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The map label for this gene is murC

Identifier: 108759161

GI number: 108759161

Start: 6965059

End: 6966477

Strand: Reverse

Name: murC

Synonym: MXAN_5603

Alternate gene names: 108759161

Gene position: 6966477-6965059 (Counterclockwise)

Preceding gene: 108761678

Following gene: 108762211

Centisome position: 76.22

GC content: 68.08

Gene sequence:

>1419_bases
GTGACACGTAACAAGCCCCCCAGCCTCTTCAAGACGCGCCATGCGGCGCAGGTCCACTTCGTGGGGCTCGGTGGTATCGG
CATGAGCGGCATCGCCGAGGTGCTGCTGAACCTGGGCTACCGGGTGTCCGGCTCAGACTTGCGCGAGAGCGACATCACCC
GGCGCCTGGTGCGCATGGGCGCGACCTTCTTCGAAGGCCACCGCGCGCAGAACCTGATTCAGGCGGACGTGGTGGTGATT
TCCTCCGCGGTGCGCAAGGACAACCCGGAGGTGGTCGCCGCCCGGCAGCGGAAGATTCCCGTCATCCCCCGCGCGGAGAT
GCTCGCGGAGTTGATGCGCCTGAAGTACGCGGTCGCCGTGGCCGGCAGTCACGGGAAGACGACGACGACGTCCATGGTGG
CCACCGTGCTGAGCGCGGCGGGGCTGGACCCGACGGCGGTGGTGGGCGGCAAGGTGAACGTGCTCGACTCCAACGCCAAG
CTGGGCAAGAGCGAGCTGATGGTGGTGGAGGCCGACGAGAGCGACGGCAGCTTCCTCCACCTGCATCCGTCCATTGCCAT
CGTCACCAACATCGACCCGGAGCACATGGACCACTACGGCGACCTGGACACGCTCCAGTCCGCCTTCGTGGAGTTCTGCA
ACCGGGTGCCGTTCTACGGCCTCAACGTGCTGTGCCTGGACAACCCCAACGTCCAGGCGCTGCTGCCGCGCATCGAGAAG
CGCTTCGTCACCTACGGCAGCTCGCACATGGCGGACTACCGGCTGGAGAACATCCAACTGGACGGCTTCACCACGCGCTT
CAACGCCTATCGCCGGGAGGAGTCGCTGGGCGAGTTCCGCGTGCGGATGGTGGGCGCGCACAACGCCTTCAACGCGCTGG
CCGTCATCGCCGTGGCGGAGGAGATGGACATCCCGCTGGAGACGGTCCGCGAGTCGCTGGCCGAGTTCGGCGGCGTGCAG
CGGCGCTTCACCGTGCGCGGCGAAGCCCAGGGCATCACCGTGGTGGACGACTACGGGCACCACCCCACGGAAGTGCTGGC
CACGCTGGCCGGCGCGCGGCGGGCCTTCGGACGCCGGGTGGTGGTGGCCTTCCAGCCGCACCGCTACACGCGCACGCATG
ACCTGATGAAGGAGTTCACCACCTCCTTCAATGATTCGGACGTGCTCTTCGTCACCAGCGTCTACGCGGCGGGTGAGGAG
CGCATCCATGGCGCCACGGGAGACGCACTGGCGGACGCCGTCCGCGCCCACGGCCACCGCGACGTCACGTTCGTGGAGAA
GCGCACCGACCTACCGGCGGCGCTGCTGCCGCGTCTGCGCGAGGGTGACCTGGTGCTGACGCTGGGAGCGGGTGACATCA
CCCACGTGGGGCCGGAGTTGCTCGAGCTGCTTCGCACCACCCCCCTGGCGAAGGACTAG

Upstream 100 bases:

>100_bases
TGGCGGACGTGTGCGTGGACCTGATGGTCCAGACGTGGGGCCCCAACGGCCGCGAGCGTACCCCCATCGAAGCCGAGAAG
AAGGCCCCCAGGAGCAATTC

Downstream 100 bases:

>100_bases
CGCCATGGTGGAAGCAGGCGTGAAGACGGCGCTGGCGGCTCGCGTGGAGTCGCTGGGCGGCTGCGAGGTGAAGGCGGGCG
AACCGCTGGCGCCTCTCACC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MTRNKPPSLFKTRHAAQVHFVGLGGIGMSGIAEVLLNLGYRVSGSDLRESDITRRLVRMGATFFEGHRAQNLIQADVVVI
SSAVRKDNPEVVAARQRKIPVIPRAEMLAELMRLKYAVAVAGSHGKTTTTSMVATVLSAAGLDPTAVVGGKVNVLDSNAK
LGKSELMVVEADESDGSFLHLHPSIAIVTNIDPEHMDHYGDLDTLQSAFVEFCNRVPFYGLNVLCLDNPNVQALLPRIEK
RFVTYGSSHMADYRLENIQLDGFTTRFNAYRREESLGEFRVRMVGAHNAFNALAVIAVAEEMDIPLETVRESLAEFGGVQ
RRFTVRGEAQGITVVDDYGHHPTEVLATLAGARRAFGRRVVVAFQPHRYTRTHDLMKEFTTSFNDSDVLFVTSVYAAGEE
RIHGATGDALADAVRAHGHRDVTFVEKRTDLPAALLPRLREGDLVLTLGAGDITHVGPELLELLRTTPLAKD

Sequences:

