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The map label for this gene is phhA [H]

Identifier: 103486046

GI number: 103486046

Start: 567703

End: 568572

Strand: Direct

Name: phhA [H]

Synonym: Sala_0553

Alternate gene names: 103486046

Gene position: 567703-568572 (Clockwise)

Preceding gene: 103486045

Following gene: 103486051

Centisome position: 16.97

GC content: 62.41

Gene sequence:

>870_bases
ATGGAAAGCCGGTTTACCCACGTCCACGAAACCCCGCCGCCGGGCGCCGCGGCCGACTGGACGATTTCGCAGAATTGGGA
CGCCTTCACCGCCGACGAACATGCGATGTGGGACCGGCTGTTCGCGCGCCAGTCGGCGATGTTGCCCGGCCGCGCGGCCG
ACGCATTTATGCGCGGCATCGACGTGCTCAAGCTGGAAAAGCCGGGCATTCCCGATTACCGCGAGCTCAACGCGCGGCTG
ATGGCGGCGACGGGGTGGCAGGTTGTCGCGGTGCCGGGACTGGTTCCCGACGACGTGTTTTTCGATCATCTGGCAAACCG
GCGCTTTCCCGCGGGCAATTTCATCCGCACACCCGACCAGCTCGATTACCTCCAGGAACCCGACGTCTTTCACGACGTCT
TCGGCCATGTCCCGATGCTCGCCGACCCGGTTTTCGCCGATTATATGGTCGCCTATGGCGAGGGCGGACTGCGCAGCCTG
AAGTTTGATGCGCTCAAACAGCTGGCGCGGCTCTATTGGTATACGGTCGAATTCGGGCTGATCCGCGAAGCCGGCGGCCT
GCGCATCTATGGCGCCGGGATCGTTTCCTCCTATGCAGAAAGCGTCTTCGCGCTCGACAGCGAGAGCCCGAACCGCCTCG
GCTTCGACCTCGCGCGCGTCATGCGCACCGATTACCGGATCGACGATTTCCAGCAGAATTATTTTGTCATCGACAGTCTG
GAACAGTTGCTCGACATAACCGTGAATACCGATTTCGCGCCGCTCTATGCCGCGAACGCCGCACTGCCGCCGATCCCCAT
TGCCGACATATTGCCGGACGACAAGGTGATCACGCGCGGCACCCAGGAATATGCCGCTGCGAAGGCCTGA

Upstream 100 bases:

>100_bases
TCAGCCACGATCACGCCGAGGTCGACCGGCTCGCAACATCGGTCGTCGCGATCGGCGAATAAGTTTCACATGAAACCATA
TTTGTGATAGAAGTCTGTCC

Downstream 100 bases:

>100_bases
TACCGAAACGTCATTGCGAGCGTAGCGAAGCAATCGCCAGCTGTCGGAGAGGCCGTCGATAGCGGGAGATTGCTTGCTCG
CTTCGCTCCTCGCAATGACG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MESRFTHVHETPPPGAAADWTISQNWDAFTADEHAMWDRLFARQSAMLPGRAADAFMRGIDVLKLEKPGIPDYRELNARL
MAATGWQVVAVPGLVPDDVFFDHLANRRFPAGNFIRTPDQLDYLQEPDVFHDVFGHVPMLADPVFADYMVAYGEGGLRSL
KFDALKQLARLYWYTVEFGLIREAGGLRIYGAGIVSSYAESVFALDSESPNRLGFDLARVMRTDYRIDDFQQNYFVIDSL
EQLLDITVNTDFAPLYAANAALPPIPIADILPDDKVITRGTQEYAAAKA

Sequences:

>Translated_289_residues
MESRFTHVHETPPPGAAADWTISQNWDAFTADEHAMWDRLFARQSAMLPGRAADAFMRGIDVLKLEKPGIPDYRELNARL
MAATGWQVVAVPGLVPDDVFFDHLANRRFPAGNFIRTPDQLDYLQEPDVFHDVFGHVPMLADPVFADYMVAYGEGGLRSL
KFDALKQLARLYWYTVEFGLIREAGGLRIYGAGIVSSYAESVFALDSESPNRLGFDLARVMRTDYRIDDFQQNYFVIDSL
EQLLDITVNTDFAPLYAANAALPPIPIADILPDDKVITRGTQEYAAAKA
>Mature_289_residues
MESRFTHVHETPPPGAAADWTISQNWDAFTADEHAMWDRLFARQSAMLPGRAADAFMRGIDVLKLEKPGIPDYRELNARL
MAATGWQVVAVPGLVPDDVFFDHLANRRFPAGNFIRTPDQLDYLQEPDVFHDVFGHVPMLADPVFADYMVAYGEGGLRSL
KFDALKQLARLYWYTVEFGLIREAGGLRIYGAGIVSSYAESVFALDSESPNRLGFDLARVMRTDYRIDDFQQNYFVIDSL
EQLLDITVNTDFAPLYAANAALPPIPIADILPDDKVITRGTQEYAAAKA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4759248, Length=265, Percent_Identity=29.811320754717, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI88900505, Length=221, Percent_Identity=32.1266968325792, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI88900501, Length=221, Percent_Identity=32.1266968325792, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI88900503, Length=221, Percent_Identity=32.1266968325792, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI31795563, Length=218, Percent_Identity=31.651376146789, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4557819, Length=218, Percent_Identity=30.2752293577982, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=222, Percent_Identity=32.4324324324324, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17531391, Length=220, Percent_Identity=34.0909090909091, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI115532103, Length=231, Percent_Identity=29.004329004329, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115533973, Length=231, Percent_Identity=29.004329004329, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71980731, Length=151, Percent_Identity=27.8145695364238, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62472054, Length=227, Percent_Identity=33.0396475770925, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24660393, Length=227, Percent_Identity=33.0396475770925, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136776, Length=219, Percent_Identity=31.0502283105023, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17136774, Length=219, Percent_Identity=31.0502283105023, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24654994, Length=175, Percent_Identity=33.1428571428571, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 32370; Mature: 32370

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRFTHVHETPPPGAAADWTISQNWDAFTADEHAMWDRLFARQSAMLPGRAADAFMRGI
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCC
DVLKLEKPGIPDYRELNARLMAATGWQVVAVPGLVPDDVFFDHLANRRFPAGNFIRTPDQ
CEEEECCCCCCCHHHHCCEEEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHH
LDYLQEPDVFHDVFGHVPMLADPVFADYMVAYGEGGLRSLKFDALKQLARLYWYTVEFGL
HHHCCCCHHHHHHHCCCCHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IREAGGLRIYGAGIVSSYAESVFALDSESPNRLGFDLARVMRTDYRIDDFQQNYFVIDSL
EECCCCEEEEEHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEHHHH
EQLLDITVNTDFAPLYAANAALPPIPIADILPDDKVITRGTQEYAAAKA
HHHHHHHCCCCCCHHHCCCCCCCCCCHHHCCCCCCHHHCCCHHHHHCCC
>Mature Secondary Structure
MESRFTHVHETPPPGAAADWTISQNWDAFTADEHAMWDRLFARQSAMLPGRAADAFMRGI
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCC
DVLKLEKPGIPDYRELNARLMAATGWQVVAVPGLVPDDVFFDHLANRRFPAGNFIRTPDQ
CEEEECCCCCCCHHHHCCEEEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCHH
LDYLQEPDVFHDVFGHVPMLADPVFADYMVAYGEGGLRSLKFDALKQLARLYWYTVEFGL
HHHCCCCHHHHHHHCCCCHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IREAGGLRIYGAGIVSSYAESVFALDSESPNRLGFDLARVMRTDYRIDDFQQNYFVIDSL
EECCCCEEEEEHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEHHHH
EQLLDITVNTDFAPLYAANAALPPIPIADILPDDKVITRGTQEYAAAKA
HHHHHHHCCCCCCHHHCCCCCCCCCCHHHCCCCCCHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]