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The map label for this gene is dcm [C]

Identifier: 108763142

GI number: 108763142

Start: 4193685

End: 4195202

Strand: Reverse

Name: dcm [C]

Synonym: MXAN_3598

Alternate gene names: 108763142

Gene position: 4195202-4193685 (Counterclockwise)

Preceding gene: 108758434

Following gene: 108759587

Centisome position: 45.9

GC content: 62.91

Gene sequence:

>1518_bases
ATGGCTCCAGGCATCAGGGCGAAGCTGGATAGGATCGGGAGAGGAGAGCCGCTGCGGCTGCTGGACCTCTTTTCCGGGTG
TGGGGGCCTCACGCTCGGCTTCGTCAGCGCGGGCTGCGTCAGCGTTGGAGGAGTCGAGATCGACGCGCATGCCGCCGAGT
CACACGCGTTGAACTTCCACCCGCTGAAAGATCGATCAGCGGCTCCCTGGCACGCGATGTCCAAGGACATCCTGCAGCTC
AAGCCCAGCTCGCTGAACCATCTGCTGAAGCGTCCCCCAAATGAGGGGGTCGACGTGATCGTCGGCGGTCCGCCCTGCCC
TGCCTTCACACGCGTCGGCCGGGCGAAGCTCCGGGAAGTGTTCCAGCATCCCGAGGCCTTCAAGCAGGACCCCCGGGCAA
CGCTCTATGTGCAGTACCTGCAGTATGTCCAGGCGCTCAAGCCCCTGGCGCTCGTCATGGAAAATGTCCCCGACATCCTC
AACTGGGGTGGGCACAACCTCGGGGATGAAATCTGCGAGTCGCTCAAGGCCATGGACTACCGCTGCGCATATACACTCCT
GAATGCGGCGAGCTACGACGTTCCGCAAATGCGCGAACGGTTCTTTCTCGTCGCAGTCCACAAGGAGACCAGGAGCGACC
CCAGCTTTCCCGTGCCGACGCGGAAGGTGGATTTTCCACGGGGCTATTCCAGCAGCCGCAATGTAGCCCTCAAGAACGTC
CTGGCGCAGTCCTCGGACAAAGGGTCCTGGTATGTCGCACCGCCTGCCGCCCCAGCGAACGCACCTCCCGCGGTGACAGT
CGCCGAGGCCCTCGCGGATTTGCCCGAATTGACGGATCATCTCCACAACAGGGATCGTCGTGGCGCGCGTCACCTCAACG
GTCGTGTGCCCCATACCACGGCCCCGCACAGCGCCTTCGCACGACTGATGCGGGAGTGGCCAGGATTCGAGTCCGACGGT
TTTCTCAGGGATCACGTCACCCGCTGCCTGACCAAGCGCGACTACCGGCTCTTCGAAGCCATGGAGCCCGGGGAGGACTA
TCCGAAGGCACATGTGCGAGCCACGCAGTTCTTCGCACAGGAATTGGAGAAGCGACGGAGATCGGGTGCTCGCCTCACAG
AGGGCTCACTTGAGTACGAGGAGCTCAAAGCCGCATTCGTTCCGCCGTACAACCCCGGAAAGTTCCCCAACAAGTGGCGC
AAGATGGCCGCCGATGAGCCCGCCAGAACGCTGATGGCTCACCTGGGCAAGGATACCTACAGCCACATCCACTACGACTC
AGGTCAGCAGCGAGTGATTTCGGTGCGTGAGGCTGCGCGCCTCCAGTCCTTTCCCGATGGGTTCCGCTTCGCCGGAACCA
TGAACCCCGCTTTCCGACAGATCGGCAACAGCGTCCCACCACTCCTGGCCTGGCACATCGCGGACGAACTACTCCGTAGC
CTGGGCATCACCCCGAAAGCGCGGCCGAAGCTCTCGGAGGATCCCCGAAAGACACAGGCCAAAACCCGCGTGGCGTAA

Upstream 100 bases:

>100_bases
GACGGAGCACGAAGAAGTGGAAGAGGCCATGAACTCCGGGCCGAAGCAGCAGATCAAGAAGTGGGATGGCCGGAGACCCT
ACGGTATAAGTCCGGACGGC

Downstream 100 bases:

>100_bases
TGACGCCGTAAAGAACTGCAGGAGCGGCTCCAGCGCGCCCCTATGAACTGGCATCGACGGGAGCGCGGCCGTCGCTAGCG
TGCGCGGCGTTGCTGGGCAC

Product: DNA-cytosine methyltransferase

Products: NA

Alternate protein names: Cytosine-specific methyltransferase; M.OihORF3336P [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MAPGIRAKLDRIGRGEPLRLLDLFSGCGGLTLGFVSAGCVSVGGVEIDAHAAESHALNFHPLKDRSAAPWHAMSKDILQL
KPSSLNHLLKRPPNEGVDVIVGGPPCPAFTRVGRAKLREVFQHPEAFKQDPRATLYVQYLQYVQALKPLALVMENVPDIL
NWGGHNLGDEICESLKAMDYRCAYTLLNAASYDVPQMRERFFLVAVHKETRSDPSFPVPTRKVDFPRGYSSSRNVALKNV
LAQSSDKGSWYVAPPAAPANAPPAVTVAEALADLPELTDHLHNRDRRGARHLNGRVPHTTAPHSAFARLMREWPGFESDG
FLRDHVTRCLTKRDYRLFEAMEPGEDYPKAHVRATQFFAQELEKRRRSGARLTEGSLEYEELKAAFVPPYNPGKFPNKWR
KMAADEPARTLMAHLGKDTYSHIHYDSGQQRVISVREAARLQSFPDGFRFAGTMNPAFRQIGNSVPPLLAWHIADELLRS
LGITPKARPKLSEDPRKTQAKTRVA

