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The map label for this gene is gppA [H]

Identifier: 108562705

GI number: 108562705

Start: 282796

End: 284250

Strand: Direct

Name: gppA [H]

Synonym: HPAG1_0280

Alternate gene names: 108562705

Gene position: 282796-284250 (Clockwise)

Preceding gene: 108562704

Following gene: 108562706

Centisome position: 17.71

GC content: 41.72

Gene sequence:

>1455_bases
ATGGCTAAAATCACAACCGTGATTGATATAGGCTCTAATTCAGTGCGTTTGGCTATCTTTAAAAAGACGAGTCAGTTTGG
GTTTTACTTGCTTTTTGAAACCAAATCTAGGGTTAGGATTTCAGAGGGCTGTTATGCGTTTAATGGAATCTTACAAGAAA
TCCCCATGCAAAGAGCCATTAAAGCCTTGAGCGAATTTAAAGAAATCGCCCTTAAATACAAAAGCAAAAAAATCTTATGC
GTGGCGACCTCAGCGGTGCGCGATGCCCCTAATCGGCTGGAGTTTGTAGCGAGGGTGAAAAAGGCTTGCGGTTTGCAAAT
CAAAATCATTGATGGGCAAAAAGAAGCGCTCTATGGCGGGGTTGCGTGCGCGAATTTGTTGCATAAAAATTCAGGGATCA
CGATAGATATTGGAGGGGGTAGCACCGAGTGCGCGTTGATTGAAAAAGGCAAGATTAAGGATCTCATCTCGCTTGATGTT
GGGACGATTCGCATTAAAGAAATGTTTTTAGACAAAGACTTAGAGGTCAAATTGGCTAAAGCCTTTATCCAAAAAGAGGT
TTCTAAACTGCCCTTTAAGCACAAAAACGCCTTTGGGGTGGGAGGGACGATCAGAGCGTTGAGTAAGGTATTGATGAAAC
GCTTTTGTTACCCTATTGATTCTTTGCATGGTTATGAAATAGACGCACATAAAAATTTAGCGTTCATTGAAAAGATTGTC
ACGCTCAAAGAAGATCAATTACGGCTTTTGGGGGTGAATGAAGAGCGTTTGGATAGCATCAGGAGCGGGGCGTTGATTTT
ATCAGTCGTTTTGGAGCATTTAAAAACTTCTTTGATGATCACTAGCGGCGTAGGGGTGAGAGAAGGCGTGTTTTTAAGCG
ATTTATTGCGCCACCATTACCATAAATTCCCCCCCAATATCAACCCCTCTCTCATCTCTTTAAAAGATCGCTTTTTGCCC
CATGAAAAACACAGCCAAAAGGTCAAAAAAGAATGCGTGAAATTGTTTGAAGCCTTATCGCCCTTGCATAAAATAGATGA
AAAATACCTTTTCCATTTAAAGATTGCGGGGGAATTAGCGAGCATGGGTAAGATTTTAAGCGTCTATTTAGCCCACAAGC
ACAGCGCGTATTTTATTTTAAACGCTTTGAGTTATGGCTTTAGCCACCAGGATAGAGCGATCATTTGCTTATTGGCGCAA
TTCAGCCATAAAAAAATCCCTAAAGACAACGCTATCGCCCACATGAGCGCGATGATGCCAAGCCTTTTAACCTTGCAATG
GCTGAGTTTTATCCTTTCTTTGGCCGAAAATTTGTGCCTGACAGACAGCCATCATCTAAAATACACGCTAGAAAAAAACA
AGCTTGTGATCCATTCTAGCGATACGCTTTACTTGGCTAAAGAGATGCTCCCTAAACTCGTTAAGCCCATTGCTTTGATG
ATAGAGTTTGCTTGA

Upstream 100 bases:

>100_bases
CCCTGTAGATGCGATTTTACCGGATCCTAACAATGCAGAGAGCAAAGAGGAATTGAAATACAAATACGAAAGCTTAAAAG
AGCAAGATTAAAGGCTAGCA

Downstream 100 bases:

>100_bases
AAATAGCGATTGTCAGGCTTTCAGCGCTTGGGGATATTATTGTGAGCGCGGTGTTTTTAGCGGCTATCAAAGAGCGTTTT
ACTGACGCTCAAATAGAATG

Product: guanosine pentaphosphate phosphohydrolase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFNGILQEIPMQRAIKALSEFKEIALKYKSKKILC
VATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGGVACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDV
GTIRIKEMFLDKDLEVKLAKAFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFCYPIDSLHGYEIDAHKNLAFIEKIV
TLKEDQLRLLGVNEERLDSIRSGALILSVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLISLKDRFLP
HEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQ
FSHKKIPKDNAIAHMSAMMPSLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSSDTLYLAKEMLPKLVKPIALM
IEFA

Sequences:

>Translated_484_residues
MAKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFNGILQEIPMQRAIKALSEFKEIALKYKSKKILC
VATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGGVACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDV
GTIRIKEMFLDKDLEVKLAKAFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFCYPIDSLHGYEIDAHKNLAFIEKIV
TLKEDQLRLLGVNEERLDSIRSGALILSVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLISLKDRFLP
HEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQ
FSHKKIPKDNAIAHMSAMMPSLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSSDTLYLAKEMLPKLVKPIALM
IEFA
>Mature_483_residues
AKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFNGILQEIPMQRAIKALSEFKEIALKYKSKKILCV
ATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGGVACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDVG
TIRIKEMFLDKDLEVKLAKAFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFCYPIDSLHGYEIDAHKNLAFIEKIVT
LKEDQLRLLGVNEERLDSIRSGALILSVVLEHLKTSLMITSGVGVREGVFLSDLLRHHYHKFPPNINPSLISLKDRFLPH
EKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELASMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQF
SHKKIPKDNAIAHMSAMMPSLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSSDTLYLAKEMLPKLVKPIALMI
EFA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=455, Percent_Identity=24.3956043956044, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788848, Length=430, Percent_Identity=25.3488372093023, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321185, Length=442, Percent_Identity=23.3031674208145, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 54337; Mature: 54206

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFNGILQEIPMQRAI
CCEEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCEEECCCHHHHHHHHHHCCHHHHH
KALSEFKEIALKYKSKKILCVATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGG
HHHHHHHHHHHHHCCCEEEEEEEHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
VACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDVGTIRIKEMFLDKDLEVKLAK
HHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHCCCCCEEEEHHHHCCCCHHHHHH
AFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFCYPIDSLHGYEIDAHKNLAFIEKIV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHH
TLKEDQLRLLGVNEERLDSIRSGALILSVVLEHLKTSLMITSGVGVREGVFLSDLLRHHY
HCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
HKFPPNINPSLISLKDRFLPHEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELA
HCCCCCCCCHHEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHH
SMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQFSHKKIPKDNAIAHMSAMMP
HHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHH
SLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSSDTLYLAKEMLPKLVKPIALM
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHH
IEFA
EECC
>Mature Secondary Structure 
AKITTVIDIGSNSVRLAIFKKTSQFGFYLLFETKSRVRISEGCYAFNGILQEIPMQRAI
CEEEEEEEECCCCEEEEEEEECCCCEEEEEEECCCCEEECCCHHHHHHHHHHCCHHHHH
KALSEFKEIALKYKSKKILCVATSAVRDAPNRLEFVARVKKACGLQIKIIDGQKEALYGG
HHHHHHHHHHHHHCCCEEEEEEEHHHHCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
VACANLLHKNSGITIDIGGGSTECALIEKGKIKDLISLDVGTIRIKEMFLDKDLEVKLAK
HHHHHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHCCCCCEEEEHHHHCCCCHHHHHH
AFIQKEVSKLPFKHKNAFGVGGTIRALSKVLMKRFCYPIDSLHGYEIDAHKNLAFIEKIV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHH
TLKEDQLRLLGVNEERLDSIRSGALILSVVLEHLKTSLMITSGVGVREGVFLSDLLRHHY
HCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHH
HKFPPNINPSLISLKDRFLPHEKHSQKVKKECVKLFEALSPLHKIDEKYLFHLKIAGELA
HCCCCCCCCHHEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEHHHHH
SMGKILSVYLAHKHSAYFILNALSYGFSHQDRAIICLLAQFSHKKIPKDNAIAHMSAMMP
HHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHHH
SLLTLQWLSFILSLAENLCLTDSHHLKYTLEKNKLVIHSSDTLYLAKEMLPKLVKPIALM
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHH
IEFA
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA