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The map label for this gene is ptrB [C]

Identifier: 103487461

GI number: 103487461

Start: 2085053

End: 2087212

Strand: Direct

Name: ptrB [C]

Synonym: Sala_1978

Alternate gene names: 103487461

Gene position: 2085053-2087212 (Clockwise)

Preceding gene: 103487460

Following gene: 103487462

Centisome position: 62.33

GC content: 65.14

Gene sequence:

>2160_bases
ATGCCCGCCAAACGCCTGTCCGCGCCGCTCGCGCTGGTCGCCCTTGCCTTGACCCCCACCGCAGCACAGGCGGCCGCGGC
CGCGGCCGCATCGGCGCCCGCCGCCGCGCTCGCCTATCCCGACACGGCGCGCGGCGATACGGTCGATCCGCAGTTCGGCG
TCGACGTCGCCGACCCCTATCGCTGGCTGGAGGACGACGTCCGCGTCAATCCGGAGGTTGCGGCGTGGGTCGAAGCGCAG
AACAGGGTGACCGACGCCTATCTCGACACGCTGCCCGGTCGCGACGCCTTCCGGGCGCGGATGACTGAGCTGTACGATTA
TGAACGCTTCGGCCTGCCGACCAAGGCGGGCGCGCGCTATTTCTACACGCGCAACGACGGGCTCCAGCCGCAGTCGGTGC
TCTATGTCCGCGAAGGGTTGAAAGGCGAGGGCCGCGTGCTCATCGACCCCAATCTGTGGGCCAGGGACGGTGCGACCGCG
CTCGCCGAATGGGAACCGTCGGAGGATGGCAAATATCTTCTCTATGCGGTGCAGGACGGCGGCACCGACTGGCGCATCGT
GCGCGTCAAGGATGTCGCGACGGGGCAGGACCTGCCCGACGAGGTGCGCTGGGTGAAGTTTTCGGCGCTCGACTGGGCAA
AGGACGGCAGCGGCTTTTACTATTCGCGCTTCCCGGAGCCAAAGGAGGGCGAAGCCTTCCAGTCGCTCAACGAAAATCAC
GCCGTCTATTTCCACCGCCTCGGCACGCCGCAAAGCGCCGATGTGCTGATCCACGCGACGCCCGACAAGCCCAAGCTCAA
CAACAGCGCACTCGTCACCGACGATGGCGACTATCTGCTTGTCGTCTCGTCCGAAGGGACCGACGAACGCTATGGCCTGA
CGCTGCATCCGCTCGGCAGGCCGGGGGCGAAGCCGATCGTCCTTGTCGACGATTATGCGAACAACTGGGAATATGTGACC
AACGCGGGAACGCGCTTCACTTTCCTCACCAACAAGGGCGCGCCGCGCGGCCGCCTCGTTTCGTTCGACATCCGCAAGCC
GGACAAACTCACCGAACTCGTCGCCGAAAACCCCGCCACGCTCGTCGGCGCCTCGCGCGTCGGCGACCGCATCATCCTCT
CCTATCTTGGCGACGCCAAGTCGGAAGCGCGCATGGTCGCACTGAACGGCGAGCCGATCGCGAACATCAACCTCGCCGAC
ATCGGCGCGGCGTCGGGGTTCGGCGGCAAGTCGAGCGACCCCGAAACCTTCTATGCCTTTTCCAGCTTTGCGCGGCCGAC
GACCATCTATCGCTTCGACACCGAAACCGGAAATAGCGAGATTTTCGCCGAACCCAGGCTGACCTTCAACCCTGCCGATT
TCAGCGTCGAGCAACGCTTCTATAAATCAAAGGACGGCACCGAAGTGCCGATGTTCCTCGTGATGAAAAAGGGCCTCGAC
CGCAGCAAGGGCTCGCCGACGCTGCTTTACGGCTATGGCGGCTTCAACGTCTCGCTGACCCCAGGCTTTTCGCCGACGCG
GCTCGCGTGGGTCGACAAGGGCGGCGTGCTCGCGATCGCGAACCTGCGGGGCGGCGGCGAATATGGCAAGGCGTGGCACG
ACGCCGGCCGCCTTGCGAACAAGCAGAATGTCTTCGACGATTTCATCGCCGCGGGCGAATATCTGATCGCCGAGGGCATC
ACCGGCAAGGGTCAGCTTGCGATCGAGGGCGGATCGAACGGCGGCCTGCTCGTCGGCGCCGTCACCAACCAGCGCCCCGA
CCTGTTCGCCGCGGCGCTGCCTGCGGTCGGCGTGATGGACATGCTGCGCTTCGACCGCTTCACTGCGGGTCGTTACTGGG
TCGACGATTATGGCTATCCGTCGAAGGAGGCCGATTTCCGGAACCTGCTCAGCTATTCGCCCTACCACAATATCCGCAGC
GGCGTGGCCTATCCGGCGGTGCTGGTGACGACCGCCGACACCGACGACCGCGTCGTGCCGGGGCACAGTTTCAAATATAC
CGCCGCGCTCCAGCACGCGAAGGCGGGCAGCAAGCCGCACCTCATCCGCATCGAAACGCGCGCGGGCCATGGCAGCGGCA
AGCCGACCGACAAGATCATCGCCGAGGCCGCCGACAAATATGCCTTTGCGGCGAAATGGACCGGGCTGGACGTCGAATAG

Upstream 100 bases:

>100_bases
AGCGGCGTGCTGTATATCAAATCCGCTTGCCCCGCCCTTTTCCATCCTTACATATCGGCGCACGATAATGTCTTTTCCGG
ATAATGAGGATCGCCTTGCC

Downstream 100 bases:

>100_bases
GATGAGCTACACCCTCTCCTTCACCGCCACCGAGGCCGCCGAGCGGTGGGCCGAGGCGGGCGAGGCTGCGGCGGCGCTCG
TCGCAGGCGAGCATGACGGG

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MPAKRLSAPLALVALALTPTAAQAAAAAAASAPAAALAYPDTARGDTVDPQFGVDVADPYRWLEDDVRVNPEVAAWVEAQ
NRVTDAYLDTLPGRDAFRARMTELYDYERFGLPTKAGARYFYTRNDGLQPQSVLYVREGLKGEGRVLIDPNLWARDGATA
LAEWEPSEDGKYLLYAVQDGGTDWRIVRVKDVATGQDLPDEVRWVKFSALDWAKDGSGFYYSRFPEPKEGEAFQSLNENH
AVYFHRLGTPQSADVLIHATPDKPKLNNSALVTDDGDYLLVVSSEGTDERYGLTLHPLGRPGAKPIVLVDDYANNWEYVT
NAGTRFTFLTNKGAPRGRLVSFDIRKPDKLTELVAENPATLVGASRVGDRIILSYLGDAKSEARMVALNGEPIANINLAD
IGAASGFGGKSSDPETFYAFSSFARPTTIYRFDTETGNSEIFAEPRLTFNPADFSVEQRFYKSKDGTEVPMFLVMKKGLD
RSKGSPTLLYGYGGFNVSLTPGFSPTRLAWVDKGGVLAIANLRGGGEYGKAWHDAGRLANKQNVFDDFIAAGEYLIAEGI
TGKGQLAIEGGSNGGLLVGAVTNQRPDLFAAALPAVGVMDMLRFDRFTAGRYWVDDYGYPSKEADFRNLLSYSPYHNIRS
GVAYPAVLVTTADTDDRVVPGHSFKYTAALQHAKAGSKPHLIRIETRAGHGSGKPTDKIIAEAADKYAFAAKWTGLDVE

Sequences:

>Translated_719_residues
MPAKRLSAPLALVALALTPTAAQAAAAAAASAPAAALAYPDTARGDTVDPQFGVDVADPYRWLEDDVRVNPEVAAWVEAQ
NRVTDAYLDTLPGRDAFRARMTELYDYERFGLPTKAGARYFYTRNDGLQPQSVLYVREGLKGEGRVLIDPNLWARDGATA
LAEWEPSEDGKYLLYAVQDGGTDWRIVRVKDVATGQDLPDEVRWVKFSALDWAKDGSGFYYSRFPEPKEGEAFQSLNENH
AVYFHRLGTPQSADVLIHATPDKPKLNNSALVTDDGDYLLVVSSEGTDERYGLTLHPLGRPGAKPIVLVDDYANNWEYVT
NAGTRFTFLTNKGAPRGRLVSFDIRKPDKLTELVAENPATLVGASRVGDRIILSYLGDAKSEARMVALNGEPIANINLAD
IGAASGFGGKSSDPETFYAFSSFARPTTIYRFDTETGNSEIFAEPRLTFNPADFSVEQRFYKSKDGTEVPMFLVMKKGLD
RSKGSPTLLYGYGGFNVSLTPGFSPTRLAWVDKGGVLAIANLRGGGEYGKAWHDAGRLANKQNVFDDFIAAGEYLIAEGI
TGKGQLAIEGGSNGGLLVGAVTNQRPDLFAAALPAVGVMDMLRFDRFTAGRYWVDDYGYPSKEADFRNLLSYSPYHNIRS
GVAYPAVLVTTADTDDRVVPGHSFKYTAALQHAKAGSKPHLIRIETRAGHGSGKPTDKIIAEAADKYAFAAKWTGLDVE
>Mature_718_residues
PAKRLSAPLALVALALTPTAAQAAAAAAASAPAAALAYPDTARGDTVDPQFGVDVADPYRWLEDDVRVNPEVAAWVEAQN
RVTDAYLDTLPGRDAFRARMTELYDYERFGLPTKAGARYFYTRNDGLQPQSVLYVREGLKGEGRVLIDPNLWARDGATAL
AEWEPSEDGKYLLYAVQDGGTDWRIVRVKDVATGQDLPDEVRWVKFSALDWAKDGSGFYYSRFPEPKEGEAFQSLNENHA
VYFHRLGTPQSADVLIHATPDKPKLNNSALVTDDGDYLLVVSSEGTDERYGLTLHPLGRPGAKPIVLVDDYANNWEYVTN
AGTRFTFLTNKGAPRGRLVSFDIRKPDKLTELVAENPATLVGASRVGDRIILSYLGDAKSEARMVALNGEPIANINLADI
GAASGFGGKSSDPETFYAFSSFARPTTIYRFDTETGNSEIFAEPRLTFNPADFSVEQRFYKSKDGTEVPMFLVMKKGLDR
SKGSPTLLYGYGGFNVSLTPGFSPTRLAWVDKGGVLAIANLRGGGEYGKAWHDAGRLANKQNVFDDFIAAGEYLIAEGIT
GKGQLAIEGGSNGGLLVGAVTNQRPDLFAAALPAVGVMDMLRFDRFTAGRYWVDDYGYPSKEADFRNLLSYSPYHNIRSG
VAYPAVLVTTADTDDRVVPGHSFKYTAALQHAKAGSKPHLIRIETRAGHGSGKPTDKIIAEAADKYAFAAKWTGLDVE

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=707, Percent_Identity=42.8571428571429, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI108860686, Length=280, Percent_Identity=30.7142857142857, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI284172420, Length=280, Percent_Identity=30.7142857142857, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI284172413, Length=280, Percent_Identity=30.7142857142857, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI70778815, Length=280, Percent_Identity=30.7142857142857, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI284172438, Length=280, Percent_Identity=30.7142857142857, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI284172431, Length=280, Percent_Identity=30.7142857142857, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI108860692, Length=216, Percent_Identity=31.9444444444444, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1788150, Length=704, Percent_Identity=26.2784090909091, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24583414, Length=721, Percent_Identity=41.747572815534, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221510989, Length=743, Percent_Identity=38.3580080753701, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 78247; Mature: 78116

