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The map label for this gene is adhA [H]

Identifier: 108563467

GI number: 108563467

Start: 1097253

End: 1098299

Strand: Direct

Name: adhA [H]

Synonym: HPAG1_1042

Alternate gene names: 108563467

Gene position: 1097253-1098299 (Clockwise)

Preceding gene: 108563466

Following gene: 108563470

Centisome position: 68.73

GC content: 41.74

Gene sequence:

>1047_bases
ATGAGAGTTCCATCTAAAGGTTTTGCTATTTTTTCTAAAGACGGGCATTTCAAACCCCATGACTTTAGCCGCCATGCTGT
AGGCCCTAAAGATGTGTTGATTGACATTCTTTATGCAGGGATTTGCCATAGCGATGTTCATAGCGCTTATAGCGAATGGA
AAGAAGGCATTTACCCTATGGTTCCTGGGCATGAGATTGCTGGGGTCATCAAAGAAGTGGGTAAGGAAGTTAAGAAATTT
AAGGTTGGCGATGTGGTGGGCGTGGGCTGTTTTGTCAATTCATGCAAAGCGTGTAAGCCCTGTAAAGAACACCAAGAGCA
GTTTTGTGCCAAAGTGGTATTTACTTATGATTGTTTGGATTCTTTCCATGGCAACGAACCCCACATGGGCGGATACTCTA
ATAATATTGTCGTGGATGAAAACTATGTGATTAGCGTGGATAAAAACGCTCCTTTAGAAAAAGTAGCCCCCTTGCTTTGC
GCGGGCATCACCACTTATTCGCCCTTAAAATTTTCTAAGGTTACTAAAGGCACAAAAGTTGGCGTCGCTGGGTTTGGCGG
GCTAGGAAGCATGGCGGTTAAATACGCTGTGGCTATGGGGGCTGAAGTGAGCGTTTTTGCAAGAAACGAACACAAAAAGC
AAGACGCTTTGAGCATGGGGGTTAAACATTTCTACACTGACCCTAAACAATGCAAAGAGGAATTGGACTTTGTCATTTCA
ACCATCCCTACCCATTATGATTTAAAAGACTACCTCAAGCTCTTAACTTATAGTGGCGAATTAGCCCTTGTAGGGCTTCC
TCCTGTAGAAGTTGCTCCAGCACTCAATATTTTTGAATTTATCCATTTGGGAAATCGTAAGGTTTATGGCTCATTGATTG
GGGGCATTAAAGAAACCCAAGAGATGATGGATTTTTCTATCAAACACAATATTTACCCTGAAATAGATTTGATTTTAGGC
AAGGATATTGACACCGCTTATCATAACCTAACCCATGGGAAAGCGAAATTCCGCTATGTGATTGATATGAAAAAATCGTT
TGATTAA

Upstream 100 bases:

>100_bases
CCATATAGCCAATAACTATCAAATTAGTTAAACCTATAGAAACATAAGCAAACCACAAAAACGATACAATAGCGGTATTT
TAATGAAACAAGGAGTTTTA

Downstream 100 bases:

>100_bases
AGGCTTTGACTCTAGCTCTTTCTTAAGAGCTTGAGTTGGATTAGGATTTTTTTGGCTAGTGCATGGAGTCCTAGGATTTT
AAGGGTTTTACTAATAAGGC

Product: mannitol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MRVPSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDVHSAYSEWKEGIYPMVPGHEIAGVIKEVGKEVKKF
KVGDVVGVGCFVNSCKACKPCKEHQEQFCAKVVFTYDCLDSFHGNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLC
AGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQDALSMGVKHFYTDPKQCKEELDFVIS
TIPTHYDLKDYLKLLTYSGELALVGLPPVEVAPALNIFEFIHLGNRKVYGSLIGGIKETQEMMDFSIKHNIYPEIDLILG
KDIDTAYHNLTHGKAKFRYVIDMKKSFD

Sequences:

