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The map label for this gene is map [H]

Identifier: 108563669

GI number: 108563669

Start: 1302712

End: 1303473

Strand: Reverse

Name: map [H]

Synonym: HPAG1_1244

Alternate gene names: 108563669

Gene position: 1303473-1302712 (Counterclockwise)

Preceding gene: 108563670

Following gene: 108563668

Centisome position: 81.65

GC content: 44.75

Gene sequence:

>762_bases
ATGGCAATCTCTATTAAAAGCCCAAAAGAAATCAAAGCTCTAAGAAAAGCCGGGGAATTAACCGCTCAAGCGTTAGCCCT
TTTAGAGCGAGAAGTAAGGCCTGGGGTTTCACTTTTAGAGCTGGATAAAATGGCTGAAGATTTTATCAAATCCTCTCATG
CCAGGCCTGCTTTTAAGGGGCTTTATGGTTTCCCTAACTCGGTGTGCATGTCCTTAAATGAGGTGGTTATTCATGGCATT
CCTACGGATTATGTTTTACAAGAAGGGGATATTATAGGCTTGGATTTGGGGGTGGAGGTGGATGGCTATTATGGCGATTC
GGCTCTCACGCTTCCCATAGGCACGATAAGCCCGCAAGATGAAAAATTGCTCGCTTGTTCTGAAGAGAGCTTGATGCATG
CCATTAGTTCAATTAGAGTGGGCATGCATTTTAAAGAGTTGAGTCAGATTTTAGAGGGTGCTATTGTAGAAAGGGGCTTT
GTGCCTTTGAAGGGGTTTTGTGGGCATGGCATTGGTAAAAAACCCCATGAAGAGCCAGAAATCCCCAACTACCTAGAAAA
AGGCGTCAAAGCTAATAGCGGCCCTAAAATCAAAGAGGGCATGGTGTTTTGCTTAGAGCCTATGGTGTGTCAAAAACAGG
GCGAGCCTAAAATACTAGCGGATAAGTGGAGCGTGGTTTCAGTGGATGGGCTTAACACAAGCCACCATGAGCATACTATC
GCCATAGTTGGCAATAAAGCAGTGATTCTTACGGAGCGTTAA

Upstream 100 bases:

>100_bases
CGGTGCTGATTGTGGTTCAAGTCGCTATTGATACCATGAAAAAGATTGAAGCGCAAATTTATATGAGCAAGTATAAAACT
TTAAGCGCGGTAGGCTTTTA

Downstream 100 bases:

>100_bases
TGGCAAGAGATGATGTTATAGAAGTGGATGGGAAAGTGATTGAGGCGTTGCCTAACGCCACTTTTAAGGTGGAGTTAGAC
AATAAGCATGTGGTGTTGTG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MAISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKGLYGFPNSVCMSLNEVVIHGI
PTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGTISPQDEKLLACSEESLMHAISSIRVGMHFKELSQILEGAIVERGF
VPLKGFCGHGIGKKPHEEPEIPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
AIVGNKAVILTER

Sequences:

>Translated_253_residues
MAISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKGLYGFPNSVCMSLNEVVIHGI
PTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGTISPQDEKLLACSEESLMHAISSIRVGMHFKELSQILEGAIVERGF
VPLKGFCGHGIGKKPHEEPEIPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
AIVGNKAVILTER
>Mature_252_residues
AISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKGLYGFPNSVCMSLNEVVIHGIP
TDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGTISPQDEKLLACSEESLMHAISSIRVGMHFKELSQILEGAIVERGFV
PLKGFCGHGIGKKPHEEPEIPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTIA
IVGNKAVILTER

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=32.6693227091633, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=33.8645418326693, Blast_Score=152, Evalue=2e-37,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=38.4313725490196, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789275, Length=222, Percent_Identity=26.1261261261261, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788728, Length=209, Percent_Identity=24.4019138755981, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=252, Percent_Identity=30.5555555555556, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=34.3873517786561, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=30.2788844621514, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=33.7349397590361, Blast_Score=144, Evalue=5e-35,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27493; Mature: 27362

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKG
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHH
LYGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGTISPQD
HCCCCHHHHHHHHHHEEECCCHHHEEECCCEEEEEECEEECCEECCCEEEEEECCCCCCC
EKLLACSEESLMHAISSIRVGMHFKELSQILEGAIVERGFVPLKGFCGHGIGKKPHEEPE
CCEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
IPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
CCHHHHHCCCCCCCCCHHHCEEEEECCHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEE
AIVGNKAVILTER
EEECCEEEEEECC
>Mature Secondary Structure 
AISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHH
LYGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGTISPQD
HCCCCHHHHHHHHHHEEECCCHHHEEECCCEEEEEECEEECCEECCCEEEEEECCCCCCC
EKLLACSEESLMHAISSIRVGMHFKELSQILEGAIVERGFVPLKGFCGHGIGKKPHEEPE
CCEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
IPNYLEKGVKANSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
CCHHHHHCCCCCCCCCHHHCEEEEECCHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEE
AIVGNKAVILTER
EEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]