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The map label for this gene is ung [H]

Identifier: 108563719

GI number: 108563719

Start: 1339335

End: 1340036

Strand: Reverse

Name: ung [H]

Synonym: HPAG1_1294

Alternate gene names: 108563719

Gene position: 1340036-1339335 (Counterclockwise)

Preceding gene: 108563720

Following gene: 108563718

Centisome position: 83.94

GC content: 43.3

Gene sequence:

>702_bases
ATGAAGCTTTTTGACTACGCTCCTTTGAGTTTGGCTTGGCGGGAATTTTTGCAAAGCGAATTTAAAAAGCCTTATTTTTT
AGAAATAGAAAAACGCTACCTAGAGGCTCTAAAAAGCCCTAAAACTATTTTCCCTAAAAGCTCTAATCTGTTTTATGCGC
TCAATCTAACGCCCCCTAGCGCGGTTAAAATCATCCTTTTAGGGCAAGACCCCTACCATTCCACCTACCTAGAAAATCAG
CAAGAATTGCCTGTGGCGATGGGCCTAAGCTTTAGCGTGGAAAAAAACGCCCCCATCCCCCCAAGCTTAAAAAATATTTT
TAAAGAATTGCATGCGAATTTGGGCGTGTCTGTGCCTTGTTGTGGGGATTTGAGCGCGTGGGCTAAAAGGGGCATGCTGT
TATTGAACGCCATTTTAAGCGTGGAAAAAAATAAGGCCGCTTCGCACAAACGCATCGGTTGGGAAGCTTTTAGCGATCAA
ATATTGATGCGCCTTTTTGAAGCCAACGCCCCCTTGATCGTGGTGTTATTAGGGAAAGTCGCCCAAAAAAAGATCGCGCT
AATCCCCAAAAACAAACACATCATCATCACAGCCCCTCACCCTAGCCCCTTATCTAGAGGTTTTTTAGGGAGTGGGGTTT
TTACAAGCATCCAAAACGCTTACAGAGAGGTTTATCATAAGGATTTTGATTTCAGTTTATGA

Upstream 100 bases:

>100_bases
ATACGCCTAATTTTAACTCGCCCACCTGGTATGAAGAATTACAAGAACGCATGCAAAAAGAGTATTTAAAACACTATCAT
GAATTAAACCCTAGCGAACA

Downstream 100 bases:

>100_bases
TTAATGATTAATGAGGCAGAACCCCTTAAGAATGCCTTGATTTAAGAGCATTTGTGATAAAATGGTGGCTTTTAAATAAA
GGGAAAACATGCCAATTAGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPSAVKIILLGQDPYHSTYLENQ
QELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVSVPCCGDLSAWAKRGMLLLNAILSVEKNKAASHKRIGWEAFSDQ
ILMRLFEANAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAYREVYHKDFDFSL

Sequences:

>Translated_233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPSAVKIILLGQDPYHSTYLENQ
QELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVSVPCCGDLSAWAKRGMLLLNAILSVEKNKAASHKRIGWEAFSDQ
ILMRLFEANAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAYREVYHKDFDFSL
>Mature_233_residues
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPSAVKIILLGQDPYHSTYLENQ
QELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVSVPCCGDLSAWAKRGMLLLNAILSVEKNKAASHKRIGWEAFSDQ
ILMRLFEANAPLIVVLLGKVAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAYREVYHKDFDFSL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=223, Percent_Identity=39.9103139013453, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI6224979, Length=223, Percent_Identity=39.9103139013453, Blast_Score=156, Evalue=1e-38,
Organism=Escherichia coli, GI1788934, Length=207, Percent_Identity=40.0966183574879, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=38.9908256880734, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6323620, Length=241, Percent_Identity=36.9294605809129, Blast_Score=131, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26215; Mature: 26215

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPS
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCC
AVKIILLGQDPYHSTYLENQQELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVSVPC
CEEEEEECCCCCCHHHHCCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKNKAASHKRIGWEAFSDQILMRLFEANAPLIVVLLGKV
CCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEHHHH
AQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAYREVYHKDFDFSL
HHHHEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKLFDYAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPS
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCC
AVKIILLGQDPYHSTYLENQQELPVAMGLSFSVEKNAPIPPSLKNIFKELHANLGVSVPC
CEEEEEECCCCCCHHHHCCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKNKAASHKRIGWEAFSDQILMRLFEANAPLIVVLLGKV
CCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEHHHH
AQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAYREVYHKDFDFSL
HHHHEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA