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The map label for this gene is 108759420

Identifier: 108759420

GI number: 108759420

Start: 4590230

End: 4591801

Strand: Reverse

Name: 108759420

Synonym: MXAN_3821

Alternate gene names: NA

Gene position: 4591801-4590230 (Counterclockwise)

Preceding gene: 108760749

Following gene: 108763975

Centisome position: 50.24

GC content: 71.06

Gene sequence:

>1572_bases
GTGGCGAAGGCATCGCGGTACGACGTGGTCGTCGTGGGCTCCGGCTTTGGGGGCTCCATCAGCGCGCTGCGCCTGGCCCA
GGCAGGCAAGTCCGTGCTGGTCCTGGAGCGCGGCAAACGTTACCGGCCCGGTGACTTTCCCCGGGACGTGACGCGAACGG
ACGAGGTGCTCTGGCGCCATGCCACGCGGCGCAAGGCGCAGGGCCTCTATGACGTGCGCTTCCTGTCCGGCATCGGCACG
GTGACGGCCAGCGGCGTCGGCGGCGGCTCGCTCATCTACGCCAACGTCCACGTGCGGCCGGACGCCGAGGTGTTCGAGGA
CCCGCGCTGGCCCCGGACGTACCGCCGGGACTCGCTGGAGCCTTACTTCGACAAGGTGGCGCGGGAGCTGCGGTTGAATC
CGGTGCCGCCCTCGATTCCGCTGCGCAAGCGTGACCTCTTCCAGCGCGCGGCCCGGGGCATGGGGCGCGAGACATTCGAC
CCGCCCGTGGCCGTGGCCTTCTCGGAGCCGCCGGGACCGGGCCGGCGCGTGTGCCAGCTCTGCGCCGAGTGCGAGTTCGG
CTGCCAGCACGGCGCGAAGAACACCATGGACCTGACGTACCTGGCGCGGGCGGAGGCGCTGGGGGCGCTGGTCCTGGCCC
GCACGCTCGTCTCCCACGTGGAGCCGGTGCGGGATGGGTACCGCGTGCACTGCCAGGACCTGGTGTCGGGGGCGCGGCAC
ACCGTGGAGAGCTCGCGGGTGGTGTTGGCCGCGGGGACGCTGGGCACGGTGGAGATATTGCTGCGCAGCCGGGACGTCGC
GCGGACGCTGCCTCGGGTGAGCCGGCGGCTGGGCCATGGCTATTCGGGCAACGGGGACTTCCTGGCGTCGATGCAGGGCG
CGCGCGAGGACATCCAGCCCTGGGTGGGCCCCGACGTGTCCACCGTGATGCGCTTCACCGACCGGCAGCCGCGCTTCACG
CTGGTGACGGCCACGTTCAACCAGCCCGCCACGGAGGTCCTCGCGGGCCTGGGGCAGCCGAACCTCGGACGGCTCCAGGG
CCTGGGGGCGCCGCTGTGGACCTGCCTGGGCCCAGCCGTTCACGCGGCGCTCAAGAAGGGGCTGATGAGCCGGCCCCTGC
GTGCCGACGTGGATGCGGCCCGCACGTCCAACCTGTTTGGCATCGGCCAGGACAACGCCAACGGCCGGATGCACCTCGAT
GACGGGCAGCTCGACGTGTCGTGGGACTTCGCCGGGGAGAACGCGGAGTTGGTGCGGCGGATGACGGACGCGATGCGGGA
CCTGGCGGCCCAGTACGGTGCCAGCTTCGCGCCGCTGATCACCTGGCAGCTCTTCAAGCGGCCTTTCACGGTGCATTCGC
TTGGCGGTGCCCATCTGGCGGAAGCTCCCGAGCGCGGCGTGGTGTCCACCGAGGGAGAGGTCTTCCACTATCCCGGGCTG
CACGTGGCGGACGGCTCCGTCATCCCGACAGCCATCGGCTTCCACCCCGTGATGACCATCAGCGCGGTGGCCGAGCGCAT
CGCCGAGGCCGTGGTGCACGGATTCTCATCCCATTCGAGGAGCGCTTCATGA

Upstream 100 bases:

>100_bases
GCTGGCGAAGGCCCAGGCCCTGAAGCGTTTTGGCAGCATGTTCATGGGCAACCTCTGGGACGTCTTCGCGCGAACCAAGC
TGGAATAAGAGAGGCGCATC

Downstream 100 bases:

>100_bases
ACACGCTTCCCTCCGCCGAAAGGCACGACTTTCCCGCGGGCGACGGCGTGCCGTTGCAGCTCACGCGTTACCAGGGCGGC
GCGAAGGGGCCTGTCCTCCT

Product: hypothetical protein

Products: cholest-4-en-3-one; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MAKASRYDVVVVGSGFGGSISALRLAQAGKSVLVLERGKRYRPGDFPRDVTRTDEVLWRHATRRKAQGLYDVRFLSGIGT
VTASGVGGGSLIYANVHVRPDAEVFEDPRWPRTYRRDSLEPYFDKVARELRLNPVPPSIPLRKRDLFQRAARGMGRETFD
PPVAVAFSEPPGPGRRVCQLCAECEFGCQHGAKNTMDLTYLARAEALGALVLARTLVSHVEPVRDGYRVHCQDLVSGARH
TVESSRVVLAAGTLGTVEILLRSRDVARTLPRVSRRLGHGYSGNGDFLASMQGAREDIQPWVGPDVSTVMRFTDRQPRFT
LVTATFNQPATEVLAGLGQPNLGRLQGLGAPLWTCLGPAVHAALKKGLMSRPLRADVDAARTSNLFGIGQDNANGRMHLD
DGQLDVSWDFAGENAELVRRMTDAMRDLAAQYGASFAPLITWQLFKRPFTVHSLGGAHLAEAPERGVVSTEGEVFHYPGL
HVADGSVIPTAIGFHPVMTISAVAERIAEAVVHGFSSHSRSAS

Sequences:

>Translated_523_residues
MAKASRYDVVVVGSGFGGSISALRLAQAGKSVLVLERGKRYRPGDFPRDVTRTDEVLWRHATRRKAQGLYDVRFLSGIGT
VTASGVGGGSLIYANVHVRPDAEVFEDPRWPRTYRRDSLEPYFDKVARELRLNPVPPSIPLRKRDLFQRAARGMGRETFD
PPVAVAFSEPPGPGRRVCQLCAECEFGCQHGAKNTMDLTYLARAEALGALVLARTLVSHVEPVRDGYRVHCQDLVSGARH
TVESSRVVLAAGTLGTVEILLRSRDVARTLPRVSRRLGHGYSGNGDFLASMQGAREDIQPWVGPDVSTVMRFTDRQPRFT
LVTATFNQPATEVLAGLGQPNLGRLQGLGAPLWTCLGPAVHAALKKGLMSRPLRADVDAARTSNLFGIGQDNANGRMHLD
DGQLDVSWDFAGENAELVRRMTDAMRDLAAQYGASFAPLITWQLFKRPFTVHSLGGAHLAEAPERGVVSTEGEVFHYPGL
HVADGSVIPTAIGFHPVMTISAVAERIAEAVVHGFSSHSRSAS
>Mature_522_residues
AKASRYDVVVVGSGFGGSISALRLAQAGKSVLVLERGKRYRPGDFPRDVTRTDEVLWRHATRRKAQGLYDVRFLSGIGTV
TASGVGGGSLIYANVHVRPDAEVFEDPRWPRTYRRDSLEPYFDKVARELRLNPVPPSIPLRKRDLFQRAARGMGRETFDP
PVAVAFSEPPGPGRRVCQLCAECEFGCQHGAKNTMDLTYLARAEALGALVLARTLVSHVEPVRDGYRVHCQDLVSGARHT
VESSRVVLAAGTLGTVEILLRSRDVARTLPRVSRRLGHGYSGNGDFLASMQGAREDIQPWVGPDVSTVMRFTDRQPRFTL
VTATFNQPATEVLAGLGQPNLGRLQGLGAPLWTCLGPAVHAALKKGLMSRPLRADVDAARTSNLFGIGQDNANGRMHLDD
GQLDVSWDFAGENAELVRRMTDAMRDLAAQYGASFAPLITWQLFKRPFTVHSLGGAHLAEAPERGVVSTEGEVFHYPGLH
VADGSVIPTAIGFHPVMTISAVAERIAEAVVHGFSSHSRSAS

