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The map label for this gene is mdlA [H]

Identifier: 108757882

GI number: 108757882

Start: 4357303

End: 4358457

Strand: Direct

Name: mdlA [H]

Synonym: MXAN_3652

Alternate gene names: 108757882

Gene position: 4357303-4358457 (Clockwise)

Preceding gene: 108757931

Following gene: 108759231

Centisome position: 47.67

GC content: 70.04

Gene sequence:

>1155_bases
ATGATGGGGGCGGGGGCTGATGCACGGGGAGAGACCATGGTCCAGAGGCTCAGCGAGGCGGTGCCCATCGAGCGCTGCGA
GGTTTCTGCGTACGAGGTCCCAACGGACGCGCAGGAGGCGGACGGCACCATCGAGTGGGACAGCACGACGCTCGTGGTGG
TGGAGTTGACGGCGGGAGGCACGCGCGGGCTCGGCTACACGTACGCGGACGCGTCGGCGGCGAGCCTCATCCGCTGCTCG
CTCATCCGGGCGCTTGAGGGACACGACGTGATGGACGTGCCGGCGCGGATGCGCTCATTGCTGAGGCAGGTCCGCAACAA
GGGGAGGCCGGGGCTGGTGGCCATGGCGCTCTCCGCGGTGGACGTGGCGTTGTGGGACACGAAGGCGCGCTTACTGGACG
TGCCGCTGGTGCGGTTGCTGGGCGCCTCAAGGGATGCGGCACCTGTCTACGGCAGCGGGGGCTTTACCTCGTACTCCATC
GAGCGGCTCCAGGCGCAGCTCGCCGGCTGGGTGGAGCAGGGGATTCCACGAGTGAAGATGAAGGTGGGCAGCCACCCCGA
GGAGGACCCAGCCCGGGTGGAGGCCGCGCGGCGCGCCATCGGGCCACGCGCGGAGCTCTTCGTGGATGGCAACGGTGCAT
ACACGGTGCCGCAGGCCCTCTTGCTCGCGGAGCGCTTCGTAGCGCACGGCGTCTCCTGGTTCGAAGAGCCCGTCTCCAGT
GATGACCTGGAGGGGCTCCACCGCCTGCGAGCTCGCGTCCCCGCCGGCATGGCCGTGGCGGCGGGCGAGTATGGGGACAG
CGGCCTCTACTTCCGGCGCATGCTGGAGGCAGGCGCGGTGGATGTTCTCCAGGCGGACGCCACGCGCTGCCTGGGCATCA
GCGGGTTCCTTCAGGCAGACGCGCTGTGCGATGCGTTCGGCGTGCCTCTCTCTGCCCACTGCGCCCCCGCGCTCCATGCC
CATGTGGCGTGCGCGGCGCGGCGACTGGTGCACATCGAGTACTTTCACGACCACGCACGTTTGGAGCGGATGCTCTTCGA
CGGCGTGGCTTCGGTCAGGCATGGGACGCTCGCGCCGGACCTGTCACGTCCGGGCCTGGGGCTGGAGTTGAAGCGGGCGG
ACGCGGCCCGCTACGAGGTGGGCGCCCCCTCCTGA

Upstream 100 bases:

>100_bases
CATGTTGGAATGCTGCCCACGCGCGCCCCCTCCGGTTGGCGTGGGAGCTCTCACCCAGACATCCCCAGGGCAGCCGGAGC
GGGCAAGGACTCTCTCAAGG

Downstream 100 bases:

>100_bases
GGCACGTCATCCTGGGCGGGCTGCTCGACGCTCTCTACCCGCTGTAGACACGGCTCAGACGGCGCCGTGGTGCCGGACGG
GCGCGCGAGGTGCTCAGCCG

Product: mandelate racemase/muconate lactonizing enzyme family protein

Products: NA

Alternate protein names: MR [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MMGAGADARGETMVQRLSEAVPIERCEVSAYEVPTDAQEADGTIEWDSTTLVVVELTAGGTRGLGYTYADASAASLIRCS
LIRALEGHDVMDVPARMRSLLRQVRNKGRPGLVAMALSAVDVALWDTKARLLDVPLVRLLGASRDAAPVYGSGGFTSYSI
ERLQAQLAGWVEQGIPRVKMKVGSHPEEDPARVEAARRAIGPRAELFVDGNGAYTVPQALLLAERFVAHGVSWFEEPVSS
DDLEGLHRLRARVPAGMAVAAGEYGDSGLYFRRMLEAGAVDVLQADATRCLGISGFLQADALCDAFGVPLSAHCAPALHA
HVACAARRLVHIEYFHDHARLERMLFDGVASVRHGTLAPDLSRPGLGLELKRADAARYEVGAPS

Sequences:

>Translated_384_residues
MMGAGADARGETMVQRLSEAVPIERCEVSAYEVPTDAQEADGTIEWDSTTLVVVELTAGGTRGLGYTYADASAASLIRCS
LIRALEGHDVMDVPARMRSLLRQVRNKGRPGLVAMALSAVDVALWDTKARLLDVPLVRLLGASRDAAPVYGSGGFTSYSI
ERLQAQLAGWVEQGIPRVKMKVGSHPEEDPARVEAARRAIGPRAELFVDGNGAYTVPQALLLAERFVAHGVSWFEEPVSS
DDLEGLHRLRARVPAGMAVAAGEYGDSGLYFRRMLEAGAVDVLQADATRCLGISGFLQADALCDAFGVPLSAHCAPALHA
HVACAARRLVHIEYFHDHARLERMLFDGVASVRHGTLAPDLSRPGLGLELKRADAARYEVGAPS
>Mature_384_residues
MMGAGADARGETMVQRLSEAVPIERCEVSAYEVPTDAQEADGTIEWDSTTLVVVELTAGGTRGLGYTYADASAASLIRCS
LIRALEGHDVMDVPARMRSLLRQVRNKGRPGLVAMALSAVDVALWDTKARLLDVPLVRLLGASRDAAPVYGSGGFTSYSI
ERLQAQLAGWVEQGIPRVKMKVGSHPEEDPARVEAARRAIGPRAELFVDGNGAYTVPQALLLAERFVAHGVSWFEEPVSS
DDLEGLHRLRARVPAGMAVAAGEYGDSGLYFRRMLEAGAVDVLQADATRCLGISGFLQADALCDAFGVPLSAHCAPALHA
HVACAARRLVHIEYFHDHARLERMLFDGVASVRHGTLAPDLSRPGLGLELKRADAARYEVGAPS

Specific function: Unknown

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=402, Percent_Identity=23.8805970149254, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI186972148, Length=248, Percent_Identity=26.2096774193548, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI42544117, Length=404, Percent_Identity=22.5247524752475, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI226510960, Length=339, Percent_Identity=25.3687315634218, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI48994953, Length=321, Percent_Identity=27.7258566978193, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787864, Length=371, Percent_Identity=26.4150943396226, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR015654
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =5.1.2.2 [H]

Molecular weight: Translated: 41104; Mature: 41104

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGAGADARGETMVQRLSEAVPIERCEVSAYEVPTDAQEADGTIEWDSTTLVVVELTAGG
CCCCCCCCCHHHHHHHHHHCCCHHHHCCCEEECCCCCHHCCCEEEECCEEEEEEEEECCC
TRGLGYTYADASAASLIRCSLIRALEGHDVMDVPARMRSLLRQVRNKGRPGLVAMALSAV
CCCCCEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DVALWDTKARLLDVPLVRLLGASRDAAPVYGSGGFTSYSIERLQAQLAGWVEQGIPRVKM
HHHHCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
KVGSHPEEDPARVEAARRAIGPRAELFVDGNGAYTVPQALLLAERFVAHGVSWFEEPVSS
ECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DDLEGLHRLRARVPAGMAVAAGEYGDSGLYFRRMLEAGAVDVLQADATRCLGISGFLQAD
CHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHCHHHHCCCHHHHHHH
ALCDAFGVPLSAHCAPALHAHVACAARRLVHIEYFHDHARLERMLFDGVASVRHGTLAPD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LSRPGLGLELKRADAARYEVGAPS
CCCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MMGAGADARGETMVQRLSEAVPIERCEVSAYEVPTDAQEADGTIEWDSTTLVVVELTAGG
CCCCCCCCCHHHHHHHHHHCCCHHHHCCCEEECCCCCHHCCCEEEECCEEEEEEEEECCC
TRGLGYTYADASAASLIRCSLIRALEGHDVMDVPARMRSLLRQVRNKGRPGLVAMALSAV
CCCCCEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DVALWDTKARLLDVPLVRLLGASRDAAPVYGSGGFTSYSIERLQAQLAGWVEQGIPRVKM
HHHHCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
KVGSHPEEDPARVEAARRAIGPRAELFVDGNGAYTVPQALLLAERFVAHGVSWFEEPVSS
ECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DDLEGLHRLRARVPAGMAVAAGEYGDSGLYFRRMLEAGAVDVLQADATRCLGISGFLQAD
CHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCHHHHHHCHHHHCCCHHHHHHH
ALCDAFGVPLSAHCAPALHAHVACAARRLVHIEYFHDHARLERMLFDGVASVRHGTLAPD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LSRPGLGLELKRADAARYEVGAPS
CCCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2831968; 2271624; 2215699; 1909893; 1892834; 7893689; 7893690 [H]