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The map label for this gene is fabF [H]

Identifier: 99080895

GI number: 99080895

Start: 1133065

End: 1134333

Strand: Direct

Name: fabF [H]

Synonym: TM1040_1054

Alternate gene names: 99080895

Gene position: 1133065-1134333 (Clockwise)

Preceding gene: 99080894

Following gene: 99080896

Centisome position: 35.4

GC content: 61.23

Gene sequence:

>1269_bases
ATGCGTCGAGTAGTAGTTACCGGTCTGGGCCTGGTGACCCCCCTGGCATCTGGGGTTGAGGAAACTTGGGCACGTCTTCT
GGATGGCCAGTCCGGCGCGGGCCCCATCACTCTGTTTGATGCAGAGGCCAGCGGTGTTGCAACAACCTATGCCTGTGAAG
TGCCCCGTGGCGACGGCAGCAATGGCACCTTCAATCCTGACGATTGGGTTGTGAAAAAAGATCAAAAGAAGATCGACGAT
TTCATCCTCTACGGGATCGCCGCCGCTGAAATGGCCGTGAAGGACGCAGGCTGGACCCCCGAAGCCGAAGAGGACCGTCT
GCGCACCGGCGTGATGATCGGCTCCGGTATCGGTGGTCTGAGCTCGATTGCAGATACAGCCGTCATGATTAAGGAAAAGG
GCCCGCGTCGCGTGTCTCCGTTCTTTATTCCCGGCGCGCTGATCAACCTCATCTCCGGTCAGGTCTCCATCCGTCATGGC
TTCAAAGGTCCAAACCACTCGGTTGTGACCGCGTGTTCCACGGGCGCTCATGCGATTGGCGATGCGTCGCGTCTCATTAA
ATCCGGCGATGCGGATGTGATGATCGCGGGCGGGGCCGAGGCGGCAATCTGCGAGATCGGCATTGCGGGATTTAACGCGT
GCAAGGCGCTTTCGACGAAATATGCCGAGGATCCCACCAAAGCCTCGCGTCCCTATGATGCGGACCGTGACGGCTTCGTG
ATGGGCGAGGGCGCGGGCATCGTGGTGCTCGAGGAATACGAACACGCCAAGGCGCGCGGCGCCAAGATCTACGGCGAGGT
TCTGGGCTATGGTCTGTCGGGCGATGCCTATCACATCACCGCCCCCTCCGAGGATGGCGAAGGCGGCGAACGCTCCATGC
GCGCTGCACTGGCCAATGCGGGGCTGAGCGCGGCAGATGTCGACTATATCAACGCGCATGGCACCTCCACCATGGCCGAC
ACCATCGAGCTTGGTGCCGTGGAGCGTCTGTTGGGCGATCACGCCAAGAATGCGACGATGTCCTCGACCAAATCCGCAAC
CGGGCACCTTTTGGGCGCGGCGGGTGCGATCGAGGCGATCTTCTCCATTCTGGCGATCCGCGATCAGGTGGCCCCGCCCA
CCATCAACCTCGACACCCCTGCCGTGGAAACGCCGGTTGATCTGGCCCCCAATGCCAAGCGCGAACGCAAGATCGACGTG
GCGCTGTCCAACTCCTTCGGCTTTGGCGGCACCAATGCTTCGGTGGTCTTCGGGAAAGTGAGCGACTGA

Upstream 100 bases:

>100_bases
TATGCCGGAACGCCCCGCGCGGCTTCCTGCACTTGCGCCCTTTGGTCATTCCAAGCTATTTGGGTGGGCAAATCGCCTGA
AGCGCTAAGGAGAGCAAGGA

Downstream 100 bases:

>100_bases
TATGTGGCGCAGTCTGGCCTCGAACATGCTGACGATCCTGATCGTCGGCCTGTTTCTCTTCGCGGGGGTGATCCTGTGGG
GCAAGAATGAATACACCGCC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MRRVVVTGLGLVTPLASGVEETWARLLDGQSGAGPITLFDAEASGVATTYACEVPRGDGSNGTFNPDDWVVKKDQKKIDD
FILYGIAAAEMAVKDAGWTPEAEEDRLRTGVMIGSGIGGLSSIADTAVMIKEKGPRRVSPFFIPGALINLISGQVSIRHG
FKGPNHSVVTACSTGAHAIGDASRLIKSGDADVMIAGGAEAAICEIGIAGFNACKALSTKYAEDPTKASRPYDADRDGFV
MGEGAGIVVLEEYEHAKARGAKIYGEVLGYGLSGDAYHITAPSEDGEGGERSMRAALANAGLSAADVDYINAHGTSTMAD
TIELGAVERLLGDHAKNATMSSTKSATGHLLGAAGAIEAIFSILAIRDQVAPPTINLDTPAVETPVDLAPNAKRERKIDV
ALSNSFGFGGTNASVVFGKVSD

Sequences:

>Translated_422_residues
MRRVVVTGLGLVTPLASGVEETWARLLDGQSGAGPITLFDAEASGVATTYACEVPRGDGSNGTFNPDDWVVKKDQKKIDD
FILYGIAAAEMAVKDAGWTPEAEEDRLRTGVMIGSGIGGLSSIADTAVMIKEKGPRRVSPFFIPGALINLISGQVSIRHG
FKGPNHSVVTACSTGAHAIGDASRLIKSGDADVMIAGGAEAAICEIGIAGFNACKALSTKYAEDPTKASRPYDADRDGFV
MGEGAGIVVLEEYEHAKARGAKIYGEVLGYGLSGDAYHITAPSEDGEGGERSMRAALANAGLSAADVDYINAHGTSTMAD
TIELGAVERLLGDHAKNATMSSTKSATGHLLGAAGAIEAIFSILAIRDQVAPPTINLDTPAVETPVDLAPNAKRERKIDV
ALSNSFGFGGTNASVVFGKVSD
>Mature_422_residues
MRRVVVTGLGLVTPLASGVEETWARLLDGQSGAGPITLFDAEASGVATTYACEVPRGDGSNGTFNPDDWVVKKDQKKIDD
FILYGIAAAEMAVKDAGWTPEAEEDRLRTGVMIGSGIGGLSSIADTAVMIKEKGPRRVSPFFIPGALINLISGQVSIRHG
FKGPNHSVVTACSTGAHAIGDASRLIKSGDADVMIAGGAEAAICEIGIAGFNACKALSTKYAEDPTKASRPYDADRDGFV
MGEGAGIVVLEEYEHAKARGAKIYGEVLGYGLSGDAYHITAPSEDGEGGERSMRAALANAGLSAADVDYINAHGTSTMAD
TIELGAVERLLGDHAKNATMSSTKSATGHLLGAAGAIEAIFSILAIRDQVAPPTINLDTPAVETPVDLAPNAKRERKIDV
ALSNSFGFGGTNASVVFGKVSD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=51.3126491646778, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI223972627, Length=190, Percent_Identity=47.8947368421053, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI41872631, Length=434, Percent_Identity=25.1152073732719, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787337, Length=421, Percent_Identity=50.8313539192399, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1788663, Length=425, Percent_Identity=37.6470588235294, Blast_Score=252, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=430, Percent_Identity=38.1395348837209, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71983535, Length=269, Percent_Identity=42.3791821561338, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI212642053, Length=383, Percent_Identity=26.6318537859008, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=421, Percent_Identity=24.2280285035629, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=37.9775280898876, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=46.6981132075472, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19920632, Length=365, Percent_Identity=25.7534246575342, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221330659, Length=365, Percent_Identity=25.7534246575342, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=23.953488372093, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43598; Mature: 43598

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGLVTPLASGVEETWARLLDGQSGAGPITLFDAEASGVATTYACEVPRGDGS
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCC
NGTFNPDDWVVKKDQKKIDDFILYGIAAAEMAVKDAGWTPEAEEDRLRTGVMIGSGIGGL
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCEEEECCCCCH
SSIADTAVMIKEKGPRRVSPFFIPGALINLISGQVSIRHGFKGPNHSVVTACSTGAHAIG
HHHHHHEEEEECCCCCCCCCEECCHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCHHH
DASRLIKSGDADVMIAGGAEAAICEIGIAGFNACKALSTKYAEDPTKASRPYDADRDGFV
HHHHHHHCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
MGEGAGIVVLEEYEHAKARGAKIYGEVLGYGLSGDAYHITAPSEDGEGGERSMRAALANA
EECCCCEEEEECCCHHHHCCCCEEHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
GLSAADVDYINAHGTSTMADTIELGAVERLLGDHAKNATMSSTKSATGHLLGAAGAIEAI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEHHHHHHHH
FSILAIRDQVAPPTINLDTPAVETPVDLAPNAKRERKIDVALSNSFGFGGTNASVVFGKV
HHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEC
SD
CC
>Mature Secondary Structure
MRRVVVTGLGLVTPLASGVEETWARLLDGQSGAGPITLFDAEASGVATTYACEVPRGDGS
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCC
NGTFNPDDWVVKKDQKKIDDFILYGIAAAEMAVKDAGWTPEAEEDRLRTGVMIGSGIGGL
CCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCEEEECCCCCH
SSIADTAVMIKEKGPRRVSPFFIPGALINLISGQVSIRHGFKGPNHSVVTACSTGAHAIG
HHHHHHEEEEECCCCCCCCCEECCHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCHHH
DASRLIKSGDADVMIAGGAEAAICEIGIAGFNACKALSTKYAEDPTKASRPYDADRDGFV
HHHHHHHCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
MGEGAGIVVLEEYEHAKARGAKIYGEVLGYGLSGDAYHITAPSEDGEGGERSMRAALANA
EECCCCEEEEECCCHHHHCCCCEEHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
GLSAADVDYINAHGTSTMADTIELGAVERLLGDHAKNATMSSTKSATGHLLGAAGAIEAI
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEHHHHHHHH
FSILAIRDQVAPPTINLDTPAVETPVDLAPNAKRERKIDVALSNSFGFGGTNASVVFGKV
HHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEC
SD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]