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The map label for this gene is birA [C]

Identifier: 108563503

GI number: 108563503

Start: 1131848

End: 1132486

Strand: Reverse

Name: birA [C]

Synonym: HPAG1_1078

Alternate gene names: 108563503

Gene position: 1132486-1131848 (Counterclockwise)

Preceding gene: 108563504

Following gene: 108563502

Centisome position: 70.94

GC content: 39.59

Gene sequence:

>639_bases
ATGAGAAAATGTGAAAAAAGGGTTTTTGATAGCCTGCCTTCCACGCAAACCTATCTTTTAGAAAAACTTAAAAGTAATGA
ACTCAAAGCCCCTGTTTTAGTCTTGGCTAAAAACCAAAGCGCTGGGATAGGCAGTAGGGGGAATATTTGGGAGGGCGCAA
AAAGCGCTTTGACTTTTTCGCTCGCTTTAAACGCAAGCGATTTGCCTAACGATTTACCCATGCAAGCGAACGCTTTGTAT
TTAGGGTTTTTATTCAAAGAAGTTTTAAAAGAGCTAGGCTCTCAAACCTGGCTTAAATGGCCTAACGACTTGTATTTAGG
GGATCAAAAAATAGGGGGCGTGTTGGTTAATGTTTATAAAGACATGCGGGTGTGTGGGATTGGCGTGAATAGGGTTTCAA
AGAAATGGGCATGTTTAGATATTGGTGCGAGCGACGATTTGATTATAGAGGGCTTTTTAAAAAAAATAGAAGAAAATCTG
TTTTGGGGGGAAGTTTTAAGTAAGTATGCGTTAGAATTCCATAAAAACCACTCTTTTAGCTTCCATAATGATTGGGGCGA
AGCGGTGAGTTTGAAAGATGCGGAATTGTTAGAAGACGGCCGCATTTGTATTAAAGGTAAGATTTATGATAGGATGTGA

Upstream 100 bases:

>100_bases
GCAGCGTGCGTGTAGCTTGGTTGCAAGCGGTGGGTAAAAAGCCTTTGAAAGCGAAGGATTATTTGAATGGCAGGCGTTTG
AAAATAGGCGGTATTTTGGC

Downstream 100 bases:

>100_bases
GTATGATGAGTGAAATCATTGCAGTGGCTAATCAAAAAGGGGGTGTGGGCAAAACGACAACAGCGGTTAATTTATCGGCT
TCTTTAGCGGTGCATGAAAA

Product: biotin--protein ligase

Products: AMP; diphosphate; [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

Alternate protein names: Biotin/Acetyl-CoA-Carboxylase Ligase; Biotin-[Acetyl-CoA-Carboxylase] Synthetase; Biotin-[Acetyl-CoA-Carboxylase] Ligase; Biotin Operon Repressor; Biotin-(Acetyl-CoA-Carboxylase) Ligase; Biotin-Acetyl-CoA-Carboxylase Ligase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRKCEKRVFDSLPSTQTYLLEKLKSNELKAPVLVLAKNQSAGIGSRGNIWEGAKSALTFSLALNASDLPNDLPMQANALY
LGFLFKEVLKELGSQTWLKWPNDLYLGDQKIGGVLVNVYKDMRVCGIGVNRVSKKWACLDIGASDDLIIEGFLKKIEENL
FWGEVLSKYALEFHKNHSFSFHNDWGEAVSLKDAELLEDGRICIKGKIYDRM

Sequences:

>Translated_212_residues
MRKCEKRVFDSLPSTQTYLLEKLKSNELKAPVLVLAKNQSAGIGSRGNIWEGAKSALTFSLALNASDLPNDLPMQANALY
LGFLFKEVLKELGSQTWLKWPNDLYLGDQKIGGVLVNVYKDMRVCGIGVNRVSKKWACLDIGASDDLIIEGFLKKIEENL
FWGEVLSKYALEFHKNHSFSFHNDWGEAVSLKDAELLEDGRICIKGKIYDRM
>Mature_212_residues
MRKCEKRVFDSLPSTQTYLLEKLKSNELKAPVLVLAKNQSAGIGSRGNIWEGAKSALTFSLALNASDLPNDLPMQANALY
LGFLFKEVLKELGSQTWLKWPNDLYLGDQKIGGVLVNVYKDMRVCGIGVNRVSKKWACLDIGASDDLIIEGFLKKIEENL
FWGEVLSKYALEFHKNHSFSFHNDWGEAVSLKDAELLEDGRICIKGKIYDRM

Specific function: Bira Acts Both As A Biotin-Operon Repressor And As The Enzyme That Synthesizes The Corepressor, Acetyl-CoA:Carbon- Dioxide Ligase. This Protein Also Activates Biotin To Form Biotinyl-5'-Adenylate And Transfers The Biotin Moiety To Biotin-Accepting Protei

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.4.15

Molecular weight: Translated: 23877; Mature: 23877

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKCEKRVFDSLPSTQTYLLEKLKSNELKAPVLVLAKNQSAGIGSRGNIWEGAKSALTFS
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEE
LALNASDLPNDLPMQANALYLGFLFKEVLKELGSQTWLKWPNDLYLGDQKIGGVLVNVYK
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHH
DMRVCGIGVNRVSKKWACLDIGASDDLIIEGFLKKIEENLFWGEVLSKYALEFHKNHSFS
HHHHCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
FHNDWGEAVSLKDAELLEDGRICIKGKIYDRM
EECCCCCEECCCCHHHHCCCCEEEEEEECCCC
>Mature Secondary Structure
MRKCEKRVFDSLPSTQTYLLEKLKSNELKAPVLVLAKNQSAGIGSRGNIWEGAKSALTFS
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEE
LALNASDLPNDLPMQANALYLGFLFKEVLKELGSQTWLKWPNDLYLGDQKIGGVLVNVYK
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHH
DMRVCGIGVNRVSKKWACLDIGASDDLIIEGFLKKIEENLFWGEVLSKYALEFHKNHSFS
HHHHCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
FHNDWGEAVSLKDAELLEDGRICIKGKIYDRM
EECCCCCEECCCCHHHHCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; biotin; apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

Specific reaction: ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

General reaction: Amination; Carboxylic acid formation (carboxamide formation [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA