCAGTGCCCACCCCACCGCCCATCTTCGACGCCCACCTCCACCCGGAGAGCCTGAGCGACCAGGATTTGGAGTCCATGCG
CTTCTTCGGCGTGGAGCGGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MDCSDSARRAEPVKDTSFRGAVLKRGLLAAVMMVACVAQAARPYRGGAVATAYPQASAAALEMLEKGGNATDAAVAAAFV
AAVVGPYHSGVGGGGFALVHDAKSGDTKVLDFREVAPKAATRDMYVKDGKVVPGLSTDGALSVAVPGAVAGYLELLKAHG
KLKPAVVLAPAIAAARKGMWVTPRYRTMAEGRLACLSRDAEASRVFLVKNAQGQWEPPPVGHVIRQPDLARTLSSIAKGG
AKAFYAGPVAKAIATSVQAGGGILTQEDLAAYKTRSATPLEGTYRGHRILTMPPPSAGGVAVIQVLTAMEQLRPQGVTFR
DAEALHLYAEAVRRAYVDRAKYLGDPAFVDVPLARLVSPGHVADLAGSIDPKKATPSASLLAPKEGVRGSTLTDEPTTLT
PEPEKKNTTHISVIDKDGNAVAMTTTVNYGFGSCVVAKGTGVLLNDEMDDFAAQPGVPNAYGLVTGEPNAIAPGKVPLSS
MAPTLVFSKEDPRRVMLAVGSPGGSTIPTTVIQVISNVVDHGMDVARAVNEGRVHHQYLPDELWVDKWGLEPATLSVLEA
KGHKVRRVEQWGDAEAVYSDPKTGLRFSASDPRNEGAALGQD

Sequences:

>Translated_602_residues
MDCSDSARRAEPVKDTSFRGAVLKRGLLAAVMMVACVAQAARPYRGGAVATAYPQASAAALEMLEKGGNATDAAVAAAFV
AAVVGPYHSGVGGGGFALVHDAKSGDTKVLDFREVAPKAATRDMYVKDGKVVPGLSTDGALSVAVPGAVAGYLELLKAHG
KLKPAVVLAPAIAAARKGMWVTPRYRTMAEGRLACLSRDAEASRVFLVKNAQGQWEPPPVGHVIRQPDLARTLSSIAKGG
AKAFYAGPVAKAIATSVQAGGGILTQEDLAAYKTRSATPLEGTYRGHRILTMPPPSAGGVAVIQVLTAMEQLRPQGVTFR
DAEALHLYAEAVRRAYVDRAKYLGDPAFVDVPLARLVSPGHVADLAGSIDPKKATPSASLLAPKEGVRGSTLTDEPTTLT
PEPEKKNTTHISVIDKDGNAVAMTTTVNYGFGSCVVAKGTGVLLNDEMDDFAAQPGVPNAYGLVTGEPNAIAPGKVPLSS
MAPTLVFSKEDPRRVMLAVGSPGGSTIPTTVIQVISNVVDHGMDVARAVNEGRVHHQYLPDELWVDKWGLEPATLSVLEA
KGHKVRRVEQWGDAEAVYSDPKTGLRFSASDPRNEGAALGQD
>Mature_602_residues
MDCSDSARRAEPVKDTSFRGAVLKRGLLAAVMMVACVAQAARPYRGGAVATAYPQASAAALEMLEKGGNATDAAVAAAFV
AAVVGPYHSGVGGGGFALVHDAKSGDTKVLDFREVAPKAATRDMYVKDGKVVPGLSTDGALSVAVPGAVAGYLELLKAHG
KLKPAVVLAPAIAAARKGMWVTPRYRTMAEGRLACLSRDAEASRVFLVKNAQGQWEPPPVGHVIRQPDLARTLSSIAKGG
AKAFYAGPVAKAIATSVQAGGGILTQEDLAAYKTRSATPLEGTYRGHRILTMPPPSAGGVAVIQVLTAMEQLRPQGVTFR
DAEALHLYAEAVRRAYVDRAKYLGDPAFVDVPLARLVSPGHVADLAGSIDPKKATPSASLLAPKEGVRGSTLTDEPTTLT
PEPEKKNTTHISVIDKDGNAVAMTTTVNYGFGSCVVAKGTGVLLNDEMDDFAAQPGVPNAYGLVTGEPNAIAPGKVPLSS
MAPTLVFSKEDPRRVMLAVGSPGGSTIPTTVIQVISNVVDHGMDVARAVNEGRVHHQYLPDELWVDKWGLEPATLSVLEA
KGHKVRRVEQWGDAEAVYSDPKTGLRFSASDPRNEGAALGQD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=536, Percent_Identity=32.2761194029851, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI73915090, Length=536, Percent_Identity=32.2761194029851, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI73915096, Length=536, Percent_Identity=32.2761194029851, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI73915094, Length=536, Percent_Identity=32.2761194029851, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI113429324, Length=530, Percent_Identity=30.9433962264151, Blast_Score=203, Evalue=4e-52,
Organism=Homo sapiens, GI113429326, Length=547, Percent_Identity=30.5301645338208, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI109148539, Length=563, Percent_Identity=32.1492007104796, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI153266901, Length=488, Percent_Identity=28.0737704918033, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI153266885, Length=487, Percent_Identity=28.1314168377823, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI153266907, Length=487, Percent_Identity=26.694045174538, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI30581157, Length=165, Percent_Identity=38.1818181818182, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI30581155, Length=165, Percent_Identity=38.1818181818182, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI218505805, Length=159, Percent_Identity=37.7358490566038, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI310124095, Length=164, Percent_Identity=33.5365853658537, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789856, Length=551, Percent_Identity=42.2867513611615, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI212646519, Length=524, Percent_Identity=32.2519083969466, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI72000294, Length=524, Percent_Identity=32.2519083969466, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI193208245, Length=508, Percent_Identity=30.511811023622, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI193208247, Length=508, Percent_Identity=30.511811023622, Blast_Score=208, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17506189, Length=538, Percent_Identity=30.4832713754647, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=32.064128256513, Blast_Score=194, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6323330, Length=556, Percent_Identity=28.9568345323741, Blast_Score=163, Evalue=6e-41,
Organism=Drosophila melanogaster, GI161077496, Length=541, Percent_Identity=32.902033271719, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI18859893, Length=538, Percent_Identity=32.1561338289963, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI161077878, Length=532, Percent_Identity=29.6992481203008, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI161077880, Length=532, Percent_Identity=29.6992481203008, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24642670, Length=532, Percent_Identity=29.6992481203008, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24642666, Length=532, Percent_Identity=29.6992481203008, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI45551474, Length=532, Percent_Identity=29.6992481203008, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI18859741, Length=535, Percent_Identity=25.981308411215, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62852; Mature: 62852

