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The map label for this gene is fabG [C]

Identifier: 103486024

GI number: 103486024

Start: 545637

End: 546539

Strand: Reverse

Name: fabG [C]

Synonym: Sala_0531

Alternate gene names: 103486024

Gene position: 546539-545637 (Counterclockwise)

Preceding gene: 103486026

Following gene: 103486023

Centisome position: 16.34

GC content: 65.67

Gene sequence:

>903_bases
ATGACGATCAATTTTGACGGCCGCGTTGCCATTGTCACCGGCGCGGGCGGCGGGCTTGGCCGCGCCTATGCGCTCGAACT
CGCGCGGCGCGGCGCCAAGGTCGTGGTCAACGATCTCGGCGGTGCGCGCGACGGCACCGGCCATTCGGACGCGGCGCTTG
CGGTGGTCGAGGAAATCCGCGCCGCGGGCGGCACCGCCATGCCCGACGGCGGCAGCGTCACCGAATATGAACAGATGGTC
GAAATGGTCGCCAAGGCGAAGGAGGAATGGGGCGGCGTCCACATCCTGATCAACAACGCCGGCATCCTGCGCGACAAGAG
CTTTGCCAAGATGGACCCCGCCGATTTCGACCTGGTGGTCAAGGTCCACCTGCTCGGCAGCGCCTATGTCACCAAGGCGT
GCTGGGACATCATGCGCGACCAGGCCTATGGCCGCATCCTGATGACCGCCTCCTCGACCGGCCTTTACGGCAATTTTGGG
CAGGCGAACTATGGCGCGGCGAAGCTGGGCCTCGCGGGGCTCACCAAGACGCTCCACCTCGAAGGCGCGAAATATAATAT
CCGCTGCAACACGATCGCCCCCGTTGCGGGCACCCGGATGACCGAGGATATTTTCCCCGCCGAACTGTTCGAAAAGTTCA
CTCCCGCAAATGTCGTGCCGGCCGCGCTCTATCTCGTCAGCGAGGATGCGCCGACCAACATGATCATCGGCGCGGGCGCG
GGCGCCTATCACGCCGCCTATGTCACCATGACCCCCGGCGTGGCGCTGCCCGAGGGCGAGCGCACCCCCGAAGGCGTCGC
CGCGGCGTGGGACAAGATCATCGACCGCACCGGCGACACCGTCCCGCAATCGGGCAGCGAACAGTCGATGAATGTGATGA
GGGCACTGATGGCGCTGGGGTGA

Upstream 100 bases:

>100_bases
CGCTCTTTTTCCTGACCCCTTGCCAGCGGGGCGCGACGGGCTAAGGACGTTCCAGTTTTTTCGGGCAACCTTTTCAGAGG
GCCCTTTGCGGGAGACCATC

Downstream 100 bases:

>100_bases
TAACGACCACGCTCCCCCTTGTTGGGGGAGGCAGCGAGACTTGGCGGCTTGCCGCCTAGTCGCAGCGGTGGGGGTGCGGT
CTCAGCCTGACACTAACCAT

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTINFDGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGARDGTGHSDAALAVVEEIRAAGGTAMPDGGSVTEYEQMV
EMVAKAKEEWGGVHILINNAGILRDKSFAKMDPADFDLVVKVHLLGSAYVTKACWDIMRDQAYGRILMTASSTGLYGNFG
QANYGAAKLGLAGLTKTLHLEGAKYNIRCNTIAPVAGTRMTEDIFPAELFEKFTPANVVPAALYLVSEDAPTNMIIGAGA
GAYHAAYVTMTPGVALPEGERTPEGVAAAWDKIIDRTGDTVPQSGSEQSMNVMRALMALG

Sequences:

>Translated_300_residues
MTINFDGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGARDGTGHSDAALAVVEEIRAAGGTAMPDGGSVTEYEQMV
EMVAKAKEEWGGVHILINNAGILRDKSFAKMDPADFDLVVKVHLLGSAYVTKACWDIMRDQAYGRILMTASSTGLYGNFG
QANYGAAKLGLAGLTKTLHLEGAKYNIRCNTIAPVAGTRMTEDIFPAELFEKFTPANVVPAALYLVSEDAPTNMIIGAGA
GAYHAAYVTMTPGVALPEGERTPEGVAAAWDKIIDRTGDTVPQSGSEQSMNVMRALMALG
>Mature_299_residues
TINFDGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGARDGTGHSDAALAVVEEIRAAGGTAMPDGGSVTEYEQMVE
MVAKAKEEWGGVHILINNAGILRDKSFAKMDPADFDLVVKVHLLGSAYVTKACWDIMRDQAYGRILMTASSTGLYGNFGQ
ANYGAAKLGLAGLTKTLHLEGAKYNIRCNTIAPVAGTRMTEDIFPAELFEKFTPANVVPAALYLVSEDAPTNMIIGAGAG
AYHAAYVTMTPGVALPEGERTPEGVAAAWDKIIDRTGDTVPQSGSEQSMNVMRALMALG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=298, Percent_Identity=48.993288590604, Blast_Score=262, Evalue=2e-70,
Organism=Homo sapiens, GI15277342, Length=245, Percent_Identity=31.4285714285714, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI40254992, Length=211, Percent_Identity=31.7535545023697, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4503817, Length=190, Percent_Identity=27.3684210526316, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI40807363, Length=200, Percent_Identity=32, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI25282469, Length=257, Percent_Identity=25.6809338521401, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40254986, Length=171, Percent_Identity=28.6549707602339, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI32483357, Length=193, Percent_Identity=31.0880829015544, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI210032110, Length=192, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI109715829, Length=252, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=192, Percent_Identity=36.9791666666667, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87082100, Length=208, Percent_Identity=33.6538461538462, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787905, Length=237, Percent_Identity=29.535864978903, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789057, Length=211, Percent_Identity=30.8056872037915, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082160, Length=192, Percent_Identity=31.25, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790717, Length=234, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789208, Length=193, Percent_Identity=27.4611398963731, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786812, Length=192, Percent_Identity=28.125, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=298, Percent_Identity=46.6442953020134, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147288, Length=214, Percent_Identity=34.1121495327103, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=218, Percent_Identity=30.2752293577982, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=28.125, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=199, Percent_Identity=28.1407035175879, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=205, Percent_Identity=31.219512195122, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=29.9610894941634, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=200, Percent_Identity=33, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=197, Percent_Identity=27.4111675126904, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=176, Percent_Identity=27.8409090909091, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=28.2722513089005, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558628, Length=196, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322861, Length=278, Percent_Identity=49.2805755395683, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324126, Length=190, Percent_Identity=31.0526315789474, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859837, Length=278, Percent_Identity=47.841726618705, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=32.6424870466321, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24639444, Length=191, Percent_Identity=36.6492146596859, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24640492, Length=193, Percent_Identity=26.4248704663212, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355631, Length=179, Percent_Identity=30.1675977653631, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357673, Length=193, Percent_Identity=28.4974093264249, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281364892, Length=196, Percent_Identity=26.0204081632653, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356301, Length=201, Percent_Identity=27.363184079602, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI23397609, Length=197, Percent_Identity=27.4111675126904, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581726, Length=177, Percent_Identity=29.3785310734463, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737361, Length=198, Percent_Identity=28.2828282828283, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31443; Mature: 31312

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00626 RCC1_2 ; PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTINFDGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGARDGTGHSDAALAVVEEIR
CEEECCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
AAGGTAMPDGGSVTEYEQMVEMVAKAKEEWGGVHILINNAGILRDKSFAKMDPADFDLVV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEEE
KVHLLGSAYVTKACWDIMRDQAYGRILMTASSTGLYGNFGQANYGAAKLGLAGLTKTLHL
EEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
EGAKYNIRCNTIAPVAGTRMTEDIFPAELFEKFTPANVVPAALYLVSEDAPTNMIIGAGA
CCCEEEEEECEECCCCCCCCCHHCCHHHHHHHCCCCCHHCEEEEEEECCCCCCEEEECCC
GAYHAAYVTMTPGVALPEGERTPEGVAAAWDKIIDRTGDTVPQSGSEQSMNVMRALMALG
CCEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TINFDGRVAIVTGAGGGLGRAYALELARRGAKVVVNDLGGARDGTGHSDAALAVVEEIR
EEECCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
AAGGTAMPDGGSVTEYEQMVEMVAKAKEEWGGVHILINNAGILRDKSFAKMDPADFDLVV
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEEE
KVHLLGSAYVTKACWDIMRDQAYGRILMTASSTGLYGNFGQANYGAAKLGLAGLTKTLHL
EEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
EGAKYNIRCNTIAPVAGTRMTEDIFPAELFEKFTPANVVPAALYLVSEDAPTNMIIGAGA
CCCEEEEEECEECCCCCCCCCHHCCHHHHHHHCCCCCHHCEEEEEEECCCCCCEEEECCC
GAYHAAYVTMTPGVALPEGERTPEGVAAAWDKIIDRTGDTVPQSGSEQSMNVMRALMALG
CCEEEEEEEECCCEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]