Click here to switch to the map view.

The map label for this gene is thlA [H]

Identifier: 108757905

GI number: 108757905

Start: 4555839

End: 4557020

Strand: Reverse

Name: thlA [H]

Synonym: MXAN_3791

Alternate gene names: 108757905

Gene position: 4557020-4555839 (Counterclockwise)

Preceding gene: 108758869

Following gene: 108764087

Centisome position: 49.86

GC content: 69.46

Gene sequence:

>1182_bases
ATGGCTCGTGACGTCGTCATCGTGGGCGCGGCCCGTACCCCCATTGGTGCCTTTCAGGGCGCGCTCGCCAAGCTGACGGC
CCCGCAGCTGGGCGCGATCGCGATCAAGGCGGCGCTGGAGCGCGCGGGCGTGAAGCCCGAGGCCGTTCAGGAAGTCATCC
TGGGCTGTGTGCTCACCGCGGGCGTGGGCCAGGCGCCCGCTCGCCAGGCGGCCATCTTCGCCGGCCTGCCCGAGACGGTT
CCCGCCACCACGCTCAACAAGGTCTGTGGCTCCGGCCTCAAGGCCGTCAGCGCGGGCGCGCAGGCCATTGCCCTGGGTGA
CGCGGACGTCGTCGTCGTGGGCGGCATGGAGTCCATGAGCAACGCGCCGTACATCAGCCACACGATGCGTGGCGGCGCGC
GCATGGGCAACGTGGAATTCAAGGACGCGATGATCCACGACGGCCTCTGGGACGTGTACGGCAACGTCCACATGGGCATC
TGCGCCGAGGAGTGCGCCACGACGCAGGACATCAGCCGCTCGCAGCAGGACGAGTACGCGCTGGAGTCCACGCGCCGCGC
CATCCAGGCCCAGAAGGAAGGCCTGTTCAAGGCGGAGATCGTCCCGGTCCAGATTCCGGGCAAGAAGCCGGAGGACGTCG
TCACCGTCTCCGACGACGAGGGGCCCCGCAACGCGAAGCCGGAGAAGATTCCGGGCCTGAAGCCGGTGTTCAAGAAGGAC
GGCACGGTGACGGCCGCCAACGCGTCCTCCATCAACGACGGCGCCGCGGCGCTGGTGCTGATGAGCGAGGAGCGCGCGAA
GGCCGAGGGCCGCGCCATCCTGGGCCGCATCACGGGCTACGCCCAGGCGGCGCGCAAGCCGGTGGAGTTCACCATCGCGC
CCACGGACGCCATCAACAAGCTGCTGAAGAAGCAGGGCATCAGCGCGGGTGACGTGGACCTCTGGGAGATCAACGAGGCG
TTCGCGGTGGTGTCCATCGCGAACAACCGGCTGCTCGGCCTGGACGTGTCGAAAGTGAACGTGCGCGGCGGCGCGGTGGC
GCTGGGGCACCCGATTGGCGCGTCCGGCGCGCGCGTGCTGGTGACGCTGCTGCAGACGATGCAGGACCTGGACAAGAAGC
GTGGCGTCGCGTCGCTCTGCATCGGCGGCGGCGAGGGCATCGCGCTGATGGTGGAGCGCTGA

Upstream 100 bases:

>100_bases
ACGAGCAAGGATGCTTGAACTCAGGGAAGTGGCCGGTGATAAGGGCCCCCGACACTGTTATCGAAGAGCATCCGCACATC
CTCAAGAGGAGGCAGGTTTC

Downstream 100 bases:

>100_bases
ACTTCCTCTCCCAATAGGAGAGGGGCACGGGGTGGGGGCCTGCCAAGGGCCTTCACCCCGTTCGCACATGCGGGAGGGCG
GATGAACAAGGTCTACGCGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MARDVVIVGAARTPIGAFQGALAKLTAPQLGAIAIKAALERAGVKPEAVQEVILGCVLTAGVGQAPARQAAIFAGLPETV
PATTLNKVCGSGLKAVSAGAQAIALGDADVVVVGGMESMSNAPYISHTMRGGARMGNVEFKDAMIHDGLWDVYGNVHMGI
CAEECATTQDISRSQQDEYALESTRRAIQAQKEGLFKAEIVPVQIPGKKPEDVVTVSDDEGPRNAKPEKIPGLKPVFKKD
GTVTAANASSINDGAAALVLMSEERAKAEGRAILGRITGYAQAARKPVEFTIAPTDAINKLLKKQGISAGDVDLWEINEA
FAVVSIANNRLLGLDVSKVNVRGGAVALGHPIGASGARVLVTLLQTMQDLDKKRGVASLCIGGGEGIALMVER

Sequences:

>Translated_393_residues
MARDVVIVGAARTPIGAFQGALAKLTAPQLGAIAIKAALERAGVKPEAVQEVILGCVLTAGVGQAPARQAAIFAGLPETV
PATTLNKVCGSGLKAVSAGAQAIALGDADVVVVGGMESMSNAPYISHTMRGGARMGNVEFKDAMIHDGLWDVYGNVHMGI
CAEECATTQDISRSQQDEYALESTRRAIQAQKEGLFKAEIVPVQIPGKKPEDVVTVSDDEGPRNAKPEKIPGLKPVFKKD
GTVTAANASSINDGAAALVLMSEERAKAEGRAILGRITGYAQAARKPVEFTIAPTDAINKLLKKQGISAGDVDLWEINEA
FAVVSIANNRLLGLDVSKVNVRGGAVALGHPIGASGARVLVTLLQTMQDLDKKRGVASLCIGGGEGIALMVER
>Mature_392_residues
ARDVVIVGAARTPIGAFQGALAKLTAPQLGAIAIKAALERAGVKPEAVQEVILGCVLTAGVGQAPARQAAIFAGLPETVP
ATTLNKVCGSGLKAVSAGAQAIALGDADVVVVGGMESMSNAPYISHTMRGGARMGNVEFKDAMIHDGLWDVYGNVHMGIC
AEECATTQDISRSQQDEYALESTRRAIQAQKEGLFKAEIVPVQIPGKKPEDVVTVSDDEGPRNAKPEKIPGLKPVFKKDG
TVTAANASSINDGAAALVLMSEERAKAEGRAILGRITGYAQAARKPVEFTIAPTDAINKLLKKQGISAGDVDLWEINEAF
AVVSIANNRLLGLDVSKVNVRGGAVALGHPIGASGARVLVTLLQTMQDLDKKRGVASLCIGGGEGIALMVER

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=50.5102040816327, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=47.9591836734694, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=41.5617128463476, Blast_Score=292, Evalue=4e-79,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=40.3022670025189, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=33.0985915492958, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=31.4720812182741, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=50.2551020408163, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=51.9083969465649, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=39.1521197007481, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=38, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=29.1866028708134, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=46.0358056265985, Blast_Score=341, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=43.765903307888, Blast_Score=317, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=42.7109974424552, Blast_Score=301, Evalue=6e-82,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=37.1501272264631, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=32.0754716981132, Blast_Score=197, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=49.75, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=36.6834170854271, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=51.9181585677749, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=52.6854219948849, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=41.1616161616162, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=33.1775700934579, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40714; Mature: 40583

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARDVVIVGAARTPIGAFQGALAKLTAPQLGAIAIKAALERAGVKPEAVQEVILGCVLTA
CCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GVGQAPARQAAIFAGLPETVPATTLNKVCGSGLKAVSAGAQAIALGDADVVVVGGMESMS
CCCCCCCHHHHEECCCCCCCCHHHHHHHHCCCHHHHHCCCEEEEECCCCEEEEECHHHCC
NAPYISHTMRGGARMGNVEFKDAMIHDGLWDVYGNVHMGICAEECATTQDISRSQQDEYA
CCCCHHHHHCCCCEECCEEHHHHHHHCCHHHHHCCEEEEEEHHHHCCHHHHHHHHHHHHH
LESTRRAIQAQKEGLFKAEIVPVQIPGKKPEDVVTVSDDEGPRNAKPEKIPGLKPVFKKD
HHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHCCC
GTVTAANASSINDGAAALVLMSEERAKAEGRAILGRITGYAQAARKPVEFTIAPTDAINK
CEEEECCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
LLKKQGISAGDVDLWEINEAFAVVSIANNRLLGLDVSKVNVRGGAVALGHPIGASGARVL
HHHHCCCCCCCEEEEECCCEEEEEEECCCEEEEEEEEEEEECCCEEEECCCCCCCHHHHH
VTLLQTMQDLDKKRGVASLCIGGGEGIALMVER
HHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEC
>Mature Secondary Structure 
ARDVVIVGAARTPIGAFQGALAKLTAPQLGAIAIKAALERAGVKPEAVQEVILGCVLTA
CCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GVGQAPARQAAIFAGLPETVPATTLNKVCGSGLKAVSAGAQAIALGDADVVVVGGMESMS
CCCCCCCHHHHEECCCCCCCCHHHHHHHHCCCHHHHHCCCEEEEECCCCEEEEECHHHCC
NAPYISHTMRGGARMGNVEFKDAMIHDGLWDVYGNVHMGICAEECATTQDISRSQQDEYA
CCCCHHHHHCCCCEECCEEHHHHHHHCCHHHHHCCEEEEEEHHHHCCHHHHHHHHHHHHH
LESTRRAIQAQKEGLFKAEIVPVQIPGKKPEDVVTVSDDEGPRNAKPEKIPGLKPVFKKD
HHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHCCC
GTVTAANASSINDGAAALVLMSEERAKAEGRAILGRITGYAQAARKPVEFTIAPTDAINK
CEEEECCCCCCCCCCEEEEEEECHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
LLKKQGISAGDVDLWEINEAFAVVSIANNRLLGLDVSKVNVRGGAVALGHPIGASGARVL
HHHHCCCCCCCEEEEECCCEEEEEEECCCEEEEEEEEEEEECCCEEEECCCCCCCHHHHH
VTLLQTMQDLDKKRGVASLCIGGGEGIALMVER
HHHHHHHHHHHHHCCEEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]