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCSDSARRAEPVKDTSFRGAVLKRGLLAAVMMVACVAQAARPYRGGAVATAYPQASAAA
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHH
LEMLEKGGNATDAAVAAAFVAAVVGPYHSGVGGGGFALVHDAKSGDTKVLDFREVAPKAA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEHHHHCCCHH
TRDMYVKDGKVVPGLSTDGALSVAVPGAVAGYLELLKAHGKLKPAVVLAPAIAAARKGMW
CCCEEEECCEECCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCE
VTPRYRTMAEGRLACLSRDAEASRVFLVKNAQGQWEPPPVGHVIRQPDLARTLSSIAKGG
ECCCHHHHHCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
AKAFYAGPVAKAIATSVQAGGGILTQEDLAAYKTRSATPLEGTYRGHRILTMPPPSAGGV
CCEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHH
AVIQVLTAMEQLRPQGVTFRDAEALHLYAEAVRRAYVDRAKYLGDPAFVDVPLARLVSPG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCC
HVADLAGSIDPKKATPSASLLAPKEGVRGSTLTDEPTTLTPEPEKKNTTHISVIDKDGNA
HHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
VAMTTTVNYGFGSCVVAKGTGVLLNDEMDDFAAQPGVPNAYGLVTGEPNAIAPGKVPLSS
EEEEEEEECCCCEEEEECCCEEEECCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHH
MAPTLVFSKEDPRRVMLAVGSPGGSTIPTTVIQVISNVVDHGMDVARAVNEGRVHHQYLP
CCCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHCCC
DELWVDKWGLEPATLSVLEAKGHKVRRVEQWGDAEAVYSDPKTGLRFSASDPRNEGAALG
HHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCCCCCEECCCCCCCEECCCCCCCCCCCCC
QD
CC
>Mature Secondary Structure
MDCSDSARRAEPVKDTSFRGAVLKRGLLAAVMMVACVAQAARPYRGGAVATAYPQASAAA
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHH
LEMLEKGGNATDAAVAAAFVAAVVGPYHSGVGGGGFALVHDAKSGDTKVLDFREVAPKAA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEHHHHCCCHH
TRDMYVKDGKVVPGLSTDGALSVAVPGAVAGYLELLKAHGKLKPAVVLAPAIAAARKGMW
CCCEEEECCEECCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHCCCE
VTPRYRTMAEGRLACLSRDAEASRVFLVKNAQGQWEPPPVGHVIRQPDLARTLSSIAKGG
ECCCHHHHHCCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHCCC
AKAFYAGPVAKAIATSVQAGGGILTQEDLAAYKTRSATPLEGTYRGHRILTMPPPSAGGV
CCEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHH
AVIQVLTAMEQLRPQGVTFRDAEALHLYAEAVRRAYVDRAKYLGDPAFVDVPLARLVSPG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCC
HVADLAGSIDPKKATPSASLLAPKEGVRGSTLTDEPTTLTPEPEKKNTTHISVIDKDGNA
HHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCE
VAMTTTVNYGFGSCVVAKGTGVLLNDEMDDFAAQPGVPNAYGLVTGEPNAIAPGKVPLSS
EEEEEEEECCCCEEEEECCCEEEECCCHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHH
MAPTLVFSKEDPRRVMLAVGSPGGSTIPTTVIQVISNVVDHGMDVARAVNEGRVHHQYLP
CCCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHCCC
DELWVDKWGLEPATLSVLEAKGHKVRRVEQWGDAEAVYSDPKTGLRFSASDPRNEGAALG
HHHHHHHCCCCHHHHHHHHHCCCHHHHHHHCCCCCCEECCCCCCCEECCCCCCCCCCCCC
QD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]