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The map label for this gene is pchA [H]

Identifier: 108758468

GI number: 108758468

Start: 4107164

End: 4108474

Strand: Direct

Name: pchA [H]

Synonym: MXAN_3527

Alternate gene names: 108758468

Gene position: 4107164-4108474 (Clockwise)

Preceding gene: 108760849

Following gene: 108759318

Centisome position: 44.94

GC content: 72.77

Gene sequence:

>1311_bases
ATGAAGACGCACACTCCCGTTGAGAGCCAGCGCTGGGTGGCCGGAATGACGCCCCTTGCGGTGGTGGATCCGCTCGCGGG
TGCGGACGTATTGGGCGTTCCGACCGTCTACTGGGAGCGTCCGCTGGCGCAGGACGCGGCGGCGGGGTGGGGTGAGGCGG
CGGTGGTGGAGGCGCAGGACGCCTCCGACATTCCTGACGTGCTGGCCTCGCTGGGCCGCGTGCAGGTGCGCTGGCTGGGC
GAAGCCCCGGAGTCGATGCCGGGCCCCTGGTTTGGCGGCATCCGTTTCGGTGACTCGGGCACGGTGGACACGGCGTGGGC
GTCGCACGGTGTGACGCGCTGGACGCTGCCCGAGGTGCTGGTGTTCCGCACGGCGCGCGGCGCGTGCGTCGTGGCGTTCG
CGCAGGAAGGCCGCGGGGGTGAGGACCTGGTGCGCTCGCGGCTGGAGCGCGTCCGTGCCTGCTTCCCGGAGTCGTACCGG
CATGCGCGCGGCGAGCCCGTGGCGTTGGAGTTGCGCGCGTCGCGGCTGGACTTCGAGGTGCGGGTGCAGCGCGCGCTGGA
CGCGATTGCGTCCGGGCACCTCCAGAAGGTGGTGCTGGCGCGCCCGCTGGATGCGGAAGGGCCCGCGCCCTTTGATGTGG
TGGACGTGCTGGCGCGGCTGCGTGAGCAGAATCCCCGCTGCGCCACCTTCCTGTTCCGCGCTCCGGACGACACGTGCTTC
CTGGGCGCGACGCCGGAGACGCTGTGCCGGGTGGACGGTCAGGTGCTGGAGACGGAGGCCCTGGCGGGCACGGCCGCGCC
CGGCCAGGCGGACGGGCTGCGGGGCCATGACAAGAACGTGCGCGAGCACGCGTCCGTGGTGCGCTACCTCGTCACCGCGT
TGACGCCGCTGGCGGAGCAGGTGTCGTCGGACGCGGAGCCCGCGCTGCTGGCCTTGAAGAACGTCGTTCACCTGCGGACG
GGGTTTCGCGCCGAGCTGCGGCCGGGGGTGACGCCGGCGCAGGTGGTGGAGGCGCTGCATCCCACGCCGGCCGTGGGCGG
TACGCCTCGTGAGCGGGCACTGTCGTTCCTGGTGGAGCACGAAGGCCTGGACCGTGGGTGGTACGCGGGACCGGTGGGCT
GGGTGGGGCCTGGGCGGGCGCACTTGATGGTGGCGCTGCGCTCGGCGCGCGTGAAGGGCGCGAAGGCCCGGCTGTTCGTC
GGCGTGGGGCTGGTGGCTGGCTCCAACGCGGACTCGGAGTGGCGGGAGACGGAGATGAAGAGCCTGGCCATGTTGCGGGC
CTTGGGAGGCGGGGATGTCGTCCGACGCTAA

Upstream 100 bases:

>100_bases
GGAGTTCAAGAGGTTTTGAACTCCTTGGTGCATGTATAGCCGAGATGGCTTAGAAGACAACCGAAGGTGATTGCGACGCA
ATCGCCGATGAGGAACGCTG

Downstream 100 bases:

>100_bases
CCTCAACGTGTTGTGGGCGCGCGCGTTGCTGGAAGAGCTCGTGCGCGGTGGGGTTCGTCACGCGGTGGTGTGTCCGGGTT
CCCGGTCATCGCCCCTGGCC

Product: isochorismate synthase

Products: NA

Alternate protein names: Isochorismate mutase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKTHTPVESQRWVAGMTPLAVVDPLAGADVLGVPTVYWERPLAQDAAAGWGEAAVVEAQDASDIPDVLASLGRVQVRWLG
EAPESMPGPWFGGIRFGDSGTVDTAWASHGVTRWTLPEVLVFRTARGACVVAFAQEGRGGEDLVRSRLERVRACFPESYR
HARGEPVALELRASRLDFEVRVQRALDAIASGHLQKVVLARPLDAEGPAPFDVVDVLARLREQNPRCATFLFRAPDDTCF
LGATPETLCRVDGQVLETEALAGTAAPGQADGLRGHDKNVREHASVVRYLVTALTPLAEQVSSDAEPALLALKNVVHLRT
GFRAELRPGVTPAQVVEALHPTPAVGGTPRERALSFLVEHEGLDRGWYAGPVGWVGPGRAHLMVALRSARVKGAKARLFV
GVGLVAGSNADSEWRETEMKSLAMLRALGGGDVVRR

Sequences:

>Translated_436_residues
MKTHTPVESQRWVAGMTPLAVVDPLAGADVLGVPTVYWERPLAQDAAAGWGEAAVVEAQDASDIPDVLASLGRVQVRWLG
EAPESMPGPWFGGIRFGDSGTVDTAWASHGVTRWTLPEVLVFRTARGACVVAFAQEGRGGEDLVRSRLERVRACFPESYR
HARGEPVALELRASRLDFEVRVQRALDAIASGHLQKVVLARPLDAEGPAPFDVVDVLARLREQNPRCATFLFRAPDDTCF
LGATPETLCRVDGQVLETEALAGTAAPGQADGLRGHDKNVREHASVVRYLVTALTPLAEQVSSDAEPALLALKNVVHLRT
GFRAELRPGVTPAQVVEALHPTPAVGGTPRERALSFLVEHEGLDRGWYAGPVGWVGPGRAHLMVALRSARVKGAKARLFV
GVGLVAGSNADSEWRETEMKSLAMLRALGGGDVVRR
>Mature_436_residues
MKTHTPVESQRWVAGMTPLAVVDPLAGADVLGVPTVYWERPLAQDAAAGWGEAAVVEAQDASDIPDVLASLGRVQVRWLG
EAPESMPGPWFGGIRFGDSGTVDTAWASHGVTRWTLPEVLVFRTARGACVVAFAQEGRGGEDLVRSRLERVRACFPESYR
HARGEPVALELRASRLDFEVRVQRALDAIASGHLQKVVLARPLDAEGPAPFDVVDVLARLREQNPRCATFLFRAPDDTCF
LGATPETLCRVDGQVLETEALAGTAAPGQADGLRGHDKNVREHASVVRYLVTALTPLAEQVSSDAEPALLALKNVVHLRT
GFRAELRPGVTPAQVVEALHPTPAVGGTPRERALSFLVEHEGLDRGWYAGPVGWVGPGRAHLMVALRSARVKGAKARLFV
GVGLVAGSNADSEWRETEMKSLAMLRALGGGDVVRR

Specific function: Involved in the conversion of chorismate to salicylate (Probable) [H]

COG id: COG1169

COG function: function code HQ; Isochorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isochorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI87082077, Length=255, Percent_Identity=36.078431372549, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786809, Length=261, Percent_Identity=32.5670498084291, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787518, Length=263, Percent_Identity=29.277566539924, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=229, Percent_Identity=30.5676855895196, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR015890
- InterPro:   IPR004561 [H]

Pfam domain/function: PF00425 Chorismate_bind [H]

EC number: =5.4.4.2 [H]

Molecular weight: Translated: 46809; Mature: 46809

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHTPVESQRWVAGMTPLAVVDPLAGADVLGVPTVYWERPLAQDAAAGWGEAAVVEAQD
CCCCCCCCCCCHHCCCCCHHHHCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCEEEEECCC
ASDIPDVLASLGRVQVRWLGEAPESMPGPWFGGIRFGDSGTVDTAWASHGVTRWTLPEVL
CCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHH
VFRTARGACVVAFAQEGRGGEDLVRSRLERVRACFPESYRHARGEPVALELRASRLDFEV
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEHHHCCHHH
RVQRALDAIASGHLQKVVLARPLDAEGPAPFDVVDVLARLREQNPRCATFLFRAPDDTCF
HHHHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEE
LGATPETLCRVDGQVLETEALAGTAAPGQADGLRGHDKNVREHASVVRYLVTALTPLAEQ
ECCCHHHHHHCCCCCEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSSDAEPALLALKNVVHLRTGFRAELRPGVTPAQVVEALHPTPAVGGTPRERALSFLVEH
HCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EGLDRGWYAGPVGWVGPGRAHLMVALRSARVKGAKARLFVGVGLVAGSNADSEWRETEMK
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHHHHH
SLAMLRALGGGDVVRR
HHHHHHHCCCCHHCCC
>Mature Secondary Structure
MKTHTPVESQRWVAGMTPLAVVDPLAGADVLGVPTVYWERPLAQDAAAGWGEAAVVEAQD
CCCCCCCCCCCHHCCCCCHHHHCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCEEEEECCC
ASDIPDVLASLGRVQVRWLGEAPESMPGPWFGGIRFGDSGTVDTAWASHGVTRWTLPEVL
CCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCHHHHCCCCCHHHHHHH
VFRTARGACVVAFAQEGRGGEDLVRSRLERVRACFPESYRHARGEPVALELRASRLDFEV
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEHHHCCHHH
RVQRALDAIASGHLQKVVLARPLDAEGPAPFDVVDVLARLREQNPRCATFLFRAPDDTCF
HHHHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEE
LGATPETLCRVDGQVLETEALAGTAAPGQADGLRGHDKNVREHASVVRYLVTALTPLAEQ
ECCCHHHHHHCCCCCEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VSSDAEPALLALKNVVHLRTGFRAELRPGVTPAQVVEALHPTPAVGGTPRERALSFLVEH
HCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EGLDRGWYAGPVGWVGPGRAHLMVALRSARVKGAKARLFVGVGLVAGSNADSEWRETEMK
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHHHHH
SLAMLRALGGGDVVRR
HHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7500944; 10984043 [H]