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The map label for this gene is recQ [H]

Identifier: 108759046

GI number: 108759046

Start: 6055602

End: 6057587

Strand: Direct

Name: recQ [H]

Synonym: MXAN_4839

Alternate gene names: 108759046

Gene position: 6055602-6057587 (Clockwise)

Preceding gene: 108759194

Following gene: 108760058

Centisome position: 66.26

GC content: 67.42

Gene sequence:

>1986_bases
TTGCCGGAGTTCGCGAGTTGGAGGAGCTTCATGGATAGGGCAGATGGCGCACGACACAGCTCACTCGATACCGTTCTGCG
CGAGCGGTTCGGACTGACGGACTTCCGCCCTGGCCAGCGTGAGGTCCTCGATGCGCTGCTCGGTCCGAACGCCGCGGCGC
TCGCGGTGTTCCCCACAGGTGGCGGAAAGTCGCTCTGCTATCAGCTTCCGGCGCTGCTGCTGGAGGGCATCACGGTAGTG
GTCTCCCCGCTGATCGCGCTGATGAAGGACCAGATTGACGCCCTGGCCCGACAGGGCATTCGTGCCGCGCGGCTGGACGC
CTCGCTGTCGGTGGACGACTCACGCGAAGTCACGCAGGCGCTGCGCGATGGTTCGCTCAAGCTCTTGTACGTGGCGCCCG
AGCGCTTCAACAACGAGCGCTTCACCGCCCTGCTCCGCGAGCTGCGCATTTCCTTGTTCGCGGTGGATGAGGCGCACTGT
GTCTCGGAATGGGGCCACAACTTCCGACCGGACTATCTGAAGCTGGCGAAGGCCGCGCGGGATCTGTCGGCAGAGCGAAT
CCTCGCACTCACCGCCACGGCGACACCCTCCGTCGTGCGAGACATCTGCCAGGGCTTCGGCATCCCCGAGGAGAACGCGG
TCGTCACGGGTTTCTACCGGCAGAACCTCACGCTGGAGACGACCCCGGTTCACGCCGAGGCCCGCGACGCCTTCCTCCTG
GGGCGGCTCGGTTCCCGAGCGCCTGGCCCCACCATCGTCTACGTCACGCAGCAGAAGACCGCCGAGCGAGTGGCCGCGTT
CCTCGCCACGGAAGGTCTCCCCGCCAGCGCCTACCACGCGGGCCTGGAGCCCGAGGTCCGTGAGCGGGTGCAGGAATCCT
GGATGGCCTCCGCGAATGGCATCGTCGTGGCGACCATCGCGTTCGGGATGGGCATCGACAAGGCGGATGTACGGGCCGTG
TATCACTACAACCTGCCCAAGGGACTGGAGAGCTACAGCCAGGAAATCGGCCGAGCCGGGCGCGATGGAGCGCCATCGGT
GGTGGAGCTCTTCGCGTGTCCGGACGACGTCCCCAGCCTGGAGAACTTCGCGCTCGGGGACACACCCACGCGGGAAGCAA
TTCAAAGTCTGGTGACCGAGTTGCTCGGCCTGGGTCCCGAACTGAGCGTCGACATGTTCGCTCTGTCCACCCGGCATGAT
GTGCGGCCGCTCGTGCTGCGCACGGCGCTGACGTACCTGGAGCTCGAAGGCGTGTTGAGGCAAGGCACGCCGTACTACGC
GGGCTACAAGGTGCAGCCGCTCATGCCCATTGACGCGCTCGTGGGGCGCTTCCAAGGAGAACGGGTGCAGTTCCTGCGCG
ACGTGTTTTCCCAGGCGAAGAAGGGACGCACCTGGTACTCGCTCGACCCGGCCGAGGTGGCGAGTTCGCTTCGGCAGCCC
CGCGAGCGCGTGGTCCGGGCCATCGAATATCTCGAGGAGCAAGGGCTCGTGTTGCTCCAGGTCTCCGAGCCGCGTCAGCG
CTTCACACGGCTGCGCCCCCAGGAGGACGCAGCAGCGCTCACCGCACTCCTCCATCAGCGGTTTCAGCAGCGCGAGGCCC
AGGAGGTCACGCGTGTCCGGGACGTACTGAAGCTCGTCACCCATGCGGGGTGCCAGAGCAATGCGCTGGTCGCCCACTTC
GGTCAGCGGCGGGAGCAGCCGTGTGGGCACTGCACCTTCTGCCGGACCGGGGCGGCCCAGGTGCTTCCCGCGGTGCGCCA
GAGGCCGGCACTGCCCGCGGGCCTCGACGCGGCGGGCTTCCGAGCCCTGGCCGCGAAACATCCCGAGTCGCTCGGGCACC
CGAGGCAGGCCGCGAGGTTCCTCTGCGGATTGAGCAGCCCCGCCCTCACGCGGGCGAAGCTCGGCGGCCACAAGTTGTTT
GGCGCACTGGAGGGCTGGCCCTTCGAGGAGGTGCTGGACTTCTGTGGCCGGTCGGCCGTGGATTGA