Sequences:

>Translated_505_residues
MAPGIRAKLDRIGRGEPLRLLDLFSGCGGLTLGFVSAGCVSVGGVEIDAHAAESHALNFHPLKDRSAAPWHAMSKDILQL
KPSSLNHLLKRPPNEGVDVIVGGPPCPAFTRVGRAKLREVFQHPEAFKQDPRATLYVQYLQYVQALKPLALVMENVPDIL
NWGGHNLGDEICESLKAMDYRCAYTLLNAASYDVPQMRERFFLVAVHKETRSDPSFPVPTRKVDFPRGYSSSRNVALKNV
LAQSSDKGSWYVAPPAAPANAPPAVTVAEALADLPELTDHLHNRDRRGARHLNGRVPHTTAPHSAFARLMREWPGFESDG
FLRDHVTRCLTKRDYRLFEAMEPGEDYPKAHVRATQFFAQELEKRRRSGARLTEGSLEYEELKAAFVPPYNPGKFPNKWR
KMAADEPARTLMAHLGKDTYSHIHYDSGQQRVISVREAARLQSFPDGFRFAGTMNPAFRQIGNSVPPLLAWHIADELLRS
LGITPKARPKLSEDPRKTQAKTRVA
>Mature_504_residues
APGIRAKLDRIGRGEPLRLLDLFSGCGGLTLGFVSAGCVSVGGVEIDAHAAESHALNFHPLKDRSAAPWHAMSKDILQLK
PSSLNHLLKRPPNEGVDVIVGGPPCPAFTRVGRAKLREVFQHPEAFKQDPRATLYVQYLQYVQALKPLALVMENVPDILN
WGGHNLGDEICESLKAMDYRCAYTLLNAASYDVPQMRERFFLVAVHKETRSDPSFPVPTRKVDFPRGYSSSRNVALKNVL
AQSSDKGSWYVAPPAAPANAPPAVTVAEALADLPELTDHLHNRDRRGARHLNGRVPHTTAPHSAFARLMREWPGFESDGF
LRDHVTRCLTKRDYRLFEAMEPGEDYPKAHVRATQFFAQELEKRRRSGARLTEGSLEYEELKAAFVPPYNPGKFPNKWRK
MAADEPARTLMAHLGKDTYSHIHYDSGQQRVISVREAARLQSFPDGFRFAGTMNPAFRQIGNSVPPLLAWHIADELLRSL
GITPKARPKLSEDPRKTQAKTRVA

Specific function: This methylase recognizes the double-stranded sequence ACCGGT, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by a specific endonuclease (Potential) [H]

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI195927037, Length=520, Percent_Identity=28.4615384615385, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI4503351, Length=520, Percent_Identity=28.6538461538462, Blast_Score=121, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018117
- InterPro:   IPR001525 [H]

Pfam domain/function: PF00145 DNA_methylase [H]

EC number: =2.1.1.37 [H]

Molecular weight: Translated: 56320; Mature: 56189

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00095 C5_MTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPGIRAKLDRIGRGEPLRLLDLFSGCGGLTLGFVSAGCVSVGGVEIDAHAAESHALNFH
CCCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECHHHHCCCCCCC
PLKDRSAAPWHAMSKDILQLKPSSLNHLLKRPPNEGVDVIVGGPPCPAFTRVGRAKLREV
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
FQHPEAFKQDPRATLYVQYLQYVQALKPLALVMENVPDILNWGGHNLGDEICESLKAMDY
HHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCH
RCAYTLLNAASYDVPQMRERFFLVAVHKETRSDPSFPVPTRKVDFPRGYSSSRNVALKNV
HHHHHHHHHHCCCHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LAQSSDKGSWYVAPPAAPANAPPAVTVAEALADLPELTDHLHNRDRRGARHLNGRVPHTT
HHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
APHSAFARLMREWPGFESDGFLRDHVTRCLTKRDYRLFEAMEPGEDYPKAHVRATQFFAQ
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ELEKRRRSGARLTEGSLEYEELKAAFVPPYNPGKFPNKWRKMAADEPARTLMAHLGKDTY
HHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCHHH
SHIHYDSGQQRVISVREAARLQSFPDGFRFAGTMNPAFRQIGNSVPPLLAWHIADELLRS
HHCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
LGITPKARPKLSEDPRKTQAKTRVA
CCCCCCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
APGIRAKLDRIGRGEPLRLLDLFSGCGGLTLGFVSAGCVSVGGVEIDAHAAESHALNFH
CCCHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECHHHHCCCCCCC
PLKDRSAAPWHAMSKDILQLKPSSLNHLLKRPPNEGVDVIVGGPPCPAFTRVGRAKLREV
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
FQHPEAFKQDPRATLYVQYLQYVQALKPLALVMENVPDILNWGGHNLGDEICESLKAMDY
HHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHCCH
RCAYTLLNAASYDVPQMRERFFLVAVHKETRSDPSFPVPTRKVDFPRGYSSSRNVALKNV
HHHHHHHHHHCCCHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LAQSSDKGSWYVAPPAAPANAPPAVTVAEALADLPELTDHLHNRDRRGARHLNGRVPHTT
HHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
APHSAFARLMREWPGFESDGFLRDHVTRCLTKRDYRLFEAMEPGEDYPKAHVRATQFFAQ
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
ELEKRRRSGARLTEGSLEYEELKAAFVPPYNPGKFPNKWRKMAADEPARTLMAHLGKDTY
HHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCHHH
SHIHYDSGQQRVISVREAARLQSFPDGFRFAGTMNPAFRQIGNSVPPLLAWHIADELLRS
HHCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHH
LGITPKARPKLSEDPRKTQAKTRVA
CCCCCCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]