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKRLSAPLALVALALTPTAAQAAAAAAASAPAAALAYPDTARGDTVDPQFGVDVADPY
CCCHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCH
RWLEDDVRVNPEVAAWVEAQNRVTDAYLDTLPGRDAFRARMTELYDYERFGLPTKAGARY
HHHCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
FYTRNDGLQPQSVLYVREGLKGEGRVLIDPNLWARDGATALAEWEPSEDGKYLLYAVQDG
EEECCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCEEEECCCCCCCCEEEEEEECC
GTDWRIVRVKDVATGQDLPDEVRWVKFSALDWAKDGSGFYYSRFPEPKEGEAFQSLNENH
CCCEEEEEEEECCCCCCCCCHHEEEEEEEEECCCCCCCEEEECCCCCCCCHHHHHCCCCC
AVYFHRLGTPQSADVLIHATPDKPKLNNSALVTDDGDYLLVVSSEGTDERYGLTLHPLGR
EEEEEECCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCEEECCCCC
PGAKPIVLVDDYANNWEYVTNAGTRFTFLTNKGAPRGRLVSFDIRKPDKLTELVAENPAT
CCCCEEEEEECCCCCCEEEECCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCCCE
LVGASRVGDRIILSYLGDAKSEARMVALNGEPIANINLADIGAASGFGGKSSDPETFYAF
EEEHHHCCCHHHHHHHCCCCCCCEEEEECCCCEEEEEHHHCCCCCCCCCCCCCCCEEEEE
SSFARPTTIYRFDTETGNSEIFAEPRLTFNPADFSVEQRFYKSKDGTEVPMFLVMKKGLD
HHCCCCEEEEEEECCCCCCEEEECCCEEECCCCCCHHHHHHHCCCCCCCCEEEEECCCCC
RSKGSPTLLYGYGGFNVSLTPGFSPTRLAWVDKGGVLAIANLRGGGEYGKAWHDAGRLAN
CCCCCCEEEEEECCEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCC
KQNVFDDFIAAGEYLIAEGITGKGQLAIEGGSNGGLLVGAVTNQRPDLFAAALPAVGVMD
HHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHH
MLRFDRFTAGRYWVDDYGYPSKEADFRNLLSYSPYHNIRSGVAYPAVLVTTADTDDRVVP
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCHHHHCCCCCCEEEEEECCCCCCCCC
GHSFKYTAALQHAKAGSKPHLIRIETRAGHGSGKPTDKIIAEAADKYAFAAKWTGLDVE
CCCEEEHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCEEEEEEECCCCCC
>Mature Secondary Structure 
PAKRLSAPLALVALALTPTAAQAAAAAAASAPAAALAYPDTARGDTVDPQFGVDVADPY
CCHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCH
RWLEDDVRVNPEVAAWVEAQNRVTDAYLDTLPGRDAFRARMTELYDYERFGLPTKAGARY
HHHCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
FYTRNDGLQPQSVLYVREGLKGEGRVLIDPNLWARDGATALAEWEPSEDGKYLLYAVQDG
EEECCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCEEEECCCCCCCCEEEEEEECC
GTDWRIVRVKDVATGQDLPDEVRWVKFSALDWAKDGSGFYYSRFPEPKEGEAFQSLNENH
CCCEEEEEEEECCCCCCCCCHHEEEEEEEEECCCCCCCEEEECCCCCCCCHHHHHCCCCC
AVYFHRLGTPQSADVLIHATPDKPKLNNSALVTDDGDYLLVVSSEGTDERYGLTLHPLGR
EEEEEECCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCEEECCCCC
PGAKPIVLVDDYANNWEYVTNAGTRFTFLTNKGAPRGRLVSFDIRKPDKLTELVAENPAT
CCCCEEEEEECCCCCCEEEECCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCCCE
LVGASRVGDRIILSYLGDAKSEARMVALNGEPIANINLADIGAASGFGGKSSDPETFYAF
EEEHHHCCCHHHHHHHCCCCCCCEEEEECCCCEEEEEHHHCCCCCCCCCCCCCCCEEEEE
SSFARPTTIYRFDTETGNSEIFAEPRLTFNPADFSVEQRFYKSKDGTEVPMFLVMKKGLD
HHCCCCEEEEEEECCCCCCEEEECCCEEECCCCCCHHHHHHHCCCCCCCCEEEEECCCCC
RSKGSPTLLYGYGGFNVSLTPGFSPTRLAWVDKGGVLAIANLRGGGEYGKAWHDAGRLAN
CCCCCCEEEEEECCEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCC
KQNVFDDFIAAGEYLIAEGITGKGQLAIEGGSNGGLLVGAVTNQRPDLFAAALPAVGVMD
HHHHHHHHHHCCCEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHH
MLRFDRFTAGRYWVDDYGYPSKEADFRNLLSYSPYHNIRSGVAYPAVLVTTADTDDRVVP
HHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCHHHHCCCCCCEEEEEECCCCCCCCC
GHSFKYTAALQHAKAGSKPHLIRIETRAGHGSGKPTDKIIAEAADKYAFAAKWTGLDVE
CCCEEEHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]