Upstream 100 bases:

>100_bases
AGCAGCACGCATCGTTCGCGTCTTCGTGGACTTCGTGGCTACGCTCTTCCCTCGGTGAGCAGGGACGGAGTCGCTGGTCA
GGGCCCATGGAGGGCGTGGG

Downstream 100 bases:

>100_bases
CGACCATCACCCCTGGTCGAGCACGCCCGCGCGATAGTCGTCAAAGGCCTGCTGGATCTCCTCGCGGGTGTTCATGACGA
ACGGGCCGTACTGGACGATG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MPEFASWRSFMDRADGARHSSLDTVLRERFGLTDFRPGQREVLDALLGPNAAALAVFPTGGGKSLCYQLPALLLEGITVV
VSPLIALMKDQIDALARQGIRAARLDASLSVDDSREVTQALRDGSLKLLYVAPERFNNERFTALLRELRISLFAVDEAHC
VSEWGHNFRPDYLKLAKAARDLSAERILALTATATPSVVRDICQGFGIPEENAVVTGFYRQNLTLETTPVHAEARDAFLL
GRLGSRAPGPTIVYVTQQKTAERVAAFLATEGLPASAYHAGLEPEVRERVQESWMASANGIVVATIAFGMGIDKADVRAV
YHYNLPKGLESYSQEIGRAGRDGAPSVVELFACPDDVPSLENFALGDTPTREAIQSLVTELLGLGPELSVDMFALSTRHD
VRPLVLRTALTYLELEGVLRQGTPYYAGYKVQPLMPIDALVGRFQGERVQFLRDVFSQAKKGRTWYSLDPAEVASSLRQP
RERVVRAIEYLEEQGLVLLQVSEPRQRFTRLRPQEDAAALTALLHQRFQQREAQEVTRVRDVLKLVTHAGCQSNALVAHF
GQRREQPCGHCTFCRTGAAQVLPAVRQRPALPAGLDAAGFRALAAKHPESLGHPRQAARFLCGLSSPALTRAKLGGHKLF
GALEGWPFEEVLDFCGRSAVD

Sequences:

>Translated_661_residues
MPEFASWRSFMDRADGARHSSLDTVLRERFGLTDFRPGQREVLDALLGPNAAALAVFPTGGGKSLCYQLPALLLEGITVV
VSPLIALMKDQIDALARQGIRAARLDASLSVDDSREVTQALRDGSLKLLYVAPERFNNERFTALLRELRISLFAVDEAHC
VSEWGHNFRPDYLKLAKAARDLSAERILALTATATPSVVRDICQGFGIPEENAVVTGFYRQNLTLETTPVHAEARDAFLL
GRLGSRAPGPTIVYVTQQKTAERVAAFLATEGLPASAYHAGLEPEVRERVQESWMASANGIVVATIAFGMGIDKADVRAV
YHYNLPKGLESYSQEIGRAGRDGAPSVVELFACPDDVPSLENFALGDTPTREAIQSLVTELLGLGPELSVDMFALSTRHD
VRPLVLRTALTYLELEGVLRQGTPYYAGYKVQPLMPIDALVGRFQGERVQFLRDVFSQAKKGRTWYSLDPAEVASSLRQP
RERVVRAIEYLEEQGLVLLQVSEPRQRFTRLRPQEDAAALTALLHQRFQQREAQEVTRVRDVLKLVTHAGCQSNALVAHF
GQRREQPCGHCTFCRTGAAQVLPAVRQRPALPAGLDAAGFRALAAKHPESLGHPRQAARFLCGLSSPALTRAKLGGHKLF
GALEGWPFEEVLDFCGRSAVD
>Mature_660_residues
PEFASWRSFMDRADGARHSSLDTVLRERFGLTDFRPGQREVLDALLGPNAAALAVFPTGGGKSLCYQLPALLLEGITVVV
SPLIALMKDQIDALARQGIRAARLDASLSVDDSREVTQALRDGSLKLLYVAPERFNNERFTALLRELRISLFAVDEAHCV
SEWGHNFRPDYLKLAKAARDLSAERILALTATATPSVVRDICQGFGIPEENAVVTGFYRQNLTLETTPVHAEARDAFLLG
RLGSRAPGPTIVYVTQQKTAERVAAFLATEGLPASAYHAGLEPEVRERVQESWMASANGIVVATIAFGMGIDKADVRAVY
HYNLPKGLESYSQEIGRAGRDGAPSVVELFACPDDVPSLENFALGDTPTREAIQSLVTELLGLGPELSVDMFALSTRHDV
RPLVLRTALTYLELEGVLRQGTPYYAGYKVQPLMPIDALVGRFQGERVQFLRDVFSQAKKGRTWYSLDPAEVASSLRQPR
ERVVRAIEYLEEQGLVLLQVSEPRQRFTRLRPQEDAAALTALLHQRFQQREAQEVTRVRDVLKLVTHAGCQSNALVAHFG
QRREQPCGHCTFCRTGAAQVLPAVRQRPALPAGLDAAGFRALAAKHPESLGHPRQAARFLCGLSSPALTRAKLGGHKLFG
ALEGWPFEEVLDFCGRSAVD

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=351, Percent_Identity=41.025641025641, Blast_Score=247, Evalue=3e-65,
Organism=Homo sapiens, GI51242943, Length=351, Percent_Identity=41.025641025641, Blast_Score=247, Evalue=3e-65,
Organism=Homo sapiens, GI148612816, Length=351, Percent_Identity=41.025641025641, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI14591902, Length=385, Percent_Identity=37.1428571428571, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI14591904, Length=385, Percent_Identity=37.1428571428571, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI4557365, Length=364, Percent_Identity=39.2857142857143, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI110735439, Length=342, Percent_Identity=38.3040935672515, Blast_Score=224, Evalue=3e-58,
Organism=Homo sapiens, GI169218196, Length=342, Percent_Identity=38.3040935672515, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI284005309, Length=381, Percent_Identity=37.5328083989501, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI222352149, Length=317, Percent_Identity=23.3438485804416, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI41327771, Length=107, Percent_Identity=37.3831775700935, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4758138, Length=351, Percent_Identity=23.3618233618234, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI21071032, Length=139, Percent_Identity=27.3381294964029, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994977, Length=345, Percent_Identity=44.0579710144928, Blast_Score=275, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI25145561, Length=365, Percent_Identity=41.9178082191781, Blast_Score=256, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI32564293, Length=365, Percent_Identity=39.4520547945205, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71987997, Length=337, Percent_Identity=40.3560830860534, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71987993, Length=337, Percent_Identity=40.3560830860534, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17552866, Length=369, Percent_Identity=37.940379403794, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32565321, Length=119, Percent_Identity=33.6134453781513, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=354, Percent_Identity=37.5706214689266, Blast_Score=240, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6325138, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324778, Length=233, Percent_Identity=25.7510729613734, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646066, Length=322, Percent_Identity=42.2360248447205, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI21358123, Length=406, Percent_Identity=38.9162561576355, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24664226, Length=367, Percent_Identity=38.6920980926431, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI62472181, Length=367, Percent_Identity=38.6920980926431, Blast_Score=225, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24664230, Length=367, Percent_Identity=38.6920980926431, Blast_Score=225, Evalue=7e-59,
Organism=Drosophila melanogaster, GI17977678, Length=120, Percent_Identity=30, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24584994, Length=118, Percent_Identity=34.7457627118644, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 72580; Mature: 72449

