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The map label for this gene is pth

Identifier: 103487103

GI number: 103487103

Start: 1698583

End: 1699152

Strand: Direct

Name: pth

Synonym: Sala_1618

Alternate gene names: 103487103

Gene position: 1698583-1699152 (Clockwise)

Preceding gene: 103487102

Following gene: 103487104

Centisome position: 50.78

GC content: 63.68

Gene sequence:

>570_bases
ATGCAGCTCTGGGTCGGCCTCGGCAATCCGGGGCCCAAATATGCGATGCACCGGCACAATGTCGGCTTCATGGCCGCCGA
TGTCATCGCCGAAATCCATGATTTTCCGCCGCCTGTGAAGAAGTTCCAGGGCTGGTTGCAGGACGGGCGCATCGGCTCGA
CGCGCATCCTGTTGCTCAAACCCGGCACCTTCATGAACGAAAGCGGGCGCAGCGTGCGCGCCGCGCTCGATTTCTACAAG
CTGGCCGCCACCGACGTCACCGTCTTTTACGACGAGCTCGACCTCGCGCCGATGAAGGTCAAGGTGAAACGCGGCGGCGG
CGCGGCGGGGCACAACGGCATCCGGTCGATGATCCAGCATATCGGCGACGATTTCCGCCGCATCCGCATCGGCATCGGCC
ATCCGGGGCACAAGGACCGCGTGACCGGCCATGTCCTCGGCAATTATCACAAGAGCGAGATGGAACCGCTGGCCGACCTG
CTCGGCGCGATCGCCGCCGAAGCGGAATGGCTGGCCAAGGGCGACGATGTAAGATTCCAGAGCGATCTGGCGCTGCGGTT
GCAAGGGTGA

Upstream 100 bases:

>100_bases
CGAAGACGCTGCCGAAGGCGGCGACGAAGCCTAAACTATCCGGACCGCCCCTCCCCCATGCGGGAGGGGCGTTTCCACCA
GACCCGGGAAAGGCAACGCC

Downstream 100 bases:

>100_bases
GTTGGGGGCCGGTGGCGGCCAAAGGCGGACGTCGCGATCCCAAAGCCGCAGTCCAACCACCGATTTGGCACGCGCCGCCA
ACTAAGGCATGATGGCGTCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MQLWVGLGNPGPKYAMHRHNVGFMAADVIAEIHDFPPPVKKFQGWLQDGRIGSTRILLLKPGTFMNESGRSVRAALDFYK
LAATDVTVFYDELDLAPMKVKVKRGGGAAGHNGIRSMIQHIGDDFRRIRIGIGHPGHKDRVTGHVLGNYHKSEMEPLADL
LGAIAAEAEWLAKGDDVRFQSDLALRLQG

Sequences:

>Translated_189_residues
MQLWVGLGNPGPKYAMHRHNVGFMAADVIAEIHDFPPPVKKFQGWLQDGRIGSTRILLLKPGTFMNESGRSVRAALDFYK
LAATDVTVFYDELDLAPMKVKVKRGGGAAGHNGIRSMIQHIGDDFRRIRIGIGHPGHKDRVTGHVLGNYHKSEMEPLADL
LGAIAAEAEWLAKGDDVRFQSDLALRLQG
>Mature_189_residues
MQLWVGLGNPGPKYAMHRHNVGFMAADVIAEIHDFPPPVKKFQGWLQDGRIGSTRILLLKPGTFMNESGRSVRAALDFYK
LAATDVTVFYDELDLAPMKVKVKRGGGAAGHNGIRSMIQHIGDDFRRIRIGIGHPGHKDRVTGHVLGNYHKSEMEPLADL
LGAIAAEAEWLAKGDDVRFQSDLALRLQG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=167, Percent_Identity=35.3293413173653, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1787455, Length=180, Percent_Identity=40.5555555555556, Blast_Score=106, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_SPHAL (Q1GSP1)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616664.1
- ProteinModelPortal:   Q1GSP1
- SMR:   Q1GSP1
- GeneID:   4081891
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1618
- NMPDR:   fig|317655.9.peg.1552
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   SALA317655:SALA_1618-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20819; Mature: 20819

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLWVGLGNPGPKYAMHRHNVGFMAADVIAEIHDFPPPVKKFQGWLQDGRIGSTRILLLK
CEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEC
PGTFMNESGRSVRAALDFYKLAATDVTVFYDELDLAPMKVKVKRGGGAAGHNGIRSMIQH
CCCCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
IGDDFRRIRIGIGHPGHKDRVTGHVLGNYHKSEMEPLADLLGAIAAEAEWLAKGDDVRFQ
HCCHHEEEEEECCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SDLALRLQG
CCEEEEECC
>Mature Secondary Structure
MQLWVGLGNPGPKYAMHRHNVGFMAADVIAEIHDFPPPVKKFQGWLQDGRIGSTRILLLK
CEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEC
PGTFMNESGRSVRAALDFYKLAATDVTVFYDELDLAPMKVKVKRGGGAAGHNGIRSMIQH
CCCCCCCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHH
IGDDFRRIRIGIGHPGHKDRVTGHVLGNYHKSEMEPLADLLGAIAAEAEWLAKGDDVRFQ
HCCHHEEEEEECCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SDLALRLQG
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA