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The map label for this gene is mltA [H]

Identifier: 103487500

GI number: 103487500

Start: 2127244

End: 2128566

Strand: Direct

Name: mltA [H]

Synonym: Sala_2017

Alternate gene names: 103487500

Gene position: 2127244-2128566 (Clockwise)

Preceding gene: 103487499

Following gene: 103487501

Centisome position: 63.59

GC content: 70.52

Gene sequence:

>1323_bases
ATGATCCGGCTTGCGGGGGCGCCACGCGCGCGTCTTTTCCGGCTCGCGCTGCTCGCCGCCTTCCCGCTCCTCTCGGGCTG
CGTGTCGGTCATTCCCGGAGCGGGCGACACCGGTCGCCCGGCGGTGTCGGCGCCCGCCCCGTCGCCGGGTCAGCCTCGCC
CCTATATTCCGCGTCCGTCCGAACGCGTCGGCGTGGCGGTCCAGCCGATCACCGCCACTCCGCGCGCACCGCTTGCCGCC
CCCGCCGTTCCCGCCGACGCGGCCACAGCGACAGCCAGCGGTGTGATCGCCGGCCCCGACTTTGCATCGCTCGGTATCTC
CACCGAACAGGCCGCGGCGGCGCTCGCCGCCTTTCGCATCAGCTGCCCCGCAATCCAGCGCCGCACCGACGCGAGCGGCC
TGACGCAGACCGCCGACTGGACAGAAAGCTGCGCCGCTGCGGCCGGCTGGGCCGACGGCGACGCTTCAGCTTTCTTTGCG
CGCTATTTCGGCACGGTGCAGATCGGCACTGGCGTGGCCTTCGTCACCGGCTATTACGAGCCCGAAATCGCCGCCTCGCG
CACCAAACGGCCGGGATATGACGTTCCCATCTATCGCCGTCCCGCCGATCTGATCGAAGTCGATCTCGGCCAGTTCGCCG
ACGATCTGAAGGGCCGCAAGATCCGCGGCCGCGTCGATGGCTCCAGTTTCGTGCGCTATCACGACCGCACCGCGATCGAA
TCGGGCGCGCTCGAAGGGCGCGGTCTCGAACTGGCCTGGGCTGCCGACGCCGCCGAATTTTTCTTCCTTCAGGTACAGGG
GTCGGGCCGCCTCCGCCTCCCCGACGGCGGCATCATGCGCATCGGATATGACGGCCAGAACGGCCGCGGCTATGTCGGCA
TCGGCAAGTTGCTGCTCGACCGCGGCGAACTGGAGCGCGGGCAGGCATCGATGCAGGGCATTCTCGATTATCTGCGCGCC
GATCCGGCGCGCGGCGCCGCGGTGATGAACGAGAACCCCAGCTGGGTCTTTTTCCGCGAACTCAACGGCCCCGGCCCCCT
CGGCGCGCTCGGCGTGCCCGTCACGGCCCGCGTCAGCGTCGCCGCCGATCCCAAATATGTGCCGCTCGGCGCCCCCGTCT
TCCTCTCGCTCGATCGCGCCGAACCGAACGGCCTCTGGATTGCGCAGGACACCGGCGGCGCGATCAAGGGGGCCAACCGC
TTCGACAGCTTCTGGGGCGCGGGCGAAGAGGCGCGCGCGATCGCCGGCGGCATGGCGGCGCGCGGATCGGCGCTGCTGCT
GCTGCCGCGCGCCAGCATCGCACGCCTGCTTCCCGAAGGCTGA

Upstream 100 bases:

>100_bases
AGCGACGCCGCACAGACCGACGACCTGTGGACCTTCCGCCGCCAGATCGGCAGCAACGATCCCAACTGGCTGCTCGACGA
AGCCGAATCGGCCTGACGCC

Downstream 100 bases:

>100_bases
CCGGACGATGCCGCGGCGCCTCGCTCCCGAAGAAAGCGCGCTGTGGAAGAAGGTGGCGGCGACGGTGACGCCGCTACCGA
ACGCGCCCTCGCCGCTCGCT

Product: MltA

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MIRLAGAPRARLFRLALLAAFPLLSGCVSVIPGAGDTGRPAVSAPAPSPGQPRPYIPRPSERVGVAVQPITATPRAPLAA
PAVPADAATATASGVIAGPDFASLGISTEQAAAALAAFRISCPAIQRRTDASGLTQTADWTESCAAAAGWADGDASAFFA
RYFGTVQIGTGVAFVTGYYEPEIAASRTKRPGYDVPIYRRPADLIEVDLGQFADDLKGRKIRGRVDGSSFVRYHDRTAIE
SGALEGRGLELAWAADAAEFFFLQVQGSGRLRLPDGGIMRIGYDGQNGRGYVGIGKLLLDRGELERGQASMQGILDYLRA
DPARGAAVMNENPSWVFFRELNGPGPLGALGVPVTARVSVAADPKYVPLGAPVFLSLDRAEPNGLWIAQDTGGAIKGANR
FDSFWGAGEEARAIAGGMAARGSALLLLPRASIARLLPEG

Sequences:

>Translated_440_residues
MIRLAGAPRARLFRLALLAAFPLLSGCVSVIPGAGDTGRPAVSAPAPSPGQPRPYIPRPSERVGVAVQPITATPRAPLAA
PAVPADAATATASGVIAGPDFASLGISTEQAAAALAAFRISCPAIQRRTDASGLTQTADWTESCAAAAGWADGDASAFFA
RYFGTVQIGTGVAFVTGYYEPEIAASRTKRPGYDVPIYRRPADLIEVDLGQFADDLKGRKIRGRVDGSSFVRYHDRTAIE
SGALEGRGLELAWAADAAEFFFLQVQGSGRLRLPDGGIMRIGYDGQNGRGYVGIGKLLLDRGELERGQASMQGILDYLRA
DPARGAAVMNENPSWVFFRELNGPGPLGALGVPVTARVSVAADPKYVPLGAPVFLSLDRAEPNGLWIAQDTGGAIKGANR
FDSFWGAGEEARAIAGGMAARGSALLLLPRASIARLLPEG
>Mature_440_residues
MIRLAGAPRARLFRLALLAAFPLLSGCVSVIPGAGDTGRPAVSAPAPSPGQPRPYIPRPSERVGVAVQPITATPRAPLAA
PAVPADAATATASGVIAGPDFASLGISTEQAAAALAAFRISCPAIQRRTDASGLTQTADWTESCAAAAGWADGDASAFFA
RYFGTVQIGTGVAFVTGYYEPEIAASRTKRPGYDVPIYRRPADLIEVDLGQFADDLKGRKIRGRVDGSSFVRYHDRTAIE
SGALEGRGLELAWAADAAEFFFLQVQGSGRLRLPDGGIMRIGYDGQNGRGYVGIGKLLLDRGELERGQASMQGILDYLRA
DPARGAAVMNENPSWVFFRELNGPGPLGALGVPVTARVSVAADPKYVPLGAPVFLSLDRAEPNGLWIAQDTGGAIKGANR
FDSFWGAGEEARAIAGGMAARGSALLLLPRASIARLLPEG

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=276, Percent_Identity=32.6086956521739, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 45883; Mature: 45883

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLAGAPRARLFRLALLAAFPLLSGCVSVIPGAGDTGRPAVSAPAPSPGQPRPYIPRPS
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ERVGVAVQPITATPRAPLAAPAVPADAATATASGVIAGPDFASLGISTEQAAAALAAFRI
HHCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCEEECCCHHHCCCCHHHHHHHHHHHHH
SCPAIQRRTDASGLTQTADWTESCAAAAGWADGDASAFFARYFGTVQIGTGVAFVTGYYE
CCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCEEEECCCEEEEEECCC
PEIAASRTKRPGYDVPIYRRPADLIEVDLGQFADDLKGRKIRGRVDGSSFVRYHDRTAIE
CCHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCHHHH
SGALEGRGLELAWAADAAEFFFLQVQGSGRLRLPDGGIMRIGYDGQNGRGYVGIGKLLLD
CCCCCCCCEEEEEECCCEEEEEEEEECCCEEECCCCCEEEEEECCCCCCEEEEHHHHHHC
RGELERGQASMQGILDYLRADPARGAAVMNENPSWVFFRELNGPGPLGALGVPVTARVSV
CCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
AADPKYVPLGAPVFLSLDRAEPNGLWIAQDTGGAIKGANRFDSFWGAGEEARAIAGGMAA
ECCCCEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCC
RGSALLLLPRASIARLLPEG
CCCEEEEECCHHHHHHCCCC
>Mature Secondary Structure
MIRLAGAPRARLFRLALLAAFPLLSGCVSVIPGAGDTGRPAVSAPAPSPGQPRPYIPRPS
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ERVGVAVQPITATPRAPLAAPAVPADAATATASGVIAGPDFASLGISTEQAAAALAAFRI
HHCCEEEEECCCCCCCCCCCCCCCCCCCHHCCCCEEECCCHHHCCCCHHHHHHHHHHHHH
SCPAIQRRTDASGLTQTADWTESCAAAAGWADGDASAFFARYFGTVQIGTGVAFVTGYYE
CCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCEEEECCCEEEEEECCC
PEIAASRTKRPGYDVPIYRRPADLIEVDLGQFADDLKGRKIRGRVDGSSFVRYHDRTAIE
CCHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCHHHH
SGALEGRGLELAWAADAAEFFFLQVQGSGRLRLPDGGIMRIGYDGQNGRGYVGIGKLLLD
CCCCCCCCEEEEEECCCEEEEEEEEECCCEEECCCCCEEEEEECCCCCCEEEEHHHHHHC
RGELERGQASMQGILDYLRADPARGAAVMNENPSWVFFRELNGPGPLGALGVPVTARVSV
CCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEE
AADPKYVPLGAPVFLSLDRAEPNGLWIAQDTGGAIKGANRFDSFWGAGEEARAIAGGMAA
ECCCCEEECCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCC
RGSALLLLPRASIARLLPEG
CCCEEEEECCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]