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFASWRSFMDRADGARHSSLDTVLRERFGLTDFRPGQREVLDALLGPNAAALAVFPTG
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECC
GGKSLCYQLPALLLEGITVVVSPLIALMKDQIDALARQGIRAARLDASLSVDDSREVTQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHH
LRDGSLKLLYVAPERFNNERFTALLRELRISLFAVDEAHCVSEWGHNFRPDYLKLAKAAR
HHCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
DLSAERILALTATATPSVVRDICQGFGIPEENAVVTGFYRQNLTLETTPVHAEARDAFLL
HCCHHHEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECCCCCHHHHHHHH
GRLGSRAPGPTIVYVTQQKTAERVAAFLATEGLPASAYHAGLEPEVRERVQESWMASANG
HHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHCCCC
IVVATIAFGMGIDKADVRAVYHYNLPKGLESYSQEIGRAGRDGAPSVVELFACPDDVPSL
EEEEEEHHHCCCCHHHHEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHEEEECCCCCCCC
ENFALGDTPTREAIQSLVTELLGLGPELSVDMFALSTRHDVRPLVLRTALTYLELEGVLR
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHH
QGTPYYAGYKVQPLMPIDALVGRFQGERVQFLRDVFSQAKKGRTWYSLDPAEVASSLRQP
CCCCCCCCEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
RERVVRAIEYLEEQGLVLLQVSEPRQRFTRLRPQEDAAALTALLHQRFQQREAQEVTRVR
HHHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DVLKLVTHAGCQSNALVAHFGQRREQPCGHCTFCRTGAAQVLPAVRQRPALPAGLDAAGF
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHH
RALAAKHPESLGHPRQAARFLCGLSSPALTRAKLGGHKLFGALEGWPFEEVLDFCGRSAV
HHHHHCCCHHCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHHHCCCCC
D
C
>Mature Secondary Structure 
PEFASWRSFMDRADGARHSSLDTVLRERFGLTDFRPGQREVLDALLGPNAAALAVFPTG
CCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECC
GGKSLCYQLPALLLEGITVVVSPLIALMKDQIDALARQGIRAARLDASLSVDDSREVTQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHH
LRDGSLKLLYVAPERFNNERFTALLRELRISLFAVDEAHCVSEWGHNFRPDYLKLAKAAR
HHCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
DLSAERILALTATATPSVVRDICQGFGIPEENAVVTGFYRQNLTLETTPVHAEARDAFLL
HCCHHHEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEECCCCCHHHHHHHH
GRLGSRAPGPTIVYVTQQKTAERVAAFLATEGLPASAYHAGLEPEVRERVQESWMASANG
HHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHCCCC
IVVATIAFGMGIDKADVRAVYHYNLPKGLESYSQEIGRAGRDGAPSVVELFACPDDVPSL
EEEEEEHHHCCCCHHHHEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHEEEECCCCCCCC
ENFALGDTPTREAIQSLVTELLGLGPELSVDMFALSTRHDVRPLVLRTALTYLELEGVLR
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHH
QGTPYYAGYKVQPLMPIDALVGRFQGERVQFLRDVFSQAKKGRTWYSLDPAEVASSLRQP
CCCCCCCCEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
RERVVRAIEYLEEQGLVLLQVSEPRQRFTRLRPQEDAAALTALLHQRFQQREAQEVTRVR
HHHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DVLKLVTHAGCQSNALVAHFGQRREQPCGHCTFCRTGAAQVLPAVRQRPALPAGLDAAGF
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHH
RALAAKHPESLGHPRQAARFLCGLSSPALTRAKLGGHKLFGALEGWPFEEVLDFCGRSAV
HHHHHCCCHHCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHCCCCCCHHHHHHHHCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]