>Translated_472_residues
MTRNKPPSLFKTRHAAQVHFVGLGGIGMSGIAEVLLNLGYRVSGSDLRESDITRRLVRMGATFFEGHRAQNLIQADVVVI
SSAVRKDNPEVVAARQRKIPVIPRAEMLAELMRLKYAVAVAGSHGKTTTTSMVATVLSAAGLDPTAVVGGKVNVLDSNAK
LGKSELMVVEADESDGSFLHLHPSIAIVTNIDPEHMDHYGDLDTLQSAFVEFCNRVPFYGLNVLCLDNPNVQALLPRIEK
RFVTYGSSHMADYRLENIQLDGFTTRFNAYRREESLGEFRVRMVGAHNAFNALAVIAVAEEMDIPLETVRESLAEFGGVQ
RRFTVRGEAQGITVVDDYGHHPTEVLATLAGARRAFGRRVVVAFQPHRYTRTHDLMKEFTTSFNDSDVLFVTSVYAAGEE
RIHGATGDALADAVRAHGHRDVTFVEKRTDLPAALLPRLREGDLVLTLGAGDITHVGPELLELLRTTPLAKD
>Mature_471_residues
TRNKPPSLFKTRHAAQVHFVGLGGIGMSGIAEVLLNLGYRVSGSDLRESDITRRLVRMGATFFEGHRAQNLIQADVVVIS
SAVRKDNPEVVAARQRKIPVIPRAEMLAELMRLKYAVAVAGSHGKTTTTSMVATVLSAAGLDPTAVVGGKVNVLDSNAKL
GKSELMVVEADESDGSFLHLHPSIAIVTNIDPEHMDHYGDLDTLQSAFVEFCNRVPFYGLNVLCLDNPNVQALLPRIEKR
FVTYGSSHMADYRLENIQLDGFTTRFNAYRREESLGEFRVRMVGAHNAFNALAVIAVAEEMDIPLETVRESLAEFGGVQR
RFTVRGEAQGITVVDDYGHHPTEVLATLAGARRAFGRRVVVAFQPHRYTRTHDLMKEFTTSFNDSDVLFVTSVYAAGEER
IHGATGDALADAVRAHGHRDVTFVEKRTDLPAALLPRLREGDLVLTLGAGDITHVGPELLELLRTTPLAKD

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=468, Percent_Identity=45.2991452991453, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1790680, Length=391, Percent_Identity=30.4347826086957, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786276, Length=274, Percent_Identity=26.2773722627737, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_MYXXD (Q1D0T1)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633742.1
- ProteinModelPortal:   Q1D0T1
- SMR:   Q1D0T1
- STRING:   Q1D0T1
- GeneID:   4102773
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_5603
- TIGR:   MXAN_5603
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q1D0T1
- ProtClustDB:   PRK00421
- BioCyc:   MXAN246197:MXAN_5603-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51744; Mature: 51613

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRNKPPSLFKTRHAAQVHFVGLGGIGMSGIAEVLLNLGYRVSGSDLRESDITRRLVRMG
CCCCCCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHC
ATFFEGHRAQNLIQADVVVISSAVRKDNPEVVAARQRKIPVIPRAEMLAELMRLKYAVAV
CHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHEEE
AGSHGKTTTTSMVATVLSAAGLDPTAVVGGKVNVLDSNAKLGKSELMVVEADESDGSFLH
ECCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEEECCCCCCCCCEEEEEEECCCCCCEEE
LHPSIAIVTNIDPEHMDHYGDLDTLQSAFVEFCNRVPFYGLNVLCLDNPNVQALLPRIEK
ECCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
RFVTYGSSHMADYRLENIQLDGFTTRFNAYRREESLGEFRVRMVGAHNAFNALAVIAVAE
HHHHCCCCCCCCEEECEEEECCEEHHHHHHHHHHHHHHEEEEEEECCCHHHHHEEEEEHH
EMDIPLETVRESLAEFGGVQRRFTVRGEAQGITVVDDYGHHPTEVLATLAGARRAFGRRV
HCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEE
VVAFQPHRYTRTHDLMKEFTTSFNDSDVLFVTSVYAAGEERIHGATGDALADAVRAHGHR
EEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHCCCCCCHHHHHHHHHCCCC
DVTFVEKRTDLPAALLPRLREGDLVLTLGAGDITHVGPELLELLRTTPLAKD
CEEEEECCCCCCHHHHCCCCCCCEEEEECCCCHHHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRNKPPSLFKTRHAAQVHFVGLGGIGMSGIAEVLLNLGYRVSGSDLRESDITRRLVRMG
CCCCCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHC
ATFFEGHRAQNLIQADVVVISSAVRKDNPEVVAARQRKIPVIPRAEMLAELMRLKYAVAV
CHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHEEE
AGSHGKTTTTSMVATVLSAAGLDPTAVVGGKVNVLDSNAKLGKSELMVVEADESDGSFLH
ECCCCCCHHHHHHHHHHHHCCCCCCEEECCEEEEECCCCCCCCCEEEEEEECCCCCCEEE
LHPSIAIVTNIDPEHMDHYGDLDTLQSAFVEFCNRVPFYGLNVLCLDNPNVQALLPRIEK
ECCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
RFVTYGSSHMADYRLENIQLDGFTTRFNAYRREESLGEFRVRMVGAHNAFNALAVIAVAE
HHHHCCCCCCCCEEECEEEECCEEHHHHHHHHHHHHHHEEEEEEECCCHHHHHEEEEEHH
EMDIPLETVRESLAEFGGVQRRFTVRGEAQGITVVDDYGHHPTEVLATLAGARRAFGRRV
HCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEE
VVAFQPHRYTRTHDLMKEFTTSFNDSDVLFVTSVYAAGEERIHGATGDALADAVRAHGHR
EEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHCCCCCCHHHHHHHHHCCCC
DVTFVEKRTDLPAALLPRLREGDLVLTLGAGDITHVGPELLELLRTTPLAKD
CEEEEECCCCCCHHHHCCCCCCCEEEEECCCCHHHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA