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The map label for this gene is bioF [H]

Identifier: 103487652

GI number: 103487652

Start: 2279939

End: 2281141

Strand: Direct

Name: bioF [H]

Synonym: Sala_2171

Alternate gene names: 103487652

Gene position: 2279939-2281141 (Clockwise)

Preceding gene: 103487651

Following gene: 103487653

Centisome position: 68.16

GC content: 62.68

Gene sequence:

>1203_bases
ATGACCGACCTCTTTTCCAAATTCGACCCGCTGATCCAGCAGCGCGAGGCGCTGCTCGCGACCGGGGTCACCGATCCGTT
CAGCCTGGTGATGGAAAAGGTGCTCTCGCCCACTGTGGCGATCTGCAACGGGCGCGAGACGATCCTGCTCGGCACCTATA
ATTATATGGGCATGACCTTCGACGAGGATGTCATCGCCGCGGGCAAGGATGCACTCGACAGGTTCGGCAGCGGCACGACC
GGCAGCCGTGTGCTCAACGGCACCTATCAGGGGCACCGCGAGTGTGAAGAGGCGCTGAAGGCGTTCTACGCCATGGATCA
TGCCATGGTGTTTTCGACGGGATACCAGGCGAACCTCGGCATCATCAGCACCATCGCGGGCAAGGGCGATTATGTCATTC
TCGACATCGACAGCCATGCGTCAATCTATGACGGCTGCAAGATGGGCGACGCGGAAATCATCGCCTTTCGCCACAACGAC
GTCGAGGCGCTTGAAAAGCGCCTGAAGCGCCTGCCCCCCGATGCGGGCAAGCTGGTCGTACTCGAAGGCGTCTATTCGAT
GCTCGGCGACGTCGCGCCGCTCAAGGAAATGGTCCGCGTTTCCAGGGAAAATGGGGCGATGGTGCTGGTCGACGAGGCGC
ACTCGATGGGCTTCATCGGCGAACATGGGCGCGGGGTGGCCGAGGCGCAGGGTGTCATCGACGATGTCGATTTCATCATC
GGGACGTTCAGCAAAAGCGTCGGCACCGTCGGCGGCTTTTGCGTGTCGAACCACCCGAAGTTCGAGATCATGCGGCTCGT
CTGCCGCCCCTATGTCTTTACCGCATCGCTGCCGCCGAGCGTCGTCGCGACCGCCGCGACGAGCATTCGCAAGCTGATGC
ACGGCGGCAACAAACGCGCGCATCTGTGGGAAAACAGCAAGGCACTGCACAGCGGCCTTAAGCATCTGGGCTTCACGCTC
GGCACCGACGAGCCGCAGTCGGCGATCATCGCCGTCATCATGCCCGACCTCGAACGCGGCGCGATGATGTGGGAGGCGCT
GCTGGAGGAAGGACTCTATGTCAACCTCGCGCGCCCGCCCGCAACCCCCGCAGGCATGACGCTGCTCCGCTGTTCGCTCT
GCGCCGAACATTCGGCGGATCAGGTCGGCGAAATCCTGTCGCGCTTCGAACGCGCGGGCAAGCGCACGGGGATCATCGGC
TGA

Upstream 100 bases:

>100_bases
TTCCGTTCGCATCGAGCGAAGTCGAGATGCCCCTCGCACTTGCGCCATGCCGACGGGTGTCTCGACTTCGCTCGACACGA
GCGGACATTGGAACGATGAT

Downstream 100 bases:

>100_bases
ACCGCACCCGTCCCCCGACCAGCGGATTCCTTTTCGCGGCGAACCGAGTGCGCGAACGGGCAGCGGCGGCTTCGCGGCTT
TGCCGTGGCGCGCGTGTCCG

Product: glycine C-acetyltransferase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTDLFSKFDPLIQQREALLATGVTDPFSLVMEKVLSPTVAICNGRETILLGTYNYMGMTFDEDVIAAGKDALDRFGSGTT
GSRVLNGTYQGHRECEEALKAFYAMDHAMVFSTGYQANLGIISTIAGKGDYVILDIDSHASIYDGCKMGDAEIIAFRHND
VEALEKRLKRLPPDAGKLVVLEGVYSMLGDVAPLKEMVRVSRENGAMVLVDEAHSMGFIGEHGRGVAEAQGVIDDVDFII
GTFSKSVGTVGGFCVSNHPKFEIMRLVCRPYVFTASLPPSVVATAATSIRKLMHGGNKRAHLWENSKALHSGLKHLGFTL
GTDEPQSAIIAVIMPDLERGAMMWEALLEEGLYVNLARPPATPAGMTLLRCSLCAEHSADQVGEILSRFERAGKRTGIIG

Sequences:

>Translated_400_residues
MTDLFSKFDPLIQQREALLATGVTDPFSLVMEKVLSPTVAICNGRETILLGTYNYMGMTFDEDVIAAGKDALDRFGSGTT
GSRVLNGTYQGHRECEEALKAFYAMDHAMVFSTGYQANLGIISTIAGKGDYVILDIDSHASIYDGCKMGDAEIIAFRHND
VEALEKRLKRLPPDAGKLVVLEGVYSMLGDVAPLKEMVRVSRENGAMVLVDEAHSMGFIGEHGRGVAEAQGVIDDVDFII
GTFSKSVGTVGGFCVSNHPKFEIMRLVCRPYVFTASLPPSVVATAATSIRKLMHGGNKRAHLWENSKALHSGLKHLGFTL
GTDEPQSAIIAVIMPDLERGAMMWEALLEEGLYVNLARPPATPAGMTLLRCSLCAEHSADQVGEILSRFERAGKRTGIIG
>Mature_399_residues
TDLFSKFDPLIQQREALLATGVTDPFSLVMEKVLSPTVAICNGRETILLGTYNYMGMTFDEDVIAAGKDALDRFGSGTTG
SRVLNGTYQGHRECEEALKAFYAMDHAMVFSTGYQANLGIISTIAGKGDYVILDIDSHASIYDGCKMGDAEIIAFRHNDV
EALEKRLKRLPPDAGKLVVLEGVYSMLGDVAPLKEMVRVSRENGAMVLVDEAHSMGFIGEHGRGVAEAQGVIDDVDFIIG
TFSKSVGTVGGFCVSNHPKFEIMRLVCRPYVFTASLPPSVVATAATSIRKLMHGGNKRAHLWENSKALHSGLKHLGFTLG
TDEPQSAIIAVIMPDLERGAMMWEALLEEGLYVNLARPPATPAGMTLLRCSLCAEHSADQVGEILSRFERAGKRTGIIG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=31.8965517241379, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=31.8965517241379, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI83977442, Length=352, Percent_Identity=32.3863636363636, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI83977440, Length=352, Percent_Identity=32.3863636363636, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI83977444, Length=352, Percent_Identity=32.3863636363636, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=28.5326086956522, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4758668, Length=363, Percent_Identity=30.0275482093664, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI4502025, Length=364, Percent_Identity=30.7692307692308, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI40316939, Length=364, Percent_Identity=30.7692307692308, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI5454084, Length=298, Percent_Identity=31.5436241610738, Blast_Score=151, Evalue=8e-37,
Organism=Escherichia coli, GI1790046, Length=365, Percent_Identity=33.972602739726, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=29.8850574712644, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=347, Percent_Identity=32.8530259365994, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=28.1081081081081, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=357, Percent_Identity=26.3305322128852, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=357, Percent_Identity=26.3305322128852, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71982617, Length=299, Percent_Identity=29.0969899665552, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI71982625, Length=299, Percent_Identity=29.0969899665552, Blast_Score=124, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320438, Length=352, Percent_Identity=28.6931818181818, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=26.9021739130435, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=297, Percent_Identity=24.5791245791246, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24662918, Length=386, Percent_Identity=28.4974093264249, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI17137420, Length=343, Percent_Identity=31.4868804664723, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=31.9727891156463, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=31.9727891156463, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=31.9727891156463, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI17136286, Length=352, Percent_Identity=27.2727272727273, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 43277; Mature: 43146

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLFSKFDPLIQQREALLATGVTDPFSLVMEKVLSPTVAICNGRETILLGTYNYMGMTF
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCC
DEDVIAAGKDALDRFGSGTTGSRVLNGTYQGHRECEEALKAFYAMDHAMVFSTGYQANLG
CCHHHHCCHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCC
IISTIAGKGDYVILDIDSHASIYDGCKMGDAEIIAFRHNDVEALEKRLKRLPPDAGKLVV
EEEEECCCCCEEEEEECCCCCHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEE
LEGVYSMLGDVAPLKEMVRVSRENGAMVLVDEAHSMGFIGEHGRGVAEAQGVIDDVDFII
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHCHHHHHHHHH
GTFSKSVGTVGGFCVSNHPKFEIMRLVCRPYVFTASLPPSVVATAATSIRKLMHGGNKRA
HHHHHHHCCCCCEEECCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCE
HLWENSKALHSGLKHLGFTLGTDEPQSAIIAVIMPDLERGAMMWEALLEEGLYVNLARPP
EEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCC
ATPAGMTLLRCSLCAEHSADQVGEILSRFERAGKRTGIIG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TDLFSKFDPLIQQREALLATGVTDPFSLVMEKVLSPTVAICNGRETILLGTYNYMGMTF
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCEEEEEECCCCCCCC
DEDVIAAGKDALDRFGSGTTGSRVLNGTYQGHRECEEALKAFYAMDHAMVFSTGYQANLG
CCHHHHCCHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCC
IISTIAGKGDYVILDIDSHASIYDGCKMGDAEIIAFRHNDVEALEKRLKRLPPDAGKLVV
EEEEECCCCCEEEEEECCCCCHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEE
LEGVYSMLGDVAPLKEMVRVSRENGAMVLVDEAHSMGFIGEHGRGVAEAQGVIDDVDFII
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHCHHHHHHHHH
GTFSKSVGTVGGFCVSNHPKFEIMRLVCRPYVFTASLPPSVVATAATSIRKLMHGGNKRA
HHHHHHHCCCCCEEECCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCE
HLWENSKALHSGLKHLGFTLGTDEPQSAIIAVIMPDLERGAMMWEALLEEGLYVNLARPP
EEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCC
ATPAGMTLLRCSLCAEHSADQVGEILSRFERAGKRTGIIG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]