>Translated_348_residues
MRVPSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDVHSAYSEWKEGIYPMVPGHEIAGVIKEVGKEVKKF
KVGDVVGVGCFVNSCKACKPCKEHQEQFCAKVVFTYDCLDSFHGNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLC
AGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQDALSMGVKHFYTDPKQCKEELDFVIS
TIPTHYDLKDYLKLLTYSGELALVGLPPVEVAPALNIFEFIHLGNRKVYGSLIGGIKETQEMMDFSIKHNIYPEIDLILG
KDIDTAYHNLTHGKAKFRYVIDMKKSFD
>Mature_348_residues
MRVPSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDVHSAYSEWKEGIYPMVPGHEIAGVIKEVGKEVKKF
KVGDVVGVGCFVNSCKACKPCKEHQEQFCAKVVFTYDCLDSFHGNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLC
AGITTYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQDALSMGVKHFYTDPKQCKEELDFVIS
TIPTHYDLKDYLKLLTYSGELALVGLPPVEVAPALNIFEFIHLGNRKVYGSLIGGIKETQEMMDFSIKHNIYPEIDLILG
KDIDTAYHNLTHGKAKFRYVIDMKKSFD

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=320, Percent_Identity=28.4375, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI34577061, Length=313, Percent_Identity=28.4345047923323, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=26.775956284153, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4501939, Length=366, Percent_Identity=26.775956284153, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4501929, Length=313, Percent_Identity=27.1565495207668, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI71565154, Length=207, Percent_Identity=30.9178743961353, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI71743840, Length=319, Percent_Identity=25.705329153605, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI262073058, Length=319, Percent_Identity=25.705329153605, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1786518, Length=352, Percent_Identity=41.4772727272727, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI87082401, Length=348, Percent_Identity=32.183908045977, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI87081918, Length=347, Percent_Identity=26.8011527377522, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790045, Length=279, Percent_Identity=26.5232974910394, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788075, Length=285, Percent_Identity=27.719298245614, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788073, Length=260, Percent_Identity=26.1538461538462, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=321, Percent_Identity=28.6604361370716, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=324, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=331, Percent_Identity=26.2839879154079, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=204, Percent_Identity=33.8235294117647, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=185, Percent_Identity=33.5135135135135, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=184, Percent_Identity=33.695652173913, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=180, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=181, Percent_Identity=30.3867403314917, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=352, Percent_Identity=28.4090909090909, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323980, Length=361, Percent_Identity=31.0249307479224, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319621, Length=360, Percent_Identity=28.0555555555556, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323961, Length=359, Percent_Identity=27.2980501392758, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324486, Length=359, Percent_Identity=27.5766016713092, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319949, Length=344, Percent_Identity=29.9418604651163, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320033, Length=304, Percent_Identity=28.9473684210526, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=387, Percent_Identity=26.8733850129199, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=327, Percent_Identity=24.7706422018349, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737895, Length=185, Percent_Identity=31.8918918918919, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137530, Length=219, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=213, Percent_Identity=29.1079812206573, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 38509; Mature: 38509

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVPSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDVHSAYSEWKEGIYPM
CCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VPGHEIAGVIKEVGKEVKKFKVGDVVGVGCFVNSCKACKPCKEHQEQFCAKVVFTYDCLD
CCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SFHGNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLKFSKVTKGTKV
HHCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCEE
GVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQDALSMGVKHFYTDPKQCKEELDFVIS
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TIPTHYDLKDYLKLLTYSGELALVGLPPVEVAPALNIFEFIHLGNRKVYGSLIGGIKETQ
HCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEHHHHHCCHHHHH
EMMDFSIKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
HHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCCC
>Mature Secondary Structure
MRVPSKGFAIFSKDGHFKPHDFSRHAVGPKDVLIDILYAGICHSDVHSAYSEWKEGIYPM
CCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VPGHEIAGVIKEVGKEVKKFKVGDVVGVGCFVNSCKACKPCKEHQEQFCAKVVFTYDCLD
CCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SFHGNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLKFSKVTKGTKV
HHCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCEE
GVAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQDALSMGVKHFYTDPKQCKEELDFVIS
CCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TIPTHYDLKDYLKLLTYSGELALVGLPPVEVAPALNIFEFIHLGNRKVYGSLIGGIKETQ
HCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEHHHHHCCHHHHH
EMMDFSIKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKSFD
HHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]