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The map label for this gene is icd [H]

Identifier: 108759727

GI number: 108759727

Start: 4121250

End: 4122548

Strand: Direct

Name: icd [H]

Synonym: MXAN_3537

Alternate gene names: 108759727

Gene position: 4121250-4122548 (Clockwise)

Preceding gene: 108763094

Following gene: 108762306

Centisome position: 45.09

GC content: 65.82

Gene sequence:

>1299_bases
ATGGCGCCCCCGTCATCCGGAGAAAAGATCTCCCTGCAGAGCGGCAAGCTGTCCGTCCCGGACAACCCGATCATCCCCTT
CATCGAGGGCGATGGCACCGGCCGCGACATCTGGCGTGCGTCCCAGGCGGTGTTCGACGCCGCGGTGGAGAAGGCCTACA
AGGGCAAGAAGAAGATCGCCTGGTACGAAGTCCTGGCCGGCGAGAAGTCCTTCAAGGCGGTCAACAACTGGCTGCCCGAG
GAGACGGTCGAGGCGTTCCGCACCTATCTGGTGGGCATCAAGGGCCCCCTGACGACGCCGGTGGGCGGCGGCATCCGGTC
GCTGAACGTGGCCCTGCGGCAGATGCTGGACCTGTACGTCTGCCTGCGCCCCGTGCGCTACTTCAAGGGCGTGCCCAGCC
CGGTGAAGATGCCGGACAAGGTCGACATGACCATCTTCCGTGAGAACACGGAAGACATCTACGCGGGCATCGAGTTCGAG
GCCGGCACGGCCGCCGCGGAGAAGTTCCTGGGCCTGCTGAAGCAGGAGTTCCCGAAGGAGTTCGGGAAGATCCGCTTCCC
GTCCGACGTGGGCCTGGGCATCAAGCCGGTGTCCCACGAGGGCAGCGACCGGCTGATCCGCGCCGCCATCCAGTACGCCG
TGGACCACAAGCGCAAGAGCGTCACGCTGGTCCACAAGGGCAACATCATGAAGTTCACCGAGGGCGCCTTCCGCAAGTGG
GGCTACGAGCTGGCCGCCCGGGAGTTCGGTGACAAGGTCTACACCTGGGACCAGTGGGAGGCCACCAAGGCCGCCAAGGG
CGAGGACGCCGCCAACGCGGAGCAGAAGGCCGCGCTGGCCGCCGGGAAGATCCTGATCAAGGACTCCATCGCGGACATCA
CCCTGCAGCAGGTCCTCACCCGTCCGGATGAGTTCGACGTCATCGCCACGCTGAACCTCAACGGTGACTACCTGTCGGAC
GCGCTGGCGGCGCAGGTGGGCGGCATCGGCATCGCGCCGGGCGGCAACATCAACTACGTCACGGGCCACGCGGTGTTCGA
GGCCACGCACGGCACGGCGCCCAAGTACGCCGACCAGGACAAGGTGAACCCGGGCTCGGTCATCCTCTCCGGTGAGATGA
TGTTCCGGCACCTGGGCTGGTACGAGGCGGCCGACCTGATGATCCAGGGCATGGACCGCGCCATCGCCAGCAAGACGGTG
ACCTACGACTTCGCCCGCCTGATGAAGCAGGAAGGGCAGAGCGGCGTCTCCGAGGTCAAGTGCTCCGAGTTCGGGCAGGC
CATCATCAAGAACATGTAG

Upstream 100 bases:

>100_bases
TCCGCGTGAGCCCGTGGCCAAACTCCTTGACGTCGCGGGGCGGGTTCTCGACTATCCCGCGCCGATTCTTACACGGTCAC
ACCTTCTCAGGAGCACATCC

Downstream 100 bases:

>100_bases
TCCCCGGTCGGGGATCTGGAAGAGGCGAATCCATGGCTCAGAATGGCAAGAAGAAGATCGGCCTCATCGGCGGCGGTCAG
ATCGGCGGCAACCTGGCGCT

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MAPPSSGEKISLQSGKLSVPDNPIIPFIEGDGTGRDIWRASQAVFDAAVEKAYKGKKKIAWYEVLAGEKSFKAVNNWLPE
ETVEAFRTYLVGIKGPLTTPVGGGIRSLNVALRQMLDLYVCLRPVRYFKGVPSPVKMPDKVDMTIFRENTEDIYAGIEFE
AGTAAAEKFLGLLKQEFPKEFGKIRFPSDVGLGIKPVSHEGSDRLIRAAIQYAVDHKRKSVTLVHKGNIMKFTEGAFRKW
GYELAAREFGDKVYTWDQWEATKAAKGEDAANAEQKAALAAGKILIKDSIADITLQQVLTRPDEFDVIATLNLNGDYLSD
ALAAQVGGIGIAPGGNINYVTGHAVFEATHGTAPKYADQDKVNPGSVILSGEMMFRHLGWYEAADLMIQGMDRAIASKTV
TYDFARLMKQEGQSGVSEVKCSEFGQAIIKNM

Sequences:

>Translated_432_residues
MAPPSSGEKISLQSGKLSVPDNPIIPFIEGDGTGRDIWRASQAVFDAAVEKAYKGKKKIAWYEVLAGEKSFKAVNNWLPE
ETVEAFRTYLVGIKGPLTTPVGGGIRSLNVALRQMLDLYVCLRPVRYFKGVPSPVKMPDKVDMTIFRENTEDIYAGIEFE
AGTAAAEKFLGLLKQEFPKEFGKIRFPSDVGLGIKPVSHEGSDRLIRAAIQYAVDHKRKSVTLVHKGNIMKFTEGAFRKW
GYELAAREFGDKVYTWDQWEATKAAKGEDAANAEQKAALAAGKILIKDSIADITLQQVLTRPDEFDVIATLNLNGDYLSD
ALAAQVGGIGIAPGGNINYVTGHAVFEATHGTAPKYADQDKVNPGSVILSGEMMFRHLGWYEAADLMIQGMDRAIASKTV
TYDFARLMKQEGQSGVSEVKCSEFGQAIIKNM
>Mature_431_residues
APPSSGEKISLQSGKLSVPDNPIIPFIEGDGTGRDIWRASQAVFDAAVEKAYKGKKKIAWYEVLAGEKSFKAVNNWLPEE
TVEAFRTYLVGIKGPLTTPVGGGIRSLNVALRQMLDLYVCLRPVRYFKGVPSPVKMPDKVDMTIFRENTEDIYAGIEFEA
GTAAAEKFLGLLKQEFPKEFGKIRFPSDVGLGIKPVSHEGSDRLIRAAIQYAVDHKRKSVTLVHKGNIMKFTEGAFRKWG
YELAAREFGDKVYTWDQWEATKAAKGEDAANAEQKAALAAGKILIKDSIADITLQQVLTRPDEFDVIATLNLNGDYLSDA
LAAQVGGIGIAPGGNINYVTGHAVFEATHGTAPKYADQDKVNPGSVILSGEMMFRHLGWYEAADLMIQGMDRAIASKTVT
YDFARLMKQEGQSGVSEVKCSEFGQAIIKNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=412, Percent_Identity=29.6116504854369, Blast_Score=165, Evalue=9e-41,
Organism=Escherichia coli, GI1787381, Length=431, Percent_Identity=61.9489559164733, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1788101, Length=389, Percent_Identity=26.7352185089974, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71986051, Length=384, Percent_Identity=32.2916666666667, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI25144293, Length=322, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324709, Length=415, Percent_Identity=29.6385542168675, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=383, Percent_Identity=27.9373368146214, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322097, Length=377, Percent_Identity=28.1167108753316, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24661184, Length=409, Percent_Identity=30.0733496332518, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24643270, Length=409, Percent_Identity=30.5623471882641, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24643268, Length=409, Percent_Identity=30.5623471882641, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 47297; Mature: 47165

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPPSSGEKISLQSGKLSVPDNPIIPFIEGDGTGRDIWRASQAVFDAAVEKAYKGKKKIA
CCCCCCCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEE
WYEVLAGEKSFKAVNNWLPEETVEAFRTYLVGIKGPLTTPVGGGIRSLNVALRQMLDLYV
HHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CLRPVRYFKGVPSPVKMPDKVDMTIFRENTEDIYAGIEFEAGTAAAEKFLGLLKQEFPKE
HHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
FGKIRFPSDVGLGIKPVSHEGSDRLIRAAIQYAVDHKRKSVTLVHKGNIMKFTEGAFRKW
HCCEECCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECHHHHHHH
GYELAAREFGDKVYTWDQWEATKAAKGEDAANAEQKAALAAGKILIKDSIADITLQQVLT
HHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHHC
RPDEFDVIATLNLNGDYLSDALAAQVGGIGIAPGGNINYVTGHAVFEATHGTAPKYADQD
CCCCCCEEEEEECCCHHHHHHHHHHHCCEEECCCCCEEEEECCEEEEECCCCCCCCCCCC
KVNPGSVILSGEMMFRHLGWYEAADLMIQGMDRAIASKTVTYDFARLMKQEGQSGVSEVK
CCCCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
CSEFGQAIIKNM
HHHHHHHHHHCC
>Mature Secondary Structure 
APPSSGEKISLQSGKLSVPDNPIIPFIEGDGTGRDIWRASQAVFDAAVEKAYKGKKKIA
CCCCCCCEEEECCCEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCEE
WYEVLAGEKSFKAVNNWLPEETVEAFRTYLVGIKGPLTTPVGGGIRSLNVALRQMLDLYV
HHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
CLRPVRYFKGVPSPVKMPDKVDMTIFRENTEDIYAGIEFEAGTAAAEKFLGLLKQEFPKE
HHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHH
FGKIRFPSDVGLGIKPVSHEGSDRLIRAAIQYAVDHKRKSVTLVHKGNIMKFTEGAFRKW
HCCEECCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECHHHHHHH
GYELAAREFGDKVYTWDQWEATKAAKGEDAANAEQKAALAAGKILIKDSIADITLQQVLT
HHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHHC
RPDEFDVIATLNLNGDYLSDALAAQVGGIGIAPGGNINYVTGHAVFEATHGTAPKYADQD
CCCCCCEEEEEECCCHHHHHHHHHHHCCEEECCCCCEEEEECCEEEEECCCCCCCCCCCC
KVNPGSVILSGEMMFRHLGWYEAADLMIQGMDRAIASKTVTYDFARLMKQEGQSGVSEVK
CCCCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
CSEFGQAIIKNM
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]