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The map label for this gene is fmt [H]

Identifier: 108563504

GI number: 108563504

Start: 1132483

End: 1133400

Strand: Reverse

Name: fmt [H]

Synonym: HPAG1_1079

Alternate gene names: 108563504

Gene position: 1133400-1132483 (Counterclockwise)

Preceding gene: 108563505

Following gene: 108563503

Centisome position: 71.0

GC content: 39.54

Gene sequence:

>918_bases
ATGCGCATCGTATTTATGGGAACGCCGGGGTTTGCTGAAGTGATCTTAAGGGCGTTGGTTGAAAATAAAAATAACCATAT
AGAAGTGGTGGGGCTATTCACGCAGATGGATAAACCTTTTGGGCGTAAAAAGGAATTGAAAGCCCCAGAGACTAAAACAT
ACATTTTAGAAAATCATTTAAATATCCCTATTTTCCAGCCACAAAGTTTGAAAGAGCCTGAAGTTCAAATCTTAAAAGAT
CTAAAGCCTGATTTTATCGTGGTGGTGGCTTATGGTAAGATTTTGCCTAAAGAGGTTTTAACCATCGCTCCTTGCATCAA
TGCGCACGCCTCTTTATTGCCCAAATATAGGGGGGCTTCGCCCATTCATGAGATGATACTCAATGACGATAGGATTTATG
GCATAAGCACCATGCTTATGGATTTGGAATTGGATAGCGGGGATATTTTAGAAAGTGCTTCTTTTTTGAGAGAAGATTAT
TTGGATTTGGACGCTTTAAGTTTAAAATTAGCGCATATGGGAGCGGATCTACTTTTTTCAACGCTCAAAAATTTCTCTTC
CATCACAAGAAAGCCTCAAGATCATATGCAAGCTACTTTTTGTAAAAAAATCACCAAAGCCGATGGTTTAGTGGGTTTTA
AAGACGCTAAAAGCTTGTTTTTAAAATCGCTTGCGTTTAAATCTTGGCCAGAAATCTTTTTGGAAAATAGCCTCAAGCTT
TTAGAAGTGGGGTTGGTGGAGAATGAAAAGAGCCACAAGGAAGGCGAGATTTTAGAAATTGATGAAAAAGGCGTTCTTGT
AGGTTGTTTGAAAGGCAGCGTGCGTGTAGCTTGGTTGCAAGCGGTGGGTAAAAAGCCTTTGAAAGCGAAGGATTATTTGA
ATGGCAGGCGTTTGAAAATAGGCGGTATTTTGGCATGA

Upstream 100 bases:

>100_bases
GTCCAAGAATTTGCCAGAATAGCTATTAATGCTATGAAAATTTTAAATCCCTATCAAACACAATCTTATATGGGGAGTGT
GGATAAAAACAAGGAATAAC

Downstream 100 bases:

>100_bases
GAAAATGTGAAAAAAGGGTTTTTGATAGCCTGCCTTCCACGCAAACCTATCTTTTAGAAAAACTTAAAAGTAATGAACTC
AAAGCCCCTGTTTTAGTCTT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRIVFMGTPGFAEVILRALVENKNNHIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKEPEVQILKD
LKPDFIVVVAYGKILPKEVLTIAPCINAHASLLPKYRGASPIHEMILNDDRIYGISTMLMDLELDSGDILESASFLREDY
LDLDALSLKLAHMGADLLFSTLKNFSSITRKPQDHMQATFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKL
LEVGLVENEKSHKEGEILEIDEKGVLVGCLKGSVRVAWLQAVGKKPLKAKDYLNGRRLKIGGILA

Sequences:

>Translated_305_residues
MRIVFMGTPGFAEVILRALVENKNNHIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKEPEVQILKD
LKPDFIVVVAYGKILPKEVLTIAPCINAHASLLPKYRGASPIHEMILNDDRIYGISTMLMDLELDSGDILESASFLREDY
LDLDALSLKLAHMGADLLFSTLKNFSSITRKPQDHMQATFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKL
LEVGLVENEKSHKEGEILEIDEKGVLVGCLKGSVRVAWLQAVGKKPLKAKDYLNGRRLKIGGILA
>Mature_305_residues
MRIVFMGTPGFAEVILRALVENKNNHIEVVGLFTQMDKPFGRKKELKAPETKTYILENHLNIPIFQPQSLKEPEVQILKD
LKPDFIVVVAYGKILPKEVLTIAPCINAHASLLPKYRGASPIHEMILNDDRIYGISTMLMDLELDSGDILESASFLREDY
LDLDALSLKLAHMGADLLFSTLKNFSSITRKPQDHMQATFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKL
LEVGLVENEKSHKEGEILEIDEKGVLVGCLKGSVRVAWLQAVGKKPLKAKDYLNGRRLKIGGILA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=325, Percent_Identity=25.8461538461538, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1789683, Length=308, Percent_Identity=37.6623376623377, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1788589, Length=220, Percent_Identity=26.8181818181818, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550868, Length=312, Percent_Identity=29.8076923076923, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=31.5555555555556, Blast_Score=94, Evalue=9e-20,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34142; Mature: 34142

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVFMGTPGFAEVILRALVENKNNHIEVVGLFTQMDKPFGRKKELKAPETKTYILENHL
CEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCC
NIPIFQPQSLKEPEVQILKDLKPDFIVVVAYGKILPKEVLTIAPCINAHASLLPKYRGAS
CCCEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PIHEMILNDDRIYGISTMLMDLELDSGDILESASFLREDYLDLDALSLKLAHMGADLLFS
HHHHHHCCCCCEEEHEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TLKNFSSITRKPQDHMQATFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LEVGLVENEKSHKEGEILEIDEKGVLVGCLKGSVRVAWLQAVGKKPLKAKDYLNGRRLKI
EEEEECCCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCHHHCCCCCEEEE
GGILA
CCCCC
>Mature Secondary Structure
MRIVFMGTPGFAEVILRALVENKNNHIEVVGLFTQMDKPFGRKKELKAPETKTYILENHL
CEEEEECCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEECCC
NIPIFQPQSLKEPEVQILKDLKPDFIVVVAYGKILPKEVLTIAPCINAHASLLPKYRGAS
CCCEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
PIHEMILNDDRIYGISTMLMDLELDSGDILESASFLREDYLDLDALSLKLAHMGADLLFS
HHHHHHCCCCCEEEHEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TLKNFSSITRKPQDHMQATFCKKITKADGLVGFKDAKSLFLKSLAFKSWPEIFLENSLKL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LEVGLVENEKSHKEGEILEIDEKGVLVGCLKGSVRVAWLQAVGKKPLKAKDYLNGRRLKI
EEEEECCCCCCCCCCCEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCHHHCCCCCEEEE
GGILA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA