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The map label for this gene is comEC [H]

Identifier: 99080975

GI number: 99080975

Start: 1219862

End: 1221880

Strand: Direct

Name: comEC [H]

Synonym: TM1040_1134

Alternate gene names: 99080975

Gene position: 1219862-1221880 (Clockwise)

Preceding gene: 99080971

Following gene: 99080983

Centisome position: 38.11

GC content: 65.03

Gene sequence:

>2019_bases
GTGTTTGGCGCTCTTGATGCAAGGCTGCAGGCCCAGCGGGGACATCTGTTTCCATGGGTGCCGGTCTTCTTTGGCCTTGG
GATCGGACTGTATTTTGCCTCTCCCATGGAACCCCAGCGGTTGCATTACCTTGGCATCCTGTTTGCGGCGGTGGGGCTCG
GGGTGCGCGCGCGTCGTGGCGACGGGGTTGGTCTCCTTGCGGGGGCGTTGCTCTTGGTGGGGCTTGGGTTTTGCTACATG
GGGCTGCGCGCGCATCAGGTTGGCGCGCCGGTTCTGAGCTATCGCTATTATGGCCCGGTCGAAGGGCAGGTGCTTGCGGT
GGATCGCTCGGCTTCGGATGCGATGCGGATCACGCTCGGGTCGGTGCGGCTTCGGGATATGTCGCCCGCGCGGACGCCGG
ACAGGGTGCGAATTTCGCTCTTTGAGGGCTCCGCCCCAATGCCCGGATCATGGGTGATGACCACCGCCAATCTCTCGCCC
CCGCAGGGACCCGCCGAACCGGGCGGCTTTGATTTTCGCCGTCATGCCTGGTTCCTCGGACTGGGGGCTGTCGGCTACAG
CCGTGTGCCGGTGTTGCGGACCGGTCCACCCGAGGTCTTGCCGGTGGCGACCTTGCGGGCGCAGCTTTCTGAGCGGGTGC
GGGCGGCCATGCCGGCTGACACAGGCGGCGTCGCCACAGCGCTTATGACCGGGGACCGGGCGCATGTGCCGCGACAGGTG
ACCGAGAACCTACGCGCGAGCAATCTGGCGCATCTTCTTGCGATTTCGGGCTTGCATATGGGGCTGTTTGCAGGGGTGGT
CTTTGCCAGTCTGAGGCGTTGCTTTGCGCTCTGCCCGCCGATTGCCCTGCGCTGGCCGGTCAAGAAACTCTCGGCGGCTG
TGGCCCTTGTCGCGAGCTTTGGCTACCTGCTCCTCTCGGGCGCCAATGTCGCCACCGAACGTGCCTTCCTGATGGTGGCG
GTGATGCTGGTCGCGGTGATGCTGGATCGGCGGGCGATCTCGGTACGGGCCGTCGCCCTGGCGGCCATGCTTGTACTGCT
GCGTCGCCCCGAAAGCCTGCTGAGTGCGGGGTTTCAGATGAGTTTTTCGGCAACCCTTGCGCTTGTTGTGGCCTTTCAGC
TGTTGCAACCCTGGTTCCGCCCCGGGCGAGGAGGCGTATTGGGGGCGGCGGCACGCTGGGGGCTTGCGCTATTGGTGTCG
TCGCTGGTGGCAGGCCTTGCCACAGCCCCGTTTGGGGCGGCGCATTTCAACATGATCTCGCACTATGGGCTCTTGGCTAA
TCTGGCGGCGGTGCCGGTCATGGGCGCGGTGGTGGTGCCGGGCGCAGTGCTGGCGATCTGCCTCGCGCCCATCGGGGCCA
GCGCGGTTGGATTCTGGATCATGTCGCAGGGCATCGCATGGATCCTGAAGGTGGCAGAGACCGTGGCCACATGGCCGGGC
GCGCGCGGTCATGTAGTTGCGCCCGAGGCGTGGATCCTGCCGGTTCTGGTGGCGGGCGCCTTGTGGCTGCTTTTGTGGCA
GGGGCGATTTCGTTGGGCAGGGTTGATCCCAATTGCGCTGGCGCTTGTGGTCTGGCCATTCTCCCCCCGGCCCGAGGTTC
TGATTTCTGCCGATGGCGGGCTTGTGGGCGTGATGACAGAGACAGGGCGCGCGTTGTCGCGCCCAAGCGGCAAGAGTTTT
GTTGCAGGGATCTGGCTCGAGAATGACGGCGACGGGATGGACCAGGCCCGCGCCTATCGCCGTATTCCCGAGGGGCGAGA
TGGAAAAGTTCAGATCTTCCAATCCATTGGGAGGCGTTTTGTGCATGTGTTGGGCAAGACGGGATTGCGCGCATGGCAAC
CAAGCTGCGCGCGAGGAGAGGTCATCATCCTCTCGATAGAGGTCGAGCCCCCCGCAGCCGGAGACTGCCTCTGGCTGACG
CCCAGACAACTGCGGGAAACGGGCAGCATCGCCTTTGCCGGAAATGGCGCGATGATCACCGCCAATGGGCAGGCGCGCCG
CTTGTGGTCGGCGCCCTGA

Upstream 100 bases:

>100_bases
GACCGGTTGGGACATATGGGGCATTTACCTTTTGGAAACCTTGTGGGGTCAACGTTTGTCGCCTGTGTACCGAGCCAGAA
GGCAGGGAGCAAGCGTGCGC

Downstream 100 bases:

>100_bases
ATAAACGCCCTGACAAAAACGCCCGGCCACAGAATATGCGGCCGAGCGAGAAATGGTGCACGCAGGTGTTTGCTCAGTAG
GTGCGGATCAGCCCCACCAG

Product: ComEC/Rec2-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MFGALDARLQAQRGHLFPWVPVFFGLGIGLYFASPMEPQRLHYLGILFAAVGLGVRARRGDGVGLLAGALLLVGLGFCYM
GLRAHQVGAPVLSYRYYGPVEGQVLAVDRSASDAMRITLGSVRLRDMSPARTPDRVRISLFEGSAPMPGSWVMTTANLSP
PQGPAEPGGFDFRRHAWFLGLGAVGYSRVPVLRTGPPEVLPVATLRAQLSERVRAAMPADTGGVATALMTGDRAHVPRQV
TENLRASNLAHLLAISGLHMGLFAGVVFASLRRCFALCPPIALRWPVKKLSAAVALVASFGYLLLSGANVATERAFLMVA
VMLVAVMLDRRAISVRAVALAAMLVLLRRPESLLSAGFQMSFSATLALVVAFQLLQPWFRPGRGGVLGAAARWGLALLVS
SLVAGLATAPFGAAHFNMISHYGLLANLAAVPVMGAVVVPGAVLAICLAPIGASAVGFWIMSQGIAWILKVAETVATWPG
ARGHVVAPEAWILPVLVAGALWLLLWQGRFRWAGLIPIALALVVWPFSPRPEVLISADGGLVGVMTETGRALSRPSGKSF
VAGIWLENDGDGMDQARAYRRIPEGRDGKVQIFQSIGRRFVHVLGKTGLRAWQPSCARGEVIILSIEVEPPAAGDCLWLT
PRQLRETGSIAFAGNGAMITANGQARRLWSAP

Sequences:

>Translated_672_residues
MFGALDARLQAQRGHLFPWVPVFFGLGIGLYFASPMEPQRLHYLGILFAAVGLGVRARRGDGVGLLAGALLLVGLGFCYM
GLRAHQVGAPVLSYRYYGPVEGQVLAVDRSASDAMRITLGSVRLRDMSPARTPDRVRISLFEGSAPMPGSWVMTTANLSP
PQGPAEPGGFDFRRHAWFLGLGAVGYSRVPVLRTGPPEVLPVATLRAQLSERVRAAMPADTGGVATALMTGDRAHVPRQV
TENLRASNLAHLLAISGLHMGLFAGVVFASLRRCFALCPPIALRWPVKKLSAAVALVASFGYLLLSGANVATERAFLMVA
VMLVAVMLDRRAISVRAVALAAMLVLLRRPESLLSAGFQMSFSATLALVVAFQLLQPWFRPGRGGVLGAAARWGLALLVS
SLVAGLATAPFGAAHFNMISHYGLLANLAAVPVMGAVVVPGAVLAICLAPIGASAVGFWIMSQGIAWILKVAETVATWPG
ARGHVVAPEAWILPVLVAGALWLLLWQGRFRWAGLIPIALALVVWPFSPRPEVLISADGGLVGVMTETGRALSRPSGKSF
VAGIWLENDGDGMDQARAYRRIPEGRDGKVQIFQSIGRRFVHVLGKTGLRAWQPSCARGEVIILSIEVEPPAAGDCLWLT
PRQLRETGSIAFAGNGAMITANGQARRLWSAP
>Mature_672_residues
MFGALDARLQAQRGHLFPWVPVFFGLGIGLYFASPMEPQRLHYLGILFAAVGLGVRARRGDGVGLLAGALLLVGLGFCYM
GLRAHQVGAPVLSYRYYGPVEGQVLAVDRSASDAMRITLGSVRLRDMSPARTPDRVRISLFEGSAPMPGSWVMTTANLSP
PQGPAEPGGFDFRRHAWFLGLGAVGYSRVPVLRTGPPEVLPVATLRAQLSERVRAAMPADTGGVATALMTGDRAHVPRQV
TENLRASNLAHLLAISGLHMGLFAGVVFASLRRCFALCPPIALRWPVKKLSAAVALVASFGYLLLSGANVATERAFLMVA
VMLVAVMLDRRAISVRAVALAAMLVLLRRPESLLSAGFQMSFSATLALVVAFQLLQPWFRPGRGGVLGAAARWGLALLVS
SLVAGLATAPFGAAHFNMISHYGLLANLAAVPVMGAVVVPGAVLAICLAPIGASAVGFWIMSQGIAWILKVAETVATWPG
ARGHVVAPEAWILPVLVAGALWLLLWQGRFRWAGLIPIALALVVWPFSPRPEVLISADGGLVGVMTETGRALSRPSGKSF
VAGIWLENDGDGMDQARAYRRIPEGRDGKVQIFQSIGRRFVHVLGKTGLRAWQPSCARGEVIILSIEVEPPAAGDCLWLT
PRQLRETGSIAFAGNGAMITANGQARRLWSAP

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=420, Percent_Identity=25.7142857142857, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 71434; Mature: 71434

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGALDARLQAQRGHLFPWVPVFFGLGIGLYFASPMEPQRLHYLGILFAAVGLGVRARRG
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECC
DGVGLLAGALLLVGLGFCYMGLRAHQVGAPVLSYRYYGPVEGQVLAVDRSASDAMRITLG
CCHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHEEEEECCCCCEEEEEECCCCCCEEEEEC
SVRLRDMSPARTPDRVRISLFEGSAPMPGSWVMTTANLSPPQGPAEPGGFDFRRHAWFLG
CEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHEEEE
LGAVGYSRVPVLRTGPPEVLPVATLRAQLSERVRAAMPADTGGVATALMTGDRAHVPRQV
ECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHCCCHHH
TENLRASNLAHLLAISGLHMGLFAGVVFASLRRCFALCPPIALRWPVKKLSAAVALVASF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHH
GYLLLSGANVATERAFLMVAVMLVAVMLDRRAISVRAVALAAMLVLLRRPESLLSAGFQM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCH
SFSATLALVVAFQLLQPWFRPGRGGVLGAAARWGLALLVSSLVAGLATAPFGAAHFNMIS
HHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
HYGLLANLAAVPVMGAVVVPGAVLAICLAPIGASAVGFWIMSQGIAWILKVAETVATWPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARGHVVAPEAWILPVLVAGALWLLLWQGRFRWAGLIPIALALVVWPFSPRPEVLISADGG
CCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCC
LVGVMTETGRALSRPSGKSFVAGIWLENDGDGMDQARAYRRIPEGRDGKVQIFQSIGRRF
EEEEEECCCHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VHVLGKTGLRAWQPSCARGEVIILSIEVEPPAAGDCLWLTPRQLRETGSIAFAGNGAMIT
HHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEECHHHHHHCCCEEEECCCEEEE
ANGQARRLWSAP
ECCCCCCCCCCC
>Mature Secondary Structure
MFGALDARLQAQRGHLFPWVPVFFGLGIGLYFASPMEPQRLHYLGILFAAVGLGVRARRG
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECC
DGVGLLAGALLLVGLGFCYMGLRAHQVGAPVLSYRYYGPVEGQVLAVDRSASDAMRITLG
CCHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHEEEEECCCCCEEEEEECCCCCCEEEEEC
SVRLRDMSPARTPDRVRISLFEGSAPMPGSWVMTTANLSPPQGPAEPGGFDFRRHAWFLG
CEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHEEEE
LGAVGYSRVPVLRTGPPEVLPVATLRAQLSERVRAAMPADTGGVATALMTGDRAHVPRQV
ECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHCCCHHH
TENLRASNLAHLLAISGLHMGLFAGVVFASLRRCFALCPPIALRWPVKKLSAAVALVASF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHH
GYLLLSGANVATERAFLMVAVMLVAVMLDRRAISVRAVALAAMLVLLRRPESLLSAGFQM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCH
SFSATLALVVAFQLLQPWFRPGRGGVLGAAARWGLALLVSSLVAGLATAPFGAAHFNMIS
HHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
HYGLLANLAAVPVMGAVVVPGAVLAICLAPIGASAVGFWIMSQGIAWILKVAETVATWPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
ARGHVVAPEAWILPVLVAGALWLLLWQGRFRWAGLIPIALALVVWPFSPRPEVLISADGG
CCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCC
LVGVMTETGRALSRPSGKSFVAGIWLENDGDGMDQARAYRRIPEGRDGKVQIFQSIGRRF
EEEEEECCCHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VHVLGKTGLRAWQPSCARGEVIILSIEVEPPAAGDCLWLTPRQLRETGSIAFAGNGAMIT
HHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCEEEECHHHHHHCCCEEEECCCEEEE
ANGQARRLWSAP
ECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]