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The map label for this gene is fkpA [H]

Identifier: 108759587

GI number: 108759587

Start: 4181247

End: 4182002

Strand: Reverse

Name: fkpA [H]

Synonym: MXAN_3584

Alternate gene names: 108759587

Gene position: 4182002-4181247 (Counterclockwise)

Preceding gene: 108763142

Following gene: 108757296

Centisome position: 45.76

GC content: 69.84

Gene sequence:

>756_bases
ATGAAAGGTGGATGCATGCGATCGATGTGGACGGCGGCCCTGGTGTTCGCGCTCGGCGCGACGGGCGCCCAGGCGCAGGA
CTCGAAGTCGGCGAAGAAGCCCGCGGCCAAGGCCGCACCGGCGACTCCGGCCGCCGCGCCGGCGGCGCCCGCTGCGCTGT
CCGAGGAGGACCAGCAGACCCTCTACACGCTCGGTCTCTCCATTGGCCGTGATTTGTCCCTCTTCGCGCTGTCGCCCGAG
GAGTTGAAGGTGCTGCAACAGGGCCTGTCCGACGGACTCGGTGGAAAGACGTCCGACATCGACCCGAAGGAGCAGGCTCA
GCGGATTCAGGCCTTCGCCAAGAGCCGGCAGGCCCTTGCGGGCAAGGCCGCGCTGGAGCGCGCCGCCAAGGAGCCCGGCG
CGGAGGTGCTTCCCTCCGGCGTCATCTACAAGCAGGTCCAGGCGGGAACCGGCCGCAGCCCGCGCGCCGTCGACACCGTC
AAGGTCCACTACGAGGGCCGGCTGGTGGACGGCACCATCTTCGACACCTCCGCCCGCCGTGGAATCCCCGTCGAGTTCCC
GCTCAACGGCGTCATCCCCTGCTGGACGCAGGGCGTGGCGAAGATGAAGGTGGGCGGCAAGGCGAAGCTCACCTGCCCTG
GCAACACCGCCTACGGTGAGCGGCCGCCCTCTGGCTCGCGCATCCCGCCCAACGCCGTCCTCACCTTCGACGTCGAGCTC
ATCGACATCCCCGGCGACACGTCCCGGCAGCCGTAG

Upstream 100 bases:

>100_bases
CGCGGAGGACTCGCGCGCTTGCTGTGCTTCCTCGATGAATTCTTCGCGCGGGCTTGTGTCTTTCGAGCACGCGGCCGCGC
TCTATAGTGCGCCGGTTCTC

Downstream 100 bases:

>100_bases
GTCAGCGACTCAGGGCGGCCTCGGCGGCGCGGATCAGCGGCTCCGCGCTCACCGGGGCCCCGGTCGCATGAATCATCCAC
TGGTCCGGCGTCACCGAGCC

Product: FKBP-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKGGCMRSMWTAALVFALGATGAQAQDSKSAKKPAAKAAPATPAAAPAAPAALSEEDQQTLYTLGLSIGRDLSLFALSPE
ELKVLQQGLSDGLGGKTSDIDPKEQAQRIQAFAKSRQALAGKAALERAAKEPGAEVLPSGVIYKQVQAGTGRSPRAVDTV
KVHYEGRLVDGTIFDTSARRGIPVEFPLNGVIPCWTQGVAKMKVGGKAKLTCPGNTAYGERPPSGSRIPPNAVLTFDVEL
IDIPGDTSRQP

Sequences:

>Translated_251_residues
MKGGCMRSMWTAALVFALGATGAQAQDSKSAKKPAAKAAPATPAAAPAAPAALSEEDQQTLYTLGLSIGRDLSLFALSPE
ELKVLQQGLSDGLGGKTSDIDPKEQAQRIQAFAKSRQALAGKAALERAAKEPGAEVLPSGVIYKQVQAGTGRSPRAVDTV
KVHYEGRLVDGTIFDTSARRGIPVEFPLNGVIPCWTQGVAKMKVGGKAKLTCPGNTAYGERPPSGSRIPPNAVLTFDVEL
IDIPGDTSRQP
>Mature_251_residues
MKGGCMRSMWTAALVFALGATGAQAQDSKSAKKPAAKAAPATPAAAPAAPAALSEEDQQTLYTLGLSIGRDLSLFALSPE
ELKVLQQGLSDGLGGKTSDIDPKEQAQRIQAFAKSRQALAGKAALERAAKEPGAEVLPSGVIYKQVQAGTGRSPRAVDTV
KVHYEGRLVDGTIFDTSARRGIPVEFPLNGVIPCWTQGVAKMKVGGKAKLTCPGNTAYGERPPSGSRIPPNAVLTFDVEL
IDIPGDTSRQP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4503729, Length=122, Percent_Identity=40.9836065573771, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=44.8598130841121, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=44.8598130841121, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=42.0560747663551, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI224809329, Length=109, Percent_Identity=42.2018348623853, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI224809327, Length=109, Percent_Identity=42.2018348623853, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4758384, Length=109, Percent_Identity=42.2018348623853, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI224809331, Length=109, Percent_Identity=42.2018348623853, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=38.3838383838384, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=44.0860215053763, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=44.0860215053763, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=44.0860215053763, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082390, Length=200, Percent_Identity=41, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1789745, Length=213, Percent_Identity=39.906103286385, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17540882, Length=127, Percent_Identity=40.9448818897638, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=94, Percent_Identity=43.6170212765958, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=55.0561797752809, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=113, Percent_Identity=41.5929203539823, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323482, Length=120, Percent_Identity=35, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323566, Length=124, Percent_Identity=34.6774193548387, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24583150, Length=112, Percent_Identity=44.6428571428571, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=47.8260869565217, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356629, Length=104, Percent_Identity=47.1153846153846, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363946, Length=89, Percent_Identity=47.1910112359551, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17352457, Length=89, Percent_Identity=47.1910112359551, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24647110, Length=119, Percent_Identity=44.5378151260504, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26134; Mature: 26134

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGGCMRSMWTAALVFALGATGAQAQDSKSAKKPAAKAAPATPAAAPAAPAALSEEDQQT
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
LYTLGLSIGRDLSLFALSPEELKVLQQGLSDGLGGKTSDIDPKEQAQRIQAFAKSRQALA
HHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GKAALERAAKEPGAEVLPSGVIYKQVQAGTGRSPRAVDTVKVHYEGRLVDGTIFDTSARR
HHHHHHHHHHCCCHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEECCEEECCEEECCCCCC
GIPVEFPLNGVIPCWTQGVAKMKVGGKAKLTCPGNTAYGERPPSGSRIPPNAVLTFDVEL
CCCEEECCCCCCHHHHCCHHEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
IDIPGDTSRQP
EECCCCCCCCC
>Mature Secondary Structure
MKGGCMRSMWTAALVFALGATGAQAQDSKSAKKPAAKAAPATPAAAPAAPAALSEEDQQT
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
LYTLGLSIGRDLSLFALSPEELKVLQQGLSDGLGGKTSDIDPKEQAQRIQAFAKSRQALA
HHHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GKAALERAAKEPGAEVLPSGVIYKQVQAGTGRSPRAVDTVKVHYEGRLVDGTIFDTSARR
HHHHHHHHHHCCCHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEECCEEECCEEECCCCCC
GIPVEFPLNGVIPCWTQGVAKMKVGGKAKLTCPGNTAYGERPPSGSRIPPNAVLTFDVEL
CCCEEECCCCCCHHHHCCHHEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEE
IDIPGDTSRQP
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]