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The map label for this gene is nth [H]

Identifier: 108759427

GI number: 108759427

Start: 1688466

End: 1689182

Strand: Reverse

Name: nth [H]

Synonym: MXAN_1431

Alternate gene names: 108759427

Gene position: 1689182-1688466 (Counterclockwise)

Preceding gene: 108757022

Following gene: 108761038

Centisome position: 18.48

GC content: 69.74

Gene sequence:

>717_bases
GTGCCTGGACGTGAGACGGTCGCGGAGAAGCGAAAGCGCGCGTTGCTGGTGATGGACCGGCTGGCCGCGGACATGCCGGA
TGCCCGCATCGAGCTGGACTATCGGACGCCCCTGGAGCTGCTGGTGGCCGTCATCCTCTCCGCGCAGTGCACGGACAAGC
GCGTCAACATGGTGACGCCGGCCCTCTTCCAGCGCTTCTCCGACGCCCAGGCCTATGCGGAAGCAGAACCGTCGGACGTG
GAGCCCTTCATCCGCACCTGCGGCTTGTACCGCGCCAAGGCGAAGAACATCGTCGCGGCCGCCCGGTCGCTGGTGCAGGA
GCACGCCGGGCAGGTTCCCTTGAAGCGGGACGCGCTGGAGAAGCTGCCAGGCGTGGGCCGAAAGACGGCGGGCGTGGTGT
GCATCCACCTGGGAGGCGACGTGGCCTTCCCCGTGGACACGCACGTGAAGCGGCTCGCCTACCGGCTCGGGTTCACCACG
AAGGCGGACCCGGACAAGGTGGAAGCCGATATGCAGGCCGTGCTGCCGTCGGAGCGGTGGGCCCTGGGCCACCAGCTCCT
GGTGTGGCACGGGCGGCGGACCTGCTTTGCCCGCTCGCCCGCGTGTGAGCGCTGCGTCGTCGCGGACCTGTGCCCGAAGA
AGGGCGTGAAGGTCCAGAAGGACGCCGGCGCTACGGAGACGCCGGCGCGCTCGCCTCGCGCTCGCGCGAAGTCTTGA

Upstream 100 bases:

>100_bases
ACGGTGTCGGAACGGAAGTCGATGCGCTTCATGAATCTCCCCGAATGGGTGCGTCCAACCGGTGCTTGGGCTCGCAGCCG
GTGTGACATACAACGGCGCC

Downstream 100 bases:

>100_bases
GGCGCTTCATCCGCTTGCGGATGAACTCGCGCTTCAGGGACGAAATGTGGTCCACGAAGACGGTGCCGTTGAGGTGGTCC
GTCTCGTGCTGCACCGCGAT

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MPGRETVAEKRKRALLVMDRLAADMPDARIELDYRTPLELLVAVILSAQCTDKRVNMVTPALFQRFSDAQAYAEAEPSDV
EPFIRTCGLYRAKAKNIVAAARSLVQEHAGQVPLKRDALEKLPGVGRKTAGVVCIHLGGDVAFPVDTHVKRLAYRLGFTT
KADPDKVEADMQAVLPSERWALGHQLLVWHGRRTCFARSPACERCVVADLCPKKGVKVQKDAGATETPARSPRARAKS

Sequences:

>Translated_238_residues
MPGRETVAEKRKRALLVMDRLAADMPDARIELDYRTPLELLVAVILSAQCTDKRVNMVTPALFQRFSDAQAYAEAEPSDV
EPFIRTCGLYRAKAKNIVAAARSLVQEHAGQVPLKRDALEKLPGVGRKTAGVVCIHLGGDVAFPVDTHVKRLAYRLGFTT
KADPDKVEADMQAVLPSERWALGHQLLVWHGRRTCFARSPACERCVVADLCPKKGVKVQKDAGATETPARSPRARAKS
>Mature_237_residues
PGRETVAEKRKRALLVMDRLAADMPDARIELDYRTPLELLVAVILSAQCTDKRVNMVTPALFQRFSDAQAYAEAEPSDVE
PFIRTCGLYRAKAKNIVAAARSLVQEHAGQVPLKRDALEKLPGVGRKTAGVVCIHLGGDVAFPVDTHVKRLAYRLGFTTK
ADPDKVEADMQAVLPSERWALGHQLLVWHGRRTCFARSPACERCVVADLCPKKGVKVQKDAGATETPARSPRARAKS

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=177, Percent_Identity=31.638418079096, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787920, Length=205, Percent_Identity=40.9756097560976, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17554540, Length=196, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550361, Length=179, Percent_Identity=27.9329608938547, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 26152; Mature: 26020

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRETVAEKRKRALLVMDRLAADMPDARIELDYRTPLELLVAVILSAQCTDKRVNMVTP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCH
ALFQRFSDAQAYAEAEPSDVEPFIRTCGLYRAKAKNIVAAARSLVQEHAGQVPLKRDALE
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KLPGVGRKTAGVVCIHLGGDVAFPVDTHVKRLAYRLGFTTKADPDKVEADMQAVLPSERW
HCCCCCCCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHH
ALGHQLLVWHGRRTCFARSPACERCVVADLCPKKGVKVQKDAGATETPARSPRARAKS
HHCCEEEEEECCCCEEECCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PGRETVAEKRKRALLVMDRLAADMPDARIELDYRTPLELLVAVILSAQCTDKRVNMVTP
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCH
ALFQRFSDAQAYAEAEPSDVEPFIRTCGLYRAKAKNIVAAARSLVQEHAGQVPLKRDALE
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KLPGVGRKTAGVVCIHLGGDVAFPVDTHVKRLAYRLGFTTKADPDKVEADMQAVLPSERW
HCCCCCCCCCCEEEEEECCCEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHH
ALGHQLLVWHGRRTCFARSPACERCVVADLCPKKGVKVQKDAGATETPARSPRARAKS
HHCCEEEEEECCCCEEECCCCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]