Click here to switch to the map view.

The map label for this gene is acsA [H]

Identifier: 103487295

GI number: 103487295

Start: 1907951

End: 1909915

Strand: Direct

Name: acsA [H]

Synonym: Sala_1811

Alternate gene names: 103487295

Gene position: 1907951-1909915 (Clockwise)

Preceding gene: 103487293

Following gene: 103487300

Centisome position: 57.04

GC content: 65.7

Gene sequence:

>1965_bases
GTGTCCGACCTACCCCCCTCCGAACCCATGGTCCCCGTCCCCGCCGACGCCGCCGCCAACACGCATTGCAGCGCTGCCGA
CTATGACCGCCTCTATGCCGCGAGCATCGCCGACCCCGACGCCTTCTGGGCCGAGCAGGCGAAACGGCTCGACTGGATCA
AGGCGCCGACCAGGATCGCGGGCTGGTCCTATGACCCGGTGAGCATCAAATGGTATGAGGACGGCGTTCTCAACCTCTGC
CACAACGCCGTCGACCGCCATGTCGCCGCCGACCACGGCGACCGCACCGCGATCATTTTCGAGCCCGACGCGCCCGACGG
CGAAACGCGGCATATCAGCTATGCCGCGCTGCTCGCCGACGTCGTTCGCTTCGCGAACACGCTCAAGAAAATGGGCGTGC
GGAAGGGCGACCGCGTCACCATCTATATGCCGATGATCCCCGAGGGCGCGGTGGCGATGCTCGCCTGCGCGCGCATCGGC
GCGGTGCACAGCGTCGTCTTCGGCGGCTTCTCCCCCGAAGCGATCCACGGCCGTATCGAGGATTGCGGCAGCGACTGGGT
GATCTGCGCCGACGAGGGGCTGCGCGGCGGTAAGACCGTGCCGCTGAAAGCCAATGTCGACAAGGCGCTCGAACGAATCG
CGGTCAGGGGTGTGCTCGTCATCGCGCACACCGGCGGCGAGGTGAACATGACCGAAGGGCGCGACCATTGGTATGATGCG
CTCTCGGCCGACGTGTCCGCCGATTGCCCCTGCGAGCCGATGGGCGCCGAAGACCCGCTCTTCATCCTCTATACCTCGGG
ATCGACGGGCAAGCCCAAGGGTGTGCTCCACACCGTCGGCGGTTACAGCGTCTGGACGGCGACGACCTTCTGGTACGGTT
TCGACTATCGGCCGGGCGAGATTTTCTGGTGCAGCGCCGACATCGGCTGGGTCACCGGCCACAGCTATGTCGTTTACGGT
CCGCTCCAGAATGGCGCGACGACCCTGATGTTCGAGGGCGTCCCCAATTATCCCGACCATGACCGCTTCTGGCAGGTCGT
CGACAAGCATGGCGTCAACATCCTCTACACCGCACCGACCGCAATCCGCGCGCTGATGCGCGAGGGCGACGATTATGTCA
CGCGGCACGACCTGTCGTCGCTCCGCCTGCTCGGCAGCGTCGGCGAGCCGATCAACCCGGAGGCGTGGCGCTGGTATCAC
CAGATTGTCGGCAAGGGCCGCGTCCCCGTCATCGACACCTGGTGGCAGACCGAAACCGGCGGGATCATGATCACCACCTT
GCCCGGCGCGCATCCGATGCAGCCGGGCAGCGCGGGACGCCCCTTTTTCGGCATCCGTCCGCAGCTCGTCGATGCCGATG
GCGCAGTGCTCGTCGACGAACAGACCGGCGGCGCGGCGGAGGGCAATCTTTGCATCACCCACAGCTGGCCGGGACAGGCG
CGCACCGTCTATGGCGACCATGACCGGTTCGTGCAGACCTATTTTTCGACCTACAAGGGCAAATATTTCACCGGCGACGG
CTGCCGCCGCGACGCGAGCGGTTATTGGCGGATTACGGGGCGTGTCGATGACGTGATCAATGTGTCGGGGCACCGCATGG
GCACCGCCGAGGTCGAAAGCGCGCTGGTGCTGCACGAGGATGTGGCGGAGGCGGCGGTCGTCGGCTTTCCGCACGACATC
AAGGGCCAGGGCATTTACGCCTATGTCACGCTCAACGCCGGGGTCGAGCCGGGCGAGGACATCGTCGCGGCGCTCAAACA
GCAGGTCCGCAAGGAAATCGGTCCGATCGCGACTCCCGACCATATCCACCTGACCCCCGCGCTGCCCAAGACACGGAGCG
GCAAGATCATGCGGCGGATTTTGCGCAAGATTGCCGAAAACGACTTCGGCTCGCTGGGCGACACCTCGACGCTCGCCGAT
CCCGGCCTGGTCGATGGGCTGATCGAGGAGCGGCGGAATCGGTAA

Upstream 100 bases:

>100_bases
GAGCGCCGTCGAGACTCCCCGGAGCCGCGCACGAACGACAGGCATCTCGACTTCGCTCGATGCAAACGGCTAAGGGGAGT
GCGAACAGAGGAGAGCCATC

Downstream 100 bases:

>100_bases
ACAAGCCGAATGACCGTCGCCCCCGCGAAGGCGGGGGCCGCAATCGGCCTGACGCTTCAGCGTTACGTAAACCGCCGGCG
GCCCCTGCCTTCGCGGGGGC

Product: acetate--CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MSDLPPSEPMVPVPADAAANTHCSAADYDRLYAASIADPDAFWAEQAKRLDWIKAPTRIAGWSYDPVSIKWYEDGVLNLC
HNAVDRHVAADHGDRTAIIFEPDAPDGETRHISYAALLADVVRFANTLKKMGVRKGDRVTIYMPMIPEGAVAMLACARIG
AVHSVVFGGFSPEAIHGRIEDCGSDWVICADEGLRGGKTVPLKANVDKALERIAVRGVLVIAHTGGEVNMTEGRDHWYDA
LSADVSADCPCEPMGAEDPLFILYTSGSTGKPKGVLHTVGGYSVWTATTFWYGFDYRPGEIFWCSADIGWVTGHSYVVYG
PLQNGATTLMFEGVPNYPDHDRFWQVVDKHGVNILYTAPTAIRALMREGDDYVTRHDLSSLRLLGSVGEPINPEAWRWYH
QIVGKGRVPVIDTWWQTETGGIMITTLPGAHPMQPGSAGRPFFGIRPQLVDADGAVLVDEQTGGAAEGNLCITHSWPGQA
RTVYGDHDRFVQTYFSTYKGKYFTGDGCRRDASGYWRITGRVDDVINVSGHRMGTAEVESALVLHEDVAEAAVVGFPHDI
KGQGIYAYVTLNAGVEPGEDIVAALKQQVRKEIGPIATPDHIHLTPALPKTRSGKIMRRILRKIAENDFGSLGDTSTLAD
PGLVDGLIEERRNR

Sequences:

>Translated_654_residues
MSDLPPSEPMVPVPADAAANTHCSAADYDRLYAASIADPDAFWAEQAKRLDWIKAPTRIAGWSYDPVSIKWYEDGVLNLC
HNAVDRHVAADHGDRTAIIFEPDAPDGETRHISYAALLADVVRFANTLKKMGVRKGDRVTIYMPMIPEGAVAMLACARIG
AVHSVVFGGFSPEAIHGRIEDCGSDWVICADEGLRGGKTVPLKANVDKALERIAVRGVLVIAHTGGEVNMTEGRDHWYDA
LSADVSADCPCEPMGAEDPLFILYTSGSTGKPKGVLHTVGGYSVWTATTFWYGFDYRPGEIFWCSADIGWVTGHSYVVYG
PLQNGATTLMFEGVPNYPDHDRFWQVVDKHGVNILYTAPTAIRALMREGDDYVTRHDLSSLRLLGSVGEPINPEAWRWYH
QIVGKGRVPVIDTWWQTETGGIMITTLPGAHPMQPGSAGRPFFGIRPQLVDADGAVLVDEQTGGAAEGNLCITHSWPGQA
RTVYGDHDRFVQTYFSTYKGKYFTGDGCRRDASGYWRITGRVDDVINVSGHRMGTAEVESALVLHEDVAEAAVVGFPHDI
KGQGIYAYVTLNAGVEPGEDIVAALKQQVRKEIGPIATPDHIHLTPALPKTRSGKIMRRILRKIAENDFGSLGDTSTLAD
PGLVDGLIEERRNR
>Mature_653_residues
SDLPPSEPMVPVPADAAANTHCSAADYDRLYAASIADPDAFWAEQAKRLDWIKAPTRIAGWSYDPVSIKWYEDGVLNLCH
NAVDRHVAADHGDRTAIIFEPDAPDGETRHISYAALLADVVRFANTLKKMGVRKGDRVTIYMPMIPEGAVAMLACARIGA
VHSVVFGGFSPEAIHGRIEDCGSDWVICADEGLRGGKTVPLKANVDKALERIAVRGVLVIAHTGGEVNMTEGRDHWYDAL
SADVSADCPCEPMGAEDPLFILYTSGSTGKPKGVLHTVGGYSVWTATTFWYGFDYRPGEIFWCSADIGWVTGHSYVVYGP
LQNGATTLMFEGVPNYPDHDRFWQVVDKHGVNILYTAPTAIRALMREGDDYVTRHDLSSLRLLGSVGEPINPEAWRWYHQ
IVGKGRVPVIDTWWQTETGGIMITTLPGAHPMQPGSAGRPFFGIRPQLVDADGAVLVDEQTGGAAEGNLCITHSWPGQAR
TVYGDHDRFVQTYFSTYKGKYFTGDGCRRDASGYWRITGRVDDVINVSGHRMGTAEVESALVLHEDVAEAAVVGFPHDIK
GQGIYAYVTLNAGVEPGEDIVAALKQQVRKEIGPIATPDHIHLTPALPKTRSGKIMRRILRKIAENDFGSLGDTSTLADP
GLVDGLIEERRNR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=672, Percent_Identity=50.5952380952381, Blast_Score=654, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=685, Percent_Identity=49.6350364963504, Blast_Score=649, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=626, Percent_Identity=48.7220447284345, Blast_Score=584, Evalue=1e-167,
Organism=Homo sapiens, GI13375727, Length=643, Percent_Identity=36.8584758942457, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI42544132, Length=525, Percent_Identity=28.1904761904762, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI38505220, Length=517, Percent_Identity=29.0135396518375, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI122937307, Length=523, Percent_Identity=27.3422562141491, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI31982927, Length=634, Percent_Identity=23.0283911671924, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI115511026, Length=511, Percent_Identity=26.027397260274, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI58082049, Length=524, Percent_Identity=25, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI157311624, Length=524, Percent_Identity=24.618320610687, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI157311622, Length=524, Percent_Identity=24.618320610687, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI42544134, Length=340, Percent_Identity=24.7058823529412, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI187761345, Length=388, Percent_Identity=25.7731958762887, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI187761343, Length=388, Percent_Identity=25.7731958762887, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI195947378, Length=404, Percent_Identity=24.5049504950495, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790505, Length=645, Percent_Identity=63.2558139534884, Blast_Score=815, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=632, Percent_Identity=38.9240506329114, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI221142682, Length=553, Percent_Identity=23.1464737793852, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI145693145, Length=514, Percent_Identity=23.1517509727626, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788107, Length=546, Percent_Identity=22.8937728937729, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982997, Length=661, Percent_Identity=47.3524962178517, Blast_Score=592, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI71983001, Length=661, Percent_Identity=47.3524962178517, Blast_Score=592, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17569507, Length=596, Percent_Identity=21.8120805369128, Blast_Score=139, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17560140, Length=391, Percent_Identity=23.0179028132992, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=532, Percent_Identity=21.6165413533835, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=129, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=45.7231726283048, Blast_Score=563, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6319264, Length=645, Percent_Identity=47.2868217054264, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319699, Length=374, Percent_Identity=24.331550802139, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24667955, Length=662, Percent_Identity=51.0574018126888, Blast_Score=666, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=567, Percent_Identity=54.320987654321, Blast_Score=613, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24667959, Length=525, Percent_Identity=54.2857142857143, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI21355225, Length=619, Percent_Identity=36.8336025848142, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI18859661, Length=534, Percent_Identity=24.1573033707865, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21355181, Length=573, Percent_Identity=23.2111692844677, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24581924, Length=558, Percent_Identity=22.7598566308244, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573631, Length=559, Percent_Identity=22.5402504472272, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130353, Length=559, Percent_Identity=22.7191413237925, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648260, Length=373, Percent_Identity=24.1286863270777, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71409; Mature: 71278

