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The map label for this gene is hbpA [H]

Identifier: 108562725

GI number: 108562725

Start: 313066

End: 314715

Strand: Direct

Name: hbpA [H]

Synonym: HPAG1_0300

Alternate gene names: 108562725

Gene position: 313066-314715 (Clockwise)

Preceding gene: 108562724

Following gene: 108562726

Centisome position: 19.61

GC content: 41.58

Gene sequence:

>1650_bases
ATGAATAATGTTTTTGTTAAGGGTTTGTTTTTTTTTCTTTTTTTGTTTGGGTTCTTTTTGAAAGCTTCAGAAAGCCCAAA
CGCTACTCTTAATCCATCTAAGGAAAATGTTTCTGTTGAAGAGCAAAAGCGTTTTGGAGGCGTTTTGGTTTTTGCAAGAG
GCGCTGATGGCTCAAGCATGGATCCTGCCTTAGTAACTGATGGCGAAAGCTATGTGGCGACGGGCAATATTTATGACACG
CTCGTGCAATTCAAATACGGCACCACAGAAATTGAACCCGCCTTAGCGACAAGCTGGGACATATCCCCAGATGGTCTTGT
ATATACCTTTCATTTACGCAAAGGGGTTTATTTCCACCAGACGAAGTATTGGAATAAAAAAGTAGAGTTTAGCGCTAAAG
ATGTGCTGTTTTCGTTTGAGCGCCAAATGGACAAGGCTAAACGATACTACAGCCCAGGGGCTAAAAGCTATAAGTATTGG
GAAGGCATGGGCATGTCTCATATTATTAAGAGCATTGAAGCTTTAGATGATTACACGATCAAATTCACGCTTAATGGGCC
AGAAGCCCCGTTTTTAGCCAATTTAGGCATGGATTTTTTGAGCATTTTGAGTAAGGATTACGCTGATTATTTAGAACAAA
ATAATAAAAAAGACGAGTTAGCTAAAAAGCCTGTTGGGACAGGGCCTTTCAAATTCTTTTTGTGGAATAAAGATGAAAAA
ATCATTCTTTTAAAAAATCAGGATTATTGGGGGCCTAAAGCTTATTTAGACAAAGTGGTGGTGCGCACCATTCCTAATTC
TTCCACTCGCGCTTTAGCGTTAAGAACCGGCGAAATCATGCTAATGACCGGGCCTAACCTCAATGAAGTGGAGCAATTAG
AAAAAGTCCCTAATATCGTGGTGGACAAAAGCGCTGGGTTGTTGGCGAGTTGGCTTTCATTGAACACGCAAAAAAAGTAT
TTTAATAACCCTTTGGTGCGTTTGGCTATCAACCATGCGATTAATGTGGATGATTACATTAAGGTGATTTATGAAGGCTT
TGCCCAAAAAATGGTCAATCCTTTCCCGCCCACCATATGGGGTTATAACTACAACATCAAACCCTATGAATACGATTTGA
AAAAGGCTAAAGAGTTACTGAAAGAAGCGGGCTATCCTAACGGCTTTAAAACTACTATTTTTACCACTGCCACTCGTAAC
CCAAAAGGAGCGGTGTTCATACAAGCGAGCCTGGCTAAAATTGGCATTGATGTGAAAATTGAAGTGTATGAGTGGGGGGC
TTATTTGAAAAGAACGGGCCTGGGCGAACATGAAATGGCGTTTGCAGGCTGGATGGCAGACATTGCGGATCCGGATAATT
TCTTATACACCTTATGGAGCAAGCAAGCCGCCTCAGCCATACCCACTCAAAATGGTTCCTTTTATAAGAGCGACGCCTTT
TCCGATCTGCTCATAAAGGCTAAACGGGTTTCAGATCAAAAAGAGAGGGAAGCCCTTTATTTAAAGGCTCAAGAAATTAT
CCATAAAGACGCGCCCTATGTGCCTTTAGCCTATCCTTATTCGGTGGTGCCGCATTTGTCTAAAGTCAAAGGCTATAAGA
CGACCGGAGTGAGCGTGAATCGCTTCTTTAAGGTGTATTTAGAAAAGTGA

Upstream 100 bases:

>100_bases
TAATTAAACCTTTGGGTGTTTGTTAAACGCCTATAAACGCCATAAAATATTTATAATTTAGATCTCTATCCTTTATAGAA
TTTGTTGTGGAGACTGGCTT

Downstream 100 bases:

>100_bases
AAGGGGTTGCATGTTGAGTTTTATCATTAAGCGTATTTTGTGGGCGATCCCCACGCTGTTTGGAGTGAGCGTCATTGTGT
TTATGATGGTGCATTTAGTG

Product: periplasmic dipeptide-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MNNVFVKGLFFFLFLFGFFLKASESPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSMDPALVTDGESYVATGNIYDT
LVQFKYGTTEIEPALATSWDISPDGLVYTFHLRKGVYFHQTKYWNKKVEFSAKDVLFSFERQMDKAKRYYSPGAKSYKYW
EGMGMSHIIKSIEALDDYTIKFTLNGPEAPFLANLGMDFLSILSKDYADYLEQNNKKDELAKKPVGTGPFKFFLWNKDEK
IILLKNQDYWGPKAYLDKVVVRTIPNSSTRALALRTGEIMLMTGPNLNEVEQLEKVPNIVVDKSAGLLASWLSLNTQKKY
FNNPLVRLAINHAINVDDYIKVIYEGFAQKMVNPFPPTIWGYNYNIKPYEYDLKKAKELLKEAGYPNGFKTTIFTTATRN
PKGAVFIQASLAKIGIDVKIEVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
SDLLIKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVNRFFKVYLEK

Sequences:

>Translated_549_residues
MNNVFVKGLFFFLFLFGFFLKASESPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSMDPALVTDGESYVATGNIYDT
LVQFKYGTTEIEPALATSWDISPDGLVYTFHLRKGVYFHQTKYWNKKVEFSAKDVLFSFERQMDKAKRYYSPGAKSYKYW
EGMGMSHIIKSIEALDDYTIKFTLNGPEAPFLANLGMDFLSILSKDYADYLEQNNKKDELAKKPVGTGPFKFFLWNKDEK
IILLKNQDYWGPKAYLDKVVVRTIPNSSTRALALRTGEIMLMTGPNLNEVEQLEKVPNIVVDKSAGLLASWLSLNTQKKY
FNNPLVRLAINHAINVDDYIKVIYEGFAQKMVNPFPPTIWGYNYNIKPYEYDLKKAKELLKEAGYPNGFKTTIFTTATRN
PKGAVFIQASLAKIGIDVKIEVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
SDLLIKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVNRFFKVYLEK
>Mature_549_residues
MNNVFVKGLFFFLFLFGFFLKASESPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSMDPALVTDGESYVATGNIYDT
LVQFKYGTTEIEPALATSWDISPDGLVYTFHLRKGVYFHQTKYWNKKVEFSAKDVLFSFERQMDKAKRYYSPGAKSYKYW
EGMGMSHIIKSIEALDDYTIKFTLNGPEAPFLANLGMDFLSILSKDYADYLEQNNKKDELAKKPVGTGPFKFFLWNKDEK
IILLKNQDYWGPKAYLDKVVVRTIPNSSTRALALRTGEIMLMTGPNLNEVEQLEKVPNIVVDKSAGLLASWLSLNTQKKY
FNNPLVRLAINHAINVDDYIKVIYEGFAQKMVNPFPPTIWGYNYNIKPYEYDLKKAKELLKEAGYPNGFKTTIFTTATRN
PKGAVFIQASLAKIGIDVKIEVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
SDLLIKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVNRFFKVYLEK

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=508, Percent_Identity=39.1732283464567, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1787551, Length=481, Percent_Identity=30.1455301455301, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1787052, Length=493, Percent_Identity=31.4401622718053, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1787762, Length=493, Percent_Identity=29.8174442190669, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789887, Length=485, Percent_Identity=26.3917525773196, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1787495, Length=492, Percent_Identity=26.6260162601626, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1789397, Length=498, Percent_Identity=25.3012048192771, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081878, Length=486, Percent_Identity=25.7201646090535, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 62338; Mature: 62338

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00501 SPASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVFVKGLFFFLFLFGFFLKASESPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSM
CCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCC
DPALVTDGESYVATGNIYDTLVQFKYGTTEIEPALATSWDISPDGLVYTFHLRKGVYFHQ
CCCEEECCCCEEEECCHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEE
TKYWNKKVEFSAKDVLFSFERQMDKAKRYYSPGAKSYKYWEGMGMSHIIKSIEALDDYTI
HHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCEEE
KFTLNGPEAPFLANLGMDFLSILSKDYADYLEQNNKKDELAKKPVGTGPFKFFLWNKDEK
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCE
IILLKNQDYWGPKAYLDKVVVRTIPNSSTRALALRTGEIMLMTGPNLNEVEQLEKVPNIV
EEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEECCCHHHHHHHHHCCCEE
VDKSAGLLASWLSLNTQKKYFNNPLVRLAINHAINVDDYIKVIYEGFAQKMVNPFPPTIW
EECCCCHHHHHHHCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
GYNYNIKPYEYDLKKAKELLKEAGYPNGFKTTIFTTATRNPKGAVFIQASLAKIGIDVKI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEEHHHCCCEEEE
EVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
EEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCCEECCCCH
SDLLIKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCEECCCCHH
RFFKVYLEK
HEEEEEECC
>Mature Secondary Structure
MNNVFVKGLFFFLFLFGFFLKASESPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSM
CCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCC
DPALVTDGESYVATGNIYDTLVQFKYGTTEIEPALATSWDISPDGLVYTFHLRKGVYFHQ
CCCEEECCCCEEEECCHHHHHHHEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEE
TKYWNKKVEFSAKDVLFSFERQMDKAKRYYSPGAKSYKYWEGMGMSHIIKSIEALDDYTI
HHHCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCEEE
KFTLNGPEAPFLANLGMDFLSILSKDYADYLEQNNKKDELAKKPVGTGPFKFFLWNKDEK
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCE
IILLKNQDYWGPKAYLDKVVVRTIPNSSTRALALRTGEIMLMTGPNLNEVEQLEKVPNIV
EEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEECCCHHHHHHHHHCCCEE
VDKSAGLLASWLSLNTQKKYFNNPLVRLAINHAINVDDYIKVIYEGFAQKMVNPFPPTIW
EECCCCHHHHHHHCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
GYNYNIKPYEYDLKKAKELLKEAGYPNGFKTTIFTTATRNPKGAVFIQASLAKIGIDVKI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEEHHHCCCEEEE
EVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
EEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCCEECCCCH
SDLLIKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCEECCCCHH
RFFKVYLEK
HEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]