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The map label for this gene is degP [H]

Identifier: 108757026

GI number: 108757026

Start: 5481985

End: 5483331

Strand: Direct

Name: degP [H]

Synonym: MXAN_4433

Alternate gene names: 108757026

Gene position: 5481985-5483331 (Clockwise)

Preceding gene: 108761940

Following gene: 108763845

Centisome position: 59.98

GC content: 69.86

Gene sequence:

>1347_bases
ATGAAGCACGCAGTCATGAGGTGGAGCCTGCTGGTGATGGCCCTGCTGACCTCGGGCACGGCGAACGCGGACATGGCGCG
GCGGCGTGACGCCATCGTCGAGGTCGTGCAGAAGGTCTCCCCTGCCGTCGTCTACATCGGCACCGAGCAGGAGGTGGAGT
CGCGCTTCCGTGGACGCCGTTCTCCCCTGGAGGAGTTCTTCGGTGGCATGGGCGCGGAGCCGGAGCGTCAGAGAATCTCC
GGCCTGGGCAGCGGCGCCATCATCGACCCCAGCGGCATCATCGTCACCAATGACCACGTCATCCGGGGCGCTTCCGCCAT
CCACGTCATCCTGGCGGATGGCCGCTCGTTCGACGCGGAGGTCATCGGCAGCGACGCGGCGAACGACCTAGCGGTGCTCA
AGGTCAATGCCAAGGAGGCCCTCCCCATCGCGAAGCTGGGCACCAGCTCCGACCTGATGATTGGCGAGACGGTGGTCGCC
ATTGGCAGCCCGTTCGGCCTCAGCAAGACGGTCACCGCGGGCGTCGTCTCCGCGGTGGGCCGCACCTTCCGCGCCGACAA
CCGCGTCTACAACGACTTCGTGCAGACGGACGCCGCCATCAACCCGGGCAACTCGGGCGGCCCGCTGCTCAACGTGGATG
GGGAAATCATCGGAATCAACACCGCCATCTTCGGCGGCGGCGCGCAGGGCATCGGCTTCGCGATTCCGGCCGACAAGGTG
CGCCGCATCGTCGACGAGCTGACCCGCTTCGGGAAGGTGCGCCCGGCGTGGGTGGGCATCGATACGGCCGACCTGCCTGT
CCGCGTCGCCCGGCAGCTCGGGTGGGACCGGGCCTATGGCGCGCTGGTGACGGCGGTGGAGGCAGGGAGTCCGGCCGCGG
AGGCTGGCGTGAAGCGCGGGGACGTGGTGGCGGAGCTGGGCGGCTCGCGCATCCAGGACGCCGAGGACTTCGACACCCGC
GTGCGCGGCTACCCCGCCCGCTCCGCCTTCCCGGTGGTGCTCTTCCGCGAAGGCGGCCTGCGCACCGTCCAGGTGACGCC
GGTGGAGTTCCCCGCTCGCATGGTCGAGGGGCTGGCGTGGGAACGGCTGGGACTCCGCGTGAAGGAGATTCGCGGCGGCC
TGGCCGTGTCCGGCGTGCGCCAGGGCTCCGCGGCGGCGGACATCGGGCTTGAGCCCGGAGACATCATCCTCCGTGTGAAC
AACCAGCCCGTGACGACGAACGACGCCTTCCGGGAGTCCCTGCTCACCGCGCGACGGGGACGTAGCGTCCTGTTGCTCGT
GCGGCGCGGGCGCTACGGCTACCACGTGACGCTGCCCTTCGAGCGGGAAGCAGGCTACCGGCTGTAG

Upstream 100 bases:

>100_bases
AGCGAGACACCGCATCCAGGGGCCCCGGGTAGGCTGCGGCCTTCCCGACAATCAGAATGTCCTTCGCCCGACAATCCCTG
GCGGTGCACGGAGGGTTGGA

Downstream 100 bases:

>100_bases
CTGTCGGGAAAGGGCGACGGGCTCCCCGTATTTCAGGACCCGCGTGACTCGCACTAACATGCGATGTCATGAGTTCCGTC
CGTTACCAATCCCTTGGTCC

Product: S1C family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKHAVMRWSLLVMALLTSGTANADMARRRDAIVEVVQKVSPAVVYIGTEQEVESRFRGRRSPLEEFFGGMGAEPERQRIS
GLGSGAIIDPSGIIVTNDHVIRGASAIHVILADGRSFDAEVIGSDAANDLAVLKVNAKEALPIAKLGTSSDLMIGETVVA
IGSPFGLSKTVTAGVVSAVGRTFRADNRVYNDFVQTDAAINPGNSGGPLLNVDGEIIGINTAIFGGGAQGIGFAIPADKV
RRIVDELTRFGKVRPAWVGIDTADLPVRVARQLGWDRAYGALVTAVEAGSPAAEAGVKRGDVVAELGGSRIQDAEDFDTR
VRGYPARSAFPVVLFREGGLRTVQVTPVEFPARMVEGLAWERLGLRVKEIRGGLAVSGVRQGSAAADIGLEPGDIILRVN
NQPVTTNDAFRESLLTARRGRSVLLLVRRGRYGYHVTLPFEREAGYRL

Sequences:

>Translated_448_residues
MKHAVMRWSLLVMALLTSGTANADMARRRDAIVEVVQKVSPAVVYIGTEQEVESRFRGRRSPLEEFFGGMGAEPERQRIS
GLGSGAIIDPSGIIVTNDHVIRGASAIHVILADGRSFDAEVIGSDAANDLAVLKVNAKEALPIAKLGTSSDLMIGETVVA
IGSPFGLSKTVTAGVVSAVGRTFRADNRVYNDFVQTDAAINPGNSGGPLLNVDGEIIGINTAIFGGGAQGIGFAIPADKV
RRIVDELTRFGKVRPAWVGIDTADLPVRVARQLGWDRAYGALVTAVEAGSPAAEAGVKRGDVVAELGGSRIQDAEDFDTR
VRGYPARSAFPVVLFREGGLRTVQVTPVEFPARMVEGLAWERLGLRVKEIRGGLAVSGVRQGSAAADIGLEPGDIILRVN
NQPVTTNDAFRESLLTARRGRSVLLLVRRGRYGYHVTLPFEREAGYRL
>Mature_448_residues
MKHAVMRWSLLVMALLTSGTANADMARRRDAIVEVVQKVSPAVVYIGTEQEVESRFRGRRSPLEEFFGGMGAEPERQRIS
GLGSGAIIDPSGIIVTNDHVIRGASAIHVILADGRSFDAEVIGSDAANDLAVLKVNAKEALPIAKLGTSSDLMIGETVVA
IGSPFGLSKTVTAGVVSAVGRTFRADNRVYNDFVQTDAAINPGNSGGPLLNVDGEIIGINTAIFGGGAQGIGFAIPADKV
RRIVDELTRFGKVRPAWVGIDTADLPVRVARQLGWDRAYGALVTAVEAGSPAAEAGVKRGDVVAELGGSRIQDAEDFDTR
VRGYPARSAFPVVLFREGGLRTVQVTPVEFPARMVEGLAWERLGLRVKEIRGGLAVSGVRQGSAAADIGLEPGDIILRVN
NQPVTTNDAFRESLLTARRGRSVLLLVRRGRYGYHVTLPFEREAGYRL

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=332, Percent_Identity=35.8433734939759, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI22129776, Length=308, Percent_Identity=35.3896103896104, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4506141, Length=335, Percent_Identity=33.7313432835821, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI24308541, Length=315, Percent_Identity=36.1904761904762, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1786356, Length=450, Percent_Identity=34.8888888888889, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1789629, Length=421, Percent_Identity=36.104513064133, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1789630, Length=292, Percent_Identity=40.7534246575342, Blast_Score=182, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24646839, Length=325, Percent_Identity=35.6923076923077, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47744; Mature: 47744

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAVMRWSLLVMALLTSGTANADMARRRDAIVEVVQKVSPAVVYIGTEQEVESRFRGRR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCC
SPLEEFFGGMGAEPERQRISGLGSGAIIDPSGIIVTNDHVIRGASAIHVILADGRSFDAE
CCHHHHHCCCCCCCHHHHHHCCCCCCEECCCCEEEECCCEEECCCEEEEEEECCCCCCHH
VIGSDAANDLAVLKVNAKEALPIAKLGTSSDLMIGETVVAIGSPFGLSKTVTAGVVSAVG
EECCCCCCCEEEEEECHHHCCCCCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHH
RTFRADNRVYNDFVQTDAAINPGNSGGPLLNVDGEIIGINTAIFGGGAQGIGFAIPADKV
HHHHCCCHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEECCCCCCCEEECCHHHH
RRIVDELTRFGKVRPAWVGIDTADLPVRVARQLGWDRAYGALVTAVEAGSPAAEAGVKRG
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHEEEECCCCCHHHHCCCCC
DVVAELGGSRIQDAEDFDTRVRGYPARSAFPVVLFREGGLRTVQVTPVEFPARMVEGLAW
CCHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEECCHHHHHHHHHHHH
ERLGLRVKEIRGGLAVSGVRQGSAAADIGLEPGDIILRVNNQPVTTNDAFRESLLTARRG
HHHCCCHHHHCCCEEEECCCCCCCHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC
RSVLLLVRRGRYGYHVTLPFEREAGYRL
CEEEEEEECCCCEEEEEEEEHHCCCCCC
>Mature Secondary Structure
MKHAVMRWSLLVMALLTSGTANADMARRRDAIVEVVQKVSPAVVYIGTEQEVESRFRGRR
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCC
SPLEEFFGGMGAEPERQRISGLGSGAIIDPSGIIVTNDHVIRGASAIHVILADGRSFDAE
CCHHHHHCCCCCCCHHHHHHCCCCCCEECCCCEEEECCCEEECCCEEEEEEECCCCCCHH
VIGSDAANDLAVLKVNAKEALPIAKLGTSSDLMIGETVVAIGSPFGLSKTVTAGVVSAVG
EECCCCCCCEEEEEECHHHCCCCCCCCCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHH
RTFRADNRVYNDFVQTDAAINPGNSGGPLLNVDGEIIGINTAIFGGGAQGIGFAIPADKV
HHHHCCCHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEEEEEECCCCCCCEEECCHHHH
RRIVDELTRFGKVRPAWVGIDTADLPVRVARQLGWDRAYGALVTAVEAGSPAAEAGVKRG
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHEEEECCCCCHHHHCCCCC
DVVAELGGSRIQDAEDFDTRVRGYPARSAFPVVLFREGGLRTVQVTPVEFPARMVEGLAW
CCHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEECCHHHHHHHHHHHH
ERLGLRVKEIRGGLAVSGVRQGSAAADIGLEPGDIILRVNNQPVTTNDAFRESLLTARRG
HHHCCCHHHHCCCEEEECCCCCCCHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC
RSVLLLVRRGRYGYHVTLPFEREAGYRL
CEEEEEEECCCCEEEEEEEEHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]