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLPPSEPMVPVPADAAANTHCSAADYDRLYAASIADPDAFWAEQAKRLDWIKAPTRIA
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
GWSYDPVSIKWYEDGVLNLCHNAVDRHVAADHGDRTAIIFEPDAPDGETRHISYAALLAD
CCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHHHHHHH
VVRFANTLKKMGVRKGDRVTIYMPMIPEGAVAMLACARIGAVHSVVFGGFSPEAIHGRIE
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHH
DCGSDWVICADEGLRGGKTVPLKANVDKALERIAVRGVLVIAHTGGEVNMTEGRDHWYDA
HCCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCEEEEEEECCCEEEECCCCHHHHHH
LSADVSADCPCEPMGAEDPLFILYTSGSTGKPKGVLHTVGGYSVWTATTFWYGFDYRPGE
HCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEECCCCCE
IFWCSADIGWVTGHSYVVYGPLQNGATTLMFEGVPNYPDHDRFWQVVDKHGVNILYTAPT
EEEEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECHH
AIRALMREGDDYVTRHDLSSLRLLGSVGEPINPEAWRWYHQIVGKGRVPVIDTWWQTETG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCC
GIMITTLPGAHPMQPGSAGRPFFGIRPQLVDADGAVLVDEQTGGAAEGNLCITHSWPGQA
CEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEECCCCCC
RTVYGDHDRFVQTYFSTYKGKYFTGDGCRRDASGYWRITGRVDDVINVSGHRMGTAEVES
EEEECCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHH
ALVLHEDVAEAAVVGFPHDIKGQGIYAYVTLNAGVEPGEDIVAALKQQVRKEIGPIATPD
HHHHHHHHHHHHEECCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
HIHLTPALPKTRSGKIMRRILRKIAENDFGSLGDTSTLADPGLVDGLIEERRNR
CEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SDLPPSEPMVPVPADAAANTHCSAADYDRLYAASIADPDAFWAEQAKRLDWIKAPTRIA
CCCCCCCCEECCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
GWSYDPVSIKWYEDGVLNLCHNAVDRHVAADHGDRTAIIFEPDAPDGETRHISYAALLAD
CCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHHHHHHH
VVRFANTLKKMGVRKGDRVTIYMPMIPEGAVAMLACARIGAVHSVVFGGFSPEAIHGRIE
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHH
DCGSDWVICADEGLRGGKTVPLKANVDKALERIAVRGVLVIAHTGGEVNMTEGRDHWYDA
HCCCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCEEEEEEECCCEEEECCCCHHHHHH
LSADVSADCPCEPMGAEDPLFILYTSGSTGKPKGVLHTVGGYSVWTATTFWYGFDYRPGE
HCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEEEEEEECCCCCE
IFWCSADIGWVTGHSYVVYGPLQNGATTLMFEGVPNYPDHDRFWQVVDKHGVNILYTAPT
EEEEECCCCEEECCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECHH
AIRALMREGDDYVTRHDLSSLRLLGSVGEPINPEAWRWYHQIVGKGRVPVIDTWWQTETG
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCC
GIMITTLPGAHPMQPGSAGRPFFGIRPQLVDADGAVLVDEQTGGAAEGNLCITHSWPGQA
CEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCCCCEEEEECCCCCC
RTVYGDHDRFVQTYFSTYKGKYFTGDGCRRDASGYWRITGRVDDVINVSGHRMGTAEVES
EEEECCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHH
ALVLHEDVAEAAVVGFPHDIKGQGIYAYVTLNAGVEPGEDIVAALKQQVRKEIGPIATPD
HHHHHHHHHHHHEECCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
HIHLTPALPKTRSGKIMRRILRKIAENDFGSLGDTSTLADPGLVDGLIEERRNR
CEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275; 11726281 [H]