Specific function: Unknown

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: 1.1.3.6

Molecular weight: Translated: 56855; Mature: 56724

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKASRYDVVVVGSGFGGSISALRLAQAGKSVLVLERGKRYRPGDFPRDVTRTDEVLWRH
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ATRRKAQGLYDVRFLSGIGTVTASGVGGGSLIYANVHVRPDAEVFEDPRWPRTYRRDSLE
HHHHHHCCCHHHHHHHHCCCEEECCCCCCEEEEEEEEECCCHHHHCCCCCCHHHHHCCCC
PYFDKVARELRLNPVPPSIPLRKRDLFQRAARGMGRETFDPPVAVAFSEPPGPGRRVCQL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHH
CAECEFGCQHGAKNTMDLTYLARAEALGALVLARTLVSHVEPVRDGYRVHCQDLVSGARH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
TVESSRVVLAAGTLGTVEILLRSRDVARTLPRVSRRLGHGYSGNGDFLASMQGAREDIQP
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCHHHCCC
WVGPDVSTVMRFTDRQPRFTLVTATFNQPATEVLAGLGQPNLGRLQGLGAPLWTCLGPAV
CCCCCHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHH
HAALKKGLMSRPLRADVDAARTSNLFGIGQDNANGRMHLDDGQLDVSWDFAGENAELVRR
HHHHHHHHHCCCCCCCCHHHHCCCEEEECCCCCCCCEEECCCCEEEEEECCCCCHHHHHH
MTDAMRDLAAQYGASFAPLITWQLFKRPFTVHSLGGAHLAEAPERGVVSTEGEVFHYPGL
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCHHHCCCCCCCCCCCCCEEECCCE
HVADGSVIPTAIGFHPVMTISAVAERIAEAVVHGFSSHSRSAS
EEECCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AKASRYDVVVVGSGFGGSISALRLAQAGKSVLVLERGKRYRPGDFPRDVTRTDEVLWRH
CCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
ATRRKAQGLYDVRFLSGIGTVTASGVGGGSLIYANVHVRPDAEVFEDPRWPRTYRRDSLE
HHHHHHCCCHHHHHHHHCCCEEECCCCCCEEEEEEEEECCCHHHHCCCCCCHHHHHCCCC
PYFDKVARELRLNPVPPSIPLRKRDLFQRAARGMGRETFDPPVAVAFSEPPGPGRRVCQL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHH
CAECEFGCQHGAKNTMDLTYLARAEALGALVLARTLVSHVEPVRDGYRVHCQDLVSGARH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHH
TVESSRVVLAAGTLGTVEILLRSRDVARTLPRVSRRLGHGYSGNGDFLASMQGAREDIQP
HHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHCCHHHCCC
WVGPDVSTVMRFTDRQPRFTLVTATFNQPATEVLAGLGQPNLGRLQGLGAPLWTCLGPAV
CCCCCHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHH
HAALKKGLMSRPLRADVDAARTSNLFGIGQDNANGRMHLDDGQLDVSWDFAGENAELVRR
HHHHHHHHHCCCCCCCCHHHHCCCEEEECCCCCCCCEEECCCCEEEEEECCCCCHHHHHH
MTDAMRDLAAQYGASFAPLITWQLFKRPFTVHSLGGAHLAEAPERGVVSTEGEVFHYPGL
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCHHHCCCCCCCCCCCCCEEECCCE
HVADGSVIPTAIGFHPVMTISAVAERIAEAVVHGFSSHSRSAS
EEECCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cholesterol; O2

Specific reaction: cholesterol + O2 = cholest-4-